#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22830	uniprotkb:P22315	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-7174007|intact:MINT-1842883	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:Q78IK4	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-12523754|ensembl:ENSMUSP00000026599	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:mic27_mouse(display_long)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:Apool(gene name)|psi-mi:Apool(display_short)|uniprotkb:Fam121a(gene name synonym)|uniprotkb:Mic27(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	ensembl:ENSMUSG00000025525(gene)|ensembl:ENSMUST00000026599(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-MMU-114608|refseq:NP_080841.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:EwRruXYRyPfcpKL+Yv7brXT9fMk10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:P58281	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-776163|uniprotkb:Q3ULA5|uniprotkb:Q8BKU7|uniprotkb:Q8BLL3|uniprotkb:Q8BM08|uniprotkb:Q8R3J7|uniprotkb:A6H6Q3|ensembl:ENSMUSP00000124223	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:opa1_mouse(display_long)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)|uniprotkb:Large GTP-binding protein(gene name synonym)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_598513.1|refseq:XP_006522720.1|ensembl:ENSMUSG00000038084(gene)|ensembl:ENSMUST00000160597(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:P58281|reactome:R-MMU-169911	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:cj1HZs8CYUuCBy4KhYmtO/lvmUk10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:Q8CAQ8	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:Q80UU9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:O55022	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523198|imex:IM-25485-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:7iCrsLMFQGrL3cOxoYP3cWd+JW8	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P22315	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-7174007|intact:MINT-1842883	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q8CI59	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767480|uniprotkb:Q3TKE4|uniprotkb:Q80ZF3|uniprotkb:Q8C5F0|uniprotkb:Q924Z1	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:stea3_mouse(display_long)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Protein nm1054(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:Steap3(gene name)|psi-mi:Steap3(display_short)|uniprotkb:Tsap6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	reactome:R-MMU-6803204|reactome:R-MMU-917977|reactome:R-MMU-9013148|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9035034|refseq:NP_001078878.1|refseq:NP_573449.2|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|go:"GO:0000293"(ferric-chelate reductase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033212"(iron import into cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0098706"(iron ion import across cell outer membrane)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1990182"(exosomal secretion)|interpro:IPR036291	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:8p8Tf/zr3ZSGWgNriaa01NC6yXE10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q62351	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q9CR62	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q60930	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P51881	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P48962	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-299469|ensembl:ENSMUSP00000034049|uniprotkb:Q62164	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:adt1_mouse(display_long)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Anc1(gene name synonym)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	ensembl:ENSMUST00000034049(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P48962|reactome:R-MMU-83936|ensembl:ENSMUSG00000031633(gene)|refseq:NP_031476.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:WHXVn/8emywvVfEH5dZ7KrUTiC810090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q61102	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q9JI39	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q9Z2I9	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P08680	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767448|uniprotkb:Q64452|uniprotkb:Q9DCN0|ensembl:ENSMUSP00000066040	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hem0_mouse(display_long)|uniprotkb:5-aminolevulinic acid synthase 2(gene name synonym)|uniprotkb:Delta-ALA synthase 2(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 2(gene name synonym)|uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_001095916.1|refseq:NP_033783.1|ensembl:ENSMUST00000066337(transcript)|go:"GO:0001666"(response to hypoxia)|ensembl:ENSMUSG00000025270(gene)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0120225"(coenzyme A binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1H7D|rcsb pdb:1H7J|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:u2FJSJbEuyk+eU2flF2jrD+2Q7g10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P51175	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P58281	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-776163|uniprotkb:Q3ULA5|uniprotkb:Q8BKU7|uniprotkb:Q8BLL3|uniprotkb:Q8BM08|uniprotkb:Q8R3J7|uniprotkb:A6H6Q3|ensembl:ENSMUSP00000124223	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:opa1_mouse(display_long)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)|uniprotkb:Large GTP-binding protein(gene name synonym)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_598513.1|refseq:XP_006522720.1|ensembl:ENSMUSG00000038084(gene)|ensembl:ENSMUST00000160597(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:P58281|reactome:R-MMU-169911	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:cj1HZs8CYUuCBy4KhYmtO/lvmUk10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q8CAQ8	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q80UU9	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:O55022	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:Q78IK4	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-12523754|ensembl:ENSMUSP00000026599	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:mic27_mouse(display_long)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:Apool(gene name)|psi-mi:Apool(display_short)|uniprotkb:Fam121a(gene name synonym)|uniprotkb:Mic27(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523216|imex:IM-25485-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	ensembl:ENSMUSG00000025525(gene)|ensembl:ENSMUST00000026599(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-MMU-114608|refseq:NP_080841.