#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P27467 uniprotkb:Q9JJJ7-4 intact:EBI-2899665|ensembl:ENSMUSP00000010044 intact:EBI-13645891|ensembl:ENSMUSP00000086824 psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym) psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13645900|imex:IM-25711-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rigid:jo+b3GHLJqCOec5SB3PUmN1YDOI false myc tag:c-c ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JJJ7-4 uniprotkb:P22724 intact:EBI-13645891|ensembl:ENSMUSP00000086824 intact:EBI-1570945|ensembl:ENSMUSP00000036580 psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:wnt4_mouse(display_long)|uniprotkb:Wnt4(gene name)|psi-mi:Wnt4(display_short)|uniprotkb:Wnt-4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13645948|imex:IM-25711-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) refseq:NP_033549.1|ensembl:ENSMUSG00000036856(gene)|ensembl:ENSMUST00000045747(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001823"(mesonephros development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0001889"(liver development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007276"(gamete generation)|go:"GO:0007548"(sex differentiation)|go:"GO:0008584"(male gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030237"(female sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033080"(immature T cell proliferation in thymus)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038030"(non-canonical Wnt signaling pathway via MAPK cascade)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060126"(somatotropin secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061205"(paramesonephric duct development)|go:"GO:0061369"(negative regulation of testicular blood vessel morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072006"(nephron development)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072174"(metanephric tubule formation)|go:"GO:0072210"(metanephric nephron development)|go:"GO:0072273"(metanephric nephron morphogenesis)|go:"GO:2000019"(negative regulation of male gonad development)|go:"GO:2000066"(positive regulation of cortisol biosynthetic process)|go:"GO:2000180"(negative regulation of androgen biosynthetic process)|go:"GO:2000225"(negative regulation of testosterone biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009142(Wnt-4 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-3238698|reactome:R-MMU-4086400|go:"GO:0008585"(female gonad development) - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rogid:Mqq6P+QzlTQmFiPhRQdQeqzzS/U10090 rigid:M+CTLn6ROhqdT0191euIp5pW/xY false ha tag:n-n myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JJJ7-4 uniprotkb:P28047 intact:EBI-13645891|ensembl:ENSMUSP00000086824 intact:EBI-13645961|ensembl:ENSMUSP00000105051|uniprotkb:Q80US5 psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:wnt7b_mouse(display_long)|uniprotkb:Wnt7b(gene name)|psi-mi:Wnt7b(display_short)|uniprotkb:Wnt-7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13645956|imex:IM-25711-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) ensembl:ENSMUSG00000022382(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021871"(forebrain regionalization)|ensembl:ENSMUST00000109424(transcript)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032536"(regulation of cell projection size)|go:"GO:0036516"(chemoattraction of dopaminergic neuron axon)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042592"(homeostatic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0044237"(cellular metabolic process)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048864"(stem cell development)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0060428"(lung epithelium development)|go:"GO:0005737"(cytoplasm)|go:"GO:0060482"(lobar bronchus development)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060560"(developmental growth involved in morphogenesis)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0005886"(plasma membrane)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072060"(outer medullary collecting duct development)|go:"GO:0072061"(inner medullary collecting duct development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072236"(metanephric loop of Henle development)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902379"(chemoattractant activity involved in axon guidance)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-3238698|refseq:NP_001157105.1|refseq:NP_001157106.1|refseq:NP_033554.3 - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rogid:RY4qriFjsAKcquMWrGYyxvhjKW410090 rigid:J+8+nQvj4/nfOhz2pCiHqj17QW4 false ha tag:n-n myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04426 uniprotkb:Q9JJJ7-4 intact:EBI-1570911|ensembl:ENSMUSP00000023734 intact:EBI-13645891|ensembl:ENSMUSP00000086824 psi-mi:wnt1_mouse(display_long)|uniprotkb:Wnt1(gene name)|psi-mi:Wnt1(display_short)|uniprotkb:Int-1(gene name synonym)|uniprotkb:Wnt-1(gene name synonym)|uniprotkb:Proto-oncogene Int-1(gene name synonym) psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13646031|imex:IM-25711-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067254.1|dip:DIP-39896N|ensembl:ENSMUSG00000022997(gene)|ensembl:ENSMUST00000023734(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021588"(cerebellum formation)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0022004"(midbrain-hindbrain boundary maturation during brain