#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03148	uniprotkb:Q03144	intact:EBI-17618|uniprotkb:D6VZR9|ensemblfungi:YMR096W	intact:EBI-28190|uniprotkb:D6VZR8|ensemblfungi:YMR095C	psi-mi:snz1_yeast(display_long)|uniprotkb:SNZ1(gene name)|psi-mi:SNZ1(display_short)|uniprotkb:PDX1 homolog 1(gene name synonym)|uniprotkb:YM6543.03(orf name)|uniprotkb:YMR096W(locus name)|uniprotkb:p35(gene name synonym)	psi-mi:sno1_yeast(display_long)|uniprotkb:SNO1(gene name)|psi-mi:SNO1(display_short)|uniprotkb:PDX2 homolog 1(gene name synonym)|uniprotkb:Pyridoxal 5'-phosphate synthase glutaminase subunit(gene name synonym)|uniprotkb:YM6543.02C(orf name)|uniprotkb:YMR095C(locus name)	psi-mi:"MI:0096"(pull down)	Dong et al. (2004)	imex:IM-26451|pubmed:14764090	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16519426|imex:IM-26451-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013814.1|sgd:S000004702|ensemblfungi:YMR096W(gene)|ensemblfungi:YMR096W_mRNA(transcript)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0008615"(pyridoxine biosynthetic process)|go:"GO:0016843"(amine-lyase activity)|go:"GO:0036381"("pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity")|go:"GO:0042819"(vitamin B6 biosynthetic process)|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:1903600"(glutaminase complex)|interpro:IPR001852(Vitamin B6 biosynthesis protein)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR033755|rcsb pdb:3FEM|rcsb pdb:3O05|rcsb pdb:3O06|rcsb pdb:3O07|dip:DIP-1643N|mint:Q03148	refseq:NP_013813.1|sgd:S000004701|dip:DIP-1642N|ensemblfungi:YMR095C(gene)|ensemblfungi:YMR095C_mRNA(transcript)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0008614"(pyridoxine metabolic process)|go:"GO:0008615"(pyridoxine biosynthetic process)|go:"GO:0036001"('de novo' pyridoxal 5'-phosphate biosynthetic process)|go:"GO:0036381"("pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity")|go:"GO:0042819"(vitamin B6 biosynthetic process)|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903600"(glutaminase complex)|interpro:IPR002161(SNO glutamine amidotransferase)|interpro:IPR021196|interpro:IPR029062	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2017/10/30	2017/10/30	rogid:4TUYaAPbqY9Bmq7HO8BmACRVMQM559292	rogid:3D9QeAcHtEceo/G/r/tXbEuBITg559292	rigid:T98mdvMmuqLL5SZi2giHCRc8LQI	false	-	t7 tag:n-n|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:18050"	intenz:4.3.3.6	intact:EBI-8844631|chebi:"CHEBI:6227"|chebi:"CHEBI:13110"|chebi:"CHEBI:21308"|chebi:"CHEBI:185305"|chebi:"CHEBI:42812"|chebi:"CHEBI:42814"|chebi:"CHEBI:42899"|chebi:"CHEBI:42943"	intact:EBI-16519434|intenz:3.5.1.2	psi-mi:l-glutamine(display_short)|psi-mi:"CHEBI:18050"(display_long)|intact:"(2S)-2,5-diamino-5-oxopentanoic acid"(synonym)|intact:"(2S)-2-amino-4-carbamoylbutanoic acid"(synonym)|intact:"(S)-2,5-diamino-5-oxopentanoic acid"(synonym)|intact:Glutamic acid 5-amide(synonym)|intact:Glutamic acid amide(synonym)|intact:GLUTAMINE(synonym)|intact:"L-(+)-glutamine"(synonym)|intact:L-2-Aminoglutaramic acid(synonym)|intact:L-2-aminoglutaramic acid(synonym)|intact:L-glutamic acid gamma-amide(synonym)|intact:L-Glutamin(synonym)|intact:L-Glutamine(synonym)|intact:L-Glutaminsaeure-5-amid(synonym)|intact:Levoglutamide(synonym)|intact:Q(synonym)|intact:L-glutamine(iupac name)	psi-mi:sno1-snz1_yeast(display_short)|psi-mi:4.3.3.6(display_long)|intact:SNO1-SNZ1 pyridoxal 5'-phosphate synthase complex(complex recommended name)|intact:"SNO1:SNZ1"(complex systematic name)	psi-mi:"MI:0990"(cleavage assay)	Dong et al. (2004)	imex:IM-26451|pubmed:14764090	