#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P04629 uniprotkb:P01138 intact:EBI-1028226|uniprotkb:P08119|uniprotkb:Q15655|uniprotkb:Q15656|uniprotkb:Q5D056|uniprotkb:Q5VZS2|uniprotkb:Q7Z5C3|uniprotkb:Q9UIU7|uniprotkb:B2R6T5|uniprotkb:B7ZM34|ensembl:ENSP00000431418 intact:EBI-1028250|uniprotkb:Q6FHA0|uniprotkb:Q96P60|uniprotkb:Q9P2Q8|uniprotkb:Q9UKL8|uniprotkb:A1A4E5|ensembl:ENSP00000358525|ensembl:ENSP00000502380|ensembl:ENSP00000502831|ensembl:ENSP00000505694|ensembl:ENSP00000506492|ensembl:ENSP00000506569|ensembl:ENSP00000505558 psi-mi:ntrk1_human(display_long)|uniprotkb:NTRK1(gene name)|psi-mi:NTRK1(display_short)|uniprotkb:TRK(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:TRK1-transforming tyrosine kinase protein(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:MTC(gene name synonym)|uniprotkb:TRKA(gene name synonym)|uniprotkb:Tropomyosin-related kinase A(gene name synonym)|uniprotkb:Tyrosine kinase receptor(gene name synonym)|uniprotkb:Tyrosine kinase receptor A(gene name synonym)|uniprotkb:gp140trk(gene name synonym) psi-mi:ngf_human(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Wiesmann et al. (1999) pubmed:10490030|doi:10.1038/43705|imex:IM-24298 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15489183|imex:IM-24298-1|dip:DIP-9789E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001007793.1|refseq:NP_001012331.1|refseq:NP_002520.2|ensembl:ENSG00000198400(gene)|ensembl:ENST00000524377(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|interpro:IPR040665|mint:P04629|rcsb pdb:1HE7|rcsb pdb:1SHC|rcsb pdb:1WWA|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:2N90|rcsb pdb:4AOJ|rcsb pdb:4CRP|rcsb pdb:4F0I|rcsb pdb:4GT5|rcsb pdb:4PMM|rcsb pdb:4PMP|rcsb pdb:4PMS|rcsb pdb:4PMT|rcsb pdb:4YNE|rcsb pdb:4YPS|rcsb pdb:5H3Q|rcsb pdb:5I8A|rcsb pdb:5JFS|rcsb pdb:5JFV|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5JFX|rcsb pdb:5KMI|rcsb pdb:5KMJ|rcsb pdb:5KMK|rcsb pdb:5KML|rcsb pdb:5KMM|rcsb pdb:5KMN|rcsb pdb:5KMO|rcsb pdb:5KVT|rcsb pdb:5WR7|rcsb pdb:6D1Y|rcsb pdb:6D1Z|rcsb pdb:6D20|rcsb pdb:6D22|rcsb pdb:6DKB|rcsb pdb:6DKG|rcsb pdb:6DKI|rcsb pdb:6DKW|rcsb pdb:6IQN|rcsb pdb:6J5L|rcsb pdb:6NPT|rcsb pdb:6NSP|rcsb pdb:6NSS|rcsb pdb:6PL1|rcsb pdb:6PL2|rcsb pdb:6PL3|rcsb pdb:6PL4|rcsb pdb:6PMA|rcsb pdb:6PMB|rcsb pdb:6PMC|rcsb pdb:6PME|reactome:R-HSA-167021|reactome:R-HSA-167044|reactome:R-HSA-170968|reactome:R-HSA-170984|rcsb pdb:5JFW|reactome:R-HSA-177504|reactome:R-HSA-187024|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-198203|reactome:R-HSA-198745|dip:DIP-5714N refseq:NP_002497.2|ensembl:ENSG00000134259(gene)|ensembl:ENST00000369512(transcript)|ensembl:ENST00000675637(transcript)|ensembl:ENST00000676038(transcript)|ensembl:ENST00000679806(transcript)|ensembl:ENST00000680116(transcript)|ensembl:ENST00000680540(transcript)|ensembl:ENST00000680752(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031904"(endosome lumen)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|rcsb pdb:1SG1|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:4EDW|rcsb pdb:4EDX|rcsb pdb:4ZBN|rcsb pdb:5JZ7|rcsb pdb:6YW8|reactome:R-HSA-167021|reactome:R-HSA-167044|interpro:IPR029034|reactome:R-HSA-167060|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-177504|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-198203|reactome:R-HSA-198745|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563|refseq:XP_006710726.1|dip:DIP-5712N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:23wX9uYjIrxsAIcCHQ1IYMsICmw9606 rogid:qUmDPZg27gpyP0gOpOpUZJyV7mI9606 rigid:mEC8CD9iLVGe/JTEZfH+1NJCseY false sufficient binding region:282-382 sufficient binding region:122-241 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04629 uniprotkb:P01138 intact:EBI-1028226|uniprotkb:P08119|uniprotkb:Q15655|uniprotkb:Q15656|uniprotkb:Q5D056|uniprotkb:Q5VZS2|uniprotkb:Q7Z5C3|uniprotkb:Q9UIU7|uniprotkb:B2R6T5|uniprotkb:B7ZM34|ensembl:ENSP00000431418 