#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P17661 uniprotkb:O43812 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599346 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599344|imex:IM-25050-181 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:8oJQmVr/k28slV3HjYEIRgSvWOQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P35609 uniprotkb:O43812 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-11599346 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599362|imex:IM-25050-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:k3vEhMosSKcq4Wr86/k6uzAfj68 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q08043 uniprotkb:O43812 intact:EBI-2880652|ensembl:ENSP00000426797|uniprotkb:Q4KKV2|uniprotkb:A6NP77 intact:EBI-11599346 psi-mi:actn3_human(display_long)|uniprotkb:ACTN3(gene name)|psi-mi:ACTN3(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 3(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599366|imex:IM-25050-121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051015"(actin filament binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1901078"(negative regulation of relaxation of muscle)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904025"(positive regulation of glucose catabolic process to lactate via pyruvate)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|ensembl:ENSG00000248746(gene)|ensembl:ENST00000513398(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014728"(regulation of the force of skeletal muscle contraction)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0030018"(Z disc)|go:"GO:0031143"(pseudopodium)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0042802"(identical protein binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1TJT|rcsb pdb:1WKU|rcsb pdb:3LUE|reactome:R-HSA-373753|reactome:R-HSA-390522|refseq:NP_001245300.2|refseq:NP_001095.2 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:ihTlyeKGYaTOZTmd5oP5FeFmo089606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:O9oVcdjOPzjhYPoiX4vL4PoaVuw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P67870 uniprotkb:O43812 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 intact:EBI-11599346 psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599370|imex:IM-25050-183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:/7DlLf6vHuc3s+/p/rYkttc2sPI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q02224 uniprotkb:O43812 intact:EBI-1375040|uniprotkb:A6NKY9|uniprotkb:Q4LE75|uniprotkb:A8K2U7|ensembl:ENSP00000265148 intact:EBI-11599346 psi-mi:cenpe_human(display_long)|uniprotkb:CENPE(gene name)|psi-mi:CENPE(display_short)|uniprotkb:Kinesin-related protein CENPE(gene name synonym)|uniprotkb:Centromere protein E(gene name synonym)|uniprotkb:Kinesin-7(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599374|imex:IM-25050-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001804.2|refseq:NP_001273663.1|dip:DIP-38902N|ensembl:ENSG00000138778(gene)|ensembl:ENST00000265148(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0043515"(kinetochore binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0099606"(microtubule plus-end directed mitotic chromosome migration)|go:"GO:0099607"(lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q02224|rcsb pdb:1T5C|rcsb pdb:5JVP|rcsb pdb:6M4I|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:SbcZI5/nK0DHyrfEA5VBMSq4mX49606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:tJYd0NA+ZU5UXag7f2aA0TycJFA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P55084 uniprotkb:O43812 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 intact:EBI-11599346 psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599874|imex:IM-25050-141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:QG6airQcjR9Z+HwVB7iVbAylywQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P17661 uniprotkb:Q6RFH8 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599882|intact:EBI-28972081 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599878|imex:IM-25050-123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:nqJYT1jGgACFMpMA5D9k9AOW1jA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13643 uniprotkb:Q6RFH8 intact:EBI-741101|ensembl:ENSP00000362107|uniprotkb:Q6I9T0|uniprotkb:Q9BVA2|uniprotkb:D3DPT6 intact:EBI-11599882|intact:EBI-28972081 psi-mi:fhl3_human(display_long)|uniprotkb:FHL3(gene name)|psi-mi:FHL3(display_short)|uniprotkb:SLIM2(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 2(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599897|imex:IM-25050-185 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004459.2|ensembl:ENSG00000183386(gene)|ensembl:ENST00000373016(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0007517"(muscle organ development)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q13643|rcsb pdb:1WYH|rcsb pdb:2CUQ|rcsb pdb:2EHE|interpro:IPR037987|refseq:NP_001230807.1|dip:DIP-42030N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:RAo+b/VgFSnHSbgR+zXuxJvypxM9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:CGykZZyAw/vkqcim+/a61oZhmto false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q08043 uniprotkb:Q6RFH8 intact:EBI-2880652|ensembl:ENSP00000426797|uniprotkb:Q4KKV2|uniprotkb:A6NP77 intact:EBI-11599882|intact:EBI-28972081 psi-mi:actn3_human(display_long)|uniprotkb:ACTN3(gene name)|psi-mi:ACTN3(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 3(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599901|imex:IM-25050-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051015"(actin filament binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1901078"(negative regulation of relaxation of muscle)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904025"(positive regulation of glucose catabolic process to lactate via pyruvate)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|ensembl:ENSG00000248746(gene)|ensembl:ENST00000513398(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014728"(regulation of the force of skeletal muscle contraction)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0030018"(Z disc)|go:"GO:0031143"(pseudopodium)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0042802"(identical protein binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1TJT|rcsb pdb:1WKU|rcsb pdb:3LUE|reactome:R-HSA-373753|reactome:R-HSA-390522|refseq:NP_001245300.2|refseq:NP_001095.2 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:ihTlyeKGYaTOZTmd5oP5FeFmo089606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:XAPuOTyzMhebe/mydLk/OTS5a6Q false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P68133 uniprotkb:Q6RFH8 intact:EBI-367510|uniprotkb:P02568|uniprotkb:P99020|ensembl:ENSP00000355645|uniprotkb:Q5T8M9 intact:EBI-11599882|intact:EBI-28972081 psi-mi:acts_human(display_long)|uniprotkb:ACTA1(gene name)|psi-mi:ACTA1(display_short)|uniprotkb:ACTA(gene name synonym)|uniprotkb:Alpha-actin-1(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599906|imex:IM-25050-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143632(gene)|ensembl:ENST00000366684(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0043531"(ADP binding)|go:"GO:0044297"(cell body)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68133|reactome:R-HSA-390522|go:"GO:0001725"(stress fiber)|refseq:NP_001091.1 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:2vZu8ElmMe+6GjKBliCAatNGZR49606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:FVBZxWnQQ06MdQcSXH5adJ2YGBY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02585 uniprotkb:Q6RFH8 intact:EBI-10249681|uniprotkb:Q6FH92|ensembl:ENSP00000361636 intact:EBI-11599882|intact:EBI-28972081 psi-mi:tnnc2_human(display_long)|uniprotkb:TNNC2(gene name)|psi-mi:TNNC2(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599913|imex:IM-25050-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003270.1|ensembl:ENSG00000101470(gene)|ensembl:ENST00000372555(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:7KAA|reactome:R-HSA-390522 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:tDu01LJbvR/6jD4qOObP2jSt2b89606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:8fHKHZZwnZORhpLSyHxNN9aFVJw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UKX2 uniprotkb:Q6RFH8 intact:EBI-1049626|uniprotkb:A0AVL4|uniprotkb:Q14322|uniprotkb:Q16229|uniprotkb:Q86T56|ensembl:ENSP00000245503|ensembl:ENSP00000380367|uniprotkb:Q567P6 intact:EBI-11599882|intact:EBI-28972081 psi-mi:myh2_human(display_long)|uniprotkb:MYH2(gene name)|psi-mi:MYH2(display_short)|uniprotkb:MYHSA2(gene name synonym)|uniprotkb:Myosin heavy chain 2(gene name synonym)|uniprotkb:Myosin heavy chain 2a(gene name synonym)|uniprotkb:Myosin heavy chain IIa(gene name synonym)|uniprotkb:Myosin heavy chain, skeletal muscle, adult 2(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599917|imex:IM-25050-143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001093582.1|refseq:NP_060004.3|ensembl:ENST00000245503(transcript)|ensembl:ENST00000397183(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0032982"(myosin filament)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q9UKX2|reactome:R-HSA-2029482|reactome:R-HSA-9664422|ensembl:ENSG00000125414(gene) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:N23NJxmt8WtUT87k2VPsiB7juqQ9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:yD6FtJXOFKRlRW2h/BwrkToAJYg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UMS6 uniprotkb:Q6RFH8 intact:EBI-3453434|uniprotkb:C6H0M7|uniprotkb:Q9UK89|intact:EBI-9640076|uniprotkb:B2RWP6|uniprotkb:B2Y8J9|uniprotkb:S5XAM4|ensembl:ENSP00000395143 intact:EBI-11599882|intact:EBI-28972081 psi-mi:synp2_human(display_long)|uniprotkb:SYNPO2(gene name)|psi-mi:SYNPO2(display_short)|uniprotkb:Genethonin-2(gene name synonym)|uniprotkb:Myopodin(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599921|imex:IM-25050-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122405.1|refseq:NP_001122406.1|refseq:NP_597734.2|ensembl:ENST00000307142|ensembl:ENSP00000395143|ensembl:ENST00000434046|ensembl:ENSP00000390965|ensembl:ENST00000610556|ensembl:ENSP00000484885|ensembl:ENST00000627783|ensembl:ENSP00000498985|ensembl:ENSP00000306015|refseq:NP_001273683.1|ensembl:ENSG00000172403(gene)|ensembl:ENST00000429713(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0099023"(vesicle tethering complex)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q9UMS6|dip:DIP-47311N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:/M3mn/7+FeorqW2JcdbxjylVyDU9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:0e1ZHUsVYdvkrfVHdGIsxw14XIw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P35052 uniprotkb:Q6RFH8 intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1 intact:EBI-11599882|intact:EBI-28972081 psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599925|imex:IM-25050-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - function:Cell surface proteoglycan that bears heparan sulfate|comment:mint - figure legend:Table 2-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:sXZreYpugZcLwPBWNnVRndRkxC4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q4VC12 uniprotkb:Q6RFH8 intact:EBI-11599933|uniprotkb:A6NGH6|uniprotkb:Q2VP95|uniprotkb:Q5F2H5|uniprotkb:Q7Z3M9|uniprotkb:Q8N8G0|ensembl:ENSP00000299432|ensembl:ENSP00000362003 intact:EBI-11599882|intact:EBI-28972081 psi-mi:mss51_human(display_long)|uniprotkb:Zinc finger MYND domain-containing protein 17(gene name synonym)|uniprotkb:MSS51(gene name)|psi-mi:MSS51(display_short)|uniprotkb:ZMYND17(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599929|imex:IM-25050-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019764.1|ensembl:ENSG00000166343(gene)|ensembl:ENST00000372912(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR002893(Zinc finger, MYND-type)|ensembl:ENST00000299432(transcript) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-10|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:iNEqLJvdGCwt1ULokD5vCGFHgZk9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:rLaq0C6sqJZu0cDA4IzZNF/HRV8 false sufficient binding region:?-? - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13285 uniprotkb:Q6RFH8 intact:EBI-874629|uniprotkb:O15196|uniprotkb:Q5T6F5|ensembl:ENSP00000362690 intact:EBI-11599882|intact:EBI-28972081 psi-mi:stf1_human(display_long)|uniprotkb:Nuclear receptor subfamily 5 group A member 1(gene name synonym)|uniprotkb:Adrenal 4-binding protein(gene name synonym)|uniprotkb:Steroid hormone receptor Ad4BP(gene name synonym)|uniprotkb:Fushi tarazu factor homolog 1(gene name synonym)|uniprotkb:NR5A1(gene name)|psi-mi:NR5A1(display_short)|uniprotkb:AD4BP(gene name synonym)|uniprotkb:FTZF1(gene name synonym)|uniprotkb:SF1(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599954|imex:IM-25050-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005251928.1|refseq:NP_004950.2|refseq:XP_011516757.1|ensembl:ENSG00000136931(gene)|ensembl:ENST00000373588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007530"(sex determination)|go:"GO:0007538"(primary sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009888"(tissue development)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097210"(response to gonadotropin-releasing hormone)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000195"(negative regulation of female gonad development)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016355(Orphan nuclear receptor Fushi-tarazu factor 1)|interpro:IPR035500|rcsb pdb:1YOW|rcsb pdb:1ZDT|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:7KHT|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-452723|reactome:R-HSA-9690406 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-11|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:UC4bXFO03I1iftAyX5/CJAXeTUo9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:KTyIXgoVQ0cpyj3hctVeeHTqsmc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P17844 uniprotkb:Q6RFH8 intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794 intact:EBI-11599882|intact:EBI-28972081 psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599960|imex:IM-25050-125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-12|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:h1IKPZV0WFoP+WR0DxmH9TiUSK4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q07021 uniprotkb:Q6RFH8 intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698 intact:EBI-11599882|intact:EBI-28972081 psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599964|imex:IM-25050-145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-13|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:IY9EBRWRAlMgTwuDYL8QZLpkDtY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P36578 uniprotkb:Q6RFH8 intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502 intact:EBI-11599882|intact:EBI-28972081 psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599968|imex:IM-25050-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-14|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:ptayupMcD/p86fRHPEnjRp/kZT0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O94829 uniprotkb:Q6RFH8 intact:EBI-747310|uniprotkb:Q7LC04|uniprotkb:Q96HS3|uniprotkb:Q9H8N3|uniprotkb:Q9UFR1|uniprotkb:Q5T4X3|uniprotkb:D3DPY4|ensembl:ENSP00000361418 intact:EBI-11599882|intact:EBI-28972081 psi-mi:ipo13_human(display_long)|uniprotkb:Ran-binding protein 13(gene name synonym)|uniprotkb:Karyopherin-13(gene name synonym)|uniprotkb:IPO13(gene name)|psi-mi:IPO13(display_short)|uniprotkb:KIAA0724(gene name synonym)|uniprotkb:RANBP13(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599972|imex:IM-25050-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055467.3|ensembl:ENSG00000117408(gene)|ensembl:ENST00000372343(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040520|interpro:IPR040709|interpro:IPR040944|rcsb pdb:2X19|rcsb pdb:2XWU|rcsb pdb:3ZJY interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:HC5CjdyfnwoVeE9JNHgicwFybWc9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:G4i+FcsK5WOF7qv6pA6YEVIZco0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P45880 uniprotkb:Q6RFH8 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 intact:EBI-11599882|intact:EBI-28972081 psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599977|imex:IM-25050-187 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-16|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:/6QgAc9ixHvK/wM9zDOx24BlWHk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06732 uniprotkb:Q6RFH8 intact:EBI-4287089|uniprotkb:Q96QL9|ensembl:ENSP00000221476 intact:EBI-11599882|intact:EBI-28972081 psi-mi:kcrm_human(display_long)|uniprotkb:CKM(gene name)|psi-mi:CKM(display_short)|uniprotkb:CKMM(gene name synonym)|uniprotkb:Creatine kinase M chain(gene name synonym)|uniprotkb:M-CK(gene name synonym)|uniprotkb:Creatine phosphokinase M-type(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599981|imex:IM-25050-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001815.2|ensembl:ENSG00000104879(gene)|ensembl:ENST00000221476(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P06732|rcsb pdb:1I0E|reactome:R-HSA-71288|go:"GO:0005524"(ATP binding)|refseq:XP_016881729.1 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-17|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:zuj1pG+YNft6wFPHLPoS+CTamkE9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:1rbss/9e6aF26ghtCIvuF1WO9U8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H8M1 uniprotkb:Q6RFH8 intact:EBI-11599990|uniprotkb:B7Z1Y4|ensembl:ENSP00000263960 intact:EBI-11599882|intact:EBI-28972081 psi-mi:cq10b_human(display_long)|uniprotkb:COQ10B(gene name)|psi-mi:COQ10B(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599986|imex:IM-25050-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079423.1|refseq:NP_001307748.1|refseq:NP_001307749.1|refseq:NP_001307747.1|ensembl:ENSG00000115520(gene)|ensembl:ENST00000263960(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR005031(Streptomyces cyclase/dehydrase)|interpro:IPR023393|reactome:R-HSA-611105 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-18|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:G4FcVEx4zHGdjFxORfOWJXR9xkU9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:ZKBTx9wDH6oszSyZJ1gzde5CScQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O96000 uniprotkb:Q6RFH8 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 intact:EBI-11599882|intact:EBI-28972081 psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600002|imex:IM-25050-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-19|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:vE7fh/Kfc7cHi8RxXag9ft294kc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P62140 uniprotkb:Q6RFH8 intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769 intact:EBI-11599882|intact:EBI-28972081 psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600007|imex:IM-25050-147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 2-20|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:pYyjLeSBHqzniiXKFWcBu21A0B0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P35609 uniprotkb:O43812 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-11599346 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599416|imex:IM-25050-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:k3vEhMosSKcq4Wr86/k6uzAfj68 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P67870 uniprotkb:O43812 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 intact:EBI-11599346 psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599424|imex:IM-25050-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:/7DlLf6vHuc3s+/p/rYkttc2sPI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P17661 uniprotkb:O43812 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599346 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599428|imex:IM-25050-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table 1-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:8oJQmVr/k28slV3HjYEIRgSvWOQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P17661 uniprotkb:O43812 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599346 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11599432|imex:IM-25050-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/18 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:8oJQmVr/k28slV3HjYEIRgSvWOQ false sufficient binding region:260-470 sufficient binding region:19-78(IPR001356) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31001 uniprotkb:Q9UBX2 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600034|imex:IM-25050-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid://4Dx2eqJe72X9gmpV76pOsMaIM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Z1Y4 uniprotkb:Q9UBX2 intact:EBI-643879|uniprotkb:Q3TX74|ensembl:ENSMUSP00000024119 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:trip6_mouse(display_long)|uniprotkb:Zyxin-related protein 1(gene name synonym)|uniprotkb:Trip6(gene name)|psi-mi:Trip6(display_short)|uniprotkb:Zrp1(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600128|imex:IM-25050-189 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035769.1|ensembl:ENSMUSG00000023348(gene)|ensembl:ENSMUST00000024119(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q9Z1Y4 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:7eIRYOt0EYhXcPOpabbr1GUYO0g10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:7ian7IwK7DoSB+SWlRjr9c/e7qc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P40124 uniprotkb:Q9UBX2 intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600134|imex:IM-25050-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP, C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:UVvXBL6sVnqmjGAWjOY62PGSpQk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q2TBE6 uniprotkb:Q9UBX2 intact:EBI-8159115|ensembl:ENSMUSP00000069284|ensembl:ENSMUSP00000158574|intact:MINT-1865952|intact:MINT-8427650 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:p4k2a_mouse(display_long)|uniprotkb:Pi4k2a(gene name)|psi-mi:Pi4k2a(display_short)|uniprotkb:Phosphatidylinositol 4-kinase type II-alpha(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600141|imex:IM-25050-105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011245707.1|ensembl:ENSMUSG00000025178(gene)|ensembl:ENSMUST00000066778(transcript)|ensembl:ENSMUST00000235932(transcript)|go:"GO:0002561"(basophil degranulation)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0035838"(growing cell tip)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR039756|mint:Q2TBE6|reactome:R-MMU-1660499|reactome:R-MMU-1660514|reactome:R-MMU-1660516|refseq:NP_663476.1|uniprotkb:Q8VC15(q8vc15_mouse) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - comment:mint - figure legend:Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:215wPS5InduQ3iDmYxvPJySrxC810090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:8PgD021QHqrjqFJikOfa1uTw3+o false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VEE1 uniprotkb:Q9UBX2 intact:EBI-11600149|ensembl:ENSMUSP00000032376 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:lmcd1_mouse(display_long)|uniprotkb:Lmcd1(gene name)|psi-mi:Lmcd1(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600145|imex:IM-25050-201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_659048.1|ensembl:ENSMUSG00000057604(gene)|ensembl:ENSMUST00000032376(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010611"(regulation of cardiac muscle hypertrophy)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033724|reactome:R-MMU-5683826 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:ICJBWdzVE5ObQTkzPJNbiasrPeU10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:h0YzEzKKaVb/hRaVkBK2PBLXlPs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P63028 uniprotkb:Q9UBX2 intact:EBI-1635228|uniprotkb:P14701|uniprotkb:Q3TMT0|uniprotkb:Q3TWS8|uniprotkb:Q3TWX0|uniprotkb:Q3UAG7|uniprotkb:Q569M9|ensembl:ENSMUSP00000106519 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:tctp_mouse(display_long)|uniprotkb:Tpt1(gene name)|psi-mi:Tpt1(display_short)|uniprotkb:Trt(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:21 kDa polypeptide(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600172|imex:IM-25050-203 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033455.1|ensembl:ENSMUSG00000060126(gene)|ensembl:ENSMUST00000110894(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009615"(response to virus)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000384"(negative regulation of ectoderm development)|interpro:IPR011057(Mss4-like)|interpro:IPR011323(Mss4/translationally controlled tumour-associated TCTP)|interpro:IPR018103|interpro:IPR018105|interpro:IPR034737|mint:P63028|rcsb pdb:5O9K ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:4STBIjAMhg84kMGx/MP1PUh6g4g10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:5jZhq6xIF2ED6Kc0G6DqOW4Ial4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O35216 uniprotkb:Q9UBX2 intact:EBI-8572794|ensembl:ENSMUSP00000122831|uniprotkb:Q545C9|intact:MINT-237454 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:cenpa_mouse(display_long)|uniprotkb:Cenpa(gene name)|psi-mi:Cenpa(display_short)|uniprotkb:Centromere protein A(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600177|imex:IM-25050-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001289058.1|refseq:NP_001289059.1|refseq:NP_001289060.1|refseq:NP_001289061.1|ensembl:ENSMUSG00000029177(gene)|ensembl:ENSMUST00000144742(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-606279|reactome:R-MMU-68877|reactome:R-MMU-9648025|refseq:NP_031707.1 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - function:Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division|comment:mint - figure legend:Table 3-7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:2/sHw72w0BLhkhzSMU/R8rJzHQc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:13NbpuYnmogoq4HkTQjiWR1KopI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:G5E8P0 uniprotkb:Q9UBX2 intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600185|imex:IM-25050-149 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/07/13 rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:4Bd5xJob43FXxvmeBEfXBHcMc5g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O89086 uniprotkb:Q9UBX2 intact:EBI-645649|ensembl:ENSMUSP00000111277|ensembl:ENSMUSP00000111282|ensembl:ENSMUSP00000111284 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:rbm3_mouse(display_long)|uniprotkb:RNA-binding motif protein 3(gene name synonym)|uniprotkb:Rbm3(gene name)|psi-mi:Rbm3(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600244|imex:IM-25050-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159882.1|refseq:NP_001159883.1|ensembl:ENSMUSG00000031167(gene)|ensembl:ENSMUST00000115615(transcript)|ensembl:ENSMUST00000115619(transcript)|ensembl:ENSMUST00000115621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0009409"(response to cold)|go:"GO:0030425"(dendrite)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:O89086 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-9|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:loZc/KXvfUWniBvL99ZXgx7d9hQ10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:SdtnE0RqErhAQmNt31JHf0iy+aM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O35658 uniprotkb:Q9UBX2 intact:EBI-642072 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:c1qbp_mouse(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600260|imex:IM-25050-151 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-140837|reactome:R-MMU-8980692|reactome:R-MMU-9013106|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|dip:DIP-32249N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-10|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:tPoLimqgF2SXeVXk7Z5rCQa+wTc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:vlYjIO0avgcHy0ocfdyLcRehx9s false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9D0B0 uniprotkb:Q9UBX2 intact:EBI-8459497|uniprotkb:Q9CRN3|intact:MINT-4126379|ensembl:ENSMUSP00000031513 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:srsf9_mouse(display_long)|uniprotkb:Srsf9(gene name)|psi-mi:Srsf9(display_short)|uniprotkb:Sfrs9(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600264|imex:IM-25050-153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079849.1|ensembl:ENSMUSG00000029538(gene)|ensembl:ENSMUST00000031513(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q9D0B0|rcsb pdb:1WG4|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - function:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites|comment:mint - figure legend:Table 3-11|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:25t44o/3FTGaNAXdHibw1ibYdUc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:IKr+RzTP272HGUipP/E4TRrbUeE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q3UBZ5 uniprotkb:Q9UBX2 intact:EBI-11600284|uniprotkb:Q05CE9|uniprotkb:Q7TMH3|uniprotkb:Q8R333|ensembl:ENSMUSP00000102116|ensembl:ENSMUSP00000021087 