#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P61769-PRO_0000018779 intact:EBI-15484702 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:riiprhlql(display_short)|psi-mi:EBI-15484702(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484696|imex:IM-26239-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-1, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:4.8x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:HIzta3QvGZPKpmq5b+7WinDP0q0-2 rigid:g4s7fCrPVYQcQ5mY+LUVmeBj+NQ false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P17693 intact:EBI-13942645 intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484696|imex:IM-26239-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-1, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:4.8x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606 rigid:g4s7fCrPVYQcQ5mY+LUVmeBj+NQ false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:25-300 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484696|imex:IM-26239-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-1, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:4.8x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:g4s7fCrPVYQcQ5mY+LUVmeBj+NQ false sufficient binding region:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484736 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:ryrpgtval(display_short)|psi-mi:EBI-15484736(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484717|imex:IM-26239-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:7rM4zrDBX6hAhlGZTmtULwow4y0-2 rigid:yWLYp5goKW43gRgfeCrC1aAtqtg false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484717|imex:IM-26239-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:yWLYp5goKW43gRgfeCrC1aAtqtg false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484717|imex:IM-26239-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:yWLYp5goKW43gRgfeCrC1aAtqtg false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484759 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:nkadvilky(display_short)|psi-mi:EBI-15484759(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484742|imex:IM-26239-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2i, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:23.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:7NHqA5tfT1TsD3/VNnafbCMuRvM-2 rigid:eVFacK1hosOJtwwxDCQ0ZxIrQLo false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484742|imex:IM-26239-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2i, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:23.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:eVFacK1hosOJtwwxDCQ0ZxIrQLo false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484742|imex:IM-26239-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:"(1 A/B-2i, Supp fig 5), Table 1"|comment:Which of the two peptide sequences used was not stated for Fig 1 or Supp fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:23.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:eVFacK1hosOJtwwxDCQ0ZxIrQLo false sufficient binding region:?-?|biotin tag:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484779 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:iplteeael(display_short)|psi-mi:EBI-15484779(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484762|imex:IM-26239-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-3, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:ey4UVa39u2Z2Sjs+3XpYdsxWWvY-2 rigid:JVdhWqOvCUGmEWmESCdkO5AVsBE false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01889 intact:EBI-13942645 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484762|imex:IM-26239-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-3, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:JVdhWqOvCUGmEWmESCdkO5AVsBE false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484762|imex:IM-26239-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 A/B-3, 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:26.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:JVdhWqOvCUGmEWmESCdkO5AVsBE false sufficient binding region:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484798 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:aifqssmtk(display_short)|psi-mi:EBI-15484798(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484781|imex:IM-26239-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:45.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:/ttwTcL6NsqkYnY5ZlsTfCdQ/F4-2 rigid:MKeyuqGucYl1Ee+jCJ5HLZxTpzg false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q5S3G3 intact:EBI-13942645 intact:EBI-4290427|uniprotkb:Q9BCN0|uniprotkb:Q9MYI5|uniprotkb:Q9TQE9|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q5S3G1 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:q5s3g3_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*11(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484781|imex:IM-26239-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) uniprotkb:P13746(see-also)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR036179|interpro:IPR037055|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response) - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:45.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:zfvnDhAh7D90kAQGAuK6Ut2tWOA9606 rigid:MKeyuqGucYl1Ee+jCJ5HLZxTpzg false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484781|imex:IM-26239-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:45.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:MKeyuqGucYl1Ee+jCJ5HLZxTpzg false sufficient binding region:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484800|imex:IM-26239-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, fig 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:14.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:XbneQlEpzRyQJ+Vw5O3LacXV1MQ false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484800|imex:IM-26239-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, fig 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:14.