#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O13144	uniprotkb:P27040	intact:EBI-15529595|ensembl:ENSDARP00000148686	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	psi-mi:o13144_danre(display_long)|uniprotkb:ndr2(gene name synonym)|uniprotkb:ndr1(gene name)|psi-mi:ndr1(display_short)	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529620|imex:IM-9320-1|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051094"(positive regulation of developmental process)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|ensembl:ENSDARG00000116539(gene)|ensembl:ENSDART00000181236(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009306"(protein secretion)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016485"(protein processing)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|refseq:NP_571041.1|dip:DIP-46066N	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:Aw+waiya2cBwK6E0tVcjXWVUsBY7955	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O13144	uniprotkb:P36896	intact:EBI-15529595|ensembl:ENSDARP00000148686	intact:EBI-1384128|uniprotkb:Q15479|uniprotkb:Q15480|uniprotkb:Q15481|uniprotkb:Q15482|uniprotkb:B7Z5L8|uniprotkb:B7Z5W5|ensembl:ENSP00000257963	psi-mi:o13144_danre(display_long)|uniprotkb:ndr2(gene name synonym)|uniprotkb:ndr1(gene name)|psi-mi:ndr1(display_short)	psi-mi:acv1b_human(display_long)|uniprotkb:ACVRLK4(gene name synonym)|uniprotkb:Activin receptor type IB(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R2(gene name synonym)|uniprotkb:Activin receptor-like kinase 4(gene name synonym)|uniprotkb:ACVR1B(gene name)|psi-mi:ACVR1B(display_short)|uniprotkb:ALK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529620|imex:IM-9320-1|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051094"(positive regulation of developmental process)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|ensembl:ENSDARG00000116539(gene)|ensembl:ENSDART00000181236(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009306"(protein secretion)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016485"(protein processing)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|refseq:NP_571041.1|dip:DIP-46066N	refseq:NP_004293.1|refseq:NP_064733.3|refseq:NP_064732.3|dip:DIP-427N|ensembl:ENSG00000135503(gene)|ensembl:ENST00000257963(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001942"(hair follicle development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046545"(development of primary female sexual characteristics)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:Aw+waiya2cBwK6E0tVcjXWVUsBY7955	rogid:zZ0cv5jIYvj0J14/8LZm2+RBxHo9606	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O13144	uniprotkb:P51865	intact:EBI-15529595|ensembl:ENSDARP00000148686	intact:EBI-15529529	psi-mi:o13144_danre(display_long)|uniprotkb:ndr2(gene name synonym)|uniprotkb:ndr1(gene name)|psi-mi:ndr1(display_short)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529620|imex:IM-9320-1|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051094"(positive regulation of developmental process)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|ensembl:ENSDARG00000116539(gene)|ensembl:ENSDART00000181236(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009306"(protein secretion)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016485"(protein processing)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|refseq:NP_571041.1|dip:DIP-46066N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:Aw+waiya2cBwK6E0tVcjXWVUsBY7955	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:Q91350	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-15529647	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:q91350_xenla(display_long)|uniprotkb:inhbb.L(gene name)|psi-mi:inhbb.L(display_short)|uniprotkb:Inhibin beta B chain(gene name synonym)|uniprotkb:activin beta B subunit(gene name synonym)|uniprotkb:inhbb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529667|imex:IM-9320-9|dip:DIP-87814E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	go:"GO:0000578"(embryonic axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|interpro:IPR000381(Inhibin, beta B subunit)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001318(Inhibin, beta C subunit)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|go:"GO:0005576"(extracellular region)|refseq:NP_001084055.1|dip:DIP-46064N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:9Y1OG/+QcB76tdRg2SXTIkUPKqQ8355	rigid:0i/nebWGnN5K8Ow31k88IT8MigE	false	myc tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P36896	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-1384128|uniprotkb:Q15479|uniprotkb:Q15480|uniprotkb:Q15481|uniprotkb:Q15482|uniprotkb:B7Z5L8|uniprotkb:B7Z5W5|ensembl:ENSP00000257963	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:acv1b_human(display_long)|uniprotkb:ACVRLK4(gene name synonym)|uniprotkb:Activin receptor type IB(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R2(gene name synonym)|uniprotkb:Activin receptor-like kinase 4(gene name synonym)|uniprotkb:ACVR1B(gene name)|psi-mi:ACVR1B(display_short)|uniprotkb:ALK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529667|imex:IM-9320-9|dip:DIP-87814E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	refseq:NP_004293.1|refseq:NP_064733.3|refseq:NP_064732.3|dip:DIP-427N|ensembl:ENSG00000135503(gene)|ensembl:ENST00000257963(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001942"(hair follicle development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046545"(development of primary female sexual characteristics)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:zZ0cv5jIYvj0J14/8LZm2+RBxHo9606	rigid:0i/nebWGnN5K8Ow31k88IT8MigE	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P51865	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-15529529	