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:mi4gd_mouse(display_long)|uniprotkb:Mif4gd(gene name)|psi-mi:Mif4gd(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600280|imex:IM-25050-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230513.1|refseq:NP_081438.4|ensembl:ENSMUST00000021087(transcript)|ensembl:ENSMUST00000106507(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008494"(translation activator activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|ensembl:ENSMUSG00000020743(gene) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-12|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:mpgttfm2WX9qnydohOCHXV9aXJo10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:EDNWYuynNXIU6x2orKD5m8zewqw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9DCR4 uniprotkb:Q9UBX2 intact:EBI-11600334|uniprotkb:Q3T9D1|uniprotkb:Q8BP25|uniprotkb:Q9CQ17|uniprotkb:Q9CYM0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:eid1_mouse(display_long)|uniprotkb:CREBBP/EP300 inhibitory protein 1(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 1(gene name synonym)|uniprotkb:Eid1(gene name)|psi-mi:Eid1(display_short)|uniprotkb:Cri1(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600306|imex:IM-25050-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079889.2|rcsb pdb:4NUF|interpro:IPR033255|interpro:IPR033258|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0030154"(cell differentiation)|go:"GO:0035034"(histone acetyltransferase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-13|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:XIc7IFeXrmrFQb/8JfbFFSaT4so10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:sIS82V3RkN8Yjq8cSzvvU51DbHg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8BY71 uniprotkb:Q9UBX2 intact:EBI-2657967|ensembl:ENSMUSP00000028408 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:hat1_mouse(display_long)|uniprotkb:Hat1(gene name)|psi-mi:Hat1(display_short)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600313|imex:IM-25050-155 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080391.2|ensembl:ENSMUSG00000027018(gene)|ensembl:ENSMUST00000028408(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|reactome:R-MMU-3214847|go:"GO:0005739"(mitochondrion) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-14|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:5qGzSmbZX85IkAq65CYnMV+inpc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:j87vFy+NdM9zxTDOEYdPpVgWEKU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61039 uniprotkb:Q9UBX2 intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600384|imex:IM-25050-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:i8BnB7XbUqFvDWo7SbgFH7svDGk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8BSQ9 uniprotkb:Q9UBX2 intact:EBI-5744069|uniprotkb:E9QPW1|uniprotkb:Q05C64|uniprotkb:Q05CL6|uniprotkb:Q7TMP1|uniprotkb:Q7TNU2|uniprotkb:Q9CV51|ensembl:ENSMUSP00000107724 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:pb1_mouse(display_long)|uniprotkb:Pbrm1(gene name)|psi-mi:Pbrm1(display_short)|uniprotkb:Baf180(gene name synonym)|uniprotkb:Pb1(gene name synonym)|uniprotkb:BRG1-associated factor 180(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600388|imex:IM-25050-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001487(Bromodomain)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR018359|interpro:IPR036427|interpro:IPR036910|interpro:IPR037382|interpro:IPR037968|interpro:IPR043151|mint:Q8BSQ9|rcsb pdb:2YQD|reactome:R-MMU-3214858|ensembl:ENSMUSG00000042323(gene)|ensembl:ENSMUST00000112095(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001825"(blastocyst formation)|go:"GO:0001890"(placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003349"(epicardium-derived cardiac endothelial cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016586"(RSC-type complex)|dip:DIP-48885N|reactome:R-MMU-8939243 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-16|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:7T640XCpm6UfVO9GB/HJKZZbd7E10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:ZhuCc1nbWeLar00AC5sR6R2O3p4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P62488 uniprotkb:Q9UBX2 intact:EBI-11516140|uniprotkb:P52433|ensembl:ENSMUSP00000093980 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:rpb7_mouse(display_long)|uniprotkb:Polr2g(gene name)|psi-mi:Polr2g(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600392|imex:IM-25050-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080605.1|ensembl:ENSMUSG00000071662(gene)|ensembl:ENSMUST00000096261(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|reactome:R-MMU-112382|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|reactome:R-MMU-6782135 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-17|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:MtnIweuhSqLFov0c40uOiwv8Eas10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:Ol1Ok6uy1UaWTQwDridTJ/9hH7c false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q01320 uniprotkb:Q9UBX2 intact:EBI-642809|uniprotkb:E9PX08|ensembl:ENSMUSP00000068896 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:top2a_mouse(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:Top2a(gene name)|psi-mi:Top2a(display_short)|uniprotkb:Top2(gene name synonym)|uniprotkb:Top-2(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600396|imex:IM-25050-205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006533216.1|refseq:NP_035753.2|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:Q01320|reactome:R-MMU-4615885|interpro:IPR020568|ensembl:ENSMUSG00000020914(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|ensembl:ENSMUST00000068031(transcript)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:0051309"(female meiosis chromosome separation)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|go:"GO:0030263"(apoptotic chromosome condensation)|dip:DIP-40621N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-18|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:4bT7YxXbxkbqULDvXoFRreoX9Gs10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:qydYXUaZJmrb+42XxQPGUtqKSs8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8BPB5 uniprotkb:Q9UBX2 intact:EBI-11600414|uniprotkb:Q6Y3N6|ensembl:ENSMUSP00000020759 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:fbln3_mouse(display_long)|uniprotkb:Efemp1(gene name)|psi-mi:Efemp1(display_short)|uniprotkb:Fbln3(gene name synonym)|uniprotkb:Fibulin-3(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600410|imex:IM-25050-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_666127.2|refseq:XP_006514723.1|ensembl:ENSMUSG00000020467(gene)|ensembl:ENSMUST00000020759(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1903975"(regulation of glial cell migration)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-19|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:tFC72IET8JrL12pOHxbbhrNTlHc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:SHSMuAillrPEEovk7UogZmyxg2I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JI48 uniprotkb:Q9UBX2 intact:EBI-11600460|ensembl:ENSMUSP00000031264|ensembl:ENSMUSP00000108531|ensembl:ENSMUSP00000108533 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:plac8_mouse(display_long)|uniprotkb:Plac8(gene name)|psi-mi:Plac8(display_short)|uniprotkb:Onzin(gene name synonym)|uniprotkb:Protein C15(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600453|imex:IM-25050-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_631937.1|refseq:XP_011247732.1|ensembl:ENSMUSG00000029322(gene)|ensembl:ENSMUST00000031264(transcript)|ensembl:ENSMUST00000097437(transcript)|ensembl:ENSMUST00000112910(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009409"(response to cold)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006461(Protein of unknown function Cys-rich)|reactome:R-MMU-6798695 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-20|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:SGVzrjBWxgt6keDHZV3d3C3nPkg10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:/4v8K/18JSfsmaCqz6e7SrM6jbs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P11276 uniprotkb:Q9UBX2 intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600483|imex:IM-25050-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-21|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:CPTQQEKw5CkK4AXQ8e+gXXxq4RA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P05533 uniprotkb:Q9UBX2 intact:EBI-11600492|uniprotkb:Q8BPD0|ensembl:ENSMUSP00000023248|ensembl:ENSMUSP00000140099|ensembl:ENSMUSP00000140287|ensembl:ENSMUSP00000140638|ensembl:ENSMUSP00000140998 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ly6a_mouse(display_long)|uniprotkb:Ly6a(gene name)|psi-mi:Ly6a(display_short)|uniprotkb:Ly6(gene name synonym)|uniprotkb:Stem cell antigen 1(gene name synonym)|uniprotkb:T-cell-activating protein(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600488|imex:IM-25050-107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001258345.1|refseq:NP_001258346.1|refseq:NP_001258347.1|refseq:NP_001258348.1|refseq:NP_001258375.1|refseq:NP_034868.1|ensembl:ENSMUSG00000075602(gene)|ensembl:ENSMUST00000023248(transcript)|ensembl:ENSMUST00000186526(transcript)|ensembl:ENSMUST00000187171(transcript)|ensembl:ENSMUST00000187994(transcript)|ensembl:ENSMUST00000189068(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR018363|dip:DIP-59628N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-22|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:yHUATpMaRpp791fKl7aAxDRVDBc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:jBIahHGaNMPsPT0nwC8B7Y0zY8A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61554 uniprotkb:Q9UBX2 intact:EBI-11600525|uniprotkb:Q60826|uniprotkb:A2AQ53|ensembl:ENSMUSP00000028633|ensembl:ENSMUSP00000099524 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:fbn1_mouse(display_long)|uniprotkb:Fbn1(gene name)|psi-mi:Fbn1(display_short)|uniprotkb:Fbn-1(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600521|imex:IM-25050-207 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032019.2|refseq:XP_006498810.1|ensembl:ENSMUSG00000027204(gene)|ensembl:ENSMUST00000028633(transcript)|ensembl:ENSMUST00000103234(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0001822"(kidney development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|reactome:R-MMU-1474228|reactome:R-MMU-1566948|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-381426|reactome:R-MMU-8957275 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-23|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/07/13 rogid:iJqOIefj8mkvWoRvCnYr9OQfPms10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:kmjGJ2uQsAjqir/SkPiYk3k9PBY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61207 uniprotkb:Q9UBX2 intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600557|imex:IM-25050-109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-24|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:Cx1ybaF//x6Ml7/8CRaS5mHeXB4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P47878 uniprotkb:Q9UBX2 intact:EBI-11600565|uniprotkb:Q6PE62|ensembl:ENSMUSP00000020702|ensembl:ENSMUSP00000131670 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ibp3_mouse(display_long)|uniprotkb:Igfbp3(gene name)|psi-mi:Igfbp3(display_short)|uniprotkb:Igfbp-3(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600561|imex:IM-25050-157 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032369.2|ensembl:ENSMUSG00000020427(gene)|ensembl:ENSMUST00000020702(transcript)|ensembl:ENSMUST00000135887(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0042568"(insulin-like growth factor binary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:2000844"(negative regulation of testosterone secretion)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|reactome:R-MMU-381426|reactome:R-MMU-6803211|reactome:R-MMU-8957275 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-25|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:5kcH4xhKRFF53iP91xJ2zBBJqZI10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:ck03Ag1VwL1tpJgEd/vjecmEBSM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O08746 uniprotkb:Q9UBX2 intact:EBI-642537|uniprotkb:E9QPK9|uniprotkb:Q8R542|ensembl:ENSMUSP00000154040 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:matn2_mouse(display_long)|uniprotkb:Matn2(gene name)|psi-mi:Matn2(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600609|imex:IM-25050-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006520086.1|ensembl:ENSMUSG00000022324(gene)|ensembl:ENSMUST00000227759(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0048678"(response to axon injury)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030747|interpro:IPR036337|interpro:IPR036465|go:"GO:0062023"(collagen-containing extracellular matrix) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-26|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:eIx5dU8z6JnTeUXBbK/QKdTHw0A10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:AN6wzhNn/Mofbz1b6nA9a+WhST8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P97873 uniprotkb:Q9UBX2 intact:EBI-7935532|uniprotkb:Q99KX3|intact:MINT-6743519|uniprotkb:Q91ZY4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:loxl1_mouse(display_long)|uniprotkb:Loxl1(gene name)|psi-mi:Loxl1(display_short)|uniprotkb:Lox2(gene name synonym)|uniprotkb:Loxl(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 1(gene name synonym)|uniprotkb:Lysyl oxidase 2(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600613|imex:IM-25050-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001695(Lysyl oxidase)|refseq:NP_034859.2|interpro:IPR019828|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016641"(oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-MMU-1566948|reactome:R-MMU-2243919|go:"GO:0005615"(extracellular space)|go:"GO:0005604"(basement membrane)|mint:P97873 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - function:Active on elastin and collagen substrates|comment:mint - figure legend:Table 3-27|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:FRQSGUwMWBvmrr6+6yDeABc6U2010090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:Ce6yFhk7+s6i5op7EDvnoCB3Qzo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61810 uniprotkb:Q9UBX2 intact:EBI-11600622|uniprotkb:Q8BNQ6|ensembl:ENSMUSP00000080214|uniprotkb:F8VQ06 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ltbp3_mouse(display_long)|uniprotkb:Ltbp3(gene name)|psi-mi:Ltbp3(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600617|imex:IM-25050-111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032546.2|ensembl:ENSMUSG00000024940(gene)|ensembl:ENSMUST00000081496(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|reactome:R-MMU-2129379|dip:DIP-48641N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-28|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2019/01/24 rogid:Qd3EVkCCEbDUYJVpxp6cjRUsKdo10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:2dfBqc8vEn0bgaBm/NP5uKYz3vs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37889 uniprotkb:Q9UBX2 intact:EBI-645941|uniprotkb:Q9WUI2|uniprotkb:G5E8B3|ensembl:ENSMUSP00000048334 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:fbln2_mouse(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600653|imex:IM-25050-209 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006505593.1|refseq:NP_032018.2|ensembl:ENSMUSG00000064080(gene)|ensembl:ENSMUST00000041544(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037286|reactome:R-MMU-2129379 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-29|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:7iTuEE9p3igrawsCKRi6q2ZC/H4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P24369 uniprotkb:Q9UBX2 intact:EBI-494280|ensembl:ENSMUSP00000034947 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ppib_mouse(display_long)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Ppib(gene name)|psi-mi:Ppib(display_short)|uniprotkb:Rotamase B(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600658|imex:IM-25050-211 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035279.2|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0005737"(cytoplasm)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P24369|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|reactome:R-MMU-1650814|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|ensembl:ENSMUSG00000032383(gene)|ensembl:ENSMUST00000034947(transcript) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-30|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:Jp4wVPlfj3WNwhuh/Cvuk1TR7sY10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:0iMuLkzrV2u/SC624Nj1TST6mPQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P46412 uniprotkb:Q9UBX2 intact:EBI-8347420|uniprotkb:Q5XKR0|intact:MINT-4096578|ensembl:ENSMUSP00000081011 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:gpx3_mouse(display_long)|uniprotkb:Gpx3(gene name)|psi-mi:Gpx3(display_short)|uniprotkb:Plasma glutathione peroxidase(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600662|imex:IM-25050-213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032187.2|refseq:NP_001316789.1|ensembl:ENSMUSG00000018339(gene)|ensembl:ENSMUST00000082430(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008430"(selenium binding)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P46412|reactome:R-MMU-3299685 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - comment:mint|function:Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione - figure legend:Table 3-31|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:6KTUqzOcvpip/pymdBPzTQoDOM810090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:d392dEtF7W/45q3DwAdcP23yvKw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P99027 uniprotkb:Q9UBX2 intact:EBI-6261122|ensembl:ENSMUSP00000101625|ensembl:ENSMUSP00000101626|ensembl:ENSMUSP00000081474|uniprotkb:Q9CQ99|uniprotkb:Q9CZJ8|uniprotkb:Q3TKY3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:rla2_mouse(display_long)|uniprotkb:Rplp2(gene name)|psi-mi:Rplp2(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600666|imex:IM-25050-161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUST00000084434(transcript)|ensembl:ENSMUST00000106003(transcript)|ensembl:ENSMUST00000106004(transcript)|go:"GO:0002182"(cytoplasmic translational elongation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|interpro:IPR027534|interpro:IPR038716|interpro:IPR044076|mint:P99027|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000025508(gene)|refseq:XP_006536292.1|refseq:NP_080296.3 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-32|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:GYHP8hzpsOXoDDDnyOOBTMeIozg10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:dOjcU5HGBEL3Yc99VOTBu3QQfQk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q78S06 uniprotkb:Q9UBX2 intact:EBI-11600674|uniprotkb:Q3UFU1|uniprotkb:Q9DAU8|ensembl:ENSMUSP00000072275|ensembl:ENSMUSP00000104976|ensembl:ENSMUSP00000121900 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:sys1_mouse(display_long)|uniprotkb:Sys1(gene name)|psi-mi:Sys1(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600670|imex:IM-25050-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079851.2|refseq:XP_011238034.1|refseq:XP_011238035.1|ensembl:ENSMUSG00000045503(gene)|ensembl:ENSMUST00000072452(transcript)|ensembl:ENSMUST00000109352(transcript)|ensembl:ENSMUST00000125086(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR016973(SYS1 homologue)|interpro:IPR019185|reactome:R-MMU-6811440 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-33|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:nqvaYDzFCFEnCFJIOzow36coTIM10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:vRwYKMM2wKtcZKjGcdXUSKr3O7Y false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9DAS9 uniprotkb:Q9UBX2 intact:EBI-1183804|uniprotkb:Q544P3|ensembl:ENSMUSP00000046557|ensembl:ENSMUSP00000109860|ensembl:ENSMUSP00000109862|ensembl:ENSMUSP00000109863|ensembl:ENSMUSP00000109864|ensembl:ENSMUSP00000109865|ensembl:ENSMUSP00000109866 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:gbg12_mouse(display_long)|uniprotkb:Gng12(gene name)|psi-mi:Gng12(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600697|imex:IM-25050-113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171027.1|refseq:NP_001171028.1|refseq:NP_001171029.1|refseq:NP_001171030.1|refseq:NP_001171031.1|refseq:NP_079554.1|ensembl:ENSMUSG00000036402(gene)|ensembl:ENSMUST00000043148(transcript)|ensembl:ENSMUST00000114222(transcript)|ensembl:ENSMUST00000114224(transcript)|ensembl:ENSMUST00000114225(transcript)|ensembl:ENSMUST00000114226(transcript)|ensembl:ENSMUST00000114227(transcript)|ensembl:ENSMUST00000114228(transcript)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042301"(phosphate ion binding)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-381676|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272|refseq:XP_006505605.1 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-34|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:29C/KggTANGedW9+lPzudGdahYk10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:EbfIiGFC0LBJLHk7lBey/RqM92U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P15532 uniprotkb:Q9UBX2 intact:EBI-494506|ensembl:ENSMUSP00000117022 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ndka_mouse(display_long)|uniprotkb:Tumor metastatic process-associated protein(gene name synonym)|uniprotkb:Metastasis inhibition factor NM23(gene name synonym)|uniprotkb:NDPK-A(gene name synonym)|uniprotkb:nm23-M1(gene name synonym)|uniprotkb:Nme1(gene name)|psi-mi:Nme1(display_short)|uniprotkb:Nm23(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600701|imex:IM-25050-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032730.1|dip:DIP-34130N|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|ensembl:ENSMUSG00000037601(gene)|ensembl:ENSMUST00000135884(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007595"(lactation)|mint:P15532|reactome:R-MMU-499943|interpro:IPR036850 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-35|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:W7YjLO1L9xpbyRWWFhmcqCT3y3E10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:MBPfq4teWrwpTyt8waNz4ByYmGc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9CQL7 uniprotkb:Q9UBX2 intact:EBI-11600709|uniprotkb:Q9CX68|ensembl:ENSMUSP00000067135 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:mofa1_mouse(display_long)|uniprotkb:Mrfap1(gene name)|psi-mi:Mrfap1(display_short)|uniprotkb:Pam14(gene name synonym)|uniprotkb:Protein associated with MRG of 14 kDa(gene name synonym)|uniprotkb:MNCb-1039(orf name) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600705|imex:IM-25050-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080518.1|ensembl:ENSMUSG00000055302(gene)|ensembl:ENSMUST00000068795(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR029254 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-36|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:H4b9qJq5zvWcLz72HteX1nvAqJ010090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:KRzVfZlLkEd/fQ3Y54GIjOCmTe4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9R1Q7 uniprotkb:Q9UBX2 intact:EBI-644894|uniprotkb:Q3U4I3|ensembl:ENSMUSP00000033486|ensembl:ENSMUSP00000132645 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:plp2_mouse(display_long)|uniprotkb:Plp2(gene name)|psi-mi:Plp2(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600724|imex:IM-25050-163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062729.1|ensembl:ENSMUST00000071118(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|ensembl:ENSMUSG00000031146(gene)|ensembl:ENSMUSG00000057762(gene)|ensembl:ENSMUST00000033486(transcript) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-37|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:qeo2iHgGYi7vTpfHycbLsnW6jks10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:gHFEku0eHUAOUcw0U43eyeQct/M false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0DN89 uniprotkb:Q9UBX2 intact:EBI-11600732|uniprotkb:F6V0T5|uniprotkb:Q9D890|uniprotkb:Q9DCV5|ensembl:ENSMUSP00000139270 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:t254a_mouse(display_long)|uniprotkb:Tmem254a(gene name)|psi-mi:Tmem254a(display_short)|uniprotkb:D14Ertd449e(gene name synonym)|uniprotkb:Tmem254(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600728|imex:IM-25050-215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001257425.1|refseq:NP_001257428.1|refseq:NP_079587.1|refseq:NP_001257424.1|refseq:NP_001257427.1|refseq:NP_080955.1|ensembl:ENSMUSG00000072676(gene)|ensembl:ENSMUST00000185006(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR028110 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-38|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/07/13 rogid:ipf+uRXqYVuflgGWbpN9Nc6upXI10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:OG9ZfeQmWJ3un4vId7LHxNqiKVM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99KX1 uniprotkb:Q9UBX2 intact:EBI-646781|ensembl:ENSMUSP00000032214|ensembl:ENSMUSP00000135920 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:mlf2_mouse(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:Mlf2(gene name)|psi-mi:Mlf2(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600740|imex:IM-25050-127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001163812.1|refseq:NP_663360.1|ensembl:ENSMUSG00000030120(gene)|ensembl:ENSMUST00000032214(transcript)|ensembl:ENSMUST00000180095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR019376|mint:Q99KX1 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-39|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:/TTRBTfO7JkzWbvIALSR+GeA5aU10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:HYbXRRTmRHWOVs73o9fWN2JarPE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99LS1 uniprotkb:Q9UBX2 intact:EBI-11600752|ensembl:ENSMUSP00000099830 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:mmad_mouse(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial(gene name synonym)|uniprotkb:Mmadhc(gene name)|psi-mi:Mmadhc(display_short)|uniprotkb:CblD(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600744|imex:IM-25050-165 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_598600.1|refseq:XP_006497661.1|ensembl:ENSMUSG00000026766(gene)|ensembl:ENSMUST00000102769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5A4R|reactome:R-MMU-196741 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-41|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:Lusq0MN+gikEe2ej72XRmfrMzqU10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:+8STYeg8CzmqNzbYmth8HI9vhPs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:D3YY23 uniprotkb:Q9UBX2 intact:EBI-11600769|ensembl:ENSMUSP00000158932 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:lonf1_mouse(display_long)|uniprotkb:Lonrf1(gene name)|psi-mi:Lonrf1(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600765|imex:IM-25050-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000039633(gene)|ensembl:ENSMUST00000239119(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015947(PUA-like)|interpro:IPR017907|interpro:IPR019734|interpro:IPR027370|reactome:R-MMU-983168 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-42|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/07/13 rogid:KNH4mAj4JpjQIqAo/CKPW1xqE7c10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:CnDIlymBfsLKzD34WfdKcTGB9oM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9JK48 uniprotkb:Q9UBX2 intact:EBI-527471|uniprotkb:Q6A059|uniprotkb:Q8CDS9|uniprotkb:Q8VI52|uniprotkb:Q9CT31|uniprotkb:Q3TYR7|ensembl:ENSMUSP00000129800 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:shlb1_mouse(display_long)|uniprotkb:Kiaa0491(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein B1(gene name synonym)|uniprotkb:Sh3glb1(gene name)|psi-mi:Sh3glb1(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600800|imex:IM-25050-159 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062337.1|ensembl:ENSMUSG00000037062(gene)|ensembl:ENSMUST00000163279(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042171"(lysophosphatidic acid acyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0090148"(membrane fission)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1903778"(protein localization to vacuolar membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028503|interpro:IPR035695|interpro:IPR036028|mint:Q9JK48|rcsb pdb:1X43|refseq:NP_001268966.1|refseq:NP_001268971.1 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-43|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:NTyirT004c0cotBvIxsLVQz9a+A10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:j1utny4XL9QpEBtQuQvCFJGy5EU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Z1E3 uniprotkb:Q9UBX2 intact:EBI-644427|uniprotkb:Q80ZX5|ensembl:ENSMUSP00000021413|uniprotkb:Q3U9W9|uniprotkb:Q3UB40 