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:XbneQlEpzRyQJ+Vw5O3LacXV1MQ false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484800|imex:IM-26239-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1B, fig 2J, Supp fig 5, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:14.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:XbneQlEpzRyQJ+Vw5O3LacXV1MQ false sufficient binding region:?-? sufficient binding region:24-221..221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484702 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:riiprhlql(display_short)|psi-mi:EBI-15484702(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484823|imex:IM-26239-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:HIzta3QvGZPKpmq5b+7WinDP0q0-2 rigid:VdUlqh1f/QpgyAWglFKJc4qFbU4 false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P17693 intact:EBI-13942645 intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484823|imex:IM-26239-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606 rigid:VdUlqh1f/QpgyAWglFKJc4qFbU4 false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:25-300 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484823|imex:IM-26239-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:VdUlqh1f/QpgyAWglFKJc4qFbU4 false sufficient binding region:?-? sufficient binding region:24-220 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484843|imex:IM-26239-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1Di, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.5x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:24pnemMjavnLGGmOJ+w73Ml1+hI false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484843|imex:IM-26239-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1Di, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.5x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:24pnemMjavnLGGmOJ+w73Ml1+hI false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484843|imex:IM-26239-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1Di, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.5x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:24pnemMjavnLGGmOJ+w73Ml1+hI false sufficient binding region:?-? sufficient binding region:24-220 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484798 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:aifqssmtk(display_short)|psi-mi:EBI-15484798(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484860|imex:IM-26239-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:/ttwTcL6NsqkYnY5ZlsTfCdQ/F4-2 rigid:H4CSkHmNdTCtfY1Bbx/lQnT6zNk false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q5S3G3 intact:EBI-13942645 intact:EBI-4290427|uniprotkb:Q9BCN0|uniprotkb:Q9MYI5|uniprotkb:Q9TQE9|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q5S3G1 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:q5s3g3_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*11(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484860|imex:IM-26239-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) uniprotkb:P13746(see-also)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019882"(antigen processing and presentation)|interpro:IPR036179|interpro:IPR037055|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response) - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:zfvnDhAh7D90kAQGAuK6Ut2tWOA9606 rigid:H4CSkHmNdTCtfY1Bbx/lQnT6zNk false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484860|imex:IM-26239-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:H4CSkHmNdTCtfY1Bbx/lQnT6zNk false sufficient binding region:?-? sufficient binding region:24-220..220 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484779 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:iplteeael(display_short)|psi-mi:EBI-15484779(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484877|imex:IM-26239-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.8x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:ey4UVa39u2Z2Sjs+3XpYdsxWWvY-2 rigid:wpCt5vgIlW2HxBe8WbHvLyu947w false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01889 intact:EBI-13942645 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484877|imex:IM-26239-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.8x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:wpCt5vgIlW2HxBe8WbHvLyu947w false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484877|imex:IM-26239-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:1 C/D, 2J, Supp fig 4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.8x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:wpCt5vgIlW2HxBe8WbHvLyu947w false sufficient binding region:?-? sufficient binding region:24-221 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P43626 intact:EBI-13942645 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484896|imex:IM-26239-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 - chain-seq-start:21|chain-seq-end:119 comment:mint figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rigid:66ICeTJlKXdHlKLtluWmgBCxs/A false sufficient binding region:?-? sufficient binding region:22..22-245..245 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484896|imex:IM-26239-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:66ICeTJlKXdHlKLtluWmgBCxs/A false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484896|imex:IM-26239-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:66ICeTJlKXdHlKLtluWmgBCxs/A false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P43626 intact:EBI-13942645 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484913|imex:IM-26239-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 - chain-seq-start:21|chain-seq-end:119 comment:mint figure legend:2B|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rigid:f2MDbJZGhL8F1w/nrIfojHirJSg false sufficient binding region:?-? sufficient binding region:22..22-245..245 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484913|imex:IM-26239-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2B|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:f2MDbJZGhL8F1w/nrIfojHirJSg false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484913|imex:IM-26239-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:2B|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:f2MDbJZGhL8F1w/nrIfojHirJSg false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484913|imex:IM-26239-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:2B|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:f2MDbJZGhL8F1w/nrIfojHirJSg false sufficient binding region:?