#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62920	uniprotkb:P68403-1	intact:EBI-918433|ensembl:ENSRNOP00000022387	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597789|imex:IM-25597-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/11/14	2016/11/17	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:OhzoNkS08nAIgk+GyB2nwTjouEE	false	sufficient binding region:302-520	sufficient binding region:1-340	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62920	uniprotkb:P68403-1	intact:EBI-918433|ensembl:ENSRNOP00000022387	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597805|imex:IM-25597-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/17	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:OhzoNkS08nAIgk+GyB2nwTjouEE	false	flag tag:n-n	ha tag:n-n|mutation with no effect:371-371	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62920	uniprotkb:P68403-1	intact:EBI-918433|ensembl:ENSRNOP00000022387	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597816|imex:IM-25597-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/17	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:OhzoNkS08nAIgk+GyB2nwTjouEE	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P53667	uniprotkb:P63319	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	intact:EBI-12598030|ensembl:ENSRNOP00000071203|uniprotkb:P05697|uniprotkb:Q5FWS3	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:kpcg_rat(display_long)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598091|imex:IM-25597-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	ensembl:ENSRNOG00000054371(gene)|ensembl:ENSRNOT00000080032(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|mint:P63319|rcsb pdb:1TBN|rcsb pdb:1TBO|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-416993|reactome:R-RNO-5099900|reactome:R-RNO-76005|rgd:3397|refseq:NP_036760.1	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10116	rigid:2CusSZt+lwCQr3h8bFyxaZmmXOs	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09217	uniprotkb:P53667	intact:EBI-1551121|ensembl:ENSRNOP00000021285	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:kpcz_rat(display_long)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598099|imex:IM-25597-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006239598.1|rgd:3399|refseq:NP_071952.1|dip:DIP-40867N|ensembl:ENSRNOG00000015480(gene)|ensembl:ENSRNOT00000021285(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|rcsb pdb:4MJS|reactome:R-RNO-2173791|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-9634635	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:2qGiTRy5459eks3RiwpXPxWmZRk10116	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rigid:WYFb5QkQIfLroyZW8ECTM51Yi/0	false	ha tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05696	uniprotkb:P53667	intact:EBI-935801	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:kpca_rat(display_long)|uniprotkb:Prkca(gene name)|psi-mi:Prkca(display_short)|uniprotkb:Pkca(gene name synonym)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598107|imex:IM-25597-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017892|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rgd:3395|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034663|mint:P05696|interpro:IPR035892|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|rcsb pdb:1DSY|rcsb pdb:2NCE|rcsb pdb:3GPE|rcsb pdb:3RDJ|rcsb pdb:3TWY|rcsb pdb:4L1L|rcsb pdb:5W4S|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-1250196|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-2179392|reactome:R-RNO-3000170|reactome:R-RNO-399997|reactome:R-RNO-416993|reactome:R-RNO-4419969|reactome:R-RNO-450520|reactome:R-RNO-5099900|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-76005|reactome:R-RNO-8853659	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	-	-	figure legend:5B|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:wWfVnOun9EFrE7DtrG8RRwPIpLs10116	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rigid:Gwq/dvwq6VwUM2zhZuWtw6wHfC0	false	ha tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P53667	uniprotkb:P09215	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	intact:EBI-6376088|uniprotkb:Q6DG48|uniprotkb:Q9JK29|uniprotkb:Q9JL03	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:kpcd_rat(display_long)|uniprotkb:Prkcd(gene