#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P11346 uniprotkb:Q8MLP1 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 intact:EBI-15529127|ensemblmetazoa:FBpp0072270 psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:q8mlp1_drome(display_long)|uniprotkb:Plkk(gene name synonym)|uniprotkb:Plkk1(gene name synonym)|uniprotkb:Slik(gene name)|psi-mi:Slik(display_short)|uniprotkb:Dmel\CG4527(gene name synonym)|uniprotkb:PLKK1(gene name synonym)|uniprotkb:DPlkk1(gene name synonym)|uniprotkb:SLIK(gene name synonym)|uniprotkb:SLK(gene name synonym)|uniprotkb:Slik1(gene name synonym)|uniprotkb:Slk(gene name synonym)|uniprotkb:dPlkk(gene name synonym)|uniprotkb:slik(gene name synonym)|uniprotkb:CG4527(orf name)|uniprotkb:Dmel_CG4527(orf name)|uniprotkb:slk(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hipfner et al. (2003) pubmed:14624240|doi:10.1371/journal.pbio.0000035|imex:IM-9317 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15529161|imex:IM-9317-1|dip:DIP-87808E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 ensemblmetazoa:FBgn0035001(gene)|ensemblmetazoa:FBtr0072363(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032879"(regulation of localization)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|refseq:NP_611908.2|flybase:FBgn0035001|dip:DIP-46062N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/04 2017/08/10 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rogid:CDVVIkbnrVjoCRQLuEGwBnT1XXY7227 rigid:aydkZV1oj7WsTykNt+PzqStSok0 false myc tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)