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ikba_mouse(display_long)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Nfkbia(gene name)|psi-mi:Nfkbia(display_short)|uniprotkb:Ikba(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600805|imex:IM-25050-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035037.2|ensembl:ENSMUSG00000021025(gene)|ensembl:ENSMUST00000021413(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q9Z1E3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-933542|dip:DIP-36160N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-44|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:9uG+85E5n7tKNUUDcVTK2fH2UOM10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:PyHNUE1sd4DHtj7dYao0Fv+dGgs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q08274 uniprotkb:Q9UBX2 intact:EBI-11600857|uniprotkb:E9QLY4|ensembl:ENSMUSP00000032570 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:dmwd_mouse(display_long)|uniprotkb:Dmwd(gene name)|psi-mi:Dmwd(display_short)|uniprotkb:Dm9(gene name synonym)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600810|imex:IM-25050-191 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034188.2|ensembl:ENSMUSG00000030410(gene)|ensembl:ENSMUST00000032570(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Table 3-45|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/02/17 2016/02/19 rogid:oDYTNV8PMHv0aJ6VQk2KjLFYzJU10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:3gwUBa4R1MX5EggB9wnGFKwgqQg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P31001 uniprotkb:Q9UBX2 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11600969|imex:IM-25050-167 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2016/02/17 2016/02/19 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid://4Dx2eqJe72X9gmpV76pOsMaIM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31001 uniprotkb:O43812 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-11599346 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601035|imex:IM-25050-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:2i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2016/02/17 2016/02/19 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rigid:Cw1r65/XUrKGc9OWCxRts05q2nE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UBX2 uniprotkb:Q07021 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601061|imex:IM-25050-129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837 - - - figure legend:3A, Supp 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/02/17 2016/03/16 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606 rigid:0Emn9wUKfEEnCjCA8DOnq/5x65Q false sufficient binding region:1-160(IPR001356)|v5 tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UBX2 uniprotkb:P98179 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2949699|ensembl:ENSP00000365946|ensembl:ENSP00000365950 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rbm3_human(display_long)|uniprotkb:RBM3(gene name)|psi-mi:RBM3(display_short)|uniprotkb:RNPL(gene name synonym)|uniprotkb:RNA-binding motif protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601088|imex:IM-25050-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0030425"(dendrite)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:P98179|go:"GO:0006417"(regulation of translation)|ensembl:ENSG00000102317(gene)|ensembl:ENST00000376755(transcript)|ensembl:ENST00000376759(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_006734.1 - - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/02/17 2016/02/19 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:+KPnDlgXy+KGVDjTilKMXb5dJGs9606 rigid:5Tp6bOR/BBiIwMbLS+lfPAGMMC8 false v5 tag:c-c myc tag:c-c|flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBX2 uniprotkb:Q13242 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2949710|ensembl:ENSP00000229390|uniprotkb:Q52LD1 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:srsf9_human(display_long)|uniprotkb:SRSF9(gene name)|psi-mi:SRSF9(display_short)|uniprotkb:SFRS9(gene name synonym)|uniprotkb:SRP30C(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30C(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601112|imex:IM-25050-217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0006397"(mRNA processing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0006376"(mRNA splice site selection)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q13242|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|ensembl:ENSG00000111786(gene)|ensembl:ENST00000229390(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_003760.1|dip:DIP-40741N - - - figure legend:3Bi|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/02/17 2016/02/19 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:9x6TWFk1zN1YodjXBiwi/MtNJe49606 rigid:Gq/pELWrxUMaNXPaAwWrKCxg+rw false v5 tag:c-c myc tag:c-c|flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NZU5 uniprotkb:Q9UBX2 intact:EBI-5774016|uniprotkb:B4DG80|ensembl:ENSP00000157600 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:lmcd1_human(display_long)|uniprotkb:LMCD1(gene name)|psi-mi:LMCD1(display_short)|uniprotkb:Dyxin(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601124|imex:IM-25050-115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055398.1|refseq:NP_001265162.1|refseq:NP_001265163.1|refseq:NP_001265164.1|ensembl:ENSG00000071282(gene)|ensembl:ENST00000157600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010611"(regulation of cardiac muscle hypertrophy)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033724|mint:Q9NZU5|reactome:R-HSA-5683826 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/02/17 2016/02/19 rogid:m4j8sHWGlkjQimelP5ffZ31Lyeo9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:z4G/h27xc/W6hAEtSxPpaFFXb38 false myc tag:c-c|flag tag:c-c v5 tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBX2 uniprotkb:P35637 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601154|imex:IM-25050-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N - - - figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/22 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rigid:7enoaD4xnlGpqThnUwvRZHyD3nA false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q6RFH8 uniprotkb:P35637 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601296|imex:IM-25050-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N - - - figure legend:5i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/22 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rigid:bdYo07xIJ0tZqSVPjWiX/mvhKjE false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9UBX2 uniprotkb:P23246 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601300|imex:IM-25050-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N - - - figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/22 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606 rigid:Rct0dGlhVB6i3uXI6SXoGnbr98c false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q6RFH8 uniprotkb:P23246 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601304|imex:IM-25050-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N - - - figure legend:4i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/22 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606 rigid:xhPLeene7MR2zHhE3KpeyqtTBQw false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P17661 uniprotkb:Q6RFH8 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599882|intact:EBI-28972081 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601318|imex:IM-25050-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:7 B/C, Supp 6/9|comment:DUX4c and Desmin partially co-localized in elongating myotube tips.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-myoblast)|taxid:9606(Homo sapiens) - 2016/02/17 2016/02/22 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:nqJYT1jGgACFMpMA5D9k9AOW1jA false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P17661 uniprotkb:Q6RFH8 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599882|intact:EBI-28972081 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11601331|imex:IM-25050-169 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) go:"GO:0016528"(sarcoplasm) - - figure legend:8|comment:In the DMD and FSHD sections but not healthy sections , intense DUX4c staining that always partially co-localized with intense desmin labeling was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-skeletal-muscle)|taxid:9606(Homo sapiens skeletal muscle.) - 2016/02/17 2016/02/22 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:nqJYT1jGgACFMpMA5D9k9AOW1jA false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9UBX2 uniprotkb:P17661 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601579|imex:IM-25050-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:Supp 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/02/23 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rigid:mPIXVldS3p+Jm2KchXL/qDHqB10 false 35s radiolabel:?-?|necessary binding region:172-424 glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O43812 uniprotkb:P17661 intact:EBI-11599346 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:dux1_human(display_long)|uniprotkb:DUX1(gene name)|psi-mi:DUX1(display_short) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601670|imex:IM-25050-171 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036278.1|interpro:IPR017970|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:Supp 2Bi|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/02/23 rogid:vqQn91Rh2lS9tLCgNZ7tADWiGCQ9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rigid:8oJQmVr/k28slV3HjYEIRgSvWOQ false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O94829 uniprotkb:Q9UBX2 intact:EBI-747310|uniprotkb:Q7LC04|uniprotkb:Q96HS3|uniprotkb:Q9H8N3|uniprotkb:Q9UFR1|uniprotkb:Q5T4X3|uniprotkb:D3DPY4|ensembl:ENSP00000361418 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ipo13_human(display_long)|uniprotkb:Ran-binding protein 13(gene name synonym)|uniprotkb:Karyopherin-13(gene name synonym)|uniprotkb:IPO13(gene name)|psi-mi:IPO13(display_short)|uniprotkb:KIAA0724(gene name synonym)|uniprotkb:RANBP13(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601680|imex:IM-25050-131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055467.3|ensembl:ENSG00000117408(gene)|ensembl:ENST00000372343(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040520|interpro:IPR040709|interpro:IPR040944|rcsb pdb:2X19|rcsb pdb:2XWU|rcsb pdb:3ZJY ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Supp 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/02/23 rogid:HC5CjdyfnwoVeE9JNHgicwFybWc9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:PqutKKTShO320nt21g48xKpgZrE false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O94829 uniprotkb:Q6RFH8 intact:EBI-747310|uniprotkb:Q7LC04|uniprotkb:Q96HS3|uniprotkb:Q9H8N3|uniprotkb:Q9UFR1|uniprotkb:Q5T4X3|uniprotkb:D3DPY4|ensembl:ENSP00000361418 intact:EBI-11599882|intact:EBI-28972081 psi-mi:ipo13_human(display_long)|uniprotkb:Ran-binding protein 13(gene name synonym)|uniprotkb:Karyopherin-13(gene name synonym)|uniprotkb:IPO13(gene name)|psi-mi:IPO13(display_short)|uniprotkb:KIAA0724(gene name synonym)|uniprotkb:RANBP13(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601691|imex:IM-25050-173 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055467.3|ensembl:ENSG00000117408(gene)|ensembl:ENST00000372343(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040520|interpro:IPR040709|interpro:IPR040944|rcsb pdb:2X19|rcsb pdb:2XWU|rcsb pdb:3ZJY interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Supp 3Ai|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/02/23 rogid:HC5CjdyfnwoVeE9JNHgicwFybWc9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:G4i+FcsK5WOF7qv6pA6YEVIZco0 false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O94829 uniprotkb:Q9UBX2 intact:EBI-747310|uniprotkb:Q7LC04|uniprotkb:Q96HS3|uniprotkb:Q9H8N3|uniprotkb:Q9UFR1|uniprotkb:Q5T4X3|uniprotkb:D3DPY4|ensembl:ENSP00000361418 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:ipo13_human(display_long)|uniprotkb:Ran-binding protein 13(gene name synonym)|uniprotkb:Karyopherin-13(gene name synonym)|uniprotkb:IPO13(gene name)|psi-mi:IPO13(display_short)|uniprotkb:KIAA0724(gene name synonym)|uniprotkb:RANBP13(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601714|imex:IM-25050-133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055467.3|ensembl:ENSG00000117408(gene)|ensembl:ENST00000372343(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040520|interpro:IPR040709|interpro:IPR040944|rcsb pdb:2X19|rcsb pdb:2XWU|rcsb pdb:3ZJY ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0034399"(nuclear periphery) - - figure legend:Supp 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-myoblast)|taxid:9606(Homo sapiens) - 2016/02/17 2016/02/23 rogid:HC5CjdyfnwoVeE9JNHgicwFybWc9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:PqutKKTShO320nt21g48xKpgZrE false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P17661 uniprotkb:Q9UBX2 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601765|imex:IM-25050-175 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0034399"(nuclear periphery) - - figure legend:Supp 12 J|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-myoblast)|taxid:9606(Homo sapiens) - 2016/02/17 2016/02/23 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:mPIXVldS3p+Jm2KchXL/qDHqB10 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P23246 uniprotkb:Q9UBX2 intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601732|imex:IM-25050-193 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Supp 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:Rct0dGlhVB6i3uXI6SXoGnbr98c false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P23246 uniprotkb:Q6RFH8 intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748 intact:EBI-11599882|intact:EBI-28972081 psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601736|imex:IM-25050-117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Supp 4i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:xhPLeene7MR2zHhE3KpeyqtTBQw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P35637 uniprotkb:Q6RFH8 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 intact:EBI-11599882|intact:EBI-28972081 psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601740|imex:IM-25050-195 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Supp 4ii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:bdYo07xIJ0tZqSVPjWiX/mvhKjE false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P35637 uniprotkb:Q9UBX2 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601744|imex:IM-25050-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Supp 4iii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:7enoaD4xnlGpqThnUwvRZHyD3nA false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P17661 uniprotkb:Q9UBX2 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601757|imex:IM-25050-197 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Supp 12 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:mPIXVldS3p+Jm2KchXL/qDHqB10 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P17661 uniprotkb:Q6RFH8 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-11599882|intact:EBI-28972081 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-11601761|imex:IM-25050-199 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Supp 12 C--F/H/I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lhcn-m2)|taxid:9606(human-LHCN-M2 - immortalized skeletal myoblasts) - 2016/02/17 2016/02/23 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rigid:nqJYT1jGgACFMpMA5D9k9AOW1jA false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9UBX2 uniprotkb:Q5VXV3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-8456402|intact:UNK-5457610 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5vxv3_human(display_long)|uniprotkb:SET(gene name)|psi-mi:SET(display_short)|uniprotkb:hCG_40357(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001116293.1|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|go:"GO:0005654"(nucleoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0006334"(nucleosome assembly) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:CBwf28rN/LSY/vhw7jxRHKP8q0k9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q8N274 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-7950876|intact:MINT-4990473|uniprotkb:B5MEH8 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q8n274_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - comment:mint|comment:homomint figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:m6QIe1UtPMpuzUk/Rk4IWVz6iqw9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6IPH7 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-7813901|intact:MINT-4999879 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6iph7_human(display_long)|uniprotkb:RPL14(gene name)|psi-mi:RPL14(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR039660|interpro:IPR041985|mint:Q6IPH7 - - comment:mint figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5CcL53ast8OqaEim7RismPJTO0Y9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5VVD0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-8456326|intact:MINT-5001629 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5vvd0_human(display_long)|uniprotkb:RPL11(gene name)|psi-mi:RPL11(display_short)|uniprotkb:hCG_1739238(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000966.2|interpro:IPR020929|interpro:IPR022803|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR031309|interpro:IPR031310|go:"GO:0034504"(protein localization to nucleus)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5JR94 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-8456376|intact:MINT-4999522 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5jr94_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:hCG_2031852(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR018283|refseq:NP_001003.1|interpro:IPR022309|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR042563|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5CAQ5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-7198101|intact:MINT-3319501 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5caq5_human(display_long)|uniprotkb:TRA1(gene name)|psi-mi:TRA1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0042470"(melanosome)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR020568|interpro:IPR020575|interpro:IPR019805|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|mint:Q5CAQ5|interpro:IPR036890|interpro:IPR037196 - - comment:mint|comment:homomint figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6V80bKkPad7rBXjQoEWHpn8JdVw9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15717 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8MUS3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602828|ensembl:ENSP00000378396 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8mus3_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:hCG_1988529(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000198242(gene)|ensembl:ENST00000394938(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:g9rIBsOgrTudHSSpq68m6QEWWzE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53SB5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-3447339|uniprotkb:A0A024R450 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53sb5_human(display_long)|uniprotkb:tmp_locus_29(gene name)|psi-mi:tmp_locus_29(display_short)|uniprotkb:DES(gene name synonym)|uniprotkb:hCG_14764(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR039008|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|refseq:NP_001918.3|go:"GO:0005634"(nucleus)|go:"GO:0005882"(intermediate filament)|go:"GO:0005916"(fascia adherens)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0045111"(intermediate filament cytoskeleton) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:C9JPM4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601857|ensembl:ENSP00000420254 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:c9jpm4_human(display_long)|uniprotkb:ARF4(gene name)|psi-mi:ARF4(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000168374(gene)|ensembl:ENST00000463880(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GSHobxTQAHQa+KRhBlliz5l84Oo9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q13813 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96HY3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-4324545|ensembl:ENSP00000375785|ensembl:ENSP00000403491|ensembl:ENSP00000411440|ensembl:ENSP00000442853|ensembl:ENSP00000450829|ensembl:ENSP00000468877|ensembl:ENSP00000470502|ensembl:ENSP00000471225|ensembl:ENSP00000499266|ensembl:ENSP00000499357|ensembl:ENSP00000499421|ensembl:ENSP00000499498|ensembl:ENSP00000499656|ensembl:ENSP00000499706|intact:EBI-10269308|uniprotkb:E7ETZ0|uniprotkb:H0Y7A7|uniprotkb:D6W5B3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q96hy3_human(display_long)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CALM1(gene name synonym)|uniprotkb:CALM3(gene name synonym)|uniprotkb:hCG_17033(orf name)|uniprotkb:hCG_20313(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENST00000553542(transcript)|ensembl:ENST00000594523(transcript)|ensembl:ENST00000598871(transcript)|ensembl:ENST00000599839(transcript)|ensembl:ENST00000655450(transcript)|ensembl:ENST00000655728(transcript)|ensembl:ENST00000656538(transcript)|ensembl:ENST00000659177(transcript)|ensembl:ENST00000663135(transcript)|ensembl:ENST00000668667(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016301"(kinase activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|ensembl:ENST00000544280(transcript)|ensembl:ENSG00000143933(gene)|ensembl:ENSG00000160014(gene)|ensembl:ENSG00000198668(gene)|ensembl:ENST00000391918(transcript)|ensembl:ENST00000447653(transcript)|ensembl:ENST00000456319(transcript)|refseq:NP_001292554.1|refseq:NP_001292555.1|refseq:NP_001316850.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hwShIPl/5iB6b9k+xVz/CalWBfo9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B5BU28 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601847 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b5bu28_human(display_long)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR013284(Beta-catenin)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0045296"(cadherin binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:iLpMe7K1/L8UwOk/s5CgX5i/MdI9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P06753 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355607|uniprotkb:P12324|uniprotkb:Q969Q2|uniprotkb:Q9NQH8|uniprotkb:Q5VU71|uniprotkb:Q2QD06|uniprotkb:D3DV71|ensembl:ENSP00000498577|intact:EBI-11063811|uniprotkb:Q5VU66|uniprotkb:Q5VU72|intact:EBI-4289841|uniprotkb:Q5VU58|uniprotkb:Q5VU63|uniprotkb:Q8TCG3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tpm3_human(display_long)|uniprotkb:TPM3(gene name)|psi-mi:TPM3(display_short)|uniprotkb:Tropomyosin-3(gene name synonym)|uniprotkb:Gamma-tropomyosin(gene name synonym)|uniprotkb:Tropomyosin-5(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001265120.1|refseq:NP_001036816.1|refseq:NP_001036817.1|refseq:NP_689476.2|refseq:NP_705935.1|ensembl:ENSG00000143549(gene)|ensembl:ENST00000651641(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000533(Tropomyosin)|mint:P06753|rcsb pdb:6OTN|reactome:R-HSA-390522|reactome:R-HSA-445355|reactome:R-HSA-9013424|refseq:NP_001036818.1|refseq:NP_001265118.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:vHELhEyfZxpK8zHMEveODiYBZmM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35579 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P06396 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351506|uniprotkb:Q8WVV7|ensembl:ENSP00000362924|uniprotkb:Q5T0I2|uniprotkb:A8MUD1|uniprotkb:B7Z373|uniprotkb:A2A418|uniprotkb:A8MYN7|uniprotkb:B7Z5V1|uniprotkb:F5H1A8 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:gels_human(display_long)|uniprotkb:GSN(gene name)|psi-mi:GSN(display_short)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:AGEL(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000168.1|refseq:NP_001121134.1|refseq:NP_001121136.1|refseq:NP_001121137.1|refseq:NP_001121138.1|refseq:NP_001121139.1|refseq:NP_937895.1|refseq:XP_011516888.1|refseq:XP_011516889.1|refseq:XP_011516890.1|refseq:XP_011516891.1|refseq:XP_011516892.1|refseq:XP_011516893.1|refseq:XP_011516894.1|refseq:XP_011516895.1|ensembl:ENSG00000148180(gene)|ensembl:ENST00000373818(transcript)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P06396|rcsb pdb:1C0F|rcsb pdb:1C0G|rcsb pdb:1D4X|rcsb pdb:1DEJ|rcsb pdb:1EQY|rcsb pdb:1ESV|rcsb pdb:1H1V|rcsb pdb:1KCQ|rcsb pdb:1MDU|rcsb pdb:1NLV|rcsb pdb:1NM1|rcsb pdb:1NMD|rcsb pdb:1P8X|rcsb pdb:1SOL|rcsb pdb:1T44|rcsb pdb:1YAG|rcsb pdb:1YVN|rcsb pdb:2FF3|rcsb pdb:2FF6|rcsb pdb:2FH1|rcsb pdb:2FH2|rcsb pdb:2FH3|rcsb pdb:2FH4|rcsb pdb:3A5L|rcsb pdb:3A5M|rcsb pdb:3A5N|rcsb pdb:3A5O|rcsb pdb:3CI5|rcsb pdb:3CIP|rcsb pdb:3CJB|rcsb pdb:3CJC|rcsb pdb:3FFK|rcsb pdb:3FFN|rcsb pdb:3TU5|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4S10|rcsb pdb:4Z94|rcsb pdb:5DD2|rcsb pdb:5FAE|rcsb pdb:5FAF|rcsb pdb:5H3M|rcsb pdb:5H3N|rcsb pdb:5O2Z|rcsb pdb:5UBO|rcsb pdb:5ZZ0|rcsb pdb:6H1F|rcsb pdb:6JCO|rcsb pdb:6JEG|rcsb pdb:6JEH|rcsb pdb:6LJE|rcsb pdb:6LJF|rcsb pdb:6Q9R|rcsb pdb:6Q9Z|rcsb pdb:6QBF|rcsb pdb:1P8Z|rcsb pdb:6QW3|reactome:R-HSA-264870|reactome:R-HSA-6798695|reactome:R-HSA-9662361|reactome:R-HSA-977225|refseq:NP_001244958.1|refseq:NP_001244959.1|refseq:NP_001121135.2|refseq:XP_005252000.1|refseq:XP_005252001.1|refseq:XP_005252002.1|refseq:XP_006717142.1|refseq:XP_016870135.1|refseq:XP_016870136.1|refseq:XP_016870137.1|dip:DIP-2196N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:uACf9A+H6LAOAZSMGYqeDwUL1Mc9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6FI97 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-717951 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6fi97_human(display_long)|uniprotkb:BAF53A(gene name)|psi-mi:BAF53A(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:P0GKTPF0quusq7FYmJ5XZsdSWLQ9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:F8WCF6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601836|ensembl:ENSP00000412284 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:f8wcf6_human(display_long)|uniprotkb:ARPC4-TTLL3(gene name)|psi-mi:ARPC4-TTLL3(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000250151(gene)|ensembl:ENST00000424442(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042995"(cell projection)|interpro:IPR008384(ARP23 complex 20 kDa subunit)|interpro:IPR034666 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:EFLu488D0vIYoHrfn0sf71cBL/U9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DM97 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601827 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4dm97_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR043129|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR004001(Actin, conserved site) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:weZO5PaAuRP6GEKwVSXzKnIkb8c9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P12814 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:guTURyt26f1ort4NAlYyabNc+WE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P02545 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q8WVV4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2877727|ensembl:ENSP00000262753|uniprotkb:Q9H738|uniprotkb:Q9H744|uniprotkb:Q5H9F0|uniprotkb:Q8NG12|uniprotkb:Q5H9E9|uniprotkb:Q9H5Y2|uniprotkb:A8K2U5 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pof1b_human(display_long)|uniprotkb:POF1B(gene name)|psi-mi:POF1B(display_short)|uniprotkb:Premature ovarian failure protein 1B(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENST00000262753(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030057"(desmosome)|go:"GO:0051015"(actin filament binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR026186|mint:Q8WVV4|rcsb pdb:3BH9|ensembl:ENSG00000124429(gene)|refseq:NP_001294869.1|refseq:NP_079197.3|ensembl:ENSP00000262753|ensembl:ENST00000373145|ensembl:ENSP00000362238 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:rigOH+ulgEPejDWfjfmcn2M2B2M9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:D6W5C0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601803 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:d6w5c0_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:hCG_17370(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR018159|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR002017(Spectrin repeat)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0008091"(spectrin)|go:"GO:0051693"(actin filament capping)|interpro:IPR041681|interpro:IPR036872 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ca4mhGJwuUVZ2bYl95Y7zRlkoUY9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9BTI9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601787 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q9bti9_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007569"(cell aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR036824|interpro:IPR032569 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:bOUM5JTDPsTm2mSePz+IOpZN72g9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P09496 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96IF9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602945 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q96if9_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR029067|interpro:IPR027417|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR041569 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:4pNLxXA9Qfke5rU1XeKLdtrjvSM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P60900 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5JXB2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-6190823|uniprotkb:E9KL27 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ue2nl_human(display_long)|uniprotkb:Epididymis tissue protein Li 174(gene name synonym)|uniprotkb:UBE2NL(gene name)|psi-mi:UBE2NL(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0005634"(nucleus)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0000209"(protein polyubiquitination)|refseq:NP_001013007.