#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BV36 uniprotkb:P51159-1 intact:EBI-7042162|uniprotkb:B4DKW7|intact:MINT-3388002|uniprotkb:Q9HA71|uniprotkb:B3KSS2|uniprotkb:G5E9G5|ensembl:ENSP00000264605 intact:EBI-15528760|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059 psi-mi:melph_human(display_long)|uniprotkb:MLPH(gene name)|psi-mi:MLPH(display_short)|uniprotkb:SLAC2A(gene name synonym)|uniprotkb:Exophilin-3(gene name synonym)|uniprotkb:Synaptotagmin-like protein 2a(gene name synonym)|uniprotkb:Slp homolog lacking C2 domains a(gene name synonym) psi-mi:p51159-1(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Menasche et al. (2003) pubmed:12446441|doi:10.1182/blood-2002-09-2789|imex:IM-24796 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15528767|imex:IM-24796-1|dip:DIP-75022E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077006.1|refseq:NP_001035932.1|refseq:NP_001268402.1|refseq:NP_001268403.1|dip:DIP-44046N|ensembl:ENSG00000115648(gene)|ensembl:ENST00000264605(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017022"(myosin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006788("Myelin-associated oligodendrocytic basic protein (MOBP)")|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR037442|interpro:IPR041282|mint:Q9BV36 ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|intact:EBI-716881(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|function:Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A|function:"Defects in MLPH are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/04 2017/08/10 rogid:g6+punuQGoilMzUlkOu+V73nUHc9606 rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606 rigid:w0Jcy9lHsIIFmKC/TX8SbtyBPcY false myc tag:c-c|sufficient binding region:1-146 mutation disrupting interaction strength:73-73|mutation disrupting interaction strength:73-73|mutation disrupting interaction strength:73-73|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BV36 uniprotkb:P51159-1 intact:EBI-7042162|uniprotkb:B4DKW7|intact:MINT-3388002|uniprotkb:Q9HA71|uniprotkb:B3KSS2|uniprotkb:G5E9G5|ensembl:ENSP00000264605 intact:EBI-15528760|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059 psi-mi:melph_human(display_long)|uniprotkb:MLPH(gene name)|psi-mi:MLPH(display_short)|uniprotkb:SLAC2A(gene name synonym)|uniprotkb:Exophilin-3(gene name synonym)|uniprotkb:Synaptotagmin-like protein 2a(gene name synonym)|uniprotkb:Slp homolog lacking C2 domains a(gene name synonym) psi-mi:p51159-1(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Menasche et al. (2003) pubmed:12446441|doi:10.1182/blood-2002-09-2789|imex:IM-24796 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15528798|imex:IM-24796-2|dip:DIP-75022E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077006.1|refseq:NP_001035932.1|refseq:NP_001268402.1|refseq:NP_001268403.1|dip:DIP-44046N|ensembl:ENSG00000115648(gene)|ensembl:ENST00000264605(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017022"(myosin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006788("Myelin-associated oligodendrocytic basic protein (MOBP)")|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR037442|interpro:IPR041282|mint:Q9BV36 ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|intact:EBI-716881(isoform-parent) psi-mi:"MI:0465"(dip) comment:mint|function:Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A|function:"Defects in MLPH are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/04 2017/08/10 rogid:g6+punuQGoilMzUlkOu+V73nUHc9606 rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606 rigid:w0Jcy9lHsIIFmKC/TX8SbtyBPcY false myc tag:c-c|sufficient binding region:1-146 mutation disrupting interaction strength:23-23|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)