#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q93050 uniprotkb:P07195 intact:EBI-2891238|ensembl:ENSP00000342951|uniprotkb:Q8N5G7|uniprotkb:Q9NSX0|intact:EBI-4324496|uniprotkb:B7Z3B7 intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386 psi-mi:vpp1_human(display_long)|uniprotkb:ATP6V0A1(gene name)|psi-mi:ATP6V0A1(display_short)|uniprotkb:ATP6N1(gene name synonym)|uniprotkb:ATP6N1A(gene name synonym)|uniprotkb:VPP1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1(gene name synonym)|uniprotkb:Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit 1(gene name synonym)|uniprotkb:Vacuolar adenosine triphosphatase subunit Ac116(gene name synonym) psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Brisson et al. (2016) pubmed:27622334|imex:IM-25606 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-12685976|imex:IM-25606-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000033627(gene)|ensembl:ENST00000343619(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901998"(toxin transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|mint:Q93050|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|interpro:IPR026028|reactome:R-HSA-917977|reactome:R-HSA-983712|refseq:NP_001123492.1|refseq:NP_001123493.1|refseq:NP_005168.2 refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268 - - - figure legend:5A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-siha)|taxid:9606(Homo sapiens SiHa cervical carcinoma cell line) - 2016/10/20 2016/12/13 rogid:3htDhXCA9potj7i32HoA2j3Sfqw9606 rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606 rigid:twXjDodibrYiQDbvLS/8Oah1KrU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q93050 uniprotkb:P07195 intact:EBI-2891238|ensembl:ENSP00000342951|uniprotkb:Q8N5G7|uniprotkb:Q9NSX0|intact:EBI-4324496|uniprotkb:B7Z3B7 intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386 psi-mi:vpp1_human(display_long)|uniprotkb:ATP6V0A1(gene name)|psi-mi:ATP6V0A1(display_short)|uniprotkb:ATP6N1(gene name synonym)|uniprotkb:ATP6N1A(gene name synonym)|uniprotkb:VPP1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1(gene name synonym)|uniprotkb:Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit 1(gene name synonym)|uniprotkb:Vacuolar adenosine triphosphatase subunit Ac116(gene name synonym) psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Brisson et al. (2016) pubmed:27622334|imex:IM-25606 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12685989|imex:IM-25606-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000033627(gene)|ensembl:ENST00000343619(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901998"(toxin transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|mint:Q93050|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|interpro:IPR026028|reactome:R-HSA-917977|reactome:R-HSA-983712|refseq:NP_001123492.1|refseq:NP_001123493.1|refseq:NP_005168.2 refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268 - - - figure legend:5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-siha)|taxid:9606(Homo sapiens SiHa cervical carcinoma cell line) - 2016/10/20 2016/12/13 rogid:3htDhXCA9potj7i32HoA2j3Sfqw9606 rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606 rigid:twXjDodibrYiQDbvLS/8Oah1KrU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)