#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0AES4	uniprotkb:P0AES4	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0071"(molecular sieving)	Costenaro et al. (2005)	pubmed:15698572|doi:10.1016/j.str.2004.12.011|imex:IM-14186	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15551445|imex:IM-14186-1|dip:DIP-102902E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:Utg4G1mMjCPFMSoWk7Nnx1bK7M4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AES4	uniprotkb:P0AES4	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0028"(cosedimentation in solution)	Costenaro et al. (2005)	pubmed:15698572|doi:10.1016/j.str.2004.12.011|imex:IM-14186	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15551461|imex:IM-14186-2|dip:DIP-102902E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:Utg4G1mMjCPFMSoWk7Nnx1bK7M4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AES4	uniprotkb:P0AES4	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0826"(x ray scattering)	Costenaro et al. (2005)	pubmed:15698572|doi:10.1016/j.str.2004.12.011|imex:IM-14186	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15551477|imex:IM-14186-3|dip:DIP-102902E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:Utg4G1mMjCPFMSoWk7Nnx1bK7M4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)