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16519533|imex:IM-26451-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0036381"("pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity")|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|intact:EBI-16519426(exp-evidence)|go:"GO:1903600"(glutaminase complex)|complex portal:CPX-1370(complex-primary)|evidence ontology:"ECO:0000353"	-	inchi key:ZDXPYRJPNDTMRX-VKHMYHEASA-N	curated-complex:Catalyzes the hydrolysis of glutamine to glutamate and ammonia, thus supplying ammonia as a source of the ring nitrogen of pyridoxine as part of the biosynthesis of pyridoxal 5'-phosphate. SNZ1 may act as a synthetase that mediates the coupling of ammonia  with an unknown acceptor substrate, possibly via a tunnel in the synthetase subunit.	figure legend:Figs 4,5, 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:3.4x10^-3(molar)	2017/10/30	2017/10/30	-	-	-	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:138889"	chebi:"CHEBI:18050"	intact:EBI-16520078	intact:EBI-8844631|chebi:"CHEBI:6227"|chebi:"CHEBI:13110"|chebi:"CHEBI:21308"|chebi:"CHEBI:185305"|chebi:"CHEBI:42812"|chebi:"CHEBI:42814"|chebi:"CHEBI:42899"|chebi:"CHEBI:42943"	psi-mi:6-diazo-5-oxo-l-norleucine(display_short)|psi-mi:"CHEBI:138889"(display_long)	psi-mi:l-glutamine(display_short)|psi-mi:"CHEBI:18050"(display_long)|intact:"(2S)-2,5-diamino-5-oxopentanoic acid"(synonym)|intact:"(2S)-2-amino-4-carbamoylbutanoic acid"(synonym)|intact:"(S)-2,5-diamino-5-oxopentanoic acid"(synonym)|intact:Glutamic acid 5-amide(synonym)|intact:Glutamic acid amide(synonym)|intact:GLUTAMINE(synonym)|intact:"L-(+)-glutamine"(synonym)|intact:L-2-Aminoglutaramic acid(synonym)|intact:L-2-aminoglutaramic acid(synonym)|intact:L-glutamic acid gamma-amide(synonym)|intact:L-Glutamin(synonym)|intact:L-Glutamine(synonym)|intact:L-Glutaminsaeure-5-amid(synonym)|intact:Levoglutamide(synonym)|intact:Q(synonym)|intact:L-glutamine(iupac name)	psi-mi:"MI:0990"(cleavage assay)	Dong et al. (2004)	imex:IM-26451|pubmed:14764090	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16520057|imex:IM-26451-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	inchi key:ZDXPYRJPNDTMRX-VKHMYHEASA-N	figure legend:Figs 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/30	2017/10/30	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:138889"	intenz:4.3.3.6	intact:EBI-16520078	intact:EBI-16519434|intenz:3.5.1.2	psi-mi:6-diazo-5-oxo-l-norleucine(display_short)|psi-mi:"CHEBI:138889"(display_long)	psi-mi:sno1-snz1_yeast(display_short)|psi-mi:4.3.3.6(display_long)|intact:SNO1-SNZ1 pyridoxal 5'-phosphate synthase complex(complex recommended name)|intact:"SNO1:SNZ1"(complex systematic name)	psi-mi:"MI:0990"(cleavage assay)	Dong et al. (2004)	imex:IM-26451|pubmed:14764090	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16520057|imex:IM-26451-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0036381"("pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity")|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|intact:EBI-16519426(exp-evidence)|go:"GO:1903600"(glutaminase complex)|complex portal:CPX-1370(complex-primary)|evidence ontology:"ECO:0000353"	-	-	curated-complex:Catalyzes the hydrolysis of glutamine to glutamate and ammonia, thus supplying ammonia as a source of the ring nitrogen of pyridoxine as part of the biosynthesis of pyridoxal 5'-phosphate. SNZ1 may act as a synthetase that mediates the coupling of ammonia  with an unknown acceptor substrate, possibly via a tunnel in the synthetase subunit.	figure legend:Figs 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/30	2017/10/30	-	-	-	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)