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529667|imex:IM-9320-9|dip:DIP-87814E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:0i/nebWGnN5K8Ow31k88IT8MigE	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O13144	uniprotkb:P51865	intact:EBI-15529595|ensembl:ENSDARP00000148686	intact:EBI-15529529	psi-mi:o13144_danre(display_long)|uniprotkb:ndr2(gene name synonym)|uniprotkb:ndr1(gene name)|psi-mi:ndr1(display_short)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529694|imex:IM-9320-7|dip:DIP-87809E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051094"(positive regulation of developmental process)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|ensembl:ENSDARG00000116539(gene)|ensembl:ENSDART00000181236(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009306"(protein secretion)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016485"(protein processing)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|refseq:NP_571041.1|dip:DIP-46066N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:Aw+waiya2cBwK6E0tVcjXWVUsBY7955	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:mv54UgPIRDwdpP+sejNntq7GAM4	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q64280	uniprotkb:P51865	intact:EBI-15529715|ensembl:ENSMUSP00000041427|uniprotkb:Q3V2A9	intact:EBI-15529529	psi-mi:lfty1_mouse(display_long)|uniprotkb:Protein lefty-1(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 3 protein(gene name synonym)|uniprotkb:Transforming growth factor beta-4(gene name synonym)|uniprotkb:Lefty1(gene name)|psi-mi:Lefty1(display_short)|uniprotkb:Ebaf(gene name synonym)|uniprotkb:Lefty(gene name synonym)|uniprotkb:Stra3(gene name synonym)|uniprotkb:Tgfb4(gene name synonym)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529763|imex:IM-9320-2|dip:DIP-87812E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038793(gene)|ensembl:ENSMUST00000037361(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0038100"(nodal binding)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:1900108"(negative regulation of nodal signaling pathway)|go:"GO:1900124"(negative regulation of nodal receptor complex assembly)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003942(Transforming growth factor, beta 4)|interpro:IPR017948|interpro:IPR029034|reactome:R-MMU-114608|interpro:IPR015615(Transforming growth factor-beta-related)|refseq:NP_034224.1|dip:DIP-46067N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:uYM/e89HiNDHGDqUceFbC6CgaFE10090	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:Wtr7RiHgb0W4ZPMYRoTTqd3nxv0	false	-	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27040	uniprotkb:Q91350	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-15529647	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:q91350_xenla(display_long)|uniprotkb:inhbb.L(gene name)|psi-mi:inhbb.L(display_short)|uniprotkb:Inhibin beta B chain(gene name synonym)|uniprotkb:activin beta B subunit(gene name synonym)|uniprotkb:inhbb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529782|imex:IM-9320-3|dip:DIP-87815E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	go:"GO:0000578"(embryonic axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|interpro:IPR000381(Inhibin, beta B subunit)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001318(Inhibin, beta C subunit)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|go:"GO:0005576"(extracellular region)|refseq:NP_001084055.1|dip:DIP-46064N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:9Y1OG/+QcB76tdRg2SXTIkUPKqQ8355	rigid:1AvaLEMqobwWemDGVQktixsVQOI	false	myc tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P36896	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-1384128|uniprotkb:Q15479|uniprotkb:Q15480|uniprotkb:Q15481|uniprotkb:Q15482|uniprotkb:B7Z5L8|uniprotkb:B7Z5W5|ensembl:ENSP00000257963	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:acv1b_human(display_long)|uniprotkb:ACVRLK4(gene name synonym)|uniprotkb:Activin receptor type IB(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R2(gene name synonym)|uniprotkb:Activin receptor-like kinase 4(gene name synonym)|uniprotkb:ACVR1B(gene name)|psi-mi:ACVR1B(display_short)|uniprotkb:ALK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529782|imex:IM-9320-3|dip:DIP-87815E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	refseq:NP_004293.1|refseq:NP_064733.3|refseq:NP_064732.3|dip:DIP-427N|ensembl:ENSG00000135503(gene)|ensembl:ENST00000257963(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001942"(hair follicle development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046545"(development of primary female sexual characteristics)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:zZ0cv5jIYvj0J14/8LZm2+RBxHo9606	rigid:1AvaLEMqobwWemDGVQktixsVQOI	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9W6I6	uniprotkb:P51865	intact:EBI-15529806|ensembl:ENSDARP00000005312	intact:EBI-15529529	psi-mi:q9w6i6_danre(display_long)|uniprotkb:lft1(gene name)|psi-mi:lft1(display_short)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529839|imex:IM-9320-8|dip:DIP-87810E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSDARG00000019920(gene)|ensembl:ENSDART00000019196(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035462"(determination of left/right asymmetry in diencephalon)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061371"(determination of heart left/right asymmetry)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003942(Transforming growth factor, beta 4)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DRE-114608|dip:DIP-46065N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:28q3Z2827gbtIinOAx6SOF2z4g87955	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:YM68IyLXqARFf6hkW4+TbJCwh40	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9W6I6	uniprotkb:P51865	intact:EBI-15529806|ensembl:ENSDARP00000005312	