name)|psi-mi:Prkcd(display_short)|uniprotkb:Pkcd(gene name synonym)|uniprotkb:nPKC-delta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598115|imex:IM-25597-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0005634"(nucleus)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036019"(endolysosome)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900163"(positive regulation of phospholipid scramblase activity)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:2000303"(regulation of ceramide biosynthetic process)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000753"(positive regulation of glucosylceramide catabolic process)|go:"GO:2000755"(positive regulation of sphingomyelin catabolic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|rgd:67383|refseq:NP_579841.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:1BDY|interpro:IPR027436|interpro:IPR035892|reactome:R-RNO-111465|reactome:R-RNO-111933|reactome:R-RNO-114508|reactome:R-RNO-1250196|reactome:R-RNO-1489509|reactome:R-RNO-2029485|reactome:R-RNO-450520|reactome:R-RNO-5218921|reactome:R-RNO-5607764|reactome:R-RNO-6798695|reactome:R-RNO-877300|reactome:R-RNO-5668599	-	-	-	figure legend:5B|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rogid:hMdRMyAdE4EMYk0sKud7LO8EueE10116	rigid:p0bCfDrQj/4DYUQwVQuCut7dPKE	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09216	uniprotkb:P53667	intact:EBI-6049581	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:kpce_rat(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598123|imex:IM-25597-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61925|refseq:NP_058867.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR027274|interpro:IPR035892|interpro:IPR034669|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:1GMI|reactome:R-RNO-114508|reactome:R-RNO-1250196|reactome:R-RNO-1489509|reactome:R-RNO-2029485|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051301"(cell division)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	-	-	figure legend:5B|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:8KbTSbduZqvEsWszPkWFMQkprDk10116	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rigid:Qq1JgMtHAPAezNmiSWKXARqlDpE	false	ha tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62920	uniprotkb:P68403-1	intact:EBI-918433|ensembl:ENSRNOP00000022387	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597931|imex:IM-25597-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/11/14	2016/11/17	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:OhzoNkS08nAIgk+GyB2nwTjouEE	false	sufficient binding region:415-465(IPR001781)|sufficient binding region:474-524(IPR001781)|sufficient binding region:533-585(IPR001781)	sufficient binding region:1-340	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62920	uniprotkb:P68403-1	intact:EBI-918433|ensembl:ENSRNOP00000022387	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597951|imex:IM-25597-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/11/14	2016/11/17	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:OhzoNkS08nAIgk+GyB2nwTjouEE	false	sufficient binding region:415-591(IPR001781)	sufficient binding region:1-19	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09216	uniprotkb:Q62920	intact:EBI-6049581	intact:EBI-918433|ensembl:ENSRNOP00000022387	psi-mi:kpce_rat(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597968|imex:IM-25597-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61925|refseq:NP_058867.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR027274|interpro:IPR035892|interpro:IPR034669|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:1GMI|reactome:R-RNO-114508|reactome:R-RNO-1250196|reactome:R-RNO-1489509|reactome:R-RNO-2029485|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051301"(cell division)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/11/14	2016/11/15	rogid:8KbTSbduZqvEsWszPkWFMQkprDk10116	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	rigid:9I5tB6vbgVv/WRb7CB1Ysd/x/9A	false	sufficient binding region:1-133	sufficient binding region:415-591(IPR001781)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR12	uniprotkb:P68403-1	intact:EBI-350517|uniprotkb:Q14250|uniprotkb:Q5XG82|uniprotkb:Q6NVZ5|uniprotkb:Q96C91|uniprotkb:Q9BXB8|uniprotkb:Q9BXB9|intact:EBI-2556830|ensembl:ENSP00000348099	