#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92956	uniprotkb:O43557	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687195|imex:IM-25104-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:3A-1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/04/14	2016/04/14	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:vTFiRkcXSpgdYnN0lcqiW336cK8	false	fc-igg tag:?-?	his tag:n-n|mutation:138-138,160-160,221-222	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q71F55	uniprotkb:O43557	intact:EBI-11687219	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:q71f55_mouse(display_long)|uniprotkb:Tnfrsf14(gene name)|psi-mi:Tnfrsf14(display_short)|uniprotkb:Hvem(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687207|imex:IM-25104-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042742"(defense response to bacterium)|interpro:IPR034031	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:3A-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/04/14	2016/04/14	rogid:PF4vvqKhYFlkARwyPhOmc+HBZaY10090	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:Cfu9nBmq+dqKpcfrBrNW5CWrT7Y	false	fc-igg tag:?-?	his tag:n-n|mutation:138-138,160-160,221-222	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43557	uniprotkb:P36941	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	intact:EBI-3509981|intact:EBI-10982154|uniprotkb:D3DUR2|uniprotkb:B7Z1D2|uniprotkb:F5GXE7|ensembl:ENSP00000228918	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:tnr3_human(display_long)|uniprotkb:LTBR(gene name)|psi-mi:LTBR(display_short)|uniprotkb:D12S370(gene name synonym)|uniprotkb:TNFCR(gene name synonym)|uniprotkb:TNFR3(gene name synonym)|uniprotkb:TNFRSF3(gene name synonym)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Tumor necrosis factor C receptor(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 2-related protein(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type III(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687246|imex:IM-25104-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	dip:DIP-2928N|refseq:NP_002333.1|refseq:NP_001257916.1|ensembl:ENSG00000111321(gene)|ensembl:ENST00000228918(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P36941|rcsb pdb:1RF3|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5676594	-	-	-	figure legend:3A-3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/04/14	2016/04/14	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rogid:Ekl/gGxXT2EmjWLJpZEBmMpxYYw9606	rigid:QVxfs5XosQsMNNez3pf4ZxhFF5Q	false	his tag:n-n|mutation:138-138,160-160,221-222	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P50284	uniprotkb:O43557	intact:EBI-647023|ensembl:ENSMUSP00000032489	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnr3_mouse(display_long)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Ltbr(gene name)|psi-mi:Ltbr(display_short)|uniprotkb:Tnfcr(gene name synonym)|uniprotkb:Tnfrsf3(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687258|imex:IM-25104-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034866.1|dip:DIP-49695N|ensembl:ENSMUSG00000030339(gene)|ensembl:ENSMUST00000032489(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048535"(lymph node development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P50284|reactome:R-MMU-5668541|reactome:R-MMU-5676594|go:"GO:0006915"(apoptotic process)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:3A-4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/04/14	2016/04/14	rogid:4ixbHyVjgcKKRm9BtEemaW9e9h810090	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:cGNe7W4vSFT6jqqt4i0GWhoDwaY	false	fc-igg tag:?-?	his tag:n-n|mutation:138-138,160-160,221-222	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43557	uniprotkb:P36941	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	intact:EBI-3509981|intact:EBI-10982154|uniprotkb:D3DUR2|uniprotkb:B7Z1D2|uniprotkb:F5GXE7|ensembl:ENSP00000228918	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:tnr3_human(display_long)|uniprotkb:LTBR(gene name)|psi-mi:LTBR(display_short)|uniprotkb:D12S370(gene name synonym)|uniprotkb:TNFCR(gene name synonym)|uniprotkb:TNFR3(gene name synonym)|uniprotkb:TNFRSF3(gene name synonym)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Tumor necrosis factor C receptor(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 2-related protein(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type III(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702195|imex:IM-25104-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	dip:DIP-2928N|refseq:NP_002333.1|refseq:NP_001257916.1|ensembl:ENSG00000111321(gene)|ensembl:ENST00000228918(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P36941|rcsb pdb:1RF3|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5676594	-	-	-	figure legend:2 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rogid:Ekl/gGxXT2EmjWLJpZEBmMpxYYw9606	rigid:QVxfs5XosQsMNNez3pf4ZxhFF5Q	false	mutation:221-222,138-138,160-160	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43557	uniprotkb:P36941	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	intact:EBI-3509981|intact:EBI-10982154|uniprotkb:D3DUR2|uniprotkb:B7Z1D2|uniprotkb:F5GXE7|ensembl:ENSP00000228918	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:tnr3_human(display_long)|uniprotkb:LTBR(gene name)|psi-mi:LTBR(display_short)|uniprotkb:D12S370(gene name synonym)|uniprotkb:TNFCR(gene name synonym)|uniprotkb:TNFR3(gene name synonym)|uniprotkb:TNFRSF3(gene name synonym)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Tumor necrosis factor C receptor(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 2-related protein(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type III(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702224|imex:IM-25104-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	dip:DIP-2928N|refseq:NP_002333.1|refseq:NP_001257916.1|ensembl:ENSG00000111321(gene)|ensembl:ENST00000228918(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P36941|rcsb