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:sh3UsocorMe1c+Y1g5ZEhvrblEk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5TZN3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-10247554 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5tzn3_human(display_long)|uniprotkb:UBE2C(gene name)|psi-mi:UBE2C(display_short)|uniprotkb:hCG_38372(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|refseq:NP_008950.1|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0005886"(plasma membrane) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:sJ/R8NL1aVdljasuqKJbVg8gyTM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q05DH1 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602213 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q05dh1_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR029055|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR035190|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:UO/V/xaU1/MmpunFWN09gA0L8YI9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q06323 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-712149|uniprotkb:H0YNE3|ensembl:ENSP00000206451|ensembl:ENSP00000495095|uniprotkb:Q9UEF4|uniprotkb:Q6IBM2|uniprotkb:A6NJG9 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:psme1_human(display_long)|uniprotkb:Proteasome activator 28 subunit alpha(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 1(gene name synonym)|uniprotkb:11S regulator complex subunit alpha(gene name synonym)|uniprotkb:Interferon gamma up-regulated I-5111 protein(gene name synonym)|uniprotkb:PSME1(gene name)|psi-mi:PSME1(display_short)|uniprotkb:IFI5111(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 reactome:R-HSA-5678895|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-5687128|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|ensembl:ENSG00000092010(gene)|ensembl:ENSG00000284916(gene)|ensembl:ENST00000206451(transcript)|ensembl:ENST00000645537(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0019884"(antigen processing and presentation of exogenous antigen)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:Q06323|rcsb pdb:1AVO|rcsb pdb:7DR6|rcsb pdb:7DRW|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|refseq:NP_006254.1|refseq:NP_001268457.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:kyTjI3VP2S7Bvwq4R0pJudnlOC09606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4E266 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602912 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4e266_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|refseq:NP_001304893.1|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006429"(leucyl-tRNA aminoacylation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Ed/LabsT9I+GeaCPtnPcn46ycI49606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6ZTI3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602901 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6zti3_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR018149|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006430"(lysyl-tRNA aminoacylation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:sJvxvGzca7egI00YFFkPn9iZ6hg9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DQY1 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602891 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4dqy1_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000357(HEAT)|interpro:IPR021133|interpro:IPR031090|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0065003"(protein-containing complex assembly) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hjh6E7h+ep+tIEOzaLRK6uiTYhU9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P49458 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350743|uniprotkb:Q6NVX0|uniprotkb:Q8WTW0|ensembl:ENSP00000305230|uniprotkb:A8K0N0 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:srp09_human(display_long)|uniprotkb:SRP9(gene name)|psi-mi:SRP9(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:4UYJ|refseq:NP_001123912.1|refseq:NP_003124.1|ensembl:ENSG00000143742(gene)|ensembl:ENST00000304786(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0045900"(negative regulation of translational elongation)|interpro:IPR008832(Signal recognition particle, SRP9 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|interpro:IPR039432|interpro:IPR039914|mint:P49458|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-6151N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Y33fEeeXnma9oF7Fzs6zEGQjVBU9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96PV4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-10171633|uniprotkb:Q8NET3|uniprotkb:B4DI72|uniprotkb:Q495L5|uniprotkb:B7Z9Y9|ensembl:ENSP00000354834|ensembl:ENSP00000388850|ensembl:ENSP00000392342|ensembl:ENSP00000445775 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pnma5_human(display_long)|uniprotkb:KIAA1934(gene name synonym)|uniprotkb:Tumor antigen BJ-HCC-25(gene name synonym)|uniprotkb:PNMA5(gene name)|psi-mi:PNMA5(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:XP_016884741.1|refseq:XP_016884742.1|refseq:NP_001096620.1|refseq:NP_001096621.1|refseq:NP_001171853.1|refseq:NP_443158.1|ensembl:ENSG00000198883(gene)|ensembl:ENST00000361887(transcript)|ensembl:ENST00000439251(transcript)|ensembl:ENST00000452693(transcript)|ensembl:ENST00000535214(transcript)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026527 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:73p4UAMgAXdI8yIh/amIfpvOBIo9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B5MCE7 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602867|ensembl:ENSP00000384617 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b5mce7_human(display_long)|uniprotkb:BZW2(gene name)|psi-mi:BZW2(display_short)|uniprotkb:hCG_19293(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000136261(gene)|ensembl:ENST00000407633(transcript)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:IHQTW29oUSOlgsHu0gxsZ7B3/cc9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96RS2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2696165 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q96rs2_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR001865(Ribosomal protein S2)|interpro:IPR018130|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR023591|interpro:IPR032281|interpro:IPR027498|interpro:IPR027504|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043236"(laminin binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:MVL01+hZq1ml5ukIglcHL9SW20k9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q7Z4W8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602853 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q7z4w8_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR002671(Ribosomal protein L22e)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|interpro:IPR038526|rcsb pdb:6XA1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:VGWG3vaTBJN99TyC5pdP8vMScl09606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q59FS3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602846 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q59fs3_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000554(Ribosomal protein S7e)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:UletFyrqGoJlwilC97dJxp8p3n49606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53G83 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9373522 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53g83_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR004044(K Homology, type 2)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR018280|interpro:IPR036419|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005819"(spindle)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0051301"(cell division)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity") - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:YFzsiKVAKnnIT1zndT6eD3btGhs9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53G25 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9515703 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53g25_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hSTgWTI3z7w+hKE2SzQu2U5J5bE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9HBB3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602801 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q9hbb3_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR041997|go:"GO:0003677"(DNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:EVY0+ED/IWQAVWkdyeQmycTXWTM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q59GY2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602791 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q59gy2_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR025755|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR023574|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:u1Ed48vbTcz+Bk+5iqLPL7On61I9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96IR1 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602172 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q96ir1_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR032277|interpro:IPR005824(KOW)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR002942(RNA-binding S4)|interpro:IPR036986|interpro:IPR041982|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|interpro:IPR038237 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5hRZT/ShZ4d+15sD0A2HUxpkbi09606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B2R4D8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602763 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b2r4d8_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR005824(KOW)|interpro:IPR001141(Ribosomal protein L27e)|interpro:IPR018262|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR038655|interpro:IPR041991|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:9/wp/ihTMrNuM5jaqp6J6ihVh0k9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8MUD9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602746|ensembl:ENSP00000379729|ensembl:ENSP00000379730|ensembl:ENSP00000379731 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8mud9_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:XP_006716526.1|ensembl:ENSG00000147604(gene)|ensembl:ENST00000396465(transcript)|ensembl:ENST00000396466(transcript)|ensembl:ENST00000396467(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ZPGgv6gGXRetikv7sN95EYHryY89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62899 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:77LFR7/2somk6blVogZf1XFdJLk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:E7EQV9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602732|ensembl:ENSP00000405590 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:e7eqv9_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000174748(gene)|ensembl:ENST00000434031(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Dz0rovKu2Tp9y7hxxpZIUxiO6tk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:E5RI99 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602717|ensembl:ENSP00000429483 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:e5ri99_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000156482(gene)|ensembl:ENST00000521726(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/XtNkobILICE8La679+Vydnf6cs9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62424 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46781 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351206|uniprotkb:Q4QRK7|uniprotkb:Q9BVZ0|ensembl:ENSP00000302896|ensembl:ENSP00000375632|ensembl:ENSP00000375633|ensembl:ENSP00000478449|ensembl:ENSP00000479917|ensembl:ENSP00000480135|ensembl:ENSP00000480662|ensembl:ENSP00000481194|ensembl:ENSP00000481553|ensembl:ENSP00000481655|ensembl:ENSP00000481764|ensembl:ENSP00000481822|ensembl:ENSP00000482023|ensembl:ENSP00000482274|ensembl:ENSP00000482338|ensembl:ENSP00000482475|ensembl:ENSP00000483179|ensembl:ENSP00000484394|uniprotkb:A9C4C1 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs9_human(display_long)|uniprotkb:RPS9(gene name)|psi-mi:RPS9(display_short)|uniprotkb:Small ribosomal subunit protein uS4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001004.2|refseq:NP_001308630.1|refseq:NP_001308631.1|refseq:NP_001308633.1|ensembl:ENSG00000170889(gene)|ensembl:ENSG00000274005(gene)|ensembl:ENSG00000274626(gene)|ensembl:ENSG00000274646(gene)|ensembl:ENSG00000274950(gene)|ensembl:ENSG00000275323(gene)|ensembl:ENSG00000277079(gene)|ensembl:ENSG00000277359(gene)|ensembl:ENSG00000278081(gene)|ensembl:ENSG00000278270(gene)|ensembl:ENST00000302907(transcript)|ensembl:ENST00000391752(transcript)|ensembl:ENST00000391753(transcript)|ensembl:ENST00000610826(transcript)|ensembl:ENST00000610953(transcript)|ensembl:ENST00000611921(transcript)|ensembl:ENST00000614737(transcript)|ensembl:ENST00000615346(transcript)|ensembl:ENST00000616082(transcript)|ensembl:ENST00000616536(transcript)|ensembl:ENST00000616839(transcript)|ensembl:ENST00000616877(transcript)|ensembl:ENST00000616928(transcript)|ensembl:ENST00000617291(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000618751(transcript)|go:"GO:0005829"(cytosol)|ensembl:ENST00000619229(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|ensembl:ENST00000620720(transcript)|ensembl:ENST00000620940(transcript)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|mint:P46781|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|go:"GO:0005634"(nucleus)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|go:"GO:0005654"(nucleoplasm)|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9NY85 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602704 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q9ny85_human(display_long)|uniprotkb:rpl3(gene name)|psi-mi:rpl3(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000597(Ribosomal protein L3)|interpro:IPR019926|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dzTieaHUpG4ujYoSapoCB/Tk8FA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6NXR8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602692 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6nxr8_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR027500|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hNu+5bdyv2BNhWxTT2VldwPyum89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46087 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356811|uniprotkb:A1A4Z3|uniprotkb:Q0P5S5|uniprotkb:Q58F30|uniprotkb:B3KPD6|uniprotkb:Q05BA7|uniprotkb:Q3KQS4|ensembl:ENSP00000313272|ensembl:ENSP00000444437 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:nop2_human(display_long)|uniprotkb:NOP2(gene name)|psi-mi:NOP2(display_short)|uniprotkb:NSUN1(gene name synonym)|uniprotkb:Proliferating-cell nucleolar antigen p120(gene name synonym)|uniprotkb:Proliferation-associated nucleolar protein p120(gene name synonym)|uniprotkb:NOL1(gene name synonym)|uniprotkb:Nucleolar protein 2 homolog(gene name synonym)|uniprotkb:Nucleolar protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001028886.1|refseq:NP_006161.2|refseq:NP_001245237.1|refseq:NP_001245238.1|refseq:NP_001245239.1|refseq:XP_005253748.1|ensembl:ENSG00000111641(gene)|ensembl:ENST00000322166(transcript)|ensembl:ENST00000537442(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009383"("rRNA (cytosine-C5-)-methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR011023(Nop2p)|interpro:IPR012586(P120R)|interpro:IPR018314|interpro:IPR023267|interpro:IPR023273|interpro:IPR029063|interpro:IPR031341|mint:P46087|reactome:R-HSA-6790901|reactome:R-HSA-8869496 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:CvYaCDv8N8OvS0lPFy8jFEFaOTA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B3KXU8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602672 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b3kxu8_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR028816|interpro:IPR022070|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|interpro:IPR041637 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Tha04NVeD3zYrxgq6JRv41fz4pk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O75822 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-366647|uniprotkb:Q9BUD2|uniprotkb:Q9H8Q2|uniprotkb:Q9UI65|ensembl:ENSP00000261868|uniprotkb:B4DUI3|uniprotkb:F5H425 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:eif3j_human(display_long)|uniprotkb:EIF3J(gene name)|psi-mi:EIF3J(display_short)|uniprotkb:PRO0391(orf name)|uniprotkb:EIF3S1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 1(gene name synonym)|uniprotkb:eIF-3-alpha(gene name synonym)|uniprotkb:eIF3 p35(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001271264.1|refseq:NP_001271265.1|refseq:NP_003749.2|ensembl:ENSG00000104131(gene)|ensembl:ENST00000261868(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR013906(Translation initiation factor eIF3 subunit)|interpro:IPR023194|mint:O75822|rcsb pdb:2KRB|rcsb pdb:3BPJ|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31117N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dJ+uqlLn3RH30Rw3COnJ+/nkk+I9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q14152 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6IAM0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602654 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6iam0_human(display_long)|uniprotkb:EIF3G(gene name)|psi-mi:EIF3G(display_short)|uniprotkb:EIF3S4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034240|go:"GO:0005634"(nucleus)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR035979 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:cL87xunmVhG2XiqvzBMuph2qhVg9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5U0F4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602636 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5u0f4_human(display_long)|uniprotkb:EIF3S2(gene name)|psi-mi:EIF3S2(display_short)|uniprotkb:EIF3I(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:hCG_41608(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003748.1|interpro:IPR027525|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|interpro:IPR036322 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fogC6nSNmIynV2ziHZboT9laA3M9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q96G38 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602623 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q96g38_human(display_long)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034363|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR035979 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:aStPm8Z2Qeu4GTVZ4upFwgHhxGo9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P41091 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1054228|uniprotkb:B5BTZ4|intact:EBI-11602611|uniprotkb:A0A024RBY4|uniprotkb:A8K2Y2|uniprotkb:B2R5N2|uniprotkb:Q53HK3|ensembl:ENSP00000253039 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:if2g_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit gamma X(gene name synonym)|uniprotkb:EIF2S3(gene name)|psi-mi:EIF2S3(display_short)|uniprotkb:EIF2G(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001406.1|ensembl:ENSG00000130741(gene)|ensembl:ENST00000253039(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR044127|interpro:IPR044128|rcsb pdb:6FEC|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|interpro:IPR027417 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6uBTiGTvEKMfS0NqkKGIaSR61j89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8K7F6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602144 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8k7f6_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR044728|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:g4hCs7UYpTRtGPNEuclkti8BvYQ9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15366 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B3KT93 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602601 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b3kt93_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR003954(RNA recognition, region 1)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR035979|interpro:IPR036053 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:BH60d3WExev4H4+o9Ou6+v6Eg+E9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6IQ30 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602590 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6iq30_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR003954(RNA recognition, region 1)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR035979|interpro:IPR036053 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:FRpCXYxHivtQ3Ir9Aqtw7KfpsDk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q49AN9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602572|uniprotkb:C9J303|ensembl:ENSP00000391403|ensembl:ENSP00000402194|ensembl:ENSP00000441332 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q49an9_human(display_long)|uniprotkb:SNRPG(gene name)|psi-mi:SNRPG(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001304097.1|refseq:NP_001304098.1|ensembl:ENSG00000143977(gene)|ensembl:ENST00000438261(transcript)|ensembl:ENST00000449935(transcript)|ensembl:ENST00000482975(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034098|interpro:IPR044641 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2ZxG4YISM8v8xac45JEm/njU6sQ9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DUA4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602554|ensembl:ENSP00000450918|ensembl:ENSP00000452449|ensembl:ENSP00000474409 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4dua4_human(display_long)|uniprotkb:SRSF5(gene name)|psi-mi:SRSF5(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000100650(gene)|ensembl:ENST00000553369(transcript)|ensembl:ENST00000554021(transcript)|ensembl:ENST00000555547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hh4peS/NRH9N0IY5QNs8is5a4SE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8K651 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9512810 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8k651_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR036561|interpro:IPR003428(Mitochondrial glycoprotein)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Jd/FA2BQ4Eah0rGwo1KdxSEGJt89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DZZ1 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602532 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4dzz1_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR007015(DNA polymerase V)|go:"GO:0003677"(DNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3IcvPZec5NAPVM83MZCBoMHKr+c9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q8TBR3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601157 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q8tbr3_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:FD1rwOgJERs9Pg3bMnzgb/6TeEY9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q59EB5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602515 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q59eb5_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR019844|interpro:IPR011129(Cold shock protein)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0003676"(nucleic acid binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:qLqk1WX+EpB9tCc4tPanUi6LCYI9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q92769 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-301821|uniprotkb:Q5SRI8|uniprotkb:Q5SZ86|uniprotkb:Q8NEH4|uniprotkb:B4DL58|ensembl:ENSP00000430432|uniprotkb:E1P561|uniprotkb:B3KRS5 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hdac2_human(display_long)|uniprotkb:HDAC2(gene name)|psi-mi:HDAC2(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035094"(response to nicotine)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042220"(response to cocaine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q92769|rcsb pdb:3MAX|rcsb pdb:4LXZ|rcsb pdb:4LY1|rcsb pdb:5IWG|rcsb pdb:5IX0|rcsb pdb:6G3O|rcsb pdb:6WBW|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000196591(gene)|ensembl:ENST00000519065(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|rcsb pdb:6WHN|rcsb pdb:6WHO|rcsb pdb:6WHQ|rcsb pdb:6WHZ|rcsb pdb:6WI3|rcsb pdb:6XDM|rcsb pdb:6XEB|rcsb pdb:6XEC|rcsb pdb:7KBG|rcsb pdb:7KBH|rcsb pdb:7LTG|rcsb pdb:7LTK|rcsb pdb:7LTL|reactome:R-HSA-193670|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9615017|reactome:R-HSA-9619665|reactome:R-HSA-9679191|reactome:R-HSA-983231|rcsb pdb:6WBZ|refseq:NP_001518.3|dip:DIP-24220N|refseq:XP_011534090.1|refseq:XP_016866288.