#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P13501 uniprotkb:P13501 intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921 intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921 psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym) psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Shaw et al. (2004) pubmed:15530372|doi:10.1016/j.str.2004.08.014|imex:IM-14246 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15532157|imex:IM-14246-1|dip:DIP-102971E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/04 2017/08/10 rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606 rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606 rigid:Xsrz4B6TnM75yabyArJiA9WlcNg false binding-associated region:24-91 binding-associated region:24-91 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)