-? sufficient binding region:24-221..221 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P43626 intact:EBI-13942645 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484935|imex:IM-26239-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 - chain-seq-start:21|chain-seq-end:119 comment:mint figure legend:2C|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rigid:mp0mFxqL9Ql1kDi75/Sb8oYsYNc false sufficient binding region:?-? sufficient binding region:22..22-245..245 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484935|imex:IM-26239-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2C|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:mp0mFxqL9Ql1kDi75/Sb8oYsYNc false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484935|imex:IM-26239-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:2C|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:mp0mFxqL9Ql1kDi75/Sb8oYsYNc false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484935|imex:IM-26239-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:2C|comment:the binding of ILTs and KIR2DL1 to HLA-Cw4 was purely additive.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.3x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:mp0mFxqL9Ql1kDi75/Sb8oYsYNc false sufficient binding region:?-? sufficient binding region:24-220 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484957|imex:IM-26239-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:210.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:j0Q+TI8t3wQ8qaNhV3Zriw1Fozo false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484957|imex:IM-26239-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:210.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:j0Q+TI8t3wQ8qaNhV3Zriw1Fozo false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15484957|imex:IM-26239-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:210.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:j0Q+TI8t3wQ8qaNhV3Zriw1Fozo false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484779 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:iplteeael(display_short)|psi-mi:EBI-15484779(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485153|imex:IM-26239-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:126.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:ey4UVa39u2Z2Sjs+3XpYdsxWWvY-2 rigid:pgIljqtViQWSmoJgq9KiIX9Xoes false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01889 intact:EBI-13942645 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485153|imex:IM-26239-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:126.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:pgIljqtViQWSmoJgq9KiIX9Xoes false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485153|imex:IM-26239-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:126.0x10^-6(molar) 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:pgIljqtViQWSmoJgq9KiIX9Xoes false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484702 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:riiprhlql(display_short)|psi-mi:EBI-15484702(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485171|imex:IM-26239-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:Figure 2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:72.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:HIzta3QvGZPKpmq5b+7WinDP0q0-2 rigid:ylROyjoIPcOdHrHzHShJzhLjcRw false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P17693 intact:EBI-13942645 intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485171|imex:IM-26239-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N - chain-seq-start:21|chain-seq-end:119 - figure legend:Figure 2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:72.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606 rigid:ylROyjoIPcOdHrHzHShJzhLjcRw false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:25-300 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485171|imex:IM-26239-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:Figure 2 D/J, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:72.0x10^-6(molar) 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:ylROyjoIPcOdHrHzHShJzhLjcRw false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485189|imex:IM-26239-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:02wUtOCqD/p1LSJixC7G4EoDyf0 false sufficient binding region:?-? sufficient binding region:24-221..221 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484779 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:iplteeael(display_short)|psi-mi:EBI-15484779(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485189|imex:IM-26239-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:ey4UVa39u2Z2Sjs+3XpYdsxWWvY-2 rigid:02wUtOCqD/p1LSJixC7G4EoDyf0 false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01889 intact:EBI-13942645 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485189|imex:IM-26239-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - chain-seq-start:21|chain-seq-end:119 - figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:02wUtOCqD/p1LSJixC7G4EoDyf0 false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485189|imex:IM-26239-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:02wUtOCqD/p1LSJixC7G4EoDyf0 false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485209|imex:IM-26239-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:2G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:EBCd2zFM54AC+H2DQ0HiCBQE1fo false sufficient binding region:?