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:K4PpGz9E9/TrQZsgvrJuc+uYCn89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53FG3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602504 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53fg3_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001254738.1|refseq:NP_004506.2|interpro:IPR006561(DZF)|interpro:IPR043519 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/GMOmsiVeMB3YhlqwZvkhgzQCtc9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:F4ZW66 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602499 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:f4zw66_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR006561(DZF)|interpro:IPR043519|interpro:IPR033099|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051607"(defense response to virus) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:7qGsIGUhH3jEMfB//6dlGQ3qLK09606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6FHQ0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1057040 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6fhq0_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:hCG_20110(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002884.1|interpro:IPR020472|interpro:IPR022052|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0016581"(NuRD complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0048545"(response to steroid hormone)|interpro:IPR036322 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q59F66 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9393291 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q59f66_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|refseq:NP_001091974.1|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Fe+C/VPfIYgyCEz+CbaHgUCl9uA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B5BUE6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9512888 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b5bue6_human(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX5(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR012587(P68HR)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005524"(ATP binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:I9gCCvZFwMHh7il5MOI75Uzvf0c9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15233 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q86VG2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602343 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q86vg2_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_005057.1|interpro:IPR012975(NOPS)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0048511"(rhythmic process)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:EFcvyIz/XuEZLqBsuRHzjhp2D/s9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DQ50 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602487 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4dq50_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR023608|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR001102(Transglutaminase, N-terminal)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0046872"(metal ion binding)|interpro:IPR036985|interpro:IPR038765 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:jqDkltgZZdDQALX2hr78XbN+5789606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15084 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:411bo7TdfeCtMvUqyBb7bofi5To9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q7Z759 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602463 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q7z759_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:T-complex protein 1 subunit theta(gene name synonym)|uniprotkb:hCG_1810843(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001269837.1|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|interpro:IPR027410|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:aBKNyERuRMi13krz6sEqk7TZQos9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q59ET3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602432 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q59et3_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR027410|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5Xh7qYKy5RYhTYkCYUtUtAsEFQ89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P50991 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 intact:EBI-5912018 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 - psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5szy0_human(display_short)|psi-mi:EBI-5912018(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:RP11-443G18.6-002(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 uniprotkb:Q5SZY0(uniprot-removed-ac) - - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:a60d7ObJwJg/Hiq4liWr/LbpJJs9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53HV2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602444 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53hv2_human(display_long)|uniprotkb:CCT-eta(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR027410|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:FaHsvqPLiG2q17loJArr1VPe8Dk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DDU6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602418 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4ddu6_human(display_long)|uniprotkb:T-complex protein 1 subunit epsilon(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001293085.1|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|interpro:IPR027410|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR012718(T-complex protein 1, epsilon subunit) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:svqymDnDedhu1oBDMv2KQCVTOig9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P78371 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:F5H282 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602089|ensembl:ENSP00000439447 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:f5h282_human(display_long)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000120438(gene)|ensembl:ENST00000544255(transcript)|go:"GO:0005524"(ATP binding)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:n37xFYLptLg5ZWYPr2NaH4xA6MA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q06S70 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602407 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q06s70_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0006281"(DNA repair)|go:"GO:0008408"(3'-5' exonuclease activity)|interpro:IPR034926|interpro:IPR036397 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:q3LOdoDvNM0b79DiiZxbiz9w2hA9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B5MDF5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602390|ensembl:ENSP00000376174 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b5mdf5_human(display_long)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:hCG_1744585(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000132341(gene)|ensembl:ENST00000392367(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0015031"(protein transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:EUJF61ZDzP5EZBxpv45vt1aO9cE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A4D177 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602371 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a4d177_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:CCDC32(gene name synonym)|uniprotkb:hCG_1745364(orf name)|uniprotkb:hCG_1999239(orf name)|uniprotkb:tcag7.173(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR038033|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|interpro:IPR000953(Chromo domain)|interpro:IPR017984|interpro:IPR023780|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|go:"GO:0000791"(euchromatin)|go:"GO:0005634"(nucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9H2R7 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602364 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q9h2r7_human(display_long)|uniprotkb:NPD011(gene name)|psi-mi:NPD011(display_short)|uniprotkb:Nuclear migration protein nudC(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR037898|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR032572|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007049"(cell cycle)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:NliE6yuYO8dZ+7oeaNDqsBYqNPs9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9NZI8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B2R8Z8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602524 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b2r8z8_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003723"(RNA binding)|interpro:IPR041337|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:IIxBHo+ZFWUHbSQvOF4X3eYlmP49606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:D3DTW3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603101 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:d3dtw3_human(display_long)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:hCG_27512(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|go:"GO:0003723"(RNA binding)|interpro:IPR036612 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ACFeBLYcsBAke+9kzrAi/BLWbU89606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14735 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dwngN3kUOExC5qapSgF01YhBNAM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P12956 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5EFE6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-6677618 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5efe6_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:e5NP613mD+m+qr2AgZ6HRiBb78w9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B7ZLF8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603034 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b7zlf8_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR003302("Cornifin (SPRR)")|go:"GO:0005737"(cytoplasm)|go:"GO:0018149"(peptide cross-linking) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:SGlRzDt+9Si9oB/MCf4DFva5yVI9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:C9JQV0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603026|ensembl:ENSP00000420130 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:c9jqv0_human(display_long)|uniprotkb:C7orf50(gene name)|psi-mi:C7orf50(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR019327|ensembl:ENSG00000146540(gene)|ensembl:ENST00000491163(transcript) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:QR2SQCa6ELm9YUfkWDys7G0d+bE9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6FIG4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603014 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6fig4_human(display_long)|uniprotkb:RAB1B(gene name)|psi-mi:RAB1B(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR027417|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ngnltU6ZFwUqki4qt5sB9qyHaGM9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DE76 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603006 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4de76_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:XP_011528591.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR000156(Ran Binding Protein 1)|go:"GO:0046907"(intracellular transport) - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6/C3OPJXtw3BsRhxuuvrfV0Yp6Y9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8K008 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602997 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8k008_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0016020"(membrane)|interpro:IPR036179 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:kod7w5RdFRkxg/brKY5Dy/LRW4Y9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P00338 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14618 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601780|imex:IM-25050-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1 - - - figure legend:Table S3-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2019/11/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dDaoXCaqd0x6qFSElvngHusttuk9606 rigid:S/7X5onDYELWxylrQ9ii5Dc8LFs false tag:c-c|necessary binding region:1-348 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9BRL5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-10296986 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q9brl5_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|refseq:NP_005175.2|go:"GO:0005509"(calcium ion binding)|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:iAVzaz9qa9DNC5dIXkkXtsh+UmM9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53R15 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601894 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53r15_human(display_long)|uniprotkb:MYL1(gene name)|psi-mi:MYL1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding) - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:FBP94yKWbTsy7RYHFRWgBxAwHRQ9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B7Z6Z4 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11601909|ensembl:ENSP00000441750 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b7z6z4_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000092841(gene)|ensembl:ENST00000536128(transcript)|go:"GO:0005509"(calcium ion binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type) - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:8SfcWrqeHAExMGrP6Ur0M73LVoQ9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B4DF70 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602205 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b4df70_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR013766(Thioredoxin domain)|go:"GO:0004601"(peroxidase activity)|interpro:IPR036249 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ScxW8VSDtBvPRnhG2OpAWu4/7mc9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15907 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-722234|uniprotkb:Q2YDT2|uniprotkb:Q8NI07|uniprotkb:B2R7I4|uniprotkb:D6W671|uniprotkb:A5YM50|uniprotkb:Q5U0I1|uniprotkb:Q6FHR0|uniprotkb:Q6FI42|uniprotkb:B4DMK0|ensembl:ENSP00000333547 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rb11b_human(display_long)|uniprotkb:GTP-binding protein YPT3(gene name synonym)|uniprotkb:RAB11B(gene name)|psi-mi:RAB11B(display_short)|uniprotkb:YPT3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004209.2|dip:DIP-50898N|ensembl:ENSG00000185236(gene)|ensembl:ENST00000328024(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q15907|rcsb pdb:2F9L|rcsb pdb:2F9M|rcsb pdb:4OJK|reactome:R-HSA-8854214|reactome:R-HSA-8873719 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:+fsu7NPmd5fgoe0TE67IcISlscA9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8MX94 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602878|ensembl:ENSP00000381604 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8mx94_human(display_long)|uniprotkb:GSTP1(gene name)|psi-mi:GSTP1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000084207(gene)|ensembl:ENST00000398603(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0006749"(glutathione metabolic process)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:QBIH1ZaecOtF3hDhyoeXnuaW3yw9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B2R4M6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602959 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b2r4m6_human(display_long)|uniprotkb:S100 calcium-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|go:"GO:0005509"(calcium ion binding) - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6DAUOJDElWiJBqMvHLOtqOZBEfY9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:B2R4P2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602197 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:b2r4p2_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|interpro:IPR013766(Thioredoxin domain)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|interpro:IPR036249 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hGX2lLNaPzajIdaOnPP0JUyY/Lw9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q5MK14 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602860 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q5mk14_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR008195(Ribosomal protein L34e)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GthvAM/jJFAxCRo+AVts9w3RgF49606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:E7ERJ7 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11603078|ensembl:ENSP00000429395 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:e7erj7_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000070756(gene)|ensembl:ENST00000522387(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:+sWBAZrXTRLg8vZu/AwcC9aANuA9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6IAT9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-11602928 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q6iat9_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:hCG_32695(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002789.1|interpro:IPR029055|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023333|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR035140 - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q53SS8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9978003 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:q53ss8_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:HEL-S-85(gene name synonym)|uniprotkb:hCG_1776997(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11601902|imex:IM-25050-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|refseq:NP_006187.2|interpro:IPR036612|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0098847"(sequence-specific single stranded DNA binding) - - - figure legend:Supp Table 3 -2|comment:MYL6, CALM3 - calmodulin, GSTP1 and RAB11B did NOT bind to the Full length DUX4 construct, only to the construct containing the DUX4 C terminal sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606 rigid:+YnDIzWw4NdeVYULUqHndggHBxA false tag:c-c|sufficient binding region:349-424 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q5CAQ5 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-7198101|intact:MINT-3319501 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q5caq5_human(display_long)|uniprotkb:TRA1(gene name)|psi-mi:TRA1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0042470"(melanosome)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR020568|interpro:IPR020575|interpro:IPR019805|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|mint:Q5CAQ5|interpro:IPR036890|interpro:IPR037196 - - comment:mint|comment:homomint figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:6V80bKkPad7rBXjQoEWHpn8JdVw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:C9JPM4 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11601857|ensembl:ENSP00000420254 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:c9jpm4_human(display_long)|uniprotkb:ARF4(gene name)|psi-mi:ARF4(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) ensembl:ENSG00000168374(gene)|ensembl:ENST00000463880(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:GSHobxTQAHQa+KRhBlliz5l84Oo9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:F5H282 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602089|ensembl:ENSP00000439447 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:f5h282_human(display_long)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) ensembl:ENSG00000120438(gene)|ensembl:ENST00000544255(transcript)|go:"GO:0005524"(ATP binding)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:n37xFYLptLg5ZWYPr2NaH4xA6MA9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:F8VQ14 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602102|ensembl:ENSP00000450153 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:f8vq14_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:T-complex protein 1 subunit beta(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) ensembl:ENSG00000166226(gene)|ensembl:ENST00000550010(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:BqfP9hczaNEeAg5FLyp/iwGz1gA9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 intact:EBI-5912018 intact:EBI-11599882|intact:EBI-28972081 - psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q5szy0_human(display_short)|psi-mi:EBI-5912018(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:RP11-443G18.6-002(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) uniprotkb:Q5SZY0(uniprot-removed-ac) - - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:a60d7ObJwJg/Hiq4liWr/LbpJJs9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:B7Z9L0 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602119 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:b7z9l0_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR027410|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:igwGUZ5nwg6W3uH0sgj/CNaIlEo9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:P48643 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q6IBT3 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-4291299 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q6ibt3_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCT-eta(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR027410|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:3+2+oeT6KO0x9/Vw4Zgm2Hg0rMw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q53HU0 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602132 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q53hu0_human(display_long)|uniprotkb:T-complex protein 1 subunit theta(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR027410|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:iHTLv/HAYT2W6nkmSjlL5h2b8n89606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:B5BUE6 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-9512888 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:b5bue6_human(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX5(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR012587(P68HR)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005524"(ATP binding) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:I9gCCvZFwMHh7il5MOI75Uzvf0c9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q53SS8 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-9978003 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q53ss8_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:HEL-S-85(gene name synonym)|uniprotkb:hCG_1776997(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|refseq:NP_006187.2|interpro:IPR036612|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0098847"(sequence-specific single stranded DNA binding) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q15366 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:A8K7F6 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602144 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:a8k7f6_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR044728|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:g4hCs7UYpTRtGPNEuclkti8BvYQ9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:E9PD14 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602158|ensembl:ENSP00000426111|ensembl:ENSP00000486170 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:e9pd14_human(display_long)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) ensembl:ENSG00000204628(gene)|ensembl:ENST00000503494(transcript)|ensembl:ENST00000626067(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:/rn78jJZK6sr0eq0zxXKI6hljZw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q96IR1 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602172 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q96ir1_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR032277|interpro:IPR005824(KOW)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR002942(RNA-binding S4)|interpro:IPR036986|interpro:IPR041982|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|interpro:IPR038237 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:5hRZT/ShZ4d+15sD0A2HUxpkbi09606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q53G83 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-9373522 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q53g83_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR004044(K Homology, type 2)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR018280|interpro:IPR036419|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005819"(spindle)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0051301"(cell division)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity") - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:YFzsiKVAKnnIT1zndT6eD3btGhs9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q9BSW5 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602186 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q9bsw5_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR020568|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:fe2dmoceqUTT+c0afd05XTknwCs9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:B2R4P2 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602197 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:b2r4p2_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|interpro:IPR013766(Thioredoxin domain)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|interpro:IPR036249 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:hGX2lLNaPzajIdaOnPP0JUyY/Lw9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:B4DF70 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602205 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:b4df70_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR013766(Thioredoxin domain)|go:"GO:0004601"(peroxidase activity)|interpro:IPR036249 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:ScxW8VSDtBvPRnhG2OpAWu4/7mc9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q05DH1 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602213 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q05dh1_human(display_long)|uniprotkb:PSMA7(gene name)|psi-mi:PSMA7(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR029055|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR035190|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex) - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:UO/V/xaU1/MmpunFWN09gA0L8YI9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q5UGI3 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-1642188 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q5ugi3_human(display_long)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:Db8QU0QTLQFtg/SvJ7Hjnrx4zDU9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:P14618 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:dDaoXCaqd0x6qFSElvngHusttuk9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:P00338 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q5U077 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602247 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q5u077_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:HEL-S-281(gene name synonym)|uniprotkb:hCG_24788(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_001167568.1|refseq:NP_002291.1|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR018177|interpro:IPR022383|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0019752"(carboxylic acid metabolic process)|interpro:IPR036291 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q75MT9 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602270 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q75mt9_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR022383|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006108"(malate metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|interpro:IPR036291 - - - figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:tp1yjoK9kxJSa0g4WOwqLK/2mD49606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 intact:EBI-11602285 intact:EBI-11599882|intact:EBI-28972081 - psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q5szu1_human(display_short)|psi-mi:EBI-11602285(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602307|imex:IM-25050-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) uniprotkb:Q5SZU1(uniprot-removed-ac) - - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Supp table 3-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/24 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:V74bduYOcefOD2aN0RBu+Vxv6cg9606 rigid:fxCdyBayyoSf5JdgyTpNR5IxmZk false tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q13707 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11601821 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q13707_human(display_long)|uniprotkb:ACTA2(gene name)|psi-mi:ACTA2(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602338|imex:IM-25050-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR043129|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902 - - - figure legend:Supp Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:kw20DMOQ2I1hMDDGBOvaTJDT3FY9606 rigid:5idUJqHhkGW7hZQxVjz5cJFzJl4 false tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q86VG2 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11602343 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q86vg2_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602338|imex:IM-25050-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_005057.1|interpro:IPR012975(NOPS)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0048511"(rhythmic process)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979 - - - figure legend:Supp Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:EFcvyIz/XuEZLqBsuRHzjhp2D/s9606 rigid:5idUJqHhkGW7hZQxVjz5cJFzJl4 false tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:Q8TBR3 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-11601157 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:q8tbr3_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602338|imex:IM-25050-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443 - - - figure legend:Supp Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:FD1rwOgJERs9Pg3bMnzgb/6TeEY9606 rigid:5idUJqHhkGW7hZQxVjz5cJFzJl4 false tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:A8K651 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-9512810 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:a8k651_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602338|imex:IM-25050-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR036561|interpro:IPR003428(Mitochondrial glycoprotein)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane) - - - figure legend:Supp Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:Jd/FA2BQ4Eah0rGwo1KdxSEGJt89606 rigid:5idUJqHhkGW7hZQxVjz5cJFzJl4 false tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6RFH8 uniprotkb:P52926 intact:EBI-11599882|intact:EBI-28972081 intact:EBI-912511|uniprotkb:Q1M182|uniprotkb:E7EP85|uniprotkb:E7EWA2|uniprotkb:Q1M185|uniprotkb:Q1M186|uniprotkb:Q1M187|uniprotkb:Q1M188|ensembl:ENSP00000384026 psi-mi:dux4c_human(display_long)|uniprotkb:Double homeobox protein 4, centromeric(gene name synonym)|uniprotkb:Double homeobox protein 4-like protein 9(gene name synonym)|uniprotkb:DUX4L9(gene name)|psi-mi:DUX4L9(display_short)|uniprotkb:DUX4C(gene name synonym) psi-mi:hmga2_human(display_long)|uniprotkb:High mobility group AT-hook protein 2(gene name synonym)|uniprotkb:HMGA2(gene name)|psi-mi:HMGA2(display_short)|uniprotkb:HMGIC(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602338|imex:IM-25050-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_003474.1|refseq:NP_003475.1|refseq:NP_001317119.1|ensembl:ENSG00000149948(gene)|ensembl:ENST00000403681(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003131"(mesodermal-endodermal cell signaling)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009615"(response to virus)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0035501"(MH1 