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:EwRruXYRyPfcpKL+Yv7brXT9fMk10090	rigid:ZM1fvbJ/GhpOocrO4bWxImb61yI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:P22315	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-7174007|intact:MINT-1842883	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q78IK4	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-12523754|ensembl:ENSMUSP00000026599	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:mic27_mouse(display_long)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:Apool(gene name)|psi-mi:Apool(display_short)|uniprotkb:Fam121a(gene name synonym)|uniprotkb:Mic27(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	ensembl:ENSMUSG00000025525(gene)|ensembl:ENSMUST00000026599(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-MMU-114608|refseq:NP_080841.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:EwRruXYRyPfcpKL+Yv7brXT9fMk10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q8CI59	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-10767480|uniprotkb:Q3TKE4|uniprotkb:Q80ZF3|uniprotkb:Q8C5F0|uniprotkb:Q924Z1	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:stea3_mouse(display_long)|uniprotkb:Dudulin-2(gene name synonym)|uniprotkb:Protein nm1054(gene name synonym)|uniprotkb:Six-transmembrane epithelial antigen of prostate 3(gene name synonym)|uniprotkb:Tumor suppressor-activated pathway protein 6(gene name synonym)|uniprotkb:Steap3(gene name)|psi-mi:Steap3(display_short)|uniprotkb:Tsap6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	reactome:R-MMU-6803204|reactome:R-MMU-917977|reactome:R-MMU-9013148|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9035034|refseq:NP_001078878.1|refseq:NP_573449.2|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR028939|go:"GO:0000293"(ferric-chelate reductase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008823"(cupric reductase activity)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0015677"(copper ion import)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033212"(iron import into cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052851"("ferric-chelate reductase (NADPH) activity")|go:"GO:0098706"(iron ion import across cell outer membrane)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1990182"(exosomal secretion)|interpro:IPR036291	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:8p8Tf/zr3ZSGWgNriaa01NC6yXE10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q62351	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q9CR62	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q60930	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-444578|ensembl:ENSMUSP00000022293|uniprotkb:Q78MH6|uniprotkb:Q99L98	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:vdac2_mouse(display_long)|uniprotkb:Voltage-dependent anion-selective channel protein 6(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)|uniprotkb:Vdac6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_035825.1|ensembl:ENSMUSG00000021771(gene)|ensembl:ENSMUST00000022293(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:Q60930|reactome:R-MMU-5689880	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:ApSD4TVlagQ1QHePbOZw7J5rmzQ10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:P51881	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:P48962	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-299469|ensembl:ENSMUSP00000034049|uniprotkb:Q62164	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:adt1_mouse(display_long)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Anc1(gene name synonym)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	ensembl:ENSMUST00000034049(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P48962|reactome:R-MMU-83936|ensembl:ENSMUSG00000031633(gene)|refseq:NP_031476.3	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:WHXVn/8emywvVfEH5dZ7KrUTiC810090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q61102	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q9JI39	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q9Z2I9	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:P08680	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-10767448|uniprotkb:Q64452|uniprotkb:Q9DCN0|ensembl:ENSMUSP00000066040	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:hem0_mouse(display_long)|uniprotkb:5-aminolevulinic acid synthase 2(gene name synonym)|uniprotkb:Delta-ALA synthase 2(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 2(gene name synonym)|uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_001095916.1|refseq:NP_033783.1|ensembl:ENSMUST00000066337(transcript)|go:"GO:0001666"(response to hypoxia)|ensembl:ENSMUSG00000025270(gene)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0120225"(coenzyme A binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1H7D|rcsb pdb:1H7J|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:u2FJSJbEuyk+eU2flF2jrD+2Q7g10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:P58281	