intact:EBI-12559950|uniprotkb:P04410-1	psi-mi:pdli7_human(display_long)|uniprotkb:LIM mineralization protein(gene name synonym)|uniprotkb:Protein enigma(gene name synonym)|uniprotkb:PDLIM7(gene name)|psi-mi:PDLIM7(display_short)|uniprotkb:ENIGMA(gene name synonym)	psi-mi:p68403-1(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12597987|imex:IM-25597-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976227.1|refseq:NP_998801.1|refseq:NP_005442.2|ensembl:ENST00000355572|ensembl:ENSP00000347776|ensembl:ENSP00000348099|ensembl:ENST00000359895|ensembl:ENSP00000352964|ensembl:ENST00000393551|ensembl:ENSP00000377182|ensembl:ENST00000486828|ensembl:ENSP00000439157|ensembl:ENST00000493815|ensembl:ENSP00000431236|ensembl:ENSG00000196923(gene)|ensembl:ENST00000355841(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031941"(filamentous actin)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR036034|rcsb pdb:2Q3G|reactome:R-HSA-8853659	intact:EBI-397072(isoform-parent)	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/11/14	2016/11/17	rogid:XBVF0Y1DFqIYbnt/e/rYqS/m4d09606	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10116	rigid:ZbtM95VFn/yuU4fVnTZlWwCrqjs	false	glutathione s tranferase tag:?-?|sufficient binding region:280..280-457..457	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05696	uniprotkb:Q9NR12	intact:EBI-935801	intact:EBI-350517|uniprotkb:Q14250|uniprotkb:Q5XG82|uniprotkb:Q6NVZ5|uniprotkb:Q96C91|uniprotkb:Q9BXB8|uniprotkb:Q9BXB9|intact:EBI-2556830|ensembl:ENSP00000348099	psi-mi:kpca_rat(display_long)|uniprotkb:Prkca(gene name)|psi-mi:Prkca(display_short)|uniprotkb:Pkca(gene name synonym)	psi-mi:pdli7_human(display_long)|uniprotkb:LIM mineralization protein(gene name synonym)|uniprotkb:Protein enigma(gene name synonym)|uniprotkb:PDLIM7(gene name)|psi-mi:PDLIM7(display_short)|uniprotkb:ENIGMA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598004|imex:IM-25597-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017892|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rgd:3395|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034663|mint:P05696|interpro:IPR035892|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|rcsb pdb:1DSY|rcsb pdb:2NCE|rcsb pdb:3GPE|rcsb pdb:3RDJ|rcsb pdb:3TWY|rcsb pdb:4L1L|rcsb pdb:5W4S|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-1250196|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-2179392|reactome:R-RNO-3000170|reactome:R-RNO-399997|reactome:R-RNO-416993|reactome:R-RNO-4419969|reactome:R-RNO-450520|reactome:R-RNO-5099900|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-76005|reactome:R-RNO-8853659	refseq:NP_976227.1|refseq:NP_998801.1|refseq:NP_005442.2|ensembl:ENST00000355572|ensembl:ENSP00000347776|ensembl:ENSP00000348099|ensembl:ENST00000359895|ensembl:ENSP00000352964|ensembl:ENST00000393551|ensembl:ENSP00000377182|ensembl:ENST00000486828|ensembl:ENSP00000439157|ensembl:ENST00000493815|ensembl:ENSP00000431236|ensembl:ENSG00000196923(gene)|ensembl:ENST00000355841(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031941"(filamentous actin)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR036034|rcsb pdb:2Q3G|reactome:R-HSA-8853659	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/11/14	2016/11/15	rogid:wWfVnOun9EFrE7DtrG8RRwPIpLs10116	rogid:XBVF0Y1DFqIYbnt/e/rYqS/m4d09606	rigid:SWTwez3obgzEyv2X+aV0cNk3/ms	false	ha tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:280..280-457..457	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09217	uniprotkb:Q9NR12	intact:EBI-1551121|ensembl:ENSRNOP00000021285	intact:EBI-350517|uniprotkb:Q14250|uniprotkb:Q5XG82|uniprotkb:Q6NVZ5|uniprotkb:Q96C91|uniprotkb:Q9BXB8|uniprotkb:Q9BXB9|intact:EBI-2556830|ensembl:ENSP00000348099	psi-mi:kpcz_rat(display_long)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:pdli7_human(display_long)|uniprotkb:LIM mineralization protein(gene name synonym)|uniprotkb:Protein enigma(gene name synonym)|uniprotkb:PDLIM7(gene name)|psi-mi:PDLIM7(display_short)|uniprotkb:ENIGMA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598014|imex:IM-25597-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006239598.1|rgd:3399|refseq:NP_071952.1|dip:DIP-40867N|ensembl:ENSRNOG00000015480(gene)|ensembl:ENSRNOT00000021285(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|rcsb