domain binding)|go:"GO:0035978"(histone H2A-S139 phosphorylation)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000685"(positive regulation of cellular response to X-ray)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|reactome:R-HSA-2559584 - - - figure legend:Supp Table 3-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:+eexGR48sX2OuLu3D7sLRlvosXU9606 rogid:J6xNJMDK/cdxNB9cX7Ey2NIlaUo9606 rigid:5idUJqHhkGW7hZQxVjz5cJFzJl4 false tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P52926 uniprotkb:Q9UBX2 intact:EBI-912511|uniprotkb:Q1M182|uniprotkb:E7EP85|uniprotkb:E7EWA2|uniprotkb:Q1M185|uniprotkb:Q1M186|uniprotkb:Q1M187|uniprotkb:Q1M188|ensembl:ENSP00000384026 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 psi-mi:hmga2_human(display_long)|uniprotkb:High mobility group AT-hook protein 2(gene name synonym)|uniprotkb:HMGA2(gene name)|psi-mi:HMGA2(display_short)|uniprotkb:HMGIC(gene name synonym) psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11602358|imex:IM-25050-177 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003474.1|refseq:NP_003475.1|refseq:NP_001317119.1|ensembl:ENSG00000149948(gene)|ensembl:ENST00000403681(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003131"(mesodermal-endodermal cell signaling)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009615"(response to virus)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0035501"(MH1 domain binding)|go:"GO:0035978"(histone H2A-S139 phosphorylation)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000685"(positive regulation of cellular response to X-ray)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|go:"GO:2001038"(regulation of cellular response to drug)|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|reactome:R-HSA-2559584 ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 - - - figure legend:Supp Table 3-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-te671)|taxid:9606(Homo sapiens medulloblastoma) - 2016/02/17 2016/02/23 rogid:J6xNJMDK/cdxNB9cX7Ey2NIlaUo9606 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rigid:HLzv20ceUY70kUD4EnVyjwrOR9A false - tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6P2Q9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:I0ot8b3pvieXRI66omFm145sGVA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P78527 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P04406 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P17655 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1028956|uniprotkb:Q16738|uniprotkb:Q6PJT3|uniprotkb:Q8WU26|uniprotkb:Q9HBB1|uniprotkb:A6NDG7|ensembl:ENSP00000295006|uniprotkb:B7ZA96|uniprotkb:E7ES58 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:can2_human(display_long)|uniprotkb:CAPN2(gene name)|psi-mi:CAPN2(display_short)|uniprotkb:CANPL2(gene name synonym)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)|uniprotkb:Calpain large polypeptide L2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001139540.1|refseq:NP_001739.2|ensembl:ENSG00000162909(gene)|ensembl:ENST00000295006(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0005634"(nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:P17655|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:2NQA|reactome:R-HSA-1474228|reactome:R-HSA-8862803|interpro:IPR002048(Calcium-binding EF-hand) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:r60XX66kihGVLaa9888soeXjc0M9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P04843 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62826 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46940 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P11940 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:XudTSPq2h9ckKAc48X88RVafPRU9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14618 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dDaoXCaqd0x6qFSElvngHusttuk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P13010 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O14617 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P12236 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00325 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 - - crc64:78714C85931B22D5 figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O95782 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P53621 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00610 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P00338 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P31943 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15029 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P36542 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P49327 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P17844 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O00571 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P12956 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9NR30 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q7L2E3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q08211 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352022|intact:EBI-1058470|uniprotkb:Q5VY62|uniprotkb:Q6PD69|uniprotkb:Q99556|uniprotkb:B2RNV4|uniprotkb:Q05CI5|uniprotkb:Q12803|uniprotkb:Q32Q22|ensembl:ENSP00000356520 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dhx9_human(display_long)|uniprotkb:DHX9(gene name)|psi-mi:DHX9(display_short)|uniprotkb:DDX9(gene name synonym)|uniprotkb:NDH2(gene name synonym)|uniprotkb:DExH-box helicase 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:LKP(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Leukophysin(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001348.2|dip:DIP-31504N|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|mint:Q08211|rcsb pdb:3LLM|rcsb pdb:3VYX|rcsb pdb:3VYY|reactome:R-HSA-1810476|reactome:R-HSA-3134963|reactome:R-HSA-72163|go:"GO:1904973"(positive regulation of viral translation)|ensembl:ENSG00000135829(gene)|ensembl:ENST00000367549(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006260"(DNA replication)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:b0VP2Frtvwa9WbYVMwB6TbV2uGU9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P19338 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P84103 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372557|uniprotkb:P23152|uniprotkb:O08831|uniprotkb:B4E241|intact:EBI-11020748|uniprotkb:Q5R3K0|ensembl:ENSP00000362820|ensembl:ENSP00000482833 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:srsf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)|uniprotkb:SRP20(gene name synonym)|uniprotkb:SFRS3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003008.1|ensembl:ENSG00000112081(gene)|ensembl:ENST00000373715(transcript)|ensembl:ENST00000620941(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84103|rcsb pdb:2I2Y|rcsb pdb:2I38|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-32961N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:BcfyCj2cNNTH1igANKpvh4IHDVU9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P52597 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P52272 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00839 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8K651 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9512810 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8k651_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR036561|interpro:IPR003428(Mitochondrial glycoprotein)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Jd/FA2BQ4Eah0rGwo1KdxSEGJt89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P67809 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P09429 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-389432|uniprotkb:Q6IBE1|uniprotkb:A5D8W9|uniprotkb:Q14321|uniprotkb:Q5T7C3|ensembl:ENSP00000343040|ensembl:ENSP00000345347|ensembl:ENSP00000382417|ensembl:ENSP00000384678 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hmgb1_human(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002119.1|refseq:NP_001300821.1|refseq:NP_001300822.1|ensembl:ENSG00000189403(gene)|ensembl:ENST00000339872(transcript)|ensembl:ENST00000341423(transcript)|ensembl:ENST00000399494(transcript)|ensembl:ENST00000405805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006265"(DNA topological change)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|interpro:IPR036910|mint:P09429|rcsb pdb:2LY4|rcsb pdb:2RTU|rcsb pdb:2YRQ|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|reactome:R-HSA-1236974|reactome:R-HSA-140342|reactome:R-HSA-166058|reactome:R-HSA-445989|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|dip:DIP-24195N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:8iSPxYEMyB6thRmixTeyF5kfDbw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6NZI2 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2559016|uniprotkb:O00535|uniprotkb:Q96H74|uniprotkb:Q6GMY1|uniprotkb:B2RAW7|uniprotkb:Q9BT85|uniprotkb:Q9HAP4|ensembl:ENSP00000349541 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:cavn1_human(display_long)|uniprotkb:CAVIN1(gene name)|psi-mi:CAVIN1(display_short)|uniprotkb:Cavin-1(gene name synonym)|uniprotkb:PTRF(gene name synonym)|uniprotkb:Polymerase I and transcript release factor(gene name synonym)|uniprotkb:FKSG13(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_036364.2|ensembl:ENSG00000177469(gene)|ensembl:ENST00000357037(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009306"(protein secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR026752|mint:Q6NZI2|reactome:R-HSA-73863|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|interpro:IPR033297|dip:DIP-48550N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:55dzpwSSfj8aEzmgHKYdrHfgYBg9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q02878 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-359655|uniprotkb:Q2M3Q3|uniprotkb:Q8WW97|ensembl:ENSP00000202773|ensembl:ENSP00000403172 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl6_human(display_long)|uniprotkb:RPL6(gene name)|psi-mi:RPL6(display_short)|uniprotkb:TXREB1(gene name synonym)|uniprotkb:Tax-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL6(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000961.2|refseq:NP_001019833.1|ensembl:ENSG00000089009(gene)|ensembl:ENST00000202773(transcript)|ensembl:ENST00000424576(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:Q02878|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001307066.1|refseq:NP_001307067.1|refseq:NP_001307068.1|refseq:NP_001307069.1|refseq:NP_001307070.1|refseq:XP_016875270.1|refseq:XP_016875271.1|dip:DIP-27547N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Y7fx3ToInzucV2QmI8KLSdHxai09606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P08708 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358255|uniprotkb:B2R4U4|intact:EBI-8012092|intact:EBI-11603362|intact:MINT-8395037|uniprotkb:P0CW22|ensembl:ENSP00000483755|ensembl:ENSP00000498019 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs17_human(display_long)|uniprotkb:RPS17(gene name)|psi-mi:RPS17(display_short)|uniprotkb:Small ribosomal subunit protein eS17(gene name synonym)|uniprotkb:RPS17L(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001012.1|ensembl:ENSG00000182774(gene)|ensembl:ENSG00000278229(gene)|ensembl:ENST00000617731(transcript)|ensembl:ENST00000647841(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P08708|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|go:"GO:0034101"(erythrocyte homeostasis)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:st+xQCXdSObiy6cJD1cSx869V289606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P23396 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35268 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354533|intact:EBI-1055963|uniprotkb:Q6IBD1|uniprotkb:B2R495|ensembl:ENSP00000346088 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl22_human(display_long)|uniprotkb:RPL22(gene name)|psi-mi:RPL22(display_short)|uniprotkb:Heparin-binding protein HBp15(gene name synonym)|uniprotkb:Epstein-Barr virus small RNA-associated protein(gene name synonym)|uniprotkb:EBER-associated protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL22(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000974.1|ensembl:ENSG00000116251(gene)|ensembl:ENST00000234875(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526|mint:P35268|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|reactome:R-HSA-72706|rcsb pdb:6Z6L|rcsb pdb:6Z6M|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:0TVillnqDkHmdTwxIedAJCVAdzY9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P42766 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356819|uniprotkb:Q4VBY5|uniprotkb:Q9BYF4|uniprotkb:Q5JTN5|uniprotkb:Q6IBC7|uniprotkb:Q96QJ7|uniprotkb:A8K4V7|ensembl:ENSP00000259469 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl35_human(display_long)|uniprotkb:RPL35(gene name)|psi-mi:RPL35(display_short)|uniprotkb:Large ribosomal subunit protein uL29(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_009140.1|ensembl:ENSG00000136942(gene)|ensembl:ENST00000348462(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001854(Ribosomal protein L29)|interpro:IPR018254|interpro:IPR036049|mint:P42766|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:jhzt7gCff2vdUb1Ff/VTBF698Pg9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46778 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P61313 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q07020 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P27635 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62750 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353254|uniprotkb:P29316|uniprotkb:Q92774|uniprotkb:P39024|uniprotkb:B2R5B2|ensembl:ENSP00000389103 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl23a_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:Large ribosomal subunit protein uL23(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|refseq:NP_000975.2|ensembl:ENSG00000198242(gene)|ensembl:ENST00000422514(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62750|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62917 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-438527|ensembl:ENSP00000262584|ensembl:ENSP00000378378|ensembl:ENSP00000433464|uniprotkb:P25120|uniprotkb:Q567Q7|uniprotkb:Q969V7|uniprotkb:Q9BWQ9|uniprotkb:A8K094|uniprotkb:D3DWN2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl8_human(display_long)|uniprotkb:RPL8(gene name)|psi-mi:RPL8(display_short)|uniprotkb:Large ribosomal subunit protein uL2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:4CCN|rcsb pdb:4CCO|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4Y3O|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000161016(gene)|ensembl:ENST00000262584(transcript)|ensembl:ENST00000394920(transcript)|ensembl:ENST00000528957(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098794"(postsynapse)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|mint:P62917|rcsb pdb:4CCM|refseq:NP_000964.1|refseq:NP_150644.1|refseq:NP_001304700.1|refseq:NP_001304711.1|dip:DIP-37967N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62847 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354515|uniprotkb:P16632|uniprotkb:Q7Z3D1|uniprotkb:Q5T0P7|uniprotkb:Q5T0P8|uniprotkb:E7EPK6|ensembl:ENSP00000478869 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs24_human(display_long)|uniprotkb:RPS24(gene name)|psi-mi:RPS24(display_short)|uniprotkb:Small ribosomal subunit protein eS24(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001135757.1|refseq:NP_001017.1|refseq:NP_001135755.1|refseq:NP_148982.1|ensembl:ENSG00000138326(gene)|ensembl:ENST00000613865(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62847|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6XA1|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62753 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356625|uniprotkb:P08227|uniprotkb:P10660|uniprotkb:Q4VBY7|uniprotkb:Q8N6Z7|ensembl:ENSP00000369757 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS6(gene name synonym)|uniprotkb:OK/SW-cl.2(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001001.2|reactome:R-HSA-166208|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|mint:P62753|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6F4P|rcsb pdb:6F4Q|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|ensembl:ENSG00000137154(gene)|ensembl:ENST00000380394(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|dip:DIP-31507N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:beDuXCIqL99V9JlVfpzx7MdpH689606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46781 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351206|uniprotkb:Q4QRK7|uniprotkb:Q9BVZ0|ensembl:ENSP00000302896|ensembl:ENSP00000375632|ensembl:ENSP00000375633|ensembl:ENSP00000478449|ensembl:ENSP00000479917|ensembl:ENSP00000480135|ensembl:ENSP00000480662|ensembl:ENSP00000481194|ensembl:ENSP00000481553|ensembl:ENSP00000481655|ensembl:ENSP00000481764|ensembl:ENSP00000481822|ensembl:ENSP00000482023|ensembl:ENSP00000482274|ensembl:ENSP00000482338|ensembl:ENSP00000482475|ensembl:ENSP00000483179|ensembl:ENSP00000484394|uniprotkb:A9C4C1 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs9_human(display_long)|uniprotkb:RPS9(gene name)|psi-mi:RPS9(display_short)|uniprotkb:Small ribosomal subunit protein uS4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001004.2|refseq:NP_001308630.1|refseq:NP_001308631.1|refseq:NP_001308633.1|ensembl:ENSG00000170889(gene)|ensembl:ENSG00000274005(gene)|ensembl:ENSG00000274626(gene)|ensembl:ENSG00000274646(gene)|ensembl:ENSG00000274950(gene)|ensembl:ENSG00000275323(gene)|ensembl:ENSG00000277079(gene)|ensembl:ENSG00000277359(gene)|ensembl:ENSG00000278081(gene)|ensembl:ENSG00000278270(gene)|ensembl:ENST00000302907(transcript)|ensembl:ENST00000391752(transcript)|ensembl:ENST00000391753(transcript)|ensembl:ENST00000610826(transcript)|ensembl:ENST00000610953(transcript)|ensembl:ENST00000611921(transcript)|ensembl:ENST00000614737(transcript)|ensembl:ENST00000615346(transcript)|ensembl:ENST00000616082(transcript)|ensembl:ENST00000616536(transcript)|ensembl:ENST00000616839(transcript)|ensembl:ENST00000616877(transcript)|ensembl:ENST00000616928(transcript)|ensembl:ENST00000617291(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000618751(transcript)|go:"GO:0005829"(cytosol)|ensembl:ENST00000619229(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|ensembl:ENST00000620720(transcript)|ensembl:ENST00000620940(transcript)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|mint:P46781|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|go:"GO:0005634"(nucleus)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|go:"GO:0005654"(nucleoplasm)|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P30050 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:TNPEtl60cILofaPzUznvZiw6D7E9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62701 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P39023 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P18124 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62424 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9Y3U8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1057689|uniprotkb:Q6FIG1|uniprotkb:Q9UQF6|uniprotkb:B2R4Y1|uniprotkb:D6W634|ensembl:ENSP00000252543|ensembl:ENSP00000378081|ensembl:ENSP00000462609|ensembl:ENSP00000464342 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl36_human(display_long)|uniprotkb:RPL36(gene name)|psi-mi:RPL36(display_short)|uniprotkb:Large ribosomal subunit protein eL36(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_056229.2|refseq:NP_378669.1|reactome:R-HSA-975957|mint:Q9Y3U8|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|interpro:IPR038097|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|rcsb pdb:6Y6X|ensembl:ENSG00000130255(gene)|ensembl:ENST00000347512(transcript)|ensembl:ENST00000394580(transcript)|ensembl:ENST00000577222(transcript)|ensembl:ENST00000579649(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000509(Ribosomal protein L36e) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lRlRMF2jV/UHr4SX95SSCFIEV+s9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62851 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353054|ensembl:ENSP00000435096|ensembl:ENSP00000486392|uniprotkb:P25111|uniprotkb:B2R4M7 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs25_human(display_long)|uniprotkb:RPS25(gene name)|psi-mi:RPS25(display_short)|uniprotkb:Small ribosomal subunit protein eS25(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000118181(gene)|ensembl:ENSG00000280831(gene)|ensembl:ENST00000527673(transcript)|ensembl:ENST00000628770(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004977(Ribosomal protein S25)|interpro:IPR036388|mint:P62851|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y0G|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:6ZXD|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|rcsb pdb:6ZXE|reactome:R-HSA-9010553|reactome:R-HSA-9633012|rcsb pdb:6ZXF|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|refseq:NP_001019.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P36578 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P18621 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-726937|uniprotkb:Q6NZ54|uniprotkb:Q7M4M5|uniprotkb:Q3KQW2|uniprotkb:B2R4H3|uniprotkb:B4E3C2|uniprotkb:B5ME31|uniprotkb:J3QL51|ensembl:ENSP00000462023|ensembl:ENSP00000462385|ensembl:ENSP00000463842|ensembl:ENSP00000480555|ensembl:ENSP00000482577 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl17_human(display_long)|uniprotkb:60S ribosomal protein L23(gene name synonym)|uniprotkb:PD-1(gene name synonym)|uniprotkb:RPL17(gene name)|psi-mi:RPL17(display_short)|uniprotkb:Large ribosomal subunit protein uL22(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000976.1|refseq:NP_001030178.1|refseq:NP_001186269.1|refseq:NP_001186270.1|refseq:NP_001186271.1|refseq:NP_001186272.1|refseq:NP_001186273.1|refseq:NP_001186274.1|ensembl:ENSG00000265681(gene)|ensembl:ENST00000579248(transcript)|ensembl:ENST00000579408(transcript)|ensembl:ENST00000580261(transcript)|ensembl:ENST00000618613(transcript)|ensembl:ENST00000618619(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001063(Ribosomal protein L22/L17)|interpro:IPR005721(Ribosomal protein L22/L17, eukaryotic/archaeal)|interpro:IPR018260|interpro:IPR036394|mint:P18621|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/i0W3WoeFakz+8R/YMYf2JQZytI9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62277 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351850|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|uniprotkb:Q498Y0|uniprotkb:B2R549|ensembl:ENSP00000435777 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs13_human(display_long)|uniprotkb:RPS13(gene name)|psi-mi:RPS13(display_short)|uniprotkb:Small ribosomal subunit protein uS15(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001008.1|ensembl:ENSG00000110700(gene)|ensembl:ENST00000525634(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62277|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6OM7|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62263 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352783|ensembl:ENSP00000311028|ensembl:ENSP00000385425|uniprotkb:P06366|uniprotkb:Q5BJI0|uniprotkb:B2R5G5|uniprotkb:D3DQG5|ensembl:ENSP00000385958|ensembl:ENSP00000428509 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs14_human(display_long)|uniprotkb:RPS14(gene name)|psi-mi:RPS14(display_short)|uniprotkb:Small ribosomal subunit protein uS11(gene name synonym)|uniprotkb:PRO2640(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000164587(gene)|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001020242.1|refseq:NP_005608.1|refseq:NP_001020241.1|ensembl:ENST00000312037(transcript)|ensembl:ENST00000401695(transcript)|ensembl:ENST00000407193(transcript)|ensembl:ENST00000521466(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62263|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62888 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62241 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P26373 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356849|uniprotkb:Q3KQT8|uniprotkb:Q9BPX0|uniprotkb:Q567Q8|uniprotkb:B4DLX3|uniprotkb:F5H1S2|ensembl:ENSP00000307889|ensembl:ENSP00000376811|ensembl:ENSP00000455009 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl13_human(display_long)|uniprotkb:RPL13(gene name)|psi-mi:RPL13(display_short)|uniprotkb:BBC1(gene name synonym)|uniprotkb:Breast basic conserved protein 1(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL13(gene name synonym)|uniprotkb:OK/SW-cl.46(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000968.2|refseq:NP_150254.1|refseq:NP_001230059.1|refseq:NP_001230060.1|ensembl:ENSG00000167526(gene)|ensembl:ENST00000311528(transcript)|ensembl:ENST00000393099(transcript)|ensembl:ENST00000567815(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P26373|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-192823 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2SZ+AEe41Ystwj9t9I0Z1cZ5GQ49606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62269 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62829 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353303|uniprotkb:P23131|uniprotkb:Q3SWV7|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q6P5S1|ensembl:ENSP00000377865|ensembl:ENSP00000420311 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl23_human(display_long)|uniprotkb:RPL23(gene name)|psi-mi:RPL23(display_short)|uniprotkb:60S ribosomal protein L17(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL14(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|reactome:R-HSA-9010553|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|refseq:NP_000969.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62829|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|ensembl:ENSG00000125691(gene)|ensembl:ENST00000394332(transcript)|ensembl:ENST00000479035(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005730"(nucleolus)|dip:DIP-33156N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62899 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:77LFR7/2somk6blVogZf1XFdJLk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P15880 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-443446|ensembl:ENSP00000341885|uniprotkb:Q3MIB1|uniprotkb:B2R5G0|uniprotkb:D3DU82 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs2_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short)|uniprotkb:RPS4(gene name synonym)|uniprotkb:40S ribosomal protein S4(gene name synonym)|uniprotkb:Protein LLRep3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS5(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|rcsb pdb:6OLG|rcsb pdb:6OLI|interpro:IPR018192|rcsb pdb:6OLZ|interpro:IPR020568|mint:P15880|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6XA1|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6G5H|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7JQB|rcsb pdb:7JQC|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-3214858|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8876725|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:7A09|ensembl:ENSG00000140988(gene)|ensembl:ENST00000343262(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045296"(cadherin binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|refseq:NP_002943.2 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:JUr2Y3cGk00S8KaTVPymshfaHhc9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P60866 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46783 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46776 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350581|uniprotkb:B2R4B3|ensembl:ENSP00000346015 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl27a_human(display_long)|uniprotkb:RPL27A(gene name)|psi-mi:RPL27A(display_short)|uniprotkb:Large ribosomal subunit protein uL15(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000981.1|ensembl:ENSG00000166441(gene)|ensembl:ENST00000314138(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001196(Ribosomal protein L15)|interpro:IPR021131|interpro:IPR027386|interpro:IPR030878|interpro:IPR036227|mint:P46776|rcsb pdb:4BXF|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6IP6|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6OM7|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:6IP5|dip:DIP-33121N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:tUezMQBw+SWmLYq8M0pkLCF8vO89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P84098 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62841 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372635|uniprotkb:Q3KRA1|uniprotkb:P11174|uniprotkb:A5D8V9|uniprotkb:Q9UDC2|ensembl:ENSP00000467466 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs15_human(display_long)|uniprotkb:RIG protein(gene name synonym)|uniprotkb:RPS15(gene name)|psi-mi:RPS15(display_short)|uniprotkb:RIG(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS19(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001009.1|mint:P62841|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|ensembl:ENSG00000115268(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|ensembl:ENST00000592588(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0097421"(liver regeneration)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR002222(Ribosomal protein S19/S15)|interpro:IPR005713(Ribosomal protein S15, eukaryotic/archaeal)|interpro:IPR020934|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR023575|rcsb pdb:6ZVH|rcsb pdb:6ZMT|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|rcsb pdb:6ZMW|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lJJOew1txuTwFlhKu4Z+AkPS5H09606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62244 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-347895|ensembl:ENSP00000318646|ensembl:ENSP00000457000|ensembl:ENSP00000458115|ensembl:ENSP00000458528|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q3MHD9|uniprotkb:Q8C023|uniprotkb:Q9BV24 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs15a_human(display_long)|uniprotkb:RPS15A(gene name)|psi-mi:RPS15A(display_short)|uniprotkb:Small ribosomal subunit protein uS8(gene name synonym)|uniprotkb:OK/SW-cl.82(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000134419(gene)|ensembl:ENST00000322989(transcript)|ensembl:ENST00000563390(transcript)|ensembl:ENST00000565420(transcript)|ensembl:ENST00000572008(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6G4W|interpro:IPR000630(Ribosomal protein S8)|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|interpro:IPR035987|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|mint:P62244|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:4V6X|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-72695|reactome:R-HSA-975957|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZM7|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|refseq:NP_001010.2|refseq:NP_001025180.