#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3V3V9	uniprotkb:Q9CX34	intact:EBI-12601364	intact:EBI-8313522|ensembl:ENSMUSP00000052942|uniprotkb:Q3UF88|uniprotkb:Q9CRE7|uniprotkb:Q9D8M6|intact:MINT-4136085	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:sgt1_mouse(display_long)|uniprotkb:Sugt1(gene name)|psi-mi:Sugt1(display_short)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	ensembl:ENSMUSG00000022024(gene)|ensembl:ENSMUST00000054908(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9CX34|reactome:R-MMU-844456|refseq:NP_080750.1	-	-	comment:mint|function:May play a role in ubiquitination and subsequent proteosomal degradation of target proteins	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:2ZgYNnQMnd0DMy/4DubRm+KM+q410090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:O35601	intact:EBI-12601364	intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N	-	-	comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2"	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P10300	intact:EBI-12601364	intact:EBI-7541406|uniprotkb:Q60966|intact:MINT-8303335|uniprotkb:Q61811|uniprotkb:Q31127|ensembl:ENSMUSP00000070131	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:cd8b_mouse(display_long)|uniprotkb:Cd8b(gene name)|psi-mi:Cd8b(display_short)|uniprotkb:Cd8b1(gene name synonym)|uniprotkb:Ly-3(gene name synonym)|uniprotkb:Lymphocyte antigen 3(gene name synonym)|uniprotkb:Lyt-3(gene name synonym)|uniprotkb:Lyt3(gene name synonym)|uniprotkb:T-cell membrane glycoprotein Ly-3(gene name synonym)|uniprotkb:T-cell surface glycoprotein Lyt-3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_033988.1|ensembl:ENSMUSG00000053044(gene)|ensembl:ENSMUST00000065248(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0050776"(regulation of immune response)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042414|rcsb pdb:2ATP|rcsb pdb:3B9K|rcsb pdb:3DMM|reactome:R-MMU-198933	-	-	comment:mint	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:IiuCsHRcaED1wVJL89GP19x76H410090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P47754	intact:EBI-12601364	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P47757	intact:EBI-12601364	intact:EBI-299194|ensembl:ENSMUSP00000099565|uniprotkb:A2AMV7	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:capzb_mouse(display_long)|uniprotkb:Capzb(gene name)|psi-mi:Capzb(display_short)|uniprotkb:Cappb1(gene name synonym)|uniprotkb:CapZ beta(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	ensembl:ENSMUSG00000028745(gene)|ensembl:ENSMUST00000102507(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033150"(cytoskeletal calyx)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47757|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-9013405|reactome:R-MMU-9035034|reactome:R-MMU-983231|refseq:NP_001032850.1|refseq:NP_033928.1|refseq:NP_001258334.1|dip:DIP-31383N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:KuYsJ7bZNn4W7wMGSadohYIBWqM10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P47753	intact:EBI-12601364	intact:EBI-777259|uniprotkb:Q91YN7	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:caza1_mouse(display_long)|uniprotkb:CapZ alpha-1(gene name synonym)|uniprotkb:Capza1(gene name)|psi-mi:Capza1(display_short)|uniprotkb:Cappa1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	interpro:IPR017865|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR042276|interpro:IPR037282|mint:P47753|interpro:IPR042489|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0034329"(cell junction assembly)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071203"(WASH complex)|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:RHqr2/WSAoIXWooDhXO9/TSiTJ010090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P06800	intact:EBI-12601364	intact:EBI-1672|uniprotkb:E9QLT5|uniprotkb:Q61812|uniprotkb:Q61813|uniprotkb:Q61814|uniprotkb:Q61815|uniprotkb:Q78EF1|ensembl:ENSMUSP00000138350|uniprotkb:S4R1S4|uniprotkb:S4R2V1	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:ptprc_mouse(display_long)|uniprotkb:Ptprc(gene name)|psi-mi:Ptprc(display_short)|uniprotkb:Ly-5(gene name synonym)|uniprotkb:Lymphocyte antigen 5(gene name synonym)|uniprotkb:T200(gene name synonym)|uniprotkb:Leukocyte common antigen(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:XP_006529323.1|ensembl:ENSMUSG00000026395(gene)|ensembl:ENSMUST00000183301(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0002923"(regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:NP_001104786.2|refseq:XP_006529320.1|refseq:XP_006529321.1|refseq:XP_006529322.1|refseq:NP_035340.3|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032059"(bleb)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0044855"(plasma membrane raft distribution)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048539"(bone marrow development)|go:"GO:0048864"(stem cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0098857"(membrane microdomain)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000473"(positive regulation of hematopoietic stem cell migration)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050857"(positive regulation of antigen receptor-mediated signaling pathway)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016335(Leukocyte common antigen)|interpro:IPR024739|interpro:IPR029021|interpro:IPR036116|mint:P06800|reactome:R-MMU-202427|reactome:R-MMU-416700|reactome:R-MMU-6798695|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:rVsavXUDYPWKoE9O8SxF2EvjLFQ10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q8C503	intact:EBI-12601364	intact:EBI-12601456|ensembl:ENSMUSP00000030180|uniprotkb:Q9WUU5	