intact:EBI-1028250|uniprotkb:Q6FHA0|uniprotkb:Q96P60|uniprotkb:Q9P2Q8|uniprotkb:Q9UKL8|uniprotkb:A1A4E5|ensembl:ENSP00000358525|ensembl:ENSP00000502380|ensembl:ENSP00000502831|ensembl:ENSP00000505694|ensembl:ENSP00000506492|ensembl:ENSP00000506569|ensembl:ENSP00000505558 psi-mi:ntrk1_human(display_long)|uniprotkb:NTRK1(gene name)|psi-mi:NTRK1(display_short)|uniprotkb:TRK(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 1(gene name synonym)|uniprotkb:TRK1-transforming tyrosine kinase protein(gene name synonym)|uniprotkb:p140-TrkA(gene name synonym)|uniprotkb:MTC(gene name synonym)|uniprotkb:TRKA(gene name synonym)|uniprotkb:Tropomyosin-related kinase A(gene name synonym)|uniprotkb:Tyrosine kinase receptor(gene name synonym)|uniprotkb:Tyrosine kinase receptor A(gene name synonym)|uniprotkb:gp140trk(gene name synonym) psi-mi:ngf_human(display_long)|uniprotkb:NGF(gene name)|psi-mi:NGF(display_short)|uniprotkb:NGFB(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wiesmann et al. (1999) pubmed:10490030|doi:10.1038/43705|imex:IM-24298 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15489204|imex:IM-24298-2|dip:DIP-9789E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001007793.1|refseq:NP_001012331.1|refseq:NP_002520.2|ensembl:ENSG00000198400(gene)|ensembl:ENST00000524377(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061368"(behavioral response to formalin induced pain)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020461|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|interpro:IPR040665|mint:P04629|rcsb pdb:1HE7|rcsb pdb:1SHC|rcsb pdb:1WWA|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:2N90|rcsb pdb:4AOJ|rcsb pdb:4CRP|rcsb pdb:4F0I|rcsb pdb:4GT5|rcsb pdb:4PMM|rcsb pdb:4PMP|rcsb pdb:4PMS|rcsb pdb:4PMT|rcsb pdb:4YNE|rcsb pdb:4YPS|rcsb pdb:5H3Q|rcsb pdb:5I8A|rcsb pdb:5JFS|rcsb pdb:5JFV|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5JFX|rcsb pdb:5KMI|rcsb pdb:5KMJ|rcsb pdb:5KMK|rcsb pdb:5KML|rcsb pdb:5KMM|rcsb pdb:5KMN|rcsb pdb:5KMO|rcsb pdb:5KVT|rcsb pdb:5WR7|rcsb pdb:6D1Y|rcsb pdb:6D1Z|rcsb pdb:6D20|rcsb pdb:6D22|rcsb pdb:6DKB|rcsb pdb:6DKG|rcsb pdb:6DKI|rcsb pdb:6DKW|rcsb pdb:6IQN|rcsb pdb:6J5L|rcsb pdb:6NPT|rcsb pdb:6NSP|rcsb pdb:6NSS|rcsb pdb:6PL1|rcsb pdb:6PL2|rcsb pdb:6PL3|rcsb pdb:6PL4|rcsb pdb:6PMA|rcsb pdb:6PMB|rcsb pdb:6PMC|rcsb pdb:6PME|reactome:R-HSA-167021|reactome:R-HSA-167044|reactome:R-HSA-170968|reactome:R-HSA-170984|rcsb pdb:5JFW|reactome:R-HSA-177504|reactome:R-HSA-187024|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-198203|reactome:R-HSA-198745|dip:DIP-5714N refseq:NP_002497.2|ensembl:ENSG00000134259(gene)|ensembl:ENST00000369512(transcript)|ensembl:ENST00000675637(transcript)|ensembl:ENST00000676038(transcript)|ensembl:ENST00000679806(transcript)|ensembl:ENST00000680116(transcript)|ensembl:ENST00000680540(transcript)|ensembl:ENST00000680752(transcript)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021675"(nerve development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031904"(endosome lumen)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|rcsb pdb:1SG1|rcsb pdb:1WWW|rcsb pdb:2IFG|rcsb pdb:4EDW|rcsb pdb:4EDX|rcsb pdb:4ZBN|rcsb pdb:5JZ7|rcsb pdb:6YW8|reactome:R-HSA-167021|reactome:R-HSA-167044|interpro:IPR029034|reactome:R-HSA-167060|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-177504|reactome:R-HSA-187042|reactome:R-HSA-187706|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-198203|reactome:R-HSA-198745|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563|refseq:XP_006710726.1|dip:DIP-5712N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:23wX9uYjIrxsAIcCHQ1IYMsICmw9606 rogid:qUmDPZg27gpyP0gOpOpUZJyV7mI9606 rigid:mEC8CD9iLVGe/JTEZfH+1NJCseY false sufficient binding region:282-382 sufficient binding region:122-241 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)