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P32969 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62906 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P61247 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P84077 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P06748 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-78579|uniprotkb:P08693|uniprotkb:Q12826|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q14115|uniprotkb:Q5EU94|uniprotkb:Q5EU95|uniprotkb:Q5EU96|uniprotkb:Q5EU97|uniprotkb:Q5EU98|uniprotkb:Q5EU99|uniprotkb:Q6V962|uniprotkb:Q8WTW5|uniprotkb:Q96AT6|uniprotkb:Q96DC4|uniprotkb:Q96EA5|uniprotkb:A8K3N7|uniprotkb:B5BU00|uniprotkb:Q9UDJ7|uniprotkb:D3DQL6|uniprotkb:Q9BYG9|ensembl:ENSP00000296930|ensembl:ENSP00000428755 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:npm_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short)|uniprotkb:NPM(gene name synonym)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002511.1|refseq:NP_954654.1|refseq:NP_001032827.1|dip:DIP-30932N|ensembl:ENSG00000181163(gene)|ensembl:ENST00000296930(transcript)|ensembl:ENST00000517671(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042255"(ribosome assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:P06748|rcsb pdb:2LLH|rcsb pdb:2P1B|rcsb pdb:2VXD|rcsb pdb:5EHD|reactome:R-HSA-180746|reactome:R-HSA-3899300|reactome:R-HSA-606279|reactome:R-HSA-6804115|reactome:R-HSA-8869496 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:HJ7Mg+XsIhuJiScPKiI0dIa6KpM9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35579 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q14204 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P08670 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9BUF5 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14649 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358570|ensembl:ENSP00000446643|ensembl:ENSP00000450385 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myl6b_human(display_long)|uniprotkb:MYL6B(gene name)|psi-mi:MYL6B(display_short)|uniprotkb:MLC1SA(gene name synonym)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6B(gene name synonym)|uniprotkb:Myosin light chain 1 slow-twitch muscle A isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001186558.1|refseq:NP_002466.1|ensembl:ENSG00000196465(gene)|ensembl:ENST00000550443(transcript)|ensembl:ENST00000553066(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:1OE9|rcsb pdb:1W7I|rcsb pdb:1W7J|reactome:R-HSA-445355 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:S0/S5hUxfyyve1JDMojIggOSBb89606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q13509 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350989|uniprotkb:Q9BTZ0|uniprotkb:Q9BW10|ensembl:ENSP00000320295|uniprotkb:A8K854 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb3_human(display_long)|uniprotkb:TUBB3(gene name)|psi-mi:TUBB3(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:Tubulin beta-III(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001184110.1|refseq:NP_006077.2|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-6807878|ensembl:ENSG00000258947(gene)|ensembl:ENST00000315491(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007411"(axon guidance)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13509|rcsb pdb:5IJ9|rcsb pdb:5JCO|rcsb pdb:6E7B|rcsb pdb:6S8L|rcsb pdb:6WSL|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|rcsb pdb:5IJ0|dip:DIP-31505N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:A69G+idFQmuzkmCsGyBtGVqglSo9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P21333 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P63261 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351292|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|uniprotkb:Q5U032|uniprotkb:Q96E67|uniprotkb:A8K7C2|ensembl:ENSP00000505060|ensembl:ENSP00000505193|ensembl:ENSP00000505235|ensembl:ENSP00000506126|ensembl:ENSP00000506201|ensembl:ENSP00000506253|ensembl:ENSP00000458162|ensembl:ENSP00000458435|ensembl:ENSP00000459119|ensembl:ENSP00000459124|ensembl:ENSP00000460464|ensembl:ENSP00000460660|ensembl:ENSP00000461672|ensembl:ENSP00000466346|ensembl:ENSP00000477968 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:actg_human(display_long)|uniprotkb:ACTG1(gene name)|psi-mi:ACTG1(display_short)|uniprotkb:ACTG(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001186883.1|refseq:NP_001605.1|ensembl:ENST00000570382(transcript)|ensembl:ENSG00000184009(gene)|ensembl:ENST00000571721(transcript)|ensembl:ENST00000573283(transcript)|ensembl:ENST00000575087(transcript)|ensembl:ENST00000575659(transcript)|ensembl:ENST00000575842(transcript)|ensembl:ENST00000575994(transcript)|ensembl:ENST00000576544(transcript)|ensembl:ENST00000615544(transcript)|ensembl:ENST00000679480(transcript)|ensembl:ENST00000679778(transcript)|ensembl:ENST00000680227(transcript)|ensembl:ENST00000680727(transcript)|ensembl:ENST00000681052(transcript)|ensembl:ENST00000681842(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63261|rcsb pdb:5JLH|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-445095|reactome:R-HSA-446353|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9013418|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P07437 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q13885 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-711595|ensembl:ENSP00000369703|uniprotkb:Q6FGZ8|uniprotkb:Q8IWR2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb2a_human(display_long)|uniprotkb:TUBB2A(gene name)|psi-mi:TUBB2A(display_short)|uniprotkb:TUBB2(gene name synonym)|uniprotkb:Tubulin beta class IIa(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614356|imex:IM-25050-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-389957|reactome:R-HSA-983189|reactome:R-HSA-9668328|ensembl:ENSG00000137267(gene)|ensembl:ENST00000333628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13885|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|refseq:NP_001060.1|refseq:NP_001297244.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2016/03/15 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk9606 rigid:gYo+PusGs3R9TcHby5N3mgw/67c false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q6P2Q9 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:I0ot8b3pvieXRI66omFm145sGVA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P30153 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P34897 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P56192 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P40227 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P11940 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:XudTSPq2h9ckKAc48X88RVafPRU9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P41252 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P17987 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P41250 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-724143|uniprotkb:B3KQA2|uniprotkb:B4DIA0|ensembl:ENSP00000373918|uniprotkb:Q969Y1|intact:EBI-25629666|uniprotkb:A0A090N8G0 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:gars_human(display_long)|uniprotkb:GARS1(gene name)|psi-mi:GARS1(display_short)|uniprotkb:Diadenosine tetraphosphate synthetase(gene name synonym)|uniprotkb:GARS(gene name synonym)|uniprotkb:Glycyl-tRNA synthetase(gene name synonym)|uniprotkb:Glycyl-tRNA synthetase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002038.2|rcsb pdb:4KQE|rcsb pdb:4KR2|rcsb pdb:2ZT6|rcsb pdb:4KR3|rcsb pdb:4QEI|rcsb pdb:5E6M|reactome:R-HSA-379716|rcsb pdb:2ZT7|reactome:R-HSA-379726|rcsb pdb:2ZT8|rcsb pdb:2ZXF|ensembl:ENSG00000106105(gene)|ensembl:ENST00000389266(transcript)|go:"GO:0004081"("bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity")|go:"GO:0004820"(glycine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006426"(glycyl-tRNA aminoacylation)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016740"(transferase activity)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070150"(mitochondrial glycyl-tRNA aminoacylation)|interpro:IPR000738(WHEP-TRS)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002315(Glycyl-tRNA synthetase, alpha2 dimer)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR027031|interpro:IPR033731|interpro:IPR036621|mint:P41250|rcsb pdb:2PME|rcsb pdb:2PMF|rcsb pdb:2Q5H|rcsb pdb:2Q5I|rcsb pdb:2ZT5|refseq:NP_001303701.1|dip:DIP-50471N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:bBlAPOMGXKsEvu0DxGKJJLjDI1s9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14618 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:dDaoXCaqd0x6qFSElvngHusttuk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P09874 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P13010 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P55060 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O14617 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00325 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 - - crc64:78714C85931B22D5 figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P45880 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P21796 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P53621 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00610 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P06733 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P00338 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O15067 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1052653|uniprotkb:A6H8V8|ensembl:ENSP00000313490 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pur4_human(display_long)|uniprotkb:Formylglycinamide ribotide amidotransferase(gene name synonym)|uniprotkb:PFAS(gene name)|psi-mi:PFAS(display_short)|uniprotkb:KIAA0361(gene name synonym)|uniprotkb:Formylglycinamide ribonucleotide amidotransferase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_036525.1|ensembl:ENSG00000178921(gene)|ensembl:ENST00000314666(transcript)|go:"GO:0004642"(phosphoribosylformylglycinamidine synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097065"(anterior head development)|interpro:IPR010073(Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria)|interpro:IPR010918(AIR synthase related protein, C-terminal)|interpro:IPR029062|interpro:IPR036604|interpro:IPR036676|interpro:IPR036921|interpro:IPR040707|interpro:IPR041609|mint:O15067|reactome:R-HSA-73817 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:e52AyHjHUrLjnoJP+rInkcvfGJk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P31943 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q15029 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P05141 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P07814 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P36542 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P11586 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P49327 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P13639 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P17844 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O00571 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P12956 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9NR30 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P78527 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P10809 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q7L2E3 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1211456|uniprotkb:O94965|uniprotkb:Q7Z753|uniprotkb:Q96CH4|uniprotkb:Q9NUQ0|uniprotkb:A8K5F1|ensembl:ENSP00000392601|ensembl:ENSP00000405620|intact:EBI-21350949 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dhx30_human(display_long)|uniprotkb:DHX30(gene name)|psi-mi:DHX30(display_short)|uniprotkb:KIAA0890(gene name synonym)|uniprotkb:DDX30(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_055781.2|refseq:NP_619520.1|refseq:XP_011531796.1|refseq:XP_011531797.1|refseq:XP_016861406.1|ensembl:ENSG00000132153(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q7L2E3|rcsb pdb:2DB2|ensembl:ENST00000445061(transcript)|ensembl:ENST00000446256(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:tb4GzZKLycraXS0NlVqj8reV3IQ9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q08211 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352022|intact:EBI-1058470|uniprotkb:Q5VY62|uniprotkb:Q6PD69|uniprotkb:Q99556|uniprotkb:B2RNV4|uniprotkb:Q05CI5|uniprotkb:Q12803|uniprotkb:Q32Q22|ensembl:ENSP00000356520 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dhx9_human(display_long)|uniprotkb:DHX9(gene name)|psi-mi:DHX9(display_short)|uniprotkb:DDX9(gene name synonym)|uniprotkb:NDH2(gene name synonym)|uniprotkb:DExH-box helicase 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:LKP(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Leukophysin(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001348.2|dip:DIP-31504N|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|mint:Q08211|rcsb pdb:3LLM|rcsb pdb:3VYX|rcsb pdb:3VYY|reactome:R-HSA-1810476|reactome:R-HSA-3134963|reactome:R-HSA-72163|go:"GO:1904973"(positive regulation of viral translation)|ensembl:ENSG00000135829(gene)|ensembl:ENST00000367549(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006260"(DNA replication)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:b0VP2Frtvwa9WbYVMwB6TbV2uGU9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9H2U1 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1047643|uniprotkb:Q70JU3|uniprotkb:Q8IYE5|uniprotkb:Q9P240|uniprotkb:B2RB00|ensembl:ENSP00000417078 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dhx36_human(display_long)|uniprotkb:DEAD/H box polypeptide 36(gene name synonym)|uniprotkb:DEAH-box protein 36(gene name synonym)|uniprotkb:G4-resolvase-1(gene name synonym)|uniprotkb:RNA helicase associated with AU-rich element protein(gene name synonym)|uniprotkb:MLE-like protein 1(gene name synonym)|uniprotkb:DHX36(gene name)|psi-mi:DHX36(display_short)|uniprotkb:DDX36(gene name synonym)|uniprotkb:KIAA1488(gene name synonym)|uniprotkb:MLEL1(gene name synonym)|uniprotkb:RHAU(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001107869.1|refseq:NP_065916.2|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0005829"(cytosol)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070883"(pre-miRNA binding)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902064"(regulation of transcription from RNA polymerase II promoter involved in spermatogenesis)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904582"(positive regulation of intracellular mRNA localization)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR027417|ensembl:ENSG00000174953(gene)|ensembl:ENST00000496811(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001503"(ossification)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|rcsb pdb:2N16|rcsb pdb:2N21|rcsb pdb:6Q6R|reactome:R-HSA-3134963|mint:Q9H2U1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:CvYmO1OB0zu5ZCYzQmKvCYGc3+k9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P33993 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P19338 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q13310 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372844|uniprotkb:Q6P0N3|uniprotkb:B1ANQ8|ensembl:ENSP00000361948|intact:EBI-877641|uniprotkb:Q4VC03 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:pabp4_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:APP1(gene name synonym)|uniprotkb:PABP4(gene name synonym)|uniprotkb:"Inducible poly(A)-binding protein"(gene name synonym)|uniprotkb:Activated-platelet protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001129126.1|refseq:NP_003810.1|ensembl:ENSG00000090621(gene)|ensembl:ENST00000372857(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006412"(translation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q13310|refseq:NP_001129125.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:u1qCM3o5X7jLIa1vyqFCIH7v01w9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O75533 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-876542|ensembl:ENSP00000335321|uniprotkb:E9PCH3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:sf3b1_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SF3b 155 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 155(gene name synonym)|uniprotkb:SF3B1(gene name)|psi-mi:SF3B1(display_short)|uniprotkb:SAP155(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000115524(gene)|ensembl:ENST00000335508(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0034693"(U11/U12 snRNP)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015016(Splicing factor 3B subunit 1)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038737|mint:O75533|rcsb pdb:2F9D|rcsb pdb:2F9J|rcsb pdb:2FHO|rcsb pdb:2PEH|rcsb pdb:3LQV|rcsb pdb:4OZ1|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6N3E|refseq:NP_036565.2|dip:DIP-29411N|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-5250924|reactome:R-HSA-72163|reactome:R-HSA-72165 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2KqZNVdZoItavA0DFR3zZ16U0tI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q32P51 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-2556580|uniprotkb:Q5TBS2|ensembl:ENSP00000350090 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ra1l2_human(display_long)|uniprotkb:HNRNPA1L(gene name synonym)|uniprotkb:HNRNPA1L2(gene name)|psi-mi:HNRNPA1L2(display_short)|uniprotkb:hnRNP core protein A1-like 2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001011724.1|refseq:NP_001011725.1|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0051028"(mRNA transport)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR035979|mint:Q32P51|go:"GO:0005681"(spliceosomal complex)|ensembl:ENSG00000139675(gene)|ensembl:ENST00000357495(transcript)|go:"GO:0003723"(RNA binding) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Xx00SLimJrf+0e9CrvzUV9PJPcI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P84103 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372557|uniprotkb:P23152|uniprotkb:O08831|uniprotkb:B4E241|intact:EBI-11020748|uniprotkb:Q5R3K0|ensembl:ENSP00000362820|ensembl:ENSP00000482833 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:srsf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)|uniprotkb:SRP20(gene name synonym)|uniprotkb:SFRS3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003008.1|ensembl:ENSG00000112081(gene)|ensembl:ENST00000373715(transcript)|ensembl:ENST00000620941(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84103|rcsb pdb:2I2Y|rcsb pdb:2I38|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-32961N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:BcfyCj2cNNTH1igANKpvh4IHDVU9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P61978 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O00425 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1058566|ensembl:ENSP00000258729|uniprotkb:Q63HM0|uniprotkb:A0A4Z5|uniprotkb:Q6MZZ2|uniprotkb:Q86VB1|intact:EBI-2560196 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:if2b3_human(display_long)|uniprotkb:IGF2BP3(gene name)|psi-mi:IGF2BP3(display_short)|uniprotkb:IMP3(gene name synonym)|uniprotkb:KOC1(gene name synonym)|uniprotkb:VICKZ3(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 3(gene name synonym)|uniprotkb:KH domain-containing protein overexpressed in cancer(gene name synonym)|uniprotkb:VICKZ family member 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000136231(gene)|ensembl:ENST00000258729(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_006538.2|interpro:IPR004087(K Homology)|dip:DIP-44171N|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034844|interpro:IPR035979|interpro:IPR036612|mint:O00425|rcsb pdb:2E44|rcsb pdb:6FQ1|rcsb pdb:6FQR|rcsb pdb:6GQE|rcsb pdb:6GX6|reactome:R-HSA-428359 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:yGEnYHFP+P05J45ZnHUdcPXHlQA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P52597 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9NZI8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P52272 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:O75643 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q00839 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:A8K651 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-9512810 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:a8k651_human(display_long) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR036561|interpro:IPR003428(Mitochondrial glycoprotein)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Jd/FA2BQ4Eah0rGwo1KdxSEGJt89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q12906 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-78756|uniprotkb:A8K6F2|uniprotkb:O43409|uniprotkb:Q6P1X1|uniprotkb:Q86XY7|uniprotkb:Q99544|uniprotkb:Q99545|uniprotkb:Q9BZH4|uniprotkb:Q9BZH5|uniprotkb:Q9NQ95|uniprotkb:Q9NQ96|uniprotkb:Q9NQ97|uniprotkb:Q9NQ98|uniprotkb:Q9NQ99|uniprotkb:Q9NQA0|uniprotkb:Q9NQA1|uniprotkb:Q9NQA2|uniprotkb:Q9NRN2|uniprotkb:Q9NRN3|uniprotkb:Q9NRN4|uniprotkb:Q9UMZ9|uniprotkb:Q9UN00|uniprotkb:Q9UN84|uniprotkb:Q9UNA2|ensembl:ENSP00000468156|intact:EBI-10970055|uniprotkb:G5E9M5 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ilf3_human(display_long)|uniprotkb:ILF3(gene name)|psi-mi:ILF3(display_short)|uniprotkb:MPHOSPH4(gene name synonym)|uniprotkb:NF90(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 90 kDa(gene name synonym)|uniprotkb:Double-stranded RNA-binding protein 76(gene name synonym)|uniprotkb:Translational control protein 80(gene name synonym)|uniprotkb:Nuclear factor associated with dsRNA(gene name synonym)|uniprotkb:M-phase phosphoprotein 4(gene name synonym)|uniprotkb:DRBF(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000129351(gene)|ensembl:ENST00000590261(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q12906|rcsb pdb:2L33|rcsb pdb:3P1X|refseq:NP_001131145.1|refseq:NP_004507.2|refseq:NP_036350.2|refseq:NP_060090.2|refseq:NP_703194.1|refseq:XP_016882252.1|refseq:XP_011526286.2|dip:DIP-29853N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:iri+WBUtektANRSCpBO1XBCd9Wk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P67809 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q86VP6 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9BQG0 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-676973|intact:EBI-2559619|uniprotkb:Q86VM3|uniprotkb:Q9BW49|uniprotkb:Q9P0V5|uniprotkb:Q9UF99|ensembl:ENSP00000254718 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:mbb1a_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)|uniprotkb:P160(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001099008.1|refseq:NP_055335.2|ensembl:ENST00000254718(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|ensembl:ENSG00000132382(gene)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BQG0|reactome:R-HSA-5250924 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ScabTPXvbX/5VRsnaRQXUIlANow9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q02878 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-359655|uniprotkb:Q2M3Q3|uniprotkb:Q8WW97|ensembl:ENSP00000202773|ensembl:ENSP00000403172 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl6_human(display_long)|uniprotkb:RPL6(gene name)|psi-mi:RPL6(display_short)|uniprotkb:TXREB1(gene name synonym)|uniprotkb:Tax-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL6(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000961.2|refseq:NP_001019833.1|ensembl:ENSG00000089009(gene)|ensembl:ENST00000202773(transcript)|ensembl:ENST00000424576(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:Q02878|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001307066.1|refseq:NP_001307067.1|refseq:NP_001307068.1|refseq:NP_001307069.1|refseq:NP_001307070.1|refseq:XP_016875270.1|refseq:XP_016875271.1|dip:DIP-27547N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Y7fx3ToInzucV2QmI8KLSdHxai09606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P08708 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358255|uniprotkb:B2R4U4|intact:EBI-8012092|intact:EBI-11603362|intact:MINT-8395037|uniprotkb:P0CW22|ensembl:ENSP00000483755|ensembl:ENSP00000498019 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs17_human(display_long)|uniprotkb:RPS17(gene name)|psi-mi:RPS17(display_short)|uniprotkb:Small ribosomal subunit protein eS17(gene name synonym)|uniprotkb:RPS17L(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001012.1|ensembl:ENSG00000182774(gene)|ensembl:ENSG00000278229(gene)|ensembl:ENST00000617731(transcript)|ensembl:ENST00000647841(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P08708|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|go:"GO:0034101"(erythrocyte homeostasis)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:st+xQCXdSObiy6cJD1cSx869V289606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P23396 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351193|uniprotkb:Q498B5|uniprotkb:Q8NI95|uniprotkb:B2R7N5|ensembl:ENSP00000433821|ensembl:ENSP00000434643|ensembl:ENSP00000436971|uniprotkb:J3KN86 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs3_human(display_long)|uniprotkb:RPS3(gene name)|psi-mi:RPS3(display_short)|uniprotkb:Small ribosomal subunit protein uS3(gene name synonym)|uniprotkb:OK/SW-cl.26(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000996.2|ensembl:ENSG00000149273(gene)|ensembl:ENST00000524851(transcript)|ensembl:ENST00000527446(transcript)|ensembl:ENST00000531188(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR004044(K Homology, type 2)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|go:"GO:0071159"(NF-kappaB complex)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR018280|interpro:IPR036419|mint:P23396|rcsb pdb:1WH9|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|rcsb pdb:6QZP|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|refseq:NP_001243731.1|refseq:NP_001247436.1|refseq:NP_001247435.1|dip:DIP-33177N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fsDW18AMR3YyEEIhMVcngYRWkps9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35268 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354533|intact:EBI-1055963|uniprotkb:Q6IBD1|uniprotkb:B2R495|ensembl:ENSP00000346088 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl22_human(display_long)|uniprotkb:RPL22(gene name)|psi-mi:RPL22(display_short)|uniprotkb:Heparin-binding protein HBp15(gene name synonym)|uniprotkb:Epstein-Barr virus small RNA-associated protein(gene name synonym)|uniprotkb:EBER-associated protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL22(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000974.1|ensembl:ENSG00000116251(gene)|ensembl:ENST00000234875(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526|mint:P35268|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|reactome:R-HSA-72706|rcsb pdb:6Z6L|rcsb