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:sit1_mouse(display_long)|uniprotkb:Sit1(gene name)|psi-mi:Sit1(display_short)|uniprotkb:Sit(gene name synonym)|uniprotkb:SHP2-interacting transmembrane adapter protein(gene name synonym)|uniprotkb:Suppression-inducing transmembrane adapter 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	ensembl:ENSMUSG00000028460(gene)|ensembl:ENSMUST00000030180(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR033269|refseq:NP_062309.2	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:L7RYMt5UaRqKt+CoRBComR4npBY10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q8C2K5	intact:EBI-12601364	intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q8C147	intact:EBI-12601364	intact:EBI-11566633|uniprotkb:Q9DBQ2|uniprotkb:Q6PIS0|uniprotkb:Q7TMQ5|uniprotkb:Q6KAM7|uniprotkb:Q8CAP6|uniprotkb:Q8K105|ensembl:ENSMUSP00000025831	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:dock8_mouse(display_long)|uniprotkb:Dock8(gene name)|psi-mi:Dock8(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_083061.2|ensembl:ENSMUSG00000052085(gene)|ensembl:ENSMUST00000025831(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061485"(memory T cell proliferation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|rcsb pdb:3VHL|rcsb pdb:7CLX|rcsb pdb:7CLY|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013409|reactome:R-MMU-983231	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:xAjdT7y7XRy54NjvlQ6tt8Rm9ko10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:A2A8L5	intact:EBI-12601364	intact:EBI-771868|uniprotkb:Q6PG86|uniprotkb:Q9EQ17|ensembl:ENSMUSP00000039368	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:ptprf_mouse(display_long)|uniprotkb:Ptprf(gene name)|psi-mi:Ptprf(display_short)|uniprotkb:Lar(gene name synonym)|uniprotkb:Leukocyte common antigen related(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_035343.2|ensembl:ENSMUSG00000033295(gene)|ensembl:ENSMUST00000049074(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060076"(excitatory synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900121"(negative regulation of receptor binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3PXH|rcsb pdb:6X39|reactome:R-MMU-388844|reactome:R-MMU-8849932	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:+BPaDKLeYgJ+Yz6UKakFSmlXPxg10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q8CIS0	intact:EBI-12601364	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q62167	intact:EBI-12601364	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q60631	intact:EBI-12601364	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:O89100	intact:EBI-12601364	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P31041	intact:EBI-12601364	intact:EBI-5323998|ensembl:ENSMUSP00000027165|uniprotkb:Q6GSH7	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:cd28_mouse(display_long)|uniprotkb:Cd28(gene name)|psi-mi:Cd28(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	ensembl:ENSMUSG00000026012(gene)|ensembl:ENSMUST00000027165(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002020"(protease binding)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR008093(T cell antigen CD28)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:2NAE|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-6811558|refseq:NP_031668.3|dip:DIP-60858N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:DT/rBn4RC67LtoEWo40+H2Wch1Q10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q6ZQ08	intact:EBI-12601364	intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115	-	-	comment:AfCS Y2H protein 39306. Translated from nucleotide sequence.	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P27870	intact:EBI-12601364	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:P29351	intact:EBI-12601364	intact:EBI-2620699|uniprotkb:Q9QVA8|uniprotkb:Q9R0V6|uniprotkb:O35128|uniprotkb:Q63872|uniprotkb:Q63873|uniprotkb:Q63874|uniprotkb:Q921G3|uniprotkb:Q9QVA6|uniprotkb:Q9QVA7|ensembl:ENSMUSP00000108103	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:ptn6_mouse(display_long)|uniprotkb:Ptpn6(gene name)|psi-mi:Ptpn6(display_short)|uniprotkb:Hcp(gene name synonym)|uniprotkb:Hcph(gene name synonym)|uniprotkb:Ptp1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:70Z-SHP(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:PTPTY-42(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601361|imex:IM-25631-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	refseq:NP_001071173.1|refseq:NP_038573.2|ensembl:ENSMUSG00000004266(gene)|ensembl:ENSMUST00000112484(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29351|reactome:R-MMU-114604|reactome:R-MMU-1433559|reactome:R-MMU-210990|reactome:R-MMU-388841|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5690714|reactome:R-MMU-6798695|reactome:R-MMU-877300|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-983695|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|dip:DIP-41455N	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:7dtH2jT68TwvCkZu9rqVowIrEK010090	rigid:zidb5g7iY+1nImtAsqmvh40CiWA	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3V3V9	uniprotkb:Q3V3V9	intact:EBI-12601364	intact:EBI-12601364	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Roncagalli et al. (2016)	pubmed:27647348|imex:IM-25631	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12601497|imex:IM-25631-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	-	-	-	figure legend:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/10/20	2016/11/25	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rigid:B4Mk9F6m7EAqadGqDTZJCJTmgPI	false	yellow fluorescent protein tag:c-c	strep ii tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)