#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Z175 uniprotkb:P19137 intact:EBI-7935624|uniprotkb:Q9JJ39|uniprotkb:Q91VN8|intact:UNK-5561317|ensembl:ENSMUSP00000000707 intact:EBI-7176628|ensembl:ENSMUSP00000043957|intact:MINT-2635122|uniprotkb:F8VQ40 psi-mi:loxl3_mouse(display_long)|uniprotkb:Loxl3(gene name)|psi-mi:Loxl3(display_short)|uniprotkb:Lor2(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym) psi-mi:lama1_mouse(display_long)|uniprotkb:Lama1(gene name)|psi-mi:Lama1(display_short)|uniprotkb:Lama(gene name synonym)|uniprotkb:Lama-1(gene name synonym)|uniprotkb:Laminin A chain(gene name synonym)|uniprotkb:Laminin-1 subunit alpha(gene name synonym)|uniprotkb:Laminin-3 subunit alpha(gene name synonym)|uniprotkb:S-laminin subunit alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kraft-Sheleg et al. (2016) pubmed:26954549 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11659938 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038614.2|ensembl:ENSMUSG00000000693(gene)|ensembl:ENSMUST00000000707(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Z175|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0006954"(inflammatory response) ensembl:ENSMUSG00000032796(gene)|ensembl:ENSMUST00000035471(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005608"(laminin-3 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:P19137|rcsb pdb:2JD4|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-8874081|go:"GO:0045995"(regulation of embryonic development)|refseq:NP_032506.2 - comment:mint function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:mint figure legend:Fig. 6A and 6B|curation depth:imex curation taxid:10090(mouse-embryo)|taxid:10090(Mus musculus embryo) - 2016/03/18 2018/07/23 rogid:Uy9YsJRZZBcT1urV3tiuaG2LWlE10090 rogid:5L6nnYFEE3kmWteC4VtG4c87LHs10090 rigid:Y7X7LhutCek31ZsI6pCvJ2L+na8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z175 uniprotkb:P11276 intact:EBI-7935624|uniprotkb:Q9JJ39|uniprotkb:Q91VN8|intact:UNK-5561317|ensembl:ENSMUSP00000000707 intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499 psi-mi:loxl3_mouse(display_long)|uniprotkb:Loxl3(gene name)|psi-mi:Loxl3(display_short)|uniprotkb:Lor2(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym) psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kraft-Sheleg et al. (2016) pubmed:26954549 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11659938 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038614.2|ensembl:ENSMUSG00000000693(gene)|ensembl:ENSMUST00000000707(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Z175|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0006954"(inflammatory response) refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex) - comment:mint - figure legend:Fig. 6A and 6B|curation depth:imex curation taxid:10090(mouse-embryo)|taxid:10090(Mus musculus embryo) - 2016/03/18 2018/07/23 rogid:Uy9YsJRZZBcT1urV3tiuaG2LWlE10090 rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090 rigid:Y7X7LhutCek31ZsI6pCvJ2L+na8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z175 uniprotkb:P11276 intact:EBI-7935624|uniprotkb:Q9JJ39|uniprotkb:Q91VN8|intact:UNK-5561317|ensembl:ENSMUSP00000000707 intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499 psi-mi:loxl3_mouse(display_long)|uniprotkb:Loxl3(gene name)|psi-mi:Loxl3(display_short)|uniprotkb:Lor2(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym) psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kraft-Sheleg et al. (2016) pubmed:26954549 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11659950 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038614.2|ensembl:ENSMUSG00000000693(gene)|ensembl:ENSMUST00000000707(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Z175|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0006954"(inflammatory response) refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex) - comment:mint - figure legend:Figure S5A|curation depth:imex curation taxid:10090(mouse-embryo)|taxid:10090(Mus musculus embryo) - 2016/03/18 2016/03/18 rogid:Uy9YsJRZZBcT1urV3tiuaG2LWlE10090 rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090 rigid:sq2qeeMd6g9XqVsz+GyJWEFIbg8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19137 uniprotkb:Q9Z175 intact:EBI-7176628|ensembl:ENSMUSP00000043957|intact:MINT-2635122|uniprotkb:F8VQ40 intact:EBI-7935624|uniprotkb:Q9JJ39|uniprotkb:Q91VN8|intact:UNK-5561317|ensembl:ENSMUSP00000000707 psi-mi:lama1_mouse(display_long)|uniprotkb:Lama1(gene name)|psi-mi:Lama1(display_short)|uniprotkb:Lama(gene name synonym)|uniprotkb:Lama-1(gene name synonym)|uniprotkb:Laminin A chain(gene name synonym)|uniprotkb:Laminin-1 subunit alpha(gene name synonym)|uniprotkb:Laminin-3 subunit alpha(gene name synonym)|uniprotkb:S-laminin subunit alpha(gene name synonym) psi-mi:loxl3_mouse(display_long)|uniprotkb:Loxl3(gene name)|psi-mi:Loxl3(display_short)|uniprotkb:Lor2(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:Lysyl oxidase-related protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kraft-Sheleg et al. (2016) pubmed:26954549 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11659954 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000032796(gene)|ensembl:ENSMUST00000035471(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005608"(laminin-3 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043256"(laminin complex)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:P19137|rcsb pdb:2JD4|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-8874081|go:"GO:0045995"(regulation of embryonic development)|refseq:NP_032506.2 refseq:NP_038614.2|ensembl:ENSMUSG00000000693(gene)|ensembl:ENSMUST00000000707(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|mint:Q9Z175|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0006954"(inflammatory response) - function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:mint comment:mint figure legend:Figure S5A|curation depth:imex curation taxid:10090(mouse-embryo)|taxid:10090(Mus musculus embryo) - 2016/03/18 2018/07/23 rogid:5L6nnYFEE3kmWteC4VtG4c87LHs10090 rogid:Uy9YsJRZZBcT1urV3tiuaG2LWlE10090 rigid:62ZrTrPCPAFFOXzYyir/mTaYDr8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02751 uniprotkb:P58215 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 intact:EBI-723960|ensembl:ENSP00000264094|uniprotkb:Q96RS1|uniprotkb:D6W5J1|uniprotkb:Q2EHP2|uniprotkb:Q6IPL7 psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:loxl3_human(display_long)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:LOXL3(gene name)|psi-mi:LOXL3(display_short)|uniprotkb:LOXL(gene name synonym) psi-mi:"MI:0979"(oxidoreductase assay) Kraft-Sheleg et al. (2016) pubmed:26954549 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-11659965 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 refseq:NP_115992.1|ensembl:ENSG00000115318(gene)|ensembl:ENST00000264094(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|reactome:R-HSA-1566948|go:"GO:0001837"(epithelial to mesenchymal transition)|reactome:R-HSA-2243919|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|refseq:XP_011531436.1|refseq:NP_001276094.1|refseq:NP_001276093.1|refseq:XP_016860601.1 - - - figure legend:Figure 6C|inhibition:beta-aminoproprionitrile, an irreversible inhibitor of Lox family members' enzymatic activity|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/18 2019/10/18 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rogid:ZemGKB4zxFQQW1MbA4fiP/NX7ow9606 rigid:618mXbYQ9c4kBEDX3pXi0HU9qC0 false - his tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)