pdb:6Z6M|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:0TVillnqDkHmdTwxIedAJCVAdzY9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P42766 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356819|uniprotkb:Q4VBY5|uniprotkb:Q9BYF4|uniprotkb:Q5JTN5|uniprotkb:Q6IBC7|uniprotkb:Q96QJ7|uniprotkb:A8K4V7|ensembl:ENSP00000259469 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl35_human(display_long)|uniprotkb:RPL35(gene name)|psi-mi:RPL35(display_short)|uniprotkb:Large ribosomal subunit protein uL29(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_009140.1|ensembl:ENSG00000136942(gene)|ensembl:ENST00000348462(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001854(Ribosomal protein L29)|interpro:IPR018254|interpro:IPR036049|mint:P42766|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:jhzt7gCff2vdUb1Ff/VTBF698Pg9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46778 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350634|uniprotkb:Q16699|ensembl:ENSP00000346027|ensembl:ENSP00000351021|ensembl:ENSP00000370569|ensembl:ENSP00000370574 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl21_human(display_long)|uniprotkb:RPL21(gene name)|psi-mi:RPL21(display_short)|uniprotkb:Large ribosomal subunit protein eL21(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:6LU8|refseq:NP_000973.2|ensembl:ENSG00000122026(gene)|ensembl:ENST00000272274(transcript)|ensembl:ENST00000311549(transcript)|ensembl:ENST00000319826(transcript)|ensembl:ENST00000326092(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001147(Ribosomal protein L21e)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:P46778|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6OLE|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:UCth+WL9Oj1Y9I5m4i/9X0a5WHk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P61313 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q07020 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P30050 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352743|uniprotkb:Q6PB27|uniprotkb:Q5VVV2|ensembl:ENSP00000354739 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl12_human(display_long)|uniprotkb:RPL12(gene name)|psi-mi:RPL12(display_short)|uniprotkb:Large ribosomal subunit protein uL11(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000967.1|ensembl:ENSG00000197958(gene)|ensembl:ENST00000361436(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P30050|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:TNPEtl60cILofaPzUznvZiw6D7E9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62701 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354303|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|uniprotkb:Q6IPY4|ensembl:ENSP00000362744 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs4x_human(display_long)|uniprotkb:RPS4X(gene name)|psi-mi:RPS4X(display_short)|uniprotkb:CCG2(gene name synonym)|uniprotkb:RPS4(gene name synonym)|uniprotkb:SCAR(gene name synonym)|uniprotkb:Single copy abundant mRNA protein(gene name synonym)|uniprotkb:SCR10(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000998.1|rcsb pdb:6OLI|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000198034(gene)|ensembl:ENST00000316084(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62701|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|go:"GO:0045727"(positive regulation of translation)|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P39023 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P18124 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62424 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354172|uniprotkb:P11518|uniprotkb:Q5T8U4|ensembl:ENSP00000361076|ensembl:ENSP00000487443 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl7a_human(display_long)|uniprotkb:RPL7A(gene name)|psi-mi:RPL7A(display_short)|uniprotkb:SURF-3(gene name synonym)|uniprotkb:SURF3(gene name synonym)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:PLA-X polypeptide(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL8(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000963.1|dip:DIP-31502N|ensembl:ENSG00000148303(gene)|ensembl:ENSG00000280858(gene)|ensembl:ENST00000323345(transcript)|ensembl:ENST00000630979(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P62424|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|go:"GO:0005634"(nucleus)|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:shPtLmc+oabT/rSwho+tP1iJy4k9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q9Y3U8 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1057689|uniprotkb:Q6FIG1|uniprotkb:Q9UQF6|uniprotkb:B2R4Y1|uniprotkb:D6W634|ensembl:ENSP00000252543|ensembl:ENSP00000378081|ensembl:ENSP00000462609|ensembl:ENSP00000464342 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl36_human(display_long)|uniprotkb:RPL36(gene name)|psi-mi:RPL36(display_short)|uniprotkb:Large ribosomal subunit protein eL36(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_056229.2|refseq:NP_378669.1|reactome:R-HSA-975957|mint:Q9Y3U8|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|interpro:IPR038097|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|rcsb pdb:6Y6X|ensembl:ENSG00000130255(gene)|ensembl:ENST00000347512(transcript)|ensembl:ENST00000394580(transcript)|ensembl:ENST00000577222(transcript)|ensembl:ENST00000579649(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000509(Ribosomal protein L36e) - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lRlRMF2jV/UHr4SX95SSCFIEV+s9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62851 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353054|ensembl:ENSP00000435096|ensembl:ENSP00000486392|uniprotkb:P25111|uniprotkb:B2R4M7 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs25_human(display_long)|uniprotkb:RPS25(gene name)|psi-mi:RPS25(display_short)|uniprotkb:Small ribosomal subunit protein eS25(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000118181(gene)|ensembl:ENSG00000280831(gene)|ensembl:ENST00000527673(transcript)|ensembl:ENST00000628770(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004977(Ribosomal protein S25)|interpro:IPR036388|mint:P62851|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y0G|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:6ZXD|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|rcsb pdb:6ZXE|reactome:R-HSA-9010553|reactome:R-HSA-9633012|rcsb pdb:6ZXF|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|refseq:NP_001019.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P36578 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P18621 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-726937|uniprotkb:Q6NZ54|uniprotkb:Q7M4M5|uniprotkb:Q3KQW2|uniprotkb:B2R4H3|uniprotkb:B4E3C2|uniprotkb:B5ME31|uniprotkb:J3QL51|ensembl:ENSP00000462023|ensembl:ENSP00000462385|ensembl:ENSP00000463842|ensembl:ENSP00000480555|ensembl:ENSP00000482577 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl17_human(display_long)|uniprotkb:60S ribosomal protein L23(gene name synonym)|uniprotkb:PD-1(gene name synonym)|uniprotkb:RPL17(gene name)|psi-mi:RPL17(display_short)|uniprotkb:Large ribosomal subunit protein uL22(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000976.1|refseq:NP_001030178.1|refseq:NP_001186269.1|refseq:NP_001186270.1|refseq:NP_001186271.1|refseq:NP_001186272.1|refseq:NP_001186273.1|refseq:NP_001186274.1|ensembl:ENSG00000265681(gene)|ensembl:ENST00000579248(transcript)|ensembl:ENST00000579408(transcript)|ensembl:ENST00000580261(transcript)|ensembl:ENST00000618613(transcript)|ensembl:ENST00000618619(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001063(Ribosomal protein L22/L17)|interpro:IPR005721(Ribosomal protein L22/L17, eukaryotic/archaeal)|interpro:IPR018260|interpro:IPR036394|mint:P18621|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:/i0W3WoeFakz+8R/YMYf2JQZytI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62277 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351850|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|uniprotkb:Q498Y0|uniprotkb:B2R549|ensembl:ENSP00000435777 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs13_human(display_long)|uniprotkb:RPS13(gene name)|psi-mi:RPS13(display_short)|uniprotkb:Small ribosomal subunit protein uS15(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001008.1|ensembl:ENSG00000110700(gene)|ensembl:ENST00000525634(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62277|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6OM7|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62263 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352783|ensembl:ENSP00000311028|ensembl:ENSP00000385425|uniprotkb:P06366|uniprotkb:Q5BJI0|uniprotkb:B2R5G5|uniprotkb:D3DQG5|ensembl:ENSP00000385958|ensembl:ENSP00000428509 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs14_human(display_long)|uniprotkb:RPS14(gene name)|psi-mi:RPS14(display_short)|uniprotkb:Small ribosomal subunit protein uS11(gene name synonym)|uniprotkb:PRO2640(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000164587(gene)|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001020242.1|refseq:NP_005608.1|refseq:NP_001020241.1|ensembl:ENST00000312037(transcript)|ensembl:ENST00000401695(transcript)|ensembl:ENST00000407193(transcript)|ensembl:ENST00000521466(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62263|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62888 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62241 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P26373 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356849|uniprotkb:Q3KQT8|uniprotkb:Q9BPX0|uniprotkb:Q567Q8|uniprotkb:B4DLX3|uniprotkb:F5H1S2|ensembl:ENSP00000307889|ensembl:ENSP00000376811|ensembl:ENSP00000455009 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl13_human(display_long)|uniprotkb:RPL13(gene name)|psi-mi:RPL13(display_short)|uniprotkb:BBC1(gene name synonym)|uniprotkb:Breast basic conserved protein 1(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL13(gene name synonym)|uniprotkb:OK/SW-cl.46(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000968.2|refseq:NP_150254.1|refseq:NP_001230059.1|refseq:NP_001230060.1|ensembl:ENSG00000167526(gene)|ensembl:ENST00000311528(transcript)|ensembl:ENST00000393099(transcript)|ensembl:ENST00000567815(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P26373|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-192823 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:2SZ+AEe41Ystwj9t9I0Z1cZ5GQ49606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62269 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352451|ensembl:ENSP00000211372|ensembl:ENSP00000393241|ensembl:ENSP00000403175|ensembl:ENSP00000412583|ensembl:ENSP00000416110|uniprotkb:P25232|uniprotkb:Q6IPF8|uniprotkb:Q5SUJ3 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs18_human(display_long)|uniprotkb:RPS18(gene name)|psi-mi:RPS18(display_short)|uniprotkb:D6S218E(gene name synonym)|uniprotkb:Ke-3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS13(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_072045.1|ensembl:ENSG00000096150(gene)|ensembl:ENSG00000223367(gene)|ensembl:ENSG00000226225(gene)|ensembl:ENSG00000231500(gene)|ensembl:ENSG00000235650(gene)|ensembl:ENST00000211372(transcript)|ensembl:ENST00000434122(transcript)|ensembl:ENST00000439602(transcript)|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENST00000454021(transcript)|ensembl:ENST00000457341(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62269|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|dip:DIP-32892N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:yOHgKM/BuvgGdqp1OEVPeuiABg89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62829 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353303|uniprotkb:P23131|uniprotkb:Q3SWV7|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q6P5S1|ensembl:ENSP00000377865|ensembl:ENSP00000420311 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl23_human(display_long)|uniprotkb:RPL23(gene name)|psi-mi:RPL23(display_short)|uniprotkb:60S ribosomal protein L17(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL14(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|reactome:R-HSA-9010553|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|refseq:NP_000969.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62829|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|ensembl:ENSG00000125691(gene)|ensembl:ENST00000394332(transcript)|ensembl:ENST00000479035(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005730"(nucleolus)|dip:DIP-33156N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62899 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-1053664|intact:EBI-3867511|uniprotkb:B7Z4K2|uniprotkb:P12947|uniprotkb:Q53SQ5|uniprotkb:Q6LBJ6|uniprotkb:D3DVJ4|uniprotkb:Q6IRZ0|ensembl:ENSP00000264258|ensembl:ENSP00000386681 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl31_human(display_long)|uniprotkb:RPL31(gene name)|psi-mi:RPL31(display_short)|uniprotkb:Large ribosomal subunit protein eL31(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000984.1|refseq:NP_001092047.1|refseq:NP_001093163.1|ensembl:ENSG00000071082(gene)|ensembl:ENST00000264258(transcript)|ensembl:ENST00000409733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62899|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:77LFR7/2somk6blVogZf1XFdJLk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P15880 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-443446|ensembl:ENSP00000341885|uniprotkb:Q3MIB1|uniprotkb:B2R5G0|uniprotkb:D3DU82 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs2_human(display_long)|uniprotkb:RPS2(gene name)|psi-mi:RPS2(display_short)|uniprotkb:RPS4(gene name synonym)|uniprotkb:40S ribosomal protein S4(gene name synonym)|uniprotkb:Protein LLRep3(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS5(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|rcsb pdb:6OLG|rcsb pdb:6OLI|interpro:IPR018192|rcsb pdb:6OLZ|interpro:IPR020568|mint:P15880|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6EK0|rcsb pdb:6G18|rcsb pdb:6XA1|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6G5H|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7JQB|rcsb pdb:7JQC|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-3214858|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8876725|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:7A09|ensembl:ENSG00000140988(gene)|ensembl:ENST00000343262(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045296"(cadherin binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|refseq:NP_002943.2 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:JUr2Y3cGk00S8KaTVPymshfaHhc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62249 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352480|uniprotkb:P17008|uniprotkb:B2RDD5|ensembl:ENSP00000251453 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs16_human(display_long)|uniprotkb:RPS16(gene name)|psi-mi:RPS16(display_short)|uniprotkb:Small ribosomal subunit protein uS9(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001011.1|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000105193(gene)|ensembl:ENST00000251453(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62249|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|dip:DIP-33200N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:OrKriR6HsATLaO+drdUa2w3Gpd09606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P60866 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46783 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P46776 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350581|uniprotkb:B2R4B3|ensembl:ENSP00000346015 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl27a_human(display_long)|uniprotkb:RPL27A(gene name)|psi-mi:RPL27A(display_short)|uniprotkb:Large ribosomal subunit protein uL15(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000981.1|ensembl:ENSG00000166441(gene)|ensembl:ENST00000314138(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR001196(Ribosomal protein L15)|interpro:IPR021131|interpro:IPR027386|interpro:IPR030878|interpro:IPR036227|mint:P46776|rcsb pdb:4BXF|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6IP6|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6OM7|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:6IP5|dip:DIP-33121N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:tUezMQBw+SWmLYq8M0pkLCF8vO89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P84098 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62841 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-372635|uniprotkb:Q3KRA1|uniprotkb:P11174|uniprotkb:A5D8V9|uniprotkb:Q9UDC2|ensembl:ENSP00000467466 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs15_human(display_long)|uniprotkb:RIG protein(gene name synonym)|uniprotkb:RPS15(gene name)|psi-mi:RPS15(display_short)|uniprotkb:RIG(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS19(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001009.1|mint:P62841|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|ensembl:ENSG00000115268(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|ensembl:ENST00000592588(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0097421"(liver regeneration)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR002222(Ribosomal protein S19/S15)|interpro:IPR005713(Ribosomal protein S15, eukaryotic/archaeal)|interpro:IPR020934|go:"GO:0003735"(structural constituent of ribosome)|interpro:IPR023575|rcsb pdb:6ZVH|rcsb pdb:6ZMT|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|rcsb pdb:6ZMW|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lJJOew1txuTwFlhKu4Z+AkPS5H09606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62244 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-347895|ensembl:ENSP00000318646|ensembl:ENSP00000457000|ensembl:ENSP00000458115|ensembl:ENSP00000458528|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q3MHD9|uniprotkb:Q8C023|uniprotkb:Q9BV24 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs15a_human(display_long)|uniprotkb:RPS15A(gene name)|psi-mi:RPS15A(display_short)|uniprotkb:Small ribosomal subunit protein uS8(gene name synonym)|uniprotkb:OK/SW-cl.82(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 ensembl:ENSG00000134419(gene)|ensembl:ENST00000322989(transcript)|ensembl:ENST00000563390(transcript)|ensembl:ENST00000565420(transcript)|ensembl:ENST00000572008(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6G4W|interpro:IPR000630(Ribosomal protein S8)|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|interpro:IPR035987|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|mint:P62244|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:4V6X|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-72695|reactome:R-HSA-975957|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZM7|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|refseq:NP_001010.2|refseq:NP_001025180.1 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P32969 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62906 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P61247 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352378|uniprotkb:P33443|uniprotkb:P49241|uniprotkb:B2R4D4|intact:EBI-3440915|uniprotkb:D3DP05|ensembl:ENSP00000346050 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs3a_human(display_long)|uniprotkb:RPS3A(gene name)|psi-mi:RPS3A(display_short)|uniprotkb:MFTL(gene name synonym)|uniprotkb:FTE1(gene name synonym)|uniprotkb:v-fos transformation effector protein(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS1(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_000997.1|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:4V6X|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000145425(gene)|ensembl:ENST00000274065(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P61247|rcsb pdb:4UG0|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6OM7|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-29408N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:g1TMzz8OFWEuhrRCoecj7KW0qTQ9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62081 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354360|uniprotkb:Q6IPH1|uniprotkb:P23821|uniprotkb:P24818|uniprotkb:Q57Z92|ensembl:ENSP00000385018|ensembl:ENSP00000385286|ensembl:ENSP00000495273|ensembl:ENSP00000496654|ensembl:ENSP00000496757 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs7_human(display_long)|uniprotkb:RPS7(gene name)|psi-mi:RPS7(display_short)|uniprotkb:Small ribosomal subunit protein eS7(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001002.1|ensembl:ENSG00000171863(gene)|ensembl:ENST00000403564(transcript)|ensembl:ENST00000406376(transcript)|ensembl:ENST00000462576(transcript)|ensembl:ENST00000645674(transcript)|ensembl:ENST00000646909(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62081|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6G4S - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:l4aG6I34lmzYhNapbdv2CAAwRwg9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62750 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353254|uniprotkb:P29316|uniprotkb:Q92774|uniprotkb:P39024|uniprotkb:B2R5B2|ensembl:ENSP00000389103 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl23a_human(display_long)|uniprotkb:RPL23A(gene name)|psi-mi:RPL23A(display_short)|uniprotkb:Large ribosomal subunit protein uL23(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|refseq:NP_000975.2|ensembl:ENSG00000198242(gene)|ensembl:ENST00000422514(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62750|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62917 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-438527|ensembl:ENSP00000262584|ensembl:ENSP00000378378|ensembl:ENSP00000433464|uniprotkb:P25120|uniprotkb:Q567Q7|uniprotkb:Q969V7|uniprotkb:Q9BWQ9|uniprotkb:A8K094|uniprotkb:D3DWN2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl8_human(display_long)|uniprotkb:RPL8(gene name)|psi-mi:RPL8(display_short)|uniprotkb:Large ribosomal subunit protein uL2(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 rcsb pdb:4CCN|rcsb pdb:4CCO|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4Y3O|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000161016(gene)|ensembl:ENST00000262584(transcript)|ensembl:ENST00000394920(transcript)|ensembl:ENST00000528957(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098794"(postsynapse)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|mint:P62917|rcsb pdb:4CCM|refseq:NP_000964.1|refseq:NP_150644.1|refseq:NP_001304700.1|refseq:NP_001304711.1|dip:DIP-37967N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P62847 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-354515|uniprotkb:P16632|uniprotkb:Q7Z3D1|uniprotkb:Q5T0P7|uniprotkb:Q5T0P8|uniprotkb:E7EPK6|ensembl:ENSP00000478869 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rs24_human(display_long)|uniprotkb:RPS24(gene name)|psi-mi:RPS24(display_short)|uniprotkb:Small ribosomal subunit protein eS24(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001135757.1|refseq:NP_001017.1|refseq:NP_001135755.1|refseq:NP_148982.1|ensembl:ENSG00000138326(gene)|ensembl:ENST00000613865(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62847|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6XA1|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P27635 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P06748 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-78579|uniprotkb:P08693|uniprotkb:Q12826|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q14115|uniprotkb:Q5EU94|uniprotkb:Q5EU95|uniprotkb:Q5EU96|uniprotkb:Q5EU97|uniprotkb:Q5EU98|uniprotkb:Q5EU99|uniprotkb:Q6V962|uniprotkb:Q8WTW5|uniprotkb:Q96AT6|uniprotkb:Q96DC4|uniprotkb:Q96EA5|uniprotkb:A8K3N7|uniprotkb:B5BU00|uniprotkb:Q9UDJ7|uniprotkb:D3DQL6|uniprotkb:Q9BYG9|ensembl:ENSP00000296930|ensembl:ENSP00000428755 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:npm_human(display_long)|uniprotkb:NPM1(gene name)|psi-mi:NPM1(display_short)|uniprotkb:NPM(gene name synonym)|uniprotkb:Nucleolar phosphoprotein B23(gene name synonym)|uniprotkb:Numatrin(gene name synonym)|uniprotkb:Nucleolar protein NO38(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002511.1|refseq:NP_954654.1|refseq:NP_001032827.1|dip:DIP-30932N|ensembl:ENSG00000181163(gene)|ensembl:ENST00000296930(transcript)|ensembl:ENST00000517671(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001652"(granular component)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042255"(ribosome assembly)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060699"(regulation of endoribonuclease activity)|go:"GO:0060735"(regulation of eIF2 alpha phosphorylation by dsRNA)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902629"(regulation of mRNA stability involved in cellular response to UV)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR032569|interpro:IPR036824|mint:P06748|rcsb pdb:2LLH|rcsb pdb:2P1B|rcsb pdb:2VXD|rcsb pdb:5EHD|reactome:R-HSA-180746|reactome:R-HSA-3899300|reactome:R-HSA-606279|reactome:R-HSA-6804115|reactome:R-HSA-8869496 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:HJ7Mg+XsIhuJiScPKiI0dIa6KpM9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35579 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q14204 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P08670 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P14649 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-358570|ensembl:ENSP00000446643|ensembl:ENSP00000450385 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myl6b_human(display_long)|uniprotkb:MYL6B(gene name)|psi-mi:MYL6B(display_short)|uniprotkb:MLC1SA(gene name synonym)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6B(gene name synonym)|uniprotkb:Myosin light chain 1 slow-twitch muscle A isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001186558.1|refseq:NP_002466.1|ensembl:ENSG00000196465(gene)|ensembl:ENST00000550443(transcript)|ensembl:ENST00000553066(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:1OE9|rcsb pdb:1W7I|rcsb pdb:1W7J|reactome:R-HSA-445355 - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:S0/S5hUxfyyve1JDMojIggOSBb89606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:Q13509 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350989|uniprotkb:Q9BTZ0|uniprotkb:Q9BW10|ensembl:ENSP00000320295|uniprotkb:A8K854 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb3_human(display_long)|uniprotkb:TUBB3(gene name)|psi-mi:TUBB3(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:Tubulin beta-III(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001184110.1|refseq:NP_006077.2|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-6807878|ensembl:ENSG00000258947(gene)|ensembl:ENST00000315491(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007411"(axon guidance)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13509|rcsb pdb:5IJ9|rcsb pdb:5JCO|rcsb pdb:6E7B|rcsb pdb:6S8L|rcsb pdb:6WSL|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|rcsb pdb:5IJ0|dip:DIP-31505N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:A69G+idFQmuzkmCsGyBtGVqglSo9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P35580 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBX2 uniprotkb:P07437 intact:EBI-11600078|intact:EBI-28973003|ensembl:ENSP00000456539|ensembl:ENSP00000458065|ensembl:ENSP00000483555|uniprotkb:E2JJS1 intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829 psi-mi:dux4_human(display_long)|uniprotkb:Double homeobox protein 10(gene name synonym)|uniprotkb:DUX4(gene name)|psi-mi:DUX4(display_short)|uniprotkb:DUX10(gene name synonym) psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name) psi-mi:"MI:0096"(pull down) Ansseau et al. (2015) imex:IM-25050|pubmed:26816005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11614511|imex:IM-25050-119 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000458065|ensembl:ENSP00000456539|ensembl:ENST00000570263|ensembl:ENSP00000455112|ensembl:ENSP00000483555|refseq:NP_001280727.1|refseq:NP_001292997.1|rcsb pdb:5Z6Z|rcsb pdb:5ZFW|rcsb pdb:5ZFY|rcsb pdb:5ZFZ|rcsb pdb:6A8R|rcsb pdb:6DFY|rcsb pdb:6E8C|rcsb pdb:6U81|rcsb pdb:6U82|ensembl:ENSG00000260596(gene)|ensembl:ENST00000565211(transcript)|ensembl:ENST00000569241(transcript)|ensembl:ENST00000616166(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|rcsb pdb:5Z2S|rcsb pdb:5Z2T|refseq:XP_011529816.1|refseq:XP_016885822.1|refseq:XP_016885823.1|refseq:XP_016885824.1|refseq:XP_016885825.1|refseq:XP_016885826.1|refseq:XP_016885827.1|refseq:XP_016885828.1|refseq:XP_016885829.1 refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N - - - figure legend:Supp Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/17 2021/06/18 rogid:+iWx4hshAu2ZSMTwtBvCuWFSwJU9606 rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606 rigid:Jnz3EFZbutnbRwWNuLNEi2vWKMk false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)