#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60663-2 uniprotkb:Q02962 intact:EBI-10258690|ensembl:ENSP00000436930 intact:EBI-1805765|uniprotkb:Q15105|uniprotkb:Q15110|uniprotkb:Q15837|uniprotkb:Q5SZP2|uniprotkb:Q5SZP3|ensembl:ENSP00000396259 psi-mi:o60663-2(display_long)|uniprotkb:LIM/homeobox protein 1.2(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1B(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:LMX1B(gene name)|psi-mi:LMX1B(display_short) psi-mi:pax2_human(display_long)|uniprotkb:PAX2(gene name)|psi-mi:PAX2(display_short) psi-mi:"MI:0018"(two hybrid) Marini et al. (2005) imex:IM-25722|pubmed:15785774 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13950890|imex:IM-25722-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136944(gene)|ensembl:ENST00000526117(transcript)|intact:EBI-296386(isoform-parent)|uniprotkb:O60663-2(isoform-parent) refseq:NP_001291498.1|refseq:NP_003979.2|refseq:NP_000269.3|refseq:NP_003978.3|refseq:NP_003980.3|refseq:NP_003981.3|interpro:IPR043565|ensembl:ENSG00000075891(gene)|ensembl:ENST00000428433(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002072"(optic cup morphogenesis involved in camera-type eye development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0007568"(aging)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0021554"(optic nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035566"(regulation of metanephros size)|go:"GO:0035799"(ureter maturation)|go:"GO:0039003"(pronephric field specification)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048793"(pronephros development)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0061360"(optic chiasma development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072189"(ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0072305"(negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900212"(negative regulation of mesenchymal cell apoptotic process involved in metanephros development)|go:"GO:1900215"(negative regulation of apoptotic process involved in metanephric collecting duct development)|go:"GO:1900218"(negative regulation of apoptotic process involved in metanephric nephron tubule development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000594"(positive regulation of metanephric DCT cell differentiation)|go:"GO:2000597"(positive regulation of optic nerve formation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|go:"GO:0072221"(metanephric distal convoluted tubule development)|interpro:IPR043182 - - - figure legend:1a and b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/03/17 2017/03/20 rogid:cuCwa39MvAWc7sWkxjHWeNZSKns9606 rogid:cIPeBYr4MR6pVuh5R1f57uIhzzc9606 rigid:an8f+egDJlM9DibrPUlDRQoUm0o false sufficient binding region:24-251|necessary binding region:48-275(IPR001781) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60663-2 uniprotkb:Q02962 intact:EBI-10258690|ensembl:ENSP00000436930 intact:EBI-1805765|uniprotkb:Q15105|uniprotkb:Q15110|uniprotkb:Q15837|uniprotkb:Q5SZP2|uniprotkb:Q5SZP3|ensembl:ENSP00000396259 psi-mi:o60663-2(display_long)|uniprotkb:LIM/homeobox protein 1.2(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1B(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:LMX1B(gene name)|psi-mi:LMX1B(display_short) psi-mi:pax2_human(display_long)|uniprotkb:PAX2(gene name)|psi-mi:PAX2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marini et al. (2005) imex:IM-25722|pubmed:15785774 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13950900|imex:IM-25722-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136944(gene)|ensembl:ENST00000526117(transcript)|intact:EBI-296386(isoform-parent)|uniprotkb:O60663-2(isoform-parent) refseq:NP_001291498.1|refseq:NP_003979.2|refseq:NP_000269.3|refseq:NP_003978.3|refseq:NP_003980.3|refseq:NP_003981.3|interpro:IPR043565|ensembl:ENSG00000075891(gene)|ensembl:ENST00000428433(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002072"(optic cup morphogenesis involved in camera-type eye development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0007568"(aging)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0021554"(optic nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035566"(regulation of metanephros size)|go:"GO:0035799"(ureter maturation)|go:"GO:0039003"(pronephric field specification)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048793"(pronephros development)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0061360"(optic chiasma development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072189"(ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0072305"(negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900212"(negative regulation of mesenchymal cell apoptotic process involved in metanephros development)|go:"GO:1900215"(negative regulation of apoptotic process involved in metanephric collecting duct development)|go:"GO:1900218"(negative regulation of apoptotic process involved in metanephric nephron tubule development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000594"(positive regulation of metanephric DCT cell differentiation)|go:"GO:2000597"(positive regulation of optic nerve formation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|go:"GO:0072221"(metanephric distal convoluted tubule development)|interpro:IPR043182 - - - figure legend:2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/03/17 2017/03/20 rogid:cuCwa39MvAWc7sWkxjHWeNZSKns9606 rogid:cIPeBYr4MR6pVuh5R1f57uIhzzc9606 rigid:an8f+egDJlM9DibrPUlDRQoUm0o false myc tag:?-?|sufficient binding region:24-395 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60663-2 uniprotkb:Q02962 intact:EBI-10258690|ensembl:ENSP00000436930 intact:EBI-1805765|uniprotkb:Q15105|uniprotkb:Q15110|uniprotkb:Q15837|uniprotkb:Q5SZP2|uniprotkb:Q5SZP3|ensembl:ENSP00000396259 psi-mi:o60663-2(display_long)|uniprotkb:LIM/homeobox protein 1.2(gene name synonym)|uniprotkb:LIM/homeobox protein LMX1B(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:LMX1B(gene name)|psi-mi:LMX1B(display_short) psi-mi:pax2_human(display_long)|uniprotkb:PAX2(gene name)|psi-mi:PAX2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marini et al. (2005) imex:IM-25722|pubmed:15785774 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13950909|imex:IM-25722-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136944(gene)|ensembl:ENST00000526117(transcript)|intact:EBI-296386(isoform-parent)|uniprotkb:O60663-2(isoform-parent) refseq:NP_001291498.1|refseq:NP_003979.2|refseq:NP_000269.3|refseq:NP_003978.3|refseq:NP_003980.3|refseq:NP_003981.3|interpro:IPR043565|ensembl:ENSG00000075891(gene)|ensembl:ENST00000428433(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002072"(optic cup morphogenesis involved in camera-type eye development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0007568"(aging)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0021554"(optic nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035566"(regulation of metanephros size)|go:"GO:0035799"(ureter maturation)|go:"GO:0039003"(pronephric field specification)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048793"(pronephros development)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0061360"(optic chiasma development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072189"(ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0072305"(negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900212"(negative regulation of mesenchymal cell apoptotic process involved in metanephros development)|go:"GO:1900215"(negative regulation of apoptotic process involved in metanephric collecting duct development)|go:"GO:1900218"(negative regulation of apoptotic process involved in metanephric nephron tubule development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000594"(positive regulation of metanephric DCT cell differentiation)|go:"GO:2000597"(positive regulation of optic nerve formation)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR022130|interpro:IPR036388|go:"GO:0072221"(metanephric distal convoluted tubule development)|interpro:IPR043182 - - - figure legend:2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2017/03/17 2017/03/20 rogid:cuCwa39MvAWc7sWkxjHWeNZSKns9606 rogid:cIPeBYr4MR6pVuh5R1f57uIhzzc9606 rigid:an8f+egDJlM9DibrPUlDRQoUm0o false myc tag:?-?|sufficient binding region:24-395 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)