development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022037"(metencephalon development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060348"(bone development)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009139(Wnt-1 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4086400|reactome:R-MMU-4641262 ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:RIvVHDrFJM1B9GtcEv35A4nvVW010090 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rigid:LyDBFuV0IJf0btpU9qjjxCL1e4Y false myc tag:57-57 ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P22725 uniprotkb:Q9JJJ7-4 intact:EBI-1570983|ensembl:ENSMUSP00000064878|uniprotkb:Q8BM17|uniprotkb:Q8BMF9|uniprotkb:Q8VCV6 intact:EBI-13645891|ensembl:ENSMUSP00000086824 psi-mi:wnt5a_mouse(display_long)|uniprotkb:Wnt5a(gene name)|psi-mi:Wnt5a(display_short)|uniprotkb:Wnt-5a(gene name synonym) psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13646039|imex:IM-25711-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0061349"(planar cell polarity pathway involved in cardiac right atrium morphogenesis)|go:"GO:0061350"(planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:0061354"(planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097325"(melanocyte proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0061348"(planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902379"(chemoattractant activity involved in axon guidance)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0007165"(signal transduction)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0007254"(JNK cascade)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR018161|interpro:IPR026538|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4086398|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:1903827"|go:"GO:1904934"(negative regulation of cell proliferation in midbrain)|go:"GO:1904938"(planar cell polarity pathway involved in axon guidance)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|ensembl:ENSMUST00000063465(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|ensembl:ENSMUSG00000021994(gene)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003401"(axis elongation)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005115"(receptor tyrosine kinase-like orphan receptor binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036517"(chemoattraction of serotonergic neuron axon)|go:"GO:0036518"(chemorepulsion of dopaminergic neuron axon)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046546"(development of primary male sexual characteristics)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048806"(genitalia development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048850"(hypophysis morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051885"(positive regulation of timing of anagen)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060026"(convergent extension)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060067"(cervix development)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0060068"(vagina development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060157"(urinary bladder development)|go:"GO:0060324"(face development)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060606"(tube closure)|go:"GO:0060638"(mesenchymal-epithelial cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060775"(planar cell polarity pathway involved in gastrula mediolateral intercalation)|go:"GO:0060809"(mesodermal to mesenchymal transition involved in gastrulation)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061053"(somite development)|go:"GO:0061347"(planar cell polarity pathway involved in outflow tract morphogenesis)|refseq:NP_001243153.1|refseq:NP_033550.2|refseq:XP_006518987.1|refseq:XP_006518988.1|dip:DIP-39893N ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:G9K/LKijd3T0ccGcNchvUn+NHGE10090 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rigid:P9QhPsVScr6saeHMTx1IdFP/JT0 false myc tag:153-153 ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P22727 uniprotkb:Q9JJJ7-4 intact:EBI-13646095|ensembl:ENSMUSP00000006716|uniprotkb:Q80ZM9 intact:EBI-13645891|ensembl:ENSMUSP00000086824 psi-mi:wnt6_mouse(display_long)|uniprotkb:Wnt6(gene name)|psi-mi:Wnt6(display_short)|uniprotkb:Wnt-6(gene name synonym) psi-mi:q9jjj7-4(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)|uniprotkb:A(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tanaka et al. (2000) imex:IM-25711|pubmed:10866835 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-13646047|imex:IM-25711-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000033227(gene)|ensembl:ENSMUST00000006716(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009798"(axis specification)|go:"GO:0072080"(nephron tubule development)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009143(Wnt-6 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-3238698|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0070172"(positive regulation of tooth mineralization)|go:"GO:0072079"(nephron tubule formation)|refseq:NP_033552.2|refseq:XP_006495950.1|refseq:XP_006495951.1 ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000089402(transcript)|intact:EBI-16579859(isoform-parent) - - - figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2017/02/15 2017/02/15 rogid:E2idU5edd5tje81R/ofrtS2mf/g10090 rogid:PTfNcvNJJcnN6hfaKcmGcL6IYbY10090 rigid:O3Mwic5wtbzbhSqx3LplkaVzhDc false myc tag:135-135 ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)