#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O09118 uniprotkb:Q8K1S3-1 intact:EBI-1798844|uniprotkb:B1ARR0|uniprotkb:Q60832|uniprotkb:Q9QY50|ensembl:ENSMUSP00000021284|ensembl:ENSMUSP00000104314 intact:EBI-11658250|ensembl:ENSMUSP00000077080 psi-mi:net1_mouse(display_long)|uniprotkb:Ntn1(gene name)|psi-mi:Ntn1(display_short) psi-mi:q8k1s3-1(display_long)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658230|imex:IM-25053-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032770.2|ensembl:ENSMUSG00000020902(gene)|ensembl:ENSMUST00000021284(transcript)|ensembl:ENSMUST00000108674(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|rcsb pdb:4OVE|reactome:R-MMU-373752|reactome:R-MMU-418885 intact:EBI-4396886(isoform-parent)|ensembl:ENSMUSG00000020099(gene)|ensembl:ENSMUST00000077925(transcript) - - - figure legend:2A-C/G-H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:12.57x10^-9(molar) 2016/02/18 2016/03/17 rogid:03RX6IHBOrGA1HJPLlszlp+P6i410090 rogid:YqYcFUZ3Y3spL702w6mshOPjNf410090 rigid:1QPZ97oWht87pe+qNAV93D45jps false sufficient binding region:24-457|mutation decreasing interaction strength:351-351,353-353|mutation disrupting interaction strength:348-349 sufficient binding region:25-374|strep ii tag:c-c|sufficient binding region:52-153(IPR007110) - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O09118 uniprotkb:Q8K1S3-1 intact:EBI-1798844|uniprotkb:B1ARR0|uniprotkb:Q60832|uniprotkb:Q9QY50|ensembl:ENSMUSP00000021284|ensembl:ENSMUSP00000104314 intact:EBI-11658250|ensembl:ENSMUSP00000077080 psi-mi:net1_mouse(display_long)|uniprotkb:Ntn1(gene name)|psi-mi:Ntn1(display_short) psi-mi:q8k1s3-1(display_long)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658280|imex:IM-25053-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032770.2|ensembl:ENSMUSG00000020902(gene)|ensembl:ENSMUST00000021284(transcript)|ensembl:ENSMUST00000108674(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|rcsb pdb:4OVE|reactome:R-MMU-373752|reactome:R-MMU-418885 intact:EBI-4396886(isoform-parent)|ensembl:ENSMUSG00000020099(gene)|ensembl:ENSMUST00000077925(transcript) - - - figure legend:2D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/18 2016/03/17 rogid:03RX6IHBOrGA1HJPLlszlp+P6i410090 rogid:YqYcFUZ3Y3spL702w6mshOPjNf410090 rigid:1QPZ97oWht87pe+qNAV93D45jps false sufficient binding region:24-457 sufficient binding region:25-374|strep ii tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q8K1S3-1 intact:EBI-11658376 intact:EBI-11658250|ensembl:ENSMUSP00000077080 - psi-mi:q8k1s3-1(display_long)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym) psi-mi:"(arrsr)x3"(display_short)|psi-mi:EBI-11658376(display_long) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658350|imex:IM-25053-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-4396886(isoform-parent)|ensembl:ENSMUSG00000020099(gene)|ensembl:ENSMUST00000077925(transcript) - - - - figure legend:3A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/18 2016/03/17 rogid:YqYcFUZ3Y3spL702w6mshOPjNf410090 rogid:dz79Vd9PJmFDAx3IMw2Fhhpx8CI-2 rigid:1afZ2cwIzYLGkrrJK2CEZdh6GxM false sufficient binding region:25-374|strep ii tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q8K1S3-1 uniprotkb:O09118 intact:EBI-11658250|ensembl:ENSMUSP00000077080 intact:EBI-1798844|uniprotkb:B1ARR0|uniprotkb:Q60832|uniprotkb:Q9QY50|ensembl:ENSMUSP00000021284|ensembl:ENSMUSP00000104314 psi-mi:q8k1s3-1(display_long)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym) psi-mi:net1_mouse(display_long)|uniprotkb:Ntn1(gene name)|psi-mi:Ntn1(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658350|imex:IM-25053-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-4396886(isoform-parent)|ensembl:ENSMUSG00000020099(gene)|ensembl:ENSMUST00000077925(transcript) refseq:NP_032770.2|ensembl:ENSMUSG00000020902(gene)|ensembl:ENSMUST00000021284(transcript)|ensembl:ENSMUST00000108674(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|rcsb pdb:4OVE|reactome:R-MMU-373752|reactome:R-MMU-418885 - - - figure legend:3A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/18 2016/03/17 rogid:YqYcFUZ3Y3spL702w6mshOPjNf410090 rogid:03RX6IHBOrGA1HJPLlszlp+P6i410090 rigid:1afZ2cwIzYLGkrrJK2CEZdh6GxM false sufficient binding region:25-374|strep ii tag:c-c sufficient binding region:24-457 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O95631-PRO_0000017082 uniprotkb:O08722 intact:EBI-11658396 