#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N3F8 uniprotkb:Q9H4M9 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12508539|imex:IM-25581-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 - - - figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:23.2x10^-6(mol) 2016/08/17 2016/08/17 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rigid:q2pND1i+rYorjH3TeKinkSjoMhc false sufficient binding region:425-433 sufficient binding region:444..444-532..532(IPR000261) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N3F8 uniprotkb:Q9NZN3 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12508550|imex:IM-25581-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 - - - figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:17.8x10^-6(mol) 2016/08/17 2016/08/17 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rigid:1AZ9W7yZa5LhBzIotZV+V9Xilbw false sufficient binding region:425-433 sufficient binding region:444..444-532..532(IPR000261) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N3F8 uniprotkb:Q9H4M9 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12508811|imex:IM-25581-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 - comment:MICALL1 mutants with wt positions 425-433 NPFEEEED replaced with NPFEEEEA or NPFEEEEAA or NPFEEEAAA or NPFEEAAAA also interact comment:EHD1 mutant replacing wt positions 519-520 AD with NE also interacts figure legend:5C and E, 7C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rigid:q2pND1i+rYorjH3TeKinkSjoMhc false mutation decreasing interaction:429-433|mutation disrupting interaction:428-433 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N3F8 uniprotkb:Q9NZN3 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12508871|imex:IM-25581-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 - comment:MICALL1 mutants with wt positions 425-433 NPFEEEED replaced with NPFEEEEA or NPFEEEEAA or NPFEEEAAA or NPFEEAAAA or NPFEAAAAA also interact comment:EHD3 mutants NE519-520AD or AHLL523-526PHLV or D459N or M447T or A437V or KVAE532-535RHE or N519A or E520D also interact figure legend:5C and E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rigid:1AZ9W7yZa5LhBzIotZV+V9Xilbw false mutation disrupting interaction:428-433 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2R3 uniprotkb:Q9H4M9 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12508906|imex:IM-25581-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 - comment:ANKFY1/rabankyrin-5 mutants having wt positions 421-426 NPFEDV replaced with NPFEDE or NPFEDEE or NPFEDEEE also interact comment:EHD1 construct ala_asp519-520asn_glu also interacts figure legend:5C and E, 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rigid:W1r+Pdp8cf8UWseeOqW4zWXOl1o false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2R3 uniprotkb:Q9NZN3 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509316|imex:IM-25581-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 - - comment:EHD3 constructs asn_glu519-520ala_asp, ala_his_leu_leu523-526pro_his_leu_val, asp-429asn, met477thr, ala473val, lys-val_ala_glu532-535arg_his_glu, asn519ala and glu520asp also interact figure legend:5 E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rigid:GRlVzAy8hL6HMBBLh3/M7i+nrs8 false - mutation causing an interaction:519-520|mutation causing an interaction:520-520|mutation causing an interaction:519-519 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N3F8 uniprotkb:Q9H4M9 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509378|imex:IM-25581-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 - - - figure legend:8B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rigid:q2pND1i+rYorjH3TeKinkSjoMhc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZN3 uniprotkb:Q8N3F8 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957 psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509386|imex:IM-25581-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding) - - - figure legend:8B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606 rigid:1AZ9W7yZa5LhBzIotZV+V9Xilbw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2R3 uniprotkb:Q9NZN3 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509450|imex:IM-25581-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 - - - figure legend:8 B and C, 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rigid:GRlVzAy8hL6HMBBLh3/M7i+nrs8 false mutation causing an interaction:418-420|mutation causing an interaction:420-420|mutation causing an interaction:418-418|mutation causing an interaction:420-420 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H4M9 uniprotkb:Q9P2R3 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:"MI:0018"(two hybrid) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509460|imex:IM-25581-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 - - comment:ANKFY1/Rabankyrin-5 mutants wt pos 418-420 QSV changed to KPY or KSV or QSY or QSA also interact figure legend:8B and 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/08/17 2016/08/18 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rigid:W1r+Pdp8cf8UWseeOqW4zWXOl1o false - mutation disrupting interaction:419-419 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZN3 uniprotkb:Q9P2R3 intact:EBI-2870749|uniprotkb:Q9NZB3|uniprotkb:Q8N514|uniprotkb:B4DFR5|uniprotkb:D6W574|ensembl:ENSP00000327116 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 psi-mi:ehd3_human(display_long)|uniprotkb:EHD3(gene name)|psi-mi:EHD3(display_short)|uniprotkb:EHD2(gene name synonym)|uniprotkb:PAST3(gene name synonym)|uniprotkb:PAST homolog 3(gene name synonym) psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:"MI:0096"(pull down) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509013|imex:IM-25581-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055415.1|ensembl:ENSG00000013016(gene)|ensembl:ENST00000322054(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9NZN3|reactome:R-HSA-983231 refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 - - - figure legend:5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/17 2016/08/18 rogid:nyg47ipzaBxbLMl9jSWet1FffNw9606 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rigid:GRlVzAy8hL6HMBBLh3/M7i+nrs8 false sufficient binding region:444..444-532..532(IPR000261)|glutathione s tranferase tag:?-?|mutation causing an interaction:519-520 ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H4M9 uniprotkb:Q9P2R3 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:"MI:0096"(pull down) Bahl et al. (2016) imex:IM-25581|pubmed:27189942 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12509003|imex:IM-25581-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 - - - figure legend:5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/17 2016/08/18 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 rigid:W1r+Pdp8cf8UWseeOqW4zWXOl1o false sufficient binding region:444..444-532..532(IPR000261)|glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)