#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418718|imex:IM-26234-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418762|imex:IM-26234-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3A-2|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418772|imex:IM-26234-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418783|imex:IM-26234-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418792|imex:IM-26234-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3B, 4|comment:in addition to baits containing V, baits containing C in position 0 showed interaction with SITAC|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159|mutation increasing interaction strength:159-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:O00560	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418909|imex:IM-26234-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N	-	-	-	figure legend:3|comment:Most TGF-alpha mutants tested interacted with TACIP18. TACIP18 shows a very relaxed specificity in position -2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606	rigid:nRHnCXipQx/AXbY9V/6sSYXy1Bc	false	sufficient binding region:126-159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01134	uniprotkb:Q9H190	intact:EBI-16418721|ensembl:ENSRNOP00000054248|uniprotkb:Q63749	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:tgfa_rat(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418942|imex:IM-26234-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016182(gene)|ensembl:ENSRNOT00000057441(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|reactome:R-RNO-1257604|reactome:R-RNO-177929|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-204005|reactome:R-RNO-212718|reactome:R-RNO-5673001|reactome:R-RNO-5694530|reactome:R-RNO-6811558|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-9009391|refseq:NP_036803.1|rgd:3849	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:H6ddPc+UrwGUsFrCCj6q6uA9+zw10116	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:vrn1yAmYI9rcsCyjGa5Fl1p9ogU	false	mutation:157-157|sufficient binding region:126-159|mutation:159-159	sufficient binding region:90..90-292	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30408	uniprotkb:Q9H190	intact:EBI-714256|uniprotkb:Q6IB51|ensembl:ENSP00000304277	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:t4s1_human(display_long)|uniprotkb:Tumor-associated antigen L6(gene name synonym)|uniprotkb:Membrane component chromosome 3 surface marker 1(gene name synonym)|uniprotkb:TM4SF1(gene name)|psi-mi:TM4SF1(display_short)|uniprotkb:TAAL6(gene name synonym)|uniprotkb:M3S1(gene name synonym)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418955|imex:IM-26234-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055035.1|ensembl:ENSG00000169908(gene)|ensembl:ENST00000305366(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:8bUJ4R8pfga0mbUtwmz4KGnEUH09606	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:HWf9FhjwustrdkuC+f1ME++H3dc	false	sufficient binding region:194-202	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H190	uniprotkb:P78504	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418970|imex:IM-26234-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/07/10	2017/09/20	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rigid:reSh1aQ3MOO0n9SR7uJk+eWvRJM	false	-	sufficient binding region:1210-1218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H190	uniprotkb:P30408	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	intact:EBI-714256|uniprotkb:Q6IB51|ensembl:ENSP00000304277	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:t4s1_human(display_long)|uniprotkb:Tumor-associated antigen L6(gene name synonym)|uniprotkb:Membrane component chromosome 3 surface marker 1(gene name synonym)|uniprotkb:TM4SF1(gene name)|psi-mi:TM4SF1(display_short)|uniprotkb:TAAL6(gene name synonym)|uniprotkb:M3S1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418979|imex:IM-26234-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	refseq:NP_055035.1|ensembl:ENSG00000169908(gene)|ensembl:ENST00000305366(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)	-	-	-	figure legend:5B|comment:The third-loop myc tag is attached to somewhere in the more N-terminal region of the extracellular domain aas 115-161.|comment:The text above figure 5 states that Myc1/L6A was used - which has the third-loop myc tag. However the figure legend for 5B states that Myc2/L6A was used, which has an N-terminal tag.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2017/07/10	2017/09/20	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rogid:8bUJ4R8pfga0mbUtwmz4KGnEUH09606	rigid:HWf9FhjwustrdkuC+f1ME++H3dc	false	-	myc tag:115..115-125..125|mutation disrupting interaction strength:202-202	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30408	uniprotkb:Q9H190	intact:EBI-714256|uniprotkb:Q6IB51|ensembl:ENSP00000304277	intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013	psi-mi:t4s1_human(display_long)|uniprotkb:Tumor-associated antigen L6(gene name synonym)|uniprotkb:Membrane component chromosome 3 surface marker 1(gene name synonym)|uniprotkb:TM4SF1(gene name)|psi-mi:TM4SF1(display_short)|uniprotkb:TAAL6(gene name synonym)|uniprotkb:M3S1(gene name synonym)	psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Borrell-Pagès et al. (2000)	pubmed:11102519|imex:IM-26234	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16418998|imex:IM-26234-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055035.1|ensembl:ENSG00000169908(gene)|ensembl:ENST00000305366(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008661(L6 membrane)	refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript)	go:"GO:0045177"(apical part of cell)	-	-	figure legend:5C|comment:The third-loop myc tag is attached to somewhere in the more N-terminal region of the extracellular domain aas 115-161.|comment:The text above figure 5 states that Myc1/L6A was used - which has the third-loop myc tag. However the figure legend for 5B states that Myc2/L6A was used, which has an N-terminal tag.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2017/07/10	2017/10/26	rogid:8bUJ4R8pfga0mbUtwmz4KGnEUH09606	rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606	rigid:HWf9FhjwustrdkuC+f1ME++H3dc	false	myc tag:n-n|mutation disrupting interaction strength:202-202	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)