intact:EBI-15529529	psi-mi:q9w6i6_danre(display_long)|uniprotkb:lft1(gene name)|psi-mi:lft1(display_short)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529887|imex:IM-9320-6|dip:DIP-87810E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSDARG00000019920(gene)|ensembl:ENSDART00000019196(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035462"(determination of left/right asymmetry in diencephalon)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061371"(determination of heart left/right asymmetry)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003942(Transforming growth factor, beta 4)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DRE-114608|dip:DIP-46065N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:28q3Z2827gbtIinOAx6SOF2z4g87955	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:YM68IyLXqARFf6hkW4+TbJCwh40	false	tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P36896	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-1384128|uniprotkb:Q15479|uniprotkb:Q15480|uniprotkb:Q15481|uniprotkb:Q15482|uniprotkb:B7Z5L8|uniprotkb:B7Z5W5|ensembl:ENSP00000257963	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:acv1b_human(display_long)|uniprotkb:ACVRLK4(gene name synonym)|uniprotkb:Activin receptor type IB(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R2(gene name synonym)|uniprotkb:Activin receptor-like kinase 4(gene name synonym)|uniprotkb:ACVR1B(gene name)|psi-mi:ACVR1B(display_short)|uniprotkb:ALK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529860|imex:IM-9320-5|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	refseq:NP_004293.1|refseq:NP_064733.3|refseq:NP_064732.3|dip:DIP-427N|ensembl:ENSG00000135503(gene)|ensembl:ENST00000257963(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001942"(hair follicle development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046545"(development of primary female sexual characteristics)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:zZ0cv5jIYvj0J14/8LZm2+RBxHo9606	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:O13144	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-15529595|ensembl:ENSDARP00000148686	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:o13144_danre(display_long)|uniprotkb:ndr2(gene name synonym)|uniprotkb:ndr1(gene name)|psi-mi:ndr1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529860|imex:IM-9320-5|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051094"(positive regulation of developmental process)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|ensembl:ENSDARG00000116539(gene)|ensembl:ENSDART00000181236(transcript)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009306"(protein secretion)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016485"(protein processing)|go:"GO:0021854"(hypothalamus development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|refseq:NP_571041.1|dip:DIP-46066N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:Aw+waiya2cBwK6E0tVcjXWVUsBY7955	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	myc tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P51865	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-15529529	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:tdgf1_mouse(display_long)|uniprotkb:Cripto growth factor(gene name synonym)|uniprotkb:Epidermal growth factor-like Cripto protein(gene name synonym)|uniprotkb:Tdgf1(gene name)|psi-mi:Tdgf1(display_short)|uniprotkb:Cripto(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529860|imex:IM-9320-5|dip:DIP-87811E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|rcsb pdb:2J5H|dip:DIP-46063N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:1fi2mBRedIesvpPrjDt8xZeqbIg10090	rigid:YYExq94T4CYusQVoDc3biZ1tc58	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27040	uniprotkb:P36896	intact:EBI-8571194|ensembl:ENSMUSP00000126108|uniprotkb:Q3KQI1|intact:MINT-2842249	intact:EBI-1384128|uniprotkb:Q15479|uniprotkb:Q15480|uniprotkb:Q15481|uniprotkb:Q15482|uniprotkb:B7Z5L8|uniprotkb:B7Z5W5|ensembl:ENSP00000257963	psi-mi:avr2b_mouse(display_long)|uniprotkb:Acvr2b(gene name)|psi-mi:Acvr2b(display_short)|uniprotkb:Activin receptor type IIB(gene name synonym)	psi-mi:acv1b_human(display_long)|uniprotkb:ACVRLK4(gene name synonym)|uniprotkb:Activin receptor type IB(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R2(gene name synonym)|uniprotkb:Activin receptor-like kinase 4(gene name synonym)|uniprotkb:ACVR1B(gene name)|psi-mi:ACVR1B(display_short)|uniprotkb:ALK4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheng et al. (2004)	pubmed:14966532|doi:10.1371/journal.pbio.0020030|imex:IM-9320	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15529908|imex:IM-9320-4|dip:DIP-87813E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300686.1|ensembl:ENSMUSG00000061393(gene)|ensembl:ENSMUST00000165044(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030324"(lung development)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034711"(inhibin binding)|go:"GO:0035265"(organ growth)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:P27040|rcsb pdb:1S4Y|rcsb pdb:2H64|reactome:R-MMU-1502540|reactome:R-MMU-201451|refseq:NP_031423.1|refseq:XP_006511989.1|dip:DIP-5799N	refseq:NP_004293.1|refseq:NP_064733.3|refseq:NP_064732.3|dip:DIP-427N|ensembl:ENSG00000135503(gene)|ensembl:ENST00000257963(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001942"(hair follicle development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0034711"(inhibin binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046545"(development of primary female sexual characteristics)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/04	2017/08/10	rogid:PQoyUJ/vNpmPxbVBO44mMMPJoXE10090	rogid:zZ0cv5jIYvj0J14/8LZm2+RBxHo9606	rigid:fpACzs+aYbxSAD+cvzO8vUt8UTI	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)