#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O15392 uniprotkb:Q9UQB9 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596455|imex:IM-25623-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/10 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15392 uniprotkb:Q9UQB9 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596459|imex:IM-25623-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/10 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UQB9 uniprotkb:Q9NQS7 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596528|imex:IM-25623-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:tcmCpTe11kjzr9F7xuMwn7dj+MU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UQB9 uniprotkb:O15392 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596528|imex:IM-25623-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:tcmCpTe11kjzr9F7xuMwn7dj+MU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96GD4 uniprotkb:Q9NQS7 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596533|imex:IM-25623-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:Yhyg6hvKdT3xnEQPLRmgsQuCrus false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96GD4 uniprotkb:O15392 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596533|imex:IM-25623-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:Yhyg6hvKdT3xnEQPLRmgsQuCrus false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15392 uniprotkb:Q9UQB9 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0096"(pull down) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596484|imex:IM-25623-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false glutathione s tranferase tag:n-n 35s radiolabel:?-?|sufficient binding region:41-309(IPR000719)|necessary binding region:292-309 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0096"(pull down) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596704|imex:IM-25623-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:n-n|sufficient binding region:822-897 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O15392 uniprotkb:Q9UQB9 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0096"(pull down) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12687743|imex:IM-25623-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false 35s radiolabel:?-? sufficient binding region:41-309|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O15392 uniprotkb:Q9UQB9 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-12596469|imex:IM-25623-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 go:"GO:0000775"(chromosome, centromeric region) - - figure legend:1E, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/11/10 2016/11/11 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false - green fluorescent protein tag:?-?|necessary binding region:292-309 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-12596510|imex:IM-25623-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 go:"GO:0000775"(chromosome, centromeric region) - - figure legend:1E, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/11/10 2016/11/11 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false - green fluorescent protein tag:?-?|necessary binding region:292-309 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96GD4 uniprotkb:Q9UQB9 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-12596519|imex:IM-25623-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 go:"GO:0000775"(chromosome, centromeric region) - - figure legend:1E, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:VP7D55qRwjGjs2g4gIlwIzYKGO8 false - green fluorescent protein tag:?-?|necessary binding region:292-309 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9UQB9 uniprotkb:Q96GD4 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596603|imex:IM-25623-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:Q9NQS7 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596603|imex:IM-25623-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:O15392 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596603|imex:IM-25623-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:Q9NQS7 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596619|imex:IM-25623-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:Q9UQB9 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596619|imex:IM-25623-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:O15392 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596619|imex:IM-25623-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:m+LuVWSXL8O8tjzSEWercfj9K5s false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:Q9NQS7 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596633|imex:IM-25623-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:Dc8nMbS39/dVkT4PyoxnxPCwUnk false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:Q9UQB9 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596633|imex:IM-25623-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:Dc8nMbS39/dVkT4PyoxnxPCwUnk false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:O15392 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596644|imex:IM-25623-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/12/12 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:LnrjzzilQrS74Uk7yGanxESEkHg false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:Q96GD4 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596655|imex:IM-25623-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rigid:Dc8nMbS39/dVkT4PyoxnxPCwUnk false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:Q9NQS7 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596655|imex:IM-25623-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/11 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:Dc8nMbS39/dVkT4PyoxnxPCwUnk false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:O15392 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12596666|imex:IM-25623-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/12/12 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:9TN987ySKxElvH7YFJy+qmfA0w8 false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:Q9NQS7 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12597504|imex:IM-25623-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:6C, S4|antagonist:"(lamda)PPase"|comment:The S20A Survivin mutation decreased it's interaction with Aurora C, but did not affect the interaction of Aurora C with INCENP, as shown in Fig 6C.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/14 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:tcmCpTe11kjzr9F7xuMwn7dj+MU false flag tag:?-?