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-776163|uniprotkb:Q3ULA5|uniprotkb:Q8BKU7|uniprotkb:Q8BLL3|uniprotkb:Q8BM08|uniprotkb:Q8R3J7|uniprotkb:A6H6Q3|ensembl:ENSMUSP00000124223	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:opa1_mouse(display_long)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)|uniprotkb:Large GTP-binding protein(gene name synonym)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_598513.1|refseq:XP_006522720.1|ensembl:ENSMUSG00000038084(gene)|ensembl:ENSMUST00000160597(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:P58281|reactome:R-MMU-169911	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:cj1HZs8CYUuCBy4KhYmtO/lvmUk10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q8CAQ8	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:Q80UU9	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O15173	uniprotkb:O55022	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523269|imex:IM-25485-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table 1, suppl. table 1, fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/10/05	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:y5JAqDLDF9zeiQ+6b1nzLdlKniw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:P22315	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-7174007|intact:MINT-1842883	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523490|imex:IM-25485-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:s3j3L7GaRJYsdN35gU9NRLxaQO4	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:Q80UU9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523490|imex:IM-25485-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:s3j3L7GaRJYsdN35gU9NRLxaQO4	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:O55022	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523490|imex:IM-25485-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:s3j3L7GaRJYsdN35gU9NRLxaQO4	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:P22315	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-7174007|intact:MINT-1842883	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523506|imex:IM-25485-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:TA2yQeVEtRGgT6RuXMGZUahv1SY	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O00264	uniprotkb:O55022	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523506|imex:IM-25485-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:TA2yQeVEtRGgT6RuXMGZUahv1SY	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22315	uniprotkb:O15173	intact:EBI-7174007|intact:MINT-1842883	intact:EBI-1050125|uniprotkb:Q569H1|ensembl:ENSP00000296425|ensembl:ENSP00000429301	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:pgrc2_human(display_long)|uniprotkb:Progesterone membrane-binding protein(gene name synonym)|uniprotkb:Steroid receptor protein DG6(gene name synonym)|uniprotkb:PGRMC2(gene name)|psi-mi:PGRMC2(display_short)|uniprotkb:DG6(gene name synonym)|uniprotkb:PMBP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523516|imex:IM-25485-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	refseq:NP_006311.2|ensembl:ENSG00000164040(gene)|ensembl:ENST00000296425(transcript)|ensembl:ENST00000520121(transcript)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O15173|reactome:R-HSA-8980692|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	go:"GO:0005739"(mitochondrion)	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rogid:y8PU98eUcxnJLxobBcFL40xaprw9606	rigid:0fLZAg1DSX+3P3hAoyNiYggPXaU	false	-	flag tag:n-n	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P22830	uniprotkb:P22315	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-7174007|intact:MINT-1842883	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q8CAQ8	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:P51175	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q9Z2I9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q9JI39	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q61102	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:Q80UU9	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22830	uniprotkb:O55022	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523312|imex:IM-25485-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:Ley1SRlI19+rl6J61xJxe1oXzRA	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:P22315	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-7174007|intact:MINT-1842883	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hemh_mouse(display_long)|uniprotkb:Fech(gene name)|psi-mi:Fech(display_short)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	mint:P22315|interpro:IPR033644|interpro:IPR033659|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009589"(detection of UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030350"(iron-responsive element binding)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046906"(tetrapyrrole binding)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0055072"(iron ion homeostasis)|reactome:R-MMU-189451|go:"GO:0004325"(ferrochelatase activity)|interpro:IPR019772|interpro:IPR001015(Ferrochelatase)	go:"GO:0005739"(mitochondrion)	-	function:Catalyzes the ferrous insertion into protoporphyrin IX|comment:mint|function:"Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia"	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:XE7oTrCC8NCTJTGX6SBaphYeSFs10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:Q8CAQ8	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:P51175	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767384|uniprotkb:P97344|uniprotkb:Q99M34|ensembl:ENSMUSP00000072863	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:ppox_mouse(display_long)|uniprotkb:Ppox(gene