pdb:1RF3|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5676594	-	-	-	figure legend:2 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rogid:Ekl/gGxXT2EmjWLJpZEBmMpxYYw9606	rigid:QVxfs5XosQsMNNez3pf4ZxhFF5Q	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43557	uniprotkb:Q92956	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702235|imex:IM-25104-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	-	-	-	figure legend:2 Ai|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rigid:vTFiRkcXSpgdYnN0lcqiW336cK8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q92956	uniprotkb:O43557	intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702239|imex:IM-25104-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:2 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:h0mNlFr7weiZLHYvGJofgj86y249606	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:vTFiRkcXSpgdYnN0lcqiW336cK8	false	-	mutation:221-222,138-138,160-160	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QYH9	uniprotkb:P50284	intact:EBI-11702254|uniprotkb:Q059Y9|ensembl:ENSMUSP00000005976	intact:EBI-647023|ensembl:ENSMUSP00000032489	psi-mi:tnf14_mouse(display_long)|uniprotkb:Tnfsf14(gene name)|psi-mi:Tnfsf14(display_short)|uniprotkb:Light(gene name synonym)	psi-mi:tnr3_mouse(display_long)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Ltbr(gene name)|psi-mi:Ltbr(display_short)|uniprotkb:Tnfcr(gene name synonym)|uniprotkb:Tnfrsf3(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702250|imex:IM-25104-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062291.1|ensembl:ENSMUSG00000005824(gene)|ensembl:ENSMUST00000005976(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|reactome:R-MMU-5668541|reactome:R-MMU-5676594	refseq:NP_034866.1|dip:DIP-49695N|ensembl:ENSMUSG00000030339(gene)|ensembl:ENSMUST00000032489(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048535"(lymph node development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P50284|reactome:R-MMU-5668541|reactome:R-MMU-5676594|go:"GO:0006915"(apoptotic process)	-	-	-	figure legend:2 Am|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:6YYB4Dfvc0oW1JVwfu5y9sEFvf010090	rogid:4ixbHyVjgcKKRm9BtEemaW9e9h810090	rigid:FA8S6sXfm+uKh1DXglTRdsR7usI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QYH9	uniprotkb:Q71F55	intact:EBI-11702254|uniprotkb:Q059Y9|ensembl:ENSMUSP00000005976	intact:EBI-11687219	psi-mi:tnf14_mouse(display_long)|uniprotkb:Tnfsf14(gene name)|psi-mi:Tnfsf14(display_short)|uniprotkb:Light(gene name synonym)	psi-mi:q71f55_mouse(display_long)|uniprotkb:Tnfrsf14(gene name)|psi-mi:Tnfrsf14(display_short)|uniprotkb:Hvem(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702286|imex:IM-25104-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062291.1|ensembl:ENSMUSG00000005824(gene)|ensembl:ENSMUST00000005976(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|reactome:R-MMU-5668541|reactome:R-MMU-5676594	interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042742"(defense response to bacterium)|interpro:IPR034031	-	-	-	figure legend:2 Am|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:6YYB4Dfvc0oW1JVwfu5y9sEFvf010090	rogid:PF4vvqKhYFlkARwyPhOmc+HBZaY10090	rigid:nwgg5qCVc7Kmb1XTqwXqfjxoD0A	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q71F55	uniprotkb:O43557	intact:EBI-11687219	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:q71f55_mouse(display_long)|uniprotkb:Tnfrsf14(gene name)|psi-mi:Tnfrsf14(display_short)|uniprotkb:Hvem(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702290|imex:IM-25104-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042742"(defense response to bacterium)|interpro:IPR034031	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:2 Am|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:PF4vvqKhYFlkARwyPhOmc+HBZaY10090	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:Cfu9nBmq+dqKpcfrBrNW5CWrT7Y	false	-	mutation causing an interaction:138-138,160-160,221-222	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P50284	uniprotkb:O43557	intact:EBI-647023|ensembl:ENSMUSP00000032489	intact:EBI-524131|uniprotkb:Q6FHA1|uniprotkb:O75476|uniprotkb:Q8WVF8|uniprotkb:Q96LD2|ensembl:ENSP00000469049|ensembl:ENSP00000502837|uniprotkb:A8K7M2|uniprotkb:C9J5H4	psi-mi:tnr3_mouse(display_long)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Ltbr(gene name)|psi-mi:Ltbr(display_short)|uniprotkb:Tnfcr(gene name synonym)|uniprotkb:Tnfrsf3(gene name synonym)	psi-mi:tnf14_human(display_long)|uniprotkb:Herpes virus entry mediator ligand(gene name synonym)|uniprotkb:UNQ391/PRO726(orf name)|uniprotkb:TNFSF14(gene name)|psi-mi:TNFSF14(display_short)|uniprotkb:HVEML(gene name synonym)|uniprotkb:LIGHT(gene name synonym)	psi-mi:"MI:0115"(yeast display)	Tang et al. (2016)	pubmed:26977880|imex:IM-25104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11702298|imex:IM-25104-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034866.1|dip:DIP-49695N|ensembl:ENSMUSG00000030339(gene)|ensembl:ENSMUST00000032489(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048535"(lymph node development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P50284|reactome:R-MMU-5668541|reactome:R-MMU-5676594|go:"GO:0006915"(apoptotic process)	ensembl:ENSG00000125735(gene)|ensembl:ENST00000599359(transcript)|ensembl:ENST00000675206(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:4EN0|rcsb pdb:4J6G|rcsb pdb:4KG8|rcsb pdb:4KGG|rcsb pdb:4KGQ|rcsb pdb:4RSU|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_016882906.1|refseq:NP_003798.2|refseq:NP_742011.2|dip:DIP-3016N	-	-	-	figure legend:2 A/B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/04/14	2016/05/17	rogid:4ixbHyVjgcKKRm9BtEemaW9e9h810090	rogid:6Sbcq5MmsZT2GjqAblvfCc1bR449606	rigid:cGNe7W4vSFT6jqqt4i0GWhoDwaY	false	-	mutation causing an interaction:221-222,138-138,160-160	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)