#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q05397	uniprotkb:P16144	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599461|imex:IM-25611-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:f2a sf2a|comment:"we found that b4 integrin  coimmunoprecipitated with FAK from primary colon  cancer tissues but not from paired samples of normal  mucosa (Figs 2A and S2A). As expected, the interaction  between b4 integrin and FAK was also detectable  in HCT-116, SW480, Colo-205, and LoVo human  colon cancer cells but not in HeLa human cervical  cancer cells or nontumorigenic HEK-293 human  embryonic kidney cells (Figs 2B and S2B,C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon_cancer)|taxid:9606(human colonic cancer tissue)	-	2016/11/18	2016/11/21	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05397	uniprotkb:P16144	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599466|imex:IM-25611-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:f2b sf2b sf2c|comment:"we found that b4 integrin  coimmunoprecipitated with FAK from primary colon  cancer tissues but not from paired samples of normal  mucosa (Figs 2A and S2A). As expected, the interaction  between b4 integrin and FAK was also detectable  in HCT-116, SW480, Colo-205, and LoVo human  colon cancer cells but not in HeLa human cervical  cancer cells or nontumorigenic HEK-293 human  embryonic kidney cells (Figs 2B and S2B,C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon_cancer)|taxid:9606(human colonic cancer tissue)	-	2016/11/18	2016/11/21	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q05397	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599479|imex:IM-25611-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:sf3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon_cancer)|taxid:9606(human colonic cancer tissue)	-	2016/11/18	2016/11/21	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	-	necessary binding region:1-400|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q05397	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599511|imex:IM-25611-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2016/11/18	2016/11/21	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	-	binding-associated region:376-400|mutation disrupting interaction:380-382|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q05397	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599523|imex:IM-25611-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2016/11/18	2016/11/21	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	-	mutation disrupting interaction:380-382|mutation decreasing interaction:385-386|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05397	uniprotkb:P16144	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599535|imex:IM-25611-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:f3a f3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2016/11/18	2016/11/21	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	phosphorylated residue:397-397	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16144	uniprotkb:Q05397	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	intact:EBI-702142|uniprotkb:Q14291|uniprotkb:Q9UD85|intact:EBI-11047590|uniprotkb:J3QT16|uniprotkb:Q8IYN9|uniprotkb:B4E2N6|uniprotkb:F5H4S4|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tai et al. (2016)	pubmed:27178753|imex:IM-25611	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12599498|imex:IM-25611-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	refseq:NP_722560.1|refseq:NP_001186578.1|ensembl:ENST00000340930|ensembl:ENSP00000341189|ensembl:ENST00000395218|ensembl:ENSP00000378644|ensembl:ENSP00000429474|ensembl:ENSP00000429911|refseq:XP_016869162.1|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001890"(placenta development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048870"(cell motility)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q05397|rcsb pdb:1K04|rcsb pdb:1K05|rcsb pdb:1MP8|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2ETM|rcsb pdb:2IJM|rcsb pdb:3B71|rcsb pdb:3BZ3|rcsb pdb:3PXK|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4EBW|rcsb pdb:4GU6|rcsb pdb:4GU9|rcsb pdb:4I4E|rcsb pdb:4I4F|rcsb pdb:4K8A|rcsb pdb:4K9Y|rcsb pdb:4KAB|rcsb pdb:4KAO|rcsb pdb:4NY0|rcsb pdb:4Q9S|rcsb pdb:6I8Z|rcsb pdb:6LES|rcsb pdb:6PW8|rcsb pdb:6YOJ|rcsb pdb:6YQ1|rcsb pdb:6YR9|rcsb pdb:6YT6|rcsb pdb:6YVS|rcsb pdb:6YVY|rcsb pdb:6YXV|reactome:R-HSA-111465|reactome:R-HSA-2029482|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-8874081|reactome:R-HSA-9009391|reactome:R-HSA-9634638|reactome:R-HSA-9664422	-	-	-	figure legend:sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon_cancer)|taxid:9606(human colonic cancer tissue)	-	2016/11/18	2016/11/21	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	rigid:XKtC/3smepRVhX+hexSVN5FkhTU	false	binding-associated region:796-1190|ha tag:?-?	green fluorescent protein tag:?-?|binding-associated region:1-400	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)