#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92570 uniprotkb:O95343 intact:EBI-13644623|ensembl:ENSP00000378531|uniprotkb:A2A3I7|uniprotkb:Q12935|uniprotkb:Q14979|uniprotkb:Q16420|uniprotkb:Q4VXA8|uniprotkb:Q4VXA9|uniprotkb:Q9UEK2|uniprotkb:Q9UEK3 intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:nr4a3_human(display_long)|uniprotkb:NR4A3(gene name)|psi-mi:NR4A3(display_short)|uniprotkb:CHN(gene name synonym)|uniprotkb:CSMF(gene name synonym)|uniprotkb:MINOR(gene name synonym)|uniprotkb:NOR1(gene name synonym)|uniprotkb:TEC(gene name synonym)|uniprotkb:Mitogen-induced nuclear orphan receptor(gene name synonym)|uniprotkb:Neuron-derived orphan receptor 1(gene name synonym)|uniprotkb:Nuclear hormone receptor NOR-1(gene name synonym) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644711|imex:IM-25650-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119508(gene)|ensembl:ENST00000395097(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009444"(pyruvate oxidation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038097"(positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045333"(cellular respiration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003072(Orphan nuclear receptor, NOR1 type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:Q92570|reactome:R-HSA-383280|reactome:R-HSA-8936459|refseq:NP_008912.2|refseq:NP_775291.1|refseq:NP_775292.1|refseq:XP_016870651.1 ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/10 2017/02/13 rogid:gx1UaO3/tecc/17WrhwOEYtqnoM9606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:CAmgsO+qhv1+0toWsDrUn2Ddkug false glutathione s tranferase tag:n-n|necessary binding region:289-359(IPR013088) 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q92570 uniprotkb:O95343 intact:EBI-13644623|ensembl:ENSP00000378531|uniprotkb:A2A3I7|uniprotkb:Q12935|uniprotkb:Q14979|uniprotkb:Q16420|uniprotkb:Q4VXA8|uniprotkb:Q4VXA9|uniprotkb:Q9UEK2|uniprotkb:Q9UEK3 intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:nr4a3_human(display_long)|uniprotkb:NR4A3(gene name)|psi-mi:NR4A3(display_short)|uniprotkb:CHN(gene name synonym)|uniprotkb:CSMF(gene name synonym)|uniprotkb:MINOR(gene name synonym)|uniprotkb:NOR1(gene name synonym)|uniprotkb:TEC(gene name synonym)|uniprotkb:Mitogen-induced nuclear orphan receptor(gene name synonym)|uniprotkb:Neuron-derived orphan receptor 1(gene name synonym)|uniprotkb:Nuclear hormone receptor NOR-1(gene name synonym) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644780|imex:IM-25650-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119508(gene)|ensembl:ENST00000395097(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009444"(pyruvate oxidation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038097"(positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045333"(cellular respiration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003072(Orphan nuclear receptor, NOR1 type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:Q92570|reactome:R-HSA-383280|reactome:R-HSA-8936459|refseq:NP_008912.2|refseq:NP_775291.1|refseq:NP_775292.1|refseq:XP_016870651.1 ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/10 2017/02/13 rogid:gx1UaO3/tecc/17WrhwOEYtqnoM9606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:CAmgsO+qhv1+0toWsDrUn2Ddkug false glutathione s tranferase tag:n-n 35s radiolabel:?-?|necessary binding region:182-264(IPR001356) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-13644800 uniprotkb:O95343 - intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:ews_nr4a3 human fusion protein 2(display_short)|psi-mi:EBI-13644800(display_long) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644804|imex:IM-25650-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) pubmed:10359536(see-also)|pubmed:8634690(see-also) ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/10 2017/02/13 rogid:WeDbbe9eC5gSM19OA4MdtWT3t/49606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:R2olBHY9MUOeTesbAFlfkf6R58c false sufficient binding region:1-264|glutathione s tranferase tag:n-n 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-13644800 uniprotkb:O95343 - intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:ews_nr4a3 human fusion protein 2(display_short)|psi-mi:EBI-13644800(display_long) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644820|imex:IM-25650-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) pubmed:10359536(see-also)|pubmed:8634690(see-also) ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/10 2017/02/13 rogid:WeDbbe9eC5gSM19OA4MdtWT3t/49606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:R2olBHY9MUOeTesbAFlfkf6R58c false glutathione s tranferase tag:n-n 35s radiolabel:?-?|necessary binding region:182-264(IPR001356) - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-13644800 uniprotkb:O95343 - intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:ews_nr4a3 human fusion protein 2(display_short)|psi-mi:EBI-13644800(display_long) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644870|imex:IM-25650-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) pubmed:10359536(see-also)|pubmed:8634690(see-also) ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-t/c-28)|taxid:9606(human T/C-28 Immortalized Chondrocytes) - 2017/02/10 2017/02/10 rogid:WeDbbe9eC5gSM19OA4MdtWT3t/49606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:R2olBHY9MUOeTesbAFlfkf6R58c false gal4 dna binding domain:n-n vp16 activation domain:n-n|necessary binding region:182-264(IPR001356) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92570 uniprotkb:O95343 intact:EBI-13644623|ensembl:ENSP00000378531|uniprotkb:A2A3I7|uniprotkb:Q12935|uniprotkb:Q14979|uniprotkb:Q16420|uniprotkb:Q4VXA8|uniprotkb:Q4VXA9|uniprotkb:Q9UEK2|uniprotkb:Q9UEK3 intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42 psi-mi:nr4a3_human(display_long)|uniprotkb:NR4A3(gene name)|psi-mi:NR4A3(display_short)|uniprotkb:CHN(gene name synonym)|uniprotkb:CSMF(gene name synonym)|uniprotkb:MINOR(gene name synonym)|uniprotkb:NOR1(gene name synonym)|uniprotkb:TEC(gene name synonym)|uniprotkb:Mitogen-induced nuclear orphan receptor(gene name synonym)|uniprotkb:Neuron-derived orphan receptor 1(gene name synonym)|uniprotkb:Nuclear hormone receptor NOR-1(gene name synonym) psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Laflamme et al. (2003) pubmed:12543801|imex:IM-25650 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13644849|imex:IM-25650-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119508(gene)|ensembl:ENST00000395097(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009444"(pyruvate oxidation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038097"(positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045333"(cellular respiration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003072(Orphan nuclear receptor, NOR1 type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:Q92570|reactome:R-HSA-383280|reactome:R-HSA-8936459|refseq:NP_008912.2|refseq:NP_775291.1|refseq:NP_775292.1|refseq:XP_016870651.1 ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1 - - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-t/c-28)|taxid:9606(human T/C-28 Immortalized Chondrocytes) - 2017/02/10 2017/02/10 rogid:gx1UaO3/tecc/17WrhwOEYtqnoM9606 rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606 rigid:CAmgsO+qhv1+0toWsDrUn2Ddkug false gal4 dna binding domain:n-n vp16 activation domain:n-n|necessary binding region:182-264(IPR001356) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)