#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24385	uniprotkb:P49815	intact:EBI-375001|uniprotkb:Q6LEF0|ensembl:ENSP00000227507	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	psi-mi:ccnd1_human(display_long)|uniprotkb:CCND1(gene name)|psi-mi:CCND1(display_short)|uniprotkb:BCL1(gene name synonym)|uniprotkb:PRAD1(gene name synonym)|uniprotkb:PRAD1 oncogene(gene name synonym)|uniprotkb:BCL-1 oncogene(gene name synonym)|uniprotkb:B-cell lymphoma 1 protein(gene name synonym)	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Goel et al. (2016)	pubmed:26977878|imex:IM-25102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687054|imex:IM-25102-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444284.1|ensembl:ENSG00000110092(gene)|ensembl:ENST00000227507(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010039"(response to iron ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070141"(response to UV-A)|go:"GO:0097421"(liver regeneration)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P24385|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:5VZU|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-1912408|reactome:R-HSA-3214858|reactome:R-HSA-6785807|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8853884|reactome:R-HSA-8878166|reactome:R-HSA-8934593|reactome:R-HSA-8951430|reactome:R-HSA-8951936|go:"GO:0044321"(response to leptin)|reactome:R-HSA-9018519|reactome:R-HSA-9634638|reactome:R-HSA-9661069|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-123N	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	-	-	-	figure legend:6C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_453)|taxid:9606(Human breast carcinoma cell line MDA-MB-453)	-	2016/04/06	2016/04/13	rogid:XIMa4dI7+QiodOusigAjalaEIJk9606	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rigid:fVASXE8xVQ3GmXItdzfAU9Qmeg0	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11802	uniprotkb:P49815	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Goel et al. (2016)	pubmed:26977878|imex:IM-25102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11687060|imex:IM-25102-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	-	-	-	figure legend:6Ci|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_453)|taxid:9606(Human breast carcinoma cell line MDA-MB-453)	-	2016/04/06	2016/04/13	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rigid:qCofNmRClw7+8D0EJlUzxMYopas	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)