name)|psi-mi:Ppox(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_032937.1|refseq:XP_006496770.1|ensembl:ENSMUSG00000062729(gene)|ensembl:ENSMUST00000073120(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|reactome:R-MMU-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:rcR25BoqGU+V9P5N30wFKolChiU10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:Q9Z2I9	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:Q9JI39	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-10767359|uniprotkb:Q542P7|uniprotkb:Q9D0C7|ensembl:ENSMUSP00000075011	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:abcba_mouse(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Abcb10(gene name)|psi-mi:Abcb10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_062425.1|ensembl:ENSMUSG00000031974(gene)|ensembl:ENSMUST00000075578(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030260|interpro:IPR036640|interpro:IPR039421|reactome:R-MMU-1369007	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:FFg8DVqP5cFli9em7udb9C9Ei4c10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:Q61102	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-6907927|ensembl:ENSMUSP00000033695|uniprotkb:A2AC46|uniprotkb:Q3U7S8	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:abcb7_mouse(display_long)|uniprotkb:Abcb7(gene name)|psi-mi:Abcb7(display_short)|uniprotkb:Abc7(gene name synonym)|uniprotkb:ATP-binding cassette transporter 7(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 7, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036640|interpro:IPR039421|mint:Q61102|reactome:R-MMU-1369007|ensembl:ENSMUSG00000031333(gene)|ensembl:ENSMUST00000033695(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140466"(iron-sulfur cluster export from the mitochondrion)|go:"GO:0140481"(ABC-type iron-sulfur cluster transporter activity)|go:"GO:1903331"(positive regulation of iron-sulfur cluster assembly)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005743"(mitochondrial inner membrane)|refseq:NP_033722.1	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:+27KEQlgfCk6DppRFipTKUUS0wo10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:Q80UU9	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:O55022	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-770756|uniprotkb:Q99JN0|ensembl:ENSMUSP00000073061	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:pgrc1_mouse(display_long)|uniprotkb:Pgrmc1(gene name)|psi-mi:Pgrmc1(display_short)|uniprotkb:Pgrmc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523453|imex:IM-25485-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_058063.2|ensembl:ENSMUSG00000006373(gene)|ensembl:ENSMUST00000073339(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905809"(negative regulation of synapse organization)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O55022|reactome:R-MMU-6798695	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mel745acl.ds19)|taxid:10090(mouse)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:JJb2/xwky1pSXG+DPfq5+XVmbcw10090	rigid:Uzd7NB1JptNBiESulODyvR9xa6A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:P22830	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523484|imex:IM-25485-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rigid:n8/uH/kqxVgGzkK5FvdiUngdRgk	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00264	uniprotkb:P22830	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:"MI:0096"(pull down)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12523535|imex:IM-25485-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	-	-	-	figure legend:3A,3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/16	2016/09/26	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rigid:n8/uH/kqxVgGzkK5FvdiUngdRgk	false	-	his tag:n-n|mutation increasing interaction strength:110-110|mutation disrupting interaction strength:343-343	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:133626"	uniprotkb:P22830	intact:EBI-12555830	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	psi-mi:mesoporphyrin ix(display_short)|psi-mi:"CHEBI:133626"(display_long)	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:"MI:0415"(enzymatic study)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12555736|imex:IM-25485-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	go:"GO:0004325"(ferrochelatase activity)	-	-	figure legend:9|comment:In the presence of PGRMC1  the activity of the F110A variant showed a level of inhibition slightly higher than that of the WT enzyme.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/16	2016/10/05	-	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	-	false	-	mutation with no effect:110-110|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22830	uniprotkb:O00264	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12555736|imex:IM-25485-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	go:"GO:0004325"(ferrochelatase activity)	-	-	figure legend:9|comment:In the presence of PGRMC1  the activity of the F110A variant showed a level of inhibition slightly higher than that of the WT enzyme.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/16	2016/10/05	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	-	false	mutation with no effect:110-110|his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:133626"	uniprotkb:P22830	intact:EBI-12555830	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	psi-mi:mesoporphyrin ix(display_short)|psi-mi:"CHEBI:133626"(display_long)	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:"MI:0415"(enzymatic study)	Piel et al. (2016)	pubmed:27599036|imex:IM-25485	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12555807|imex:IM-25485-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	go:"GO:0004325"(ferrochelatase activity)	-	-	figure legend:9i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/16	2016/10/05	-	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	-	false	-	his tag:?-?|mutation with no effect:110-110	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)