-? sufficient binding region:24-220 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484779 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:iplteeael(display_short)|psi-mi:EBI-15484779(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485209|imex:IM-26239-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:ey4UVa39u2Z2Sjs+3XpYdsxWWvY-2 rigid:EBCd2zFM54AC+H2DQ0HiCBQE1fo false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01889 intact:EBI-13942645 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485209|imex:IM-26239-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 - chain-seq-start:21|chain-seq-end:119 - figure legend:2G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 rigid:EBCd2zFM54AC+H2DQ0HiCBQE1fo false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485209|imex:IM-26239-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:EBCd2zFM54AC+H2DQ0HiCBQE1fo false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485228|imex:IM-26239-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:dmdXeye5IghD+HcTX/wAGvvu0BU false sufficient binding region:?-? sufficient binding region:22..22-142..142 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484702 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:riiprhlql(display_short)|psi-mi:EBI-15484702(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485228|imex:IM-26239-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:HIzta3QvGZPKpmq5b+7WinDP0q0-2 rigid:dmdXeye5IghD+HcTX/wAGvvu0BU false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P17693 intact:EBI-13942645 intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485228|imex:IM-26239-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N - chain-seq-start:21|chain-seq-end:119 - figure legend:2I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606 rigid:dmdXeye5IghD+HcTX/wAGvvu0BU false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:25-300 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485228|imex:IM-26239-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:2I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:dmdXeye5IghD+HcTX/wAGvvu0BU false sufficient binding region:?-? sufficient binding region:24-220 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485248|imex:IM-26239-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:7Q6gJGfbL6KZljK9zjPirTreMF8 false sufficient binding region:?-? sufficient binding region:22..22-142..142 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484702 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:riiprhlql(display_short)|psi-mi:EBI-15484702(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485248|imex:IM-26239-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:HIzta3QvGZPKpmq5b+7WinDP0q0-2 rigid:7Q6gJGfbL6KZljK9zjPirTreMF8 false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P17693 intact:EBI-13942645 intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485248|imex:IM-26239-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N - chain-seq-start:21|chain-seq-end:119 - figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606 rigid:7Q6gJGfbL6KZljK9zjPirTreMF8 false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:25-300 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8N423 intact:EBI-13942645 intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485248|imex:IM-26239-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695 - chain-seq-start:21|chain-seq-end:119 - figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2017/07/24 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606 rigid:7Q6gJGfbL6KZljK9zjPirTreMF8 false sufficient binding region:?-? sufficient binding region:24-221..221 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:Q8NHL6 intact:EBI-13942645 intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485268|imex:IM-26239-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4 - chain-seq-start:21|chain-seq-end:119 - figure legend:2H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606 rigid:eo8ddEAcAt2jVpOyXQ7npA+ekaU false sufficient binding region:?-? sufficient binding region:24-220 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 intact:EBI-15484817 intact:EBI-13942645 - psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:qyddavykl(display_short)|psi-mi:EBI-15484817(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485268|imex:IM-26239-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-714718(chain-parent) - - chain-seq-start:21|chain-seq-end:119 - figure legend:2H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:T4sq8AzN1q/fCUeQ69BdcIux8gk-2 rigid:eo8ddEAcAt2jVpOyXQ7npA+ekaU false sufficient binding region:?-? sufficient binding region:1-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P10321 intact:EBI-13942645 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485268|imex:IM-26239-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - chain-seq-start:21|chain-seq-end:119 - figure legend:2H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:eo8ddEAcAt2jVpOyXQ7npA+ekaU false sufficient binding region:?-? biotin tag:c-c|sufficient binding region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P61769-PRO_0000018779 uniprotkb:P01732 intact:EBI-13942645 intact:EBI-2873704|ensembl:ENSP00000283635|ensembl:ENSP00000386559|uniprotkb:Q13970|uniprotkb:B4DT80|uniprotkb:Q4ZG17|uniprotkb:D6W5M8 psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:cd8a_human(display_long)|uniprotkb:CD8A(gene name)|psi-mi:CD8A(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:T-lymphocyte differentiation antigen T8/Leu-2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Shiroishi et al. (2003) pubmed:12853576|imex:IM-26239 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15485268|imex:IM-26239-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-714718(chain-parent) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:1AKJ|rcsb pdb:1CD8|rcsb pdb:1Q69|rcsb pdb:2HP4|rcsb pdb:3QZW|reactome:R-HSA-198933|ensembl:ENSG00000153563(gene)|ensembl:ENST00000283635(transcript)|ensembl:ENST00000409511(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001139345.1|refseq:NP_001759.3|refseq:NP_741969.1 - chain-seq-start:21|chain-seq-end:119 - figure legend:2H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/01 2019/10/18 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rogid:P1dPeA7yUx0TUno/Poaas9TU6gk9606 rigid:eo8ddEAcAt2jVpOyXQ7npA+ekaU false sufficient binding region:?-? sufficient binding region:22..22-142..142 - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)