#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783597|imex:IM-25320-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1a|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:368-373	binding-associated region:368-373	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783606|imex:IM-25320-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1b|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:459-465	binding-associated region:459-465	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783615|imex:IM-25320-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1c|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:42-47	binding-associated region:42-47	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783691|imex:IM-25320-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1d|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:134-140	binding-associated region:134-140	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783700|imex:IM-25320-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1e|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:185-190	binding-associated region:185-190	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783839|imex:IM-25320-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f1f|comment:"Negative staining indicated that all peptides self-assemble forming fibrous arrangements with the basic characteristics of amyloid fibrils, since they appear straight, long and unbranched with a tendency to coalesce laterally (Fig. 1). More specifically, the ‘aggregation-prone’ peptides HZP2_A and HZP3_G self-assemble into amyloid-like fibrils with a diameter of 30–50 Å that coalesce laterally forming striated ribbons of various thickness (Fig. 1A,D). The HZP2_G peptide forms amyloid-like fibrils with a diameter of 70–100 Å (Fig. 1B), whereas the HZP3_A, HZP4_A and HZP4_G peptides form superhelical arrangements composed of two to several individual fibrils that wound around each other, with diameters that vary between 70 and 120 Å, respectively (Fig. 1C,E,F)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:279-285	binding-associated region:279-285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783849|imex:IM-25320-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2a|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:368-373	binding-associated region:368-373	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783859|imex:IM-25320-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2b|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:459-465	binding-associated region:459-465	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783878|imex:IM-25320-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2c|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:42-47	binding-associated region:42-47	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783887|imex:IM-25320-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2d|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:134-140	binding-associated region:134-140	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783896|imex:IM-25320-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2e|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:185-190	binding-associated region:185-190	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783913|imex:IM-25320-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f2f|comment:"X-ray diffraction experiments were performed on fibers containing amyloid-like fibrils, derived by self-assembly of each ‘aggregation-prone’ peptide. The X-ray diffraction patterns indicate that amyloid fibrils formed in every case possess the typical ‘cross-β’-like architecture of amyloid fibrils (Fig. 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:279-285	binding-associated region:279-285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783922|imex:IM-25320-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3a t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:368-373	binding-associated region:368-373	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:Q05996	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783931|imex:IM-25320-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3b t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively. Finally, an additional shoulder determined by the second derivative spectra (Fig. S3), located in the 1690–1697 cm−1 region in all cases, suggests that the peptides form antiparallel β-sheets (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:wQFCGXU50Kioqdc/Y+B3h4ImjUo	false	binding-associated region:459-465	binding-associated region:459-465	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783940|imex:IM-25320-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3c t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively. Finally, an additional shoulder determined by the second derivative spectra (Fig. S3), located in the 1690–1697 cm−1 region in all cases, suggests that the peptides form antiparallel β-sheets (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:42-47	binding-associated region:42-47	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21754	uniprotkb:P21754	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783949|imex:IM-25320-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3d t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively. Finally, an additional shoulder determined by the second derivative spectra (Fig. S3), located in the 1690–1697 cm−1 region in all cases, suggests that the peptides form antiparallel β-sheets (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:Pt2XmDVKBWSp4CYMppJWUzs+fJk	false	binding-associated region:134-140	binding-associated region:134-140	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783958|imex:IM-25320-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3e t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively. Finally, an additional shoulder determined by the second derivative spectra (Fig. S3), located in the 1690–1697 cm−1 region in all cases, suggests that the peptides form antiparallel β-sheets (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:185-190	binding-associated region:185-190	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12836	uniprotkb:Q12836	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0964"(infrared spectroscopy)	Louros et al. (2016)	imex:IM-25320|pubmed:26879157	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11783967|imex:IM-25320-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:f3f t1|comment:"ATR FT-IR spectra obtained from thin hydrated films containing amyloid-like fibrils from the solution samples of the ‘aggregation-prone’ peptides indicate that they adopt an antiparallel β-sheet conformation, supporting our X-ray diffraction results (Fig. 3). More specifically, a preponderant amide I β-sheet band is viewed for the HZP2_A, HZP2_G, HZP3_A, HZP3_G, HZP4_A and HZP4_G peptides (Table 1), whereas similar assignments arise based on the presence of an amide II peak, viewed for spectra derived from all peptides, respectively. Finally, an additional shoulder determined by the second derivative spectra (Fig. S3), located in the 1690–1697 cm−1 region in all cases, suggests that the peptides form antiparallel β-sheets (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/19	2016/06/20	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:J1NXBdZr6hVsa83620Y7pBShc/M	false	binding-associated region:279-285	binding-associated region:279-285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)