|mutation decreasing interaction strength:76-76 ha tag:?-?|mutation decreasing interaction:893-893,894-894,892-892 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UQB9 uniprotkb:O15392 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12597504|imex:IM-25623-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N - - - figure legend:6C, S4|antagonist:"(lamda)PPase"|comment:The S20A Survivin mutation decreased it's interaction with Aurora C, but did not affect the interaction of Aurora C with INCENP, as shown in Fig 6C.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/11/14 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606 rigid:tcmCpTe11kjzr9F7xuMwn7dj+MU false flag tag:?-?|mutation decreasing interaction strength:76-76 his tag:?-?|mutation decreasing interaction:20-20 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96GD4 uniprotkb:Q9NQS7 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12687752|imex:IM-25623-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:supplemt. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/12/19 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:9tF4MrDYK8QEbZnmITHpI8WXsR4 false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12687763|imex:IM-25623-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:supplemt. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/11/10 2016/12/19 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12596889|imex:IM-25623-16 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4C|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2016/11/11 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:?-?|sufficient binding region:855-918|sufficient binding region:822-897 glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12596901|imex:IM-25623-17 - - psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4C|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2016/11/11 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:?-?|sufficient binding region:822-892 glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12596951|imex:IM-25623-18 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4D-LHS|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2016/11/11 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:?-?|sufficient binding region:822-918|mutation disrupting interaction:892-892,893-893,894-894 mutation disrupting interaction:76-76|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12596969|imex:IM-25623-19 - - psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4D -LHS|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2016/11/11 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:?-?|sufficient binding region:822-918|mutation decreasing interaction:892-892,893-893,894-894 mutation disrupting interaction:76-76|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12597012|imex:IM-25623-20 - - psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4 F|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false his tag:?-? glutathione s tranferase tag:n-n|mutation disrupting interaction:202-202|mutation disrupting interaction:198-198 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12687800|imex:IM-25623-27 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4 F|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false his tag:?-? mutation disrupting interaction:202-202|mutation disrupting interaction:198-198|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12738985|imex:IM-25623-28 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4D-RHS|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false his tag:?-?|mutation decreasing interaction strength:892-892,893-893,894-894 mutation disrupting interaction:76-76|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9NQS7 uniprotkb:Q9UQB9 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12739002|imex:IM-25623-29 - - psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 - - - figure legend:4D -RHS|comment:Aurora-C kinase activity was monitored by phosphorylation of histone H3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/10 2017/01/16 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false his tag:?-?|mutation decreasing interaction:892-892,893-893,894-894 glutathione s tranferase tag:n-n|mutation disrupting interaction:76-76 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9UQB9 uniprotkb:Q9NQS7 intact:EBI-3926851|uniprotkb:Q9UPK5|uniprotkb:O75442|uniprotkb:O60681|uniprotkb:Q6AZY8|uniprotkb:Q6DLZ0|ensembl:ENSP00000302898 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkc_human(display_long)|uniprotkb:Aurora 3(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:AURKC(gene name)|psi-mi:AURKC(display_short)|uniprotkb:AIE2(gene name synonym)|uniprotkb:AIK3(gene name synonym)|uniprotkb:ARK3(gene name synonym)|uniprotkb:STK13(gene name synonym)|uniprotkb:AIRK3(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 3(gene name synonym)|uniprotkb:Aurora/IPL1/Eg2 protein 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-C(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0096"(pull down) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12597629|imex:IM-25623-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015878.1|refseq:NP_001015879.1|refseq:NP_003151.2|ensembl:ENSG00000105146(gene)|ensembl:ENST00000302804(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016570"(histone modification)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0048599"(oocyte development)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030613|interpro:IPR030616|rcsb pdb:6GR8|rcsb pdb:6GR9 refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:S3B, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2016/11/10 2016/11/14 rogid:0q+Z74DtY6if4XGjPn7elMQRLR49606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:NJlRptMqWo7jiBlxnek0A7jkQIg false glutathione s tranferase tag:n-n mutation with no effect:893-893,894-894,892-892|ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96GD4 uniprotkb:Q9NQS7 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short) psi-mi:"MI:0096"(pull down) Sasai et al. (2015) imex:IM-25623|pubmed:27332895 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12597642|imex:IM-25623-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N - - - figure legend:S3B, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2016/11/10 2016/11/14 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606 rigid:9tF4MrDYK8QEbZnmITHpI8WXsR4 false glutathione s tranferase tag:?-? his tag:?-?|mutation decreasing interaction strength:893-893,894-894,892-892 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)