pdb:4MJS|reactome:R-RNO-2173791|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-9634635	refseq:NP_976227.1|refseq:NP_998801.1|refseq:NP_005442.2|ensembl:ENST00000355572|ensembl:ENSP00000347776|ensembl:ENSP00000348099|ensembl:ENST00000359895|ensembl:ENSP00000352964|ensembl:ENST00000393551|ensembl:ENSP00000377182|ensembl:ENST00000486828|ensembl:ENSP00000439157|ensembl:ENST00000493815|ensembl:ENSP00000431236|ensembl:ENSG00000196923(gene)|ensembl:ENST00000355841(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031941"(filamentous actin)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR036034|rcsb pdb:2Q3G|reactome:R-HSA-8853659	-	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/11/14	2016/11/15	rogid:2qGiTRy5459eks3RiwpXPxWmZRk10116	rogid:XBVF0Y1DFqIYbnt/e/rYqS/m4d09606	rigid:zMDKZOhRJBy0L9CaIyg3uGe9eaA	false	ha tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:280..280-457..457	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P63319	uniprotkb:P53667	intact:EBI-12598030|ensembl:ENSRNOP00000071203|uniprotkb:P05697|uniprotkb:Q5FWS3	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:kpcg_rat(display_long)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598160|imex:IM-25597-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000054371(gene)|ensembl:ENSRNOT00000080032(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|mint:P63319|rcsb pdb:1TBN|rcsb pdb:1TBO|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-416993|reactome:R-RNO-5099900|reactome:R-RNO-76005|rgd:3397|refseq:NP_036760.1	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	-	comment:Mutations in the LIMK1 LIM 2 domain substituting Gly for  consensus Cys residues disrupt the interaction	figure legend:5C|comment:"Three LIMK1 mutants (exact mutations not stated) were constructed , in which LIM domains were mutated not to form zinc binding by substituting Gly for consensus Cys residues.  Results indicated that the LIM2 domain of LIMK1 (group B) is critical for  binding."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10116	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rigid:2CusSZt+lwCQr3h8bFyxaZmmXOs	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63319	uniprotkb:P53667	intact:EBI-12598030|ensembl:ENSRNOP00000071203|uniprotkb:P05697|uniprotkb:Q5FWS3	intact:EBI-444403|ensembl:ENSP00000336740|uniprotkb:O15283|uniprotkb:Q15820|uniprotkb:Q15821|uniprotkb:Q75MU3|uniprotkb:Q9Y5Q1|uniprotkb:D3DXF4|uniprotkb:D3DXF5|uniprotkb:B7Z6I8	psi-mi:kpcg_rat(display_long)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)	psi-mi:limk1_human(display_long)|uniprotkb:LIMK1(gene name)|psi-mi:LIMK1(display_short)|uniprotkb:LIMK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kuroda et al. (1996)	pubmed:8940095|imex:IM-25597	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12598177|imex:IM-25597-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000054371(gene)|ensembl:ENSRNOT00000080032(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR035892|mint:P63319|rcsb pdb:1TBN|rcsb pdb:1TBO|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-416993|reactome:R-RNO-5099900|reactome:R-RNO-76005|rgd:3397|refseq:NP_036760.1	refseq:NP_001191355.1|refseq:NP_002305.1|ensembl:ENSG00000106683(gene)|ensembl:ENST00000336180(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043005"(neuron projection)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53667|rcsb pdb:3S95|rcsb pdb:5HVJ|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:5NXC|rcsb pdb:6WLY|rcsb pdb:7ATS|rcsb pdb:7ATU|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-416572|reactome:R-HSA-5627117|reactome:R-HSA-5627123|dip:DIP-31605N	-	-	comment:Mutations in the LIMK1 LIM 2 domain substituting Gly for  consensus Cys residues disrupt the interaction	figure legend:5C|comment:"Three LIMK1 mutants (exact mutations not stated) were constructed , in which LIM domains were mutated not to form zinc binding by substituting Gly for consensus Cys residues.  Results indicated that the LIM2 domain of LIMK1 (group B) is critical for  binding."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2016/11/14	2016/11/15	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10116	rogid:UvM2/wj5ZR6w0/JbJ5GvCY/b/fU9606	rigid:2CusSZt+lwCQr3h8bFyxaZmmXOs	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)