intact:EBI-4404185 psi-mi:o95631-pro_0000017082(display_long)|uniprotkb:Epididymis tissue protein Li 131P(gene name synonym)|uniprotkb:NTN1(gene name)|psi-mi:NTN1(display_short)|uniprotkb:NTN1L(gene name synonym) psi-mi:unc5b_rat(display_long)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658381|imex:IM-25053-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2678626(chain-parent) rgd:621756|refseq:NP_071543.1|dip:DIP-60743N|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR000906(ZU5)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033772|interpro:IPR036179|interpro:IPR036383|interpro:IPR037936|interpro:IPR042156|rcsb pdb:3G5B|go:"GO:0045121"(membrane raft) - chain-seq-start:25|chain-seq-end:604 - figure legend:4B|antagonist:NET1-H-mAb antibody; a humanised netrin-1-specific IgG1 monoclonal antibody.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) ic50:2.0x10^-9(molar) 2016/02/18 2016/03/17 rogid:PpOnu/LRly7yT0A9S5K4ZwgfO+s9606 rogid:eMLpHKP8+9+6y69jsrnTolsZdEI10116 rigid:HZES59WWDGjuXgsMSxZXjTThuvE false flag tag:c-c sufficient binding region:27-373|fc-igg tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O08722 uniprotkb:O95631 intact:EBI-4404185 intact:EBI-2678626|uniprotkb:E9KL51|ensembl:ENSP00000173229 psi-mi:unc5b_rat(display_long)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym) psi-mi:net1_human(display_long)|uniprotkb:NTN1(gene name)|psi-mi:NTN1(display_short)|uniprotkb:NTN1L(gene name synonym)|uniprotkb:Epididymis tissue protein Li 131P(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658419|imex:IM-25053-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621756|refseq:NP_071543.1|dip:DIP-60743N|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR000906(ZU5)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033772|interpro:IPR036179|interpro:IPR036383|interpro:IPR037936|interpro:IPR042156|rcsb pdb:3G5B|go:"GO:0045121"(membrane raft) refseq:NP_004813.2|ensembl:ENSG00000065320(gene)|ensembl:ENST00000173229(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|rcsb pdb:4URT|rcsb pdb:6FKQ|rcsb pdb:7NDG|rcsb pdb:7NE0|rcsb pdb:7NE1|reactome:R-HSA-373752|reactome:R-HSA-376172|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-418890|reactome:R-HSA-428542|refseq:XP_006721658.1|dip:DIP-46273N - - - figure legend:4E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/18 2016/03/17 rogid:eMLpHKP8+9+6y69jsrnTolsZdEI10116 rogid:lDiYjrwbQf/qcr8gt7sbXMBkuMw9606 rigid:JfsNZ89t6a3y8DpLlTsVFq5JG3E false fc-igg tag:c-c alkaline phosphatase tag:?-?|mutation decreasing interaction strength:353-353|mutation decreasing interaction strength:348-349,351-351|mutation decreasing interaction strength:358-358|mutation decreasing interaction strength:360-360|mutation with no effect:348-348|mutation with no effect:357-357 - - psi-mi:"MI:1323"(tag visualisation by alkaline phosphatase activity) psi-mi:"MI:1323"(tag visualisation by alkaline phosphatase activity) uniprotkb:O09118 uniprotkb:Q8K1S3-1 intact:EBI-1798844|uniprotkb:B1ARR0|uniprotkb:Q60832|uniprotkb:Q9QY50|ensembl:ENSMUSP00000021284|ensembl:ENSMUSP00000104314 intact:EBI-11658250|ensembl:ENSMUSP00000077080 psi-mi:net1_mouse(display_long)|uniprotkb:Ntn1(gene name)|psi-mi:Ntn1(display_short) psi-mi:q8k1s3-1(display_long)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Grandin et al. (2016) imex:IM-25053|pubmed:26859457 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11658464|imex:IM-25053-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032770.2|ensembl:ENSMUSG00000020902(gene)|ensembl:ENSMUST00000021284(transcript)|ensembl:ENSMUST00000108674(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007097"(nuclear migration)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016358"(dendrite development)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061643"(chemorepulsion of axon)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|rcsb pdb:4OVE|reactome:R-MMU-373752|reactome:R-MMU-418885 intact:EBI-4396886(isoform-parent)|ensembl:ENSMUSG00000020099(gene)|ensembl:ENSMUST00000077925(transcript) - - - figure legend:Supp 2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/18 2016/03/17 rogid:03RX6IHBOrGA1HJPLlszlp+P6i410090 rogid:YqYcFUZ3Y3spL702w6mshOPjNf410090 rigid:1QPZ97oWht87pe+qNAV93D45jps false sufficient binding region:24-457 sufficient binding region:25-374|strep ii tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)