#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60861	uniprotkb:Q99873	intact:EBI-2683717|uniprotkb:Q53Y77|uniprotkb:B2RCK9|uniprotkb:Q7Z571|uniprotkb:O43144|uniprotkb:A8KAC2|ensembl:ENSP00000407552	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:gas7_human(display_long)|uniprotkb:KIAA0394(gene name synonym)|uniprotkb:GAS7(gene name)|psi-mi:GAS7(display_short)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579302|imex:IM-25092-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011522346.1|refseq:NP_003635.2|refseq:NP_958836.1|refseq:NP_958839.1|refseq:NP_001124303.1|refseq:XP_005256888.1|refseq:XP_005256889.1|ensembl:ENSG00000007237(gene)|ensembl:ENST00000432992(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR036020|interpro:IPR036028|interpro:IPR037957|rcsb pdb:2LX7|rcsb pdb:2YSH|refseq:XP_016880728.1	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/29	2018/04/06	rogid:AGTjGZ7Nb4FN05kKzZ7POn5n+xQ9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	rigid:phcSzsd/CIWHVtOkFFS6+9UDfnY	false	glutathione s tranferase tag:n-n|sufficient binding region:73..73-110..110(IPR001202)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60861	uniprotkb:P23246	intact:EBI-2683717|uniprotkb:Q53Y77|uniprotkb:B2RCK9|uniprotkb:Q7Z571|uniprotkb:O43144|uniprotkb:A8KAC2|ensembl:ENSP00000407552	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:gas7_human(display_long)|uniprotkb:KIAA0394(gene name synonym)|uniprotkb:GAS7(gene name)|psi-mi:GAS7(display_short)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579302|imex:IM-25092-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011522346.1|refseq:NP_003635.2|refseq:NP_958836.1|refseq:NP_958839.1|refseq:NP_001124303.1|refseq:XP_005256888.1|refseq:XP_005256889.1|ensembl:ENSG00000007237(gene)|ensembl:ENST00000432992(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR036020|interpro:IPR036028|interpro:IPR037957|rcsb pdb:2LX7|rcsb pdb:2YSH|refseq:XP_016880728.1	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/29	2018/04/06	rogid:AGTjGZ7Nb4FN05kKzZ7POn5n+xQ9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:phcSzsd/CIWHVtOkFFS6+9UDfnY	false	glutathione s tranferase tag:n-n|sufficient binding region:73..73-110..110(IPR001202)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60861	uniprotkb:Q07666	intact:EBI-2683717|uniprotkb:Q53Y77|uniprotkb:B2RCK9|uniprotkb:Q7Z571|uniprotkb:O43144|uniprotkb:A8KAC2|ensembl:ENSP00000407552	intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829	psi-mi:gas7_human(display_long)|uniprotkb:KIAA0394(gene name synonym)|uniprotkb:GAS7(gene name)|psi-mi:GAS7(display_short)	psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579302|imex:IM-25092-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011522346.1|refseq:NP_003635.2|refseq:NP_958836.1|refseq:NP_958839.1|refseq:NP_001124303.1|refseq:XP_005256888.1|refseq:XP_005256889.1|ensembl:ENSG00000007237(gene)|ensembl:ENST00000432992(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR036020|interpro:IPR036028|interpro:IPR037957|rcsb pdb:2LX7|rcsb pdb:2YSH|refseq:XP_016880728.1	refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468	-	-	-	figure legend:1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/29	2018/04/06	rogid:AGTjGZ7Nb4FN05kKzZ7POn5n+xQ9606	rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606	rigid:phcSzsd/CIWHVtOkFFS6+9UDfnY	false	glutathione s tranferase tag:n-n|sufficient binding region:73..73-110..110(IPR001202)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11579188	uniprotkb:Q99873	-	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:human_mll_gas7_fusion_protein(display_short)|psi-mi:EBI-11579188(display_long)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579418|imex:IM-25092-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O60861-1(multiple parent)|uniprotkb:Q03164(multiple parent)	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	no-uniprot-update:yes	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/01/29	2018/04/06	rogid:8mHfY68ZSHbw/mk3GtftdMwdALw9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	rigid:oOhRbV+NcRwpu2YRmbhFpKcgYGs	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11579188	uniprotkb:P23246	-	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:human_mll_gas7_fusion_protein(display_short)|psi-mi:EBI-11579188(display_long)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579418|imex:IM-25092-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O60861-1(multiple parent)|uniprotkb:Q03164(multiple parent)	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	no-uniprot-update:yes	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/01/29	2018/04/06	rogid:8mHfY68ZSHbw/mk3GtftdMwdALw9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:oOhRbV+NcRwpu2YRmbhFpKcgYGs	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11579188	uniprotkb:Q07666	-	intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829	psi-mi:human_mll_gas7_fusion_protein(display_short)|psi-mi:EBI-11579188(display_long)	psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579418|imex:IM-25092-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O60861-1(multiple parent)|uniprotkb:Q03164(multiple parent)	refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468	-	no-uniprot-update:yes	-	figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/01/29	2018/04/06	rogid:8mHfY68ZSHbw/mk3GtftdMwdALw9606	rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606	rigid:oOhRbV+NcRwpu2YRmbhFpKcgYGs	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62806	ensembl:ENSMUSG00000038227	intact:EBI-299632|ensembl:ENSMUSP00000085006|ensembl:ENSMUSP00000100029|ensembl:ENSMUSP00000100030|ensembl:ENSMUSP00000100032|ensembl:ENSMUSP00000100033|ensembl:ENSMUSP00000100036|ensembl:ENSMUSP00000100037|ensembl:ENSMUSP00000100042|ensembl:ENSMUSP00000100044|ensembl:ENSMUSP00000100048|ensembl:ENSMUSP00000100546|ensembl:ENSMUSP00000129930|ensembl:ENSMUSP00000136357|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q2M2Q5|intact:EBI-302111|uniprotkb:Q6PDS7|uniprotkb:Q811M0|uniprotkb:A0AUM5|uniprotkb:A4FUP8|uniprotkb:A4QMY0|uniprotkb:Q0VDL9|uniprotkb:Q9D0C9|uniprotkb:Q9D6Q8|uniprotkb:Q5T006	intact:EBI-2891404	psi-mi:h4_mouse(display_long)|uniprotkb:H4c11(gene name)|psi-mi:H4c11(display_short)|uniprotkb:H4c12(gene name)|psi-mi:H4c12(display_short)|uniprotkb:H4c14(gene name)|psi-mi:H4c14(display_short)|uniprotkb:H4c2(gene name)|psi-mi:H4c2(display_short)|uniprotkb:H4c3(gene name)|psi-mi:H4c3(display_short)|uniprotkb:H4c4(gene name)|psi-mi:H4c4(display_short)|uniprotkb:H4c6(gene name)|psi-mi:H4c6(display_short)|uniprotkb:H4c8(gene name)|psi-mi:H4c8(display_short)|uniprotkb:H4c9(gene name)|psi-mi:H4c9(display_short)|uniprotkb:H4f16(gene name)|psi-mi:H4f16(display_short)|uniprotkb:Hist1h4a(gene name synonym)|uniprotkb:Hist4h4(gene name synonym)|uniprotkb:Hist1h4b(gene name synonym)|uniprotkb:Hist1h4c(gene name synonym)|uniprotkb:Hist1h4d(gene name synonym)|uniprotkb:Hist1h4f(gene name synonym)|uniprotkb:Hist1h4h(gene name synonym)|uniprotkb:Hist1h4i(gene name synonym)|uniprotkb:Hist1h4j(gene name synonym)|uniprotkb:Hist1h4k(gene name synonym)|uniprotkb:Hist2h4a(gene name synonym)|uniprotkb:Hist2h4(gene name synonym)|uniprotkb:Hist1h4m(gene name)|psi-mi:Hist1h4m(display_short)|uniprotkb:H4-53(gene name synonym)|uniprotkb:H4-12(gene name synonym)|uniprotkb:H4c1(gene name)|psi-mi:H4c1(display_short)	psi-mi:hoxa9_mouse_gene(display_short)|psi-mi:ENSMUSG00000038227(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11579470|imex:IM-25092-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000060093(gene)|ensembl:ENSMUSG00000060639(gene)|ensembl:ENSMUSG00000060678(gene)|ensembl:ENSMUSG00000060981(gene)|ensembl:ENSMUSG00000061482(gene)|ensembl:ENSMUSG00000064288(gene)|ensembl:ENSMUSG00000067455(gene)|ensembl:ENSMUSG00000069266(gene)|ensembl:ENSMUSG00000069274(gene)|ensembl:ENSMUSG00000069305(gene)|ensembl:ENSMUSG00000069306(gene)|ensembl:ENSMUSG00000091405(gene)|ensembl:ENSMUST00000087714(transcript)|ensembl:ENSMUST00000102964(transcript)|ensembl:ENSMUST00000102965(transcript)|ensembl:ENSMUST00000102967(transcript)|ensembl:ENSMUST00000102968(transcript)|ensembl:ENSMUST00000102971(transcript)|ensembl:ENSMUST00000102972(transcript)|ensembl:ENSMUST00000102977(transcript)|ensembl:ENSMUST00000102979(transcript)|ensembl:ENSMUST00000102983(transcript)|ensembl:ENSMUST00000104941(transcript)|ensembl:ENSMUST00000171473(transcript)|ensembl:ENSMUST00000179285(transcript)|go:"GO:0000228"(nuclear chromosome)|ensembl:ENSMUSG00000096010(gene)|go:"GO:0000786"(nucleosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|mint:P62806|rcsb pdb:1F66|rcsb pdb:1U35|rcsb pdb:2WP2|go:"GO:0003677"(DNA binding)|rcsb pdb:4AU7|rcsb pdb:4DOW|rcsb pdb:5B1L|rcsb pdb:5B1M|rcsb pdb:5XM0|rcsb pdb:5XM1|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-110330|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-4551638|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|refseq:NP_001182350.1|refseq:NP_291074.1|refseq:NP_694813.1|refseq:NP_783583.1|refseq:NP_783585.1|refseq:NP_783586.1|refseq:NP_783587.1|refseq:NP_783588.1|refseq:NP_835499.1|refseq:NP_835500.1|refseq:NP_835515.1|refseq:NP_835582.1|refseq:NP_835583.1|dip:DIP-45837N	-	-	-	-	figure legend:1E, 2B|agonist:MLL-GAS7 or MOZ-TIF2 fusion proteins;in the absence of these proteins there is no interaction.|causality statement:Q99873 is required for the binding of P62806 to ENSMUSG00000038227|causality statement:Q99873 increases the expression  at the RNA level  of ENSMUSG00000038227|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA10090	-	-	false	asymmetric dimethyl-L-arginine:4-4	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q9JIF0	ensembl:ENSMUSG00000020160	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	intact:EBI-11580332	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)|ensembl:meis1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000020160(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580294|imex:IM-25092-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1	refseq:NP_001180200.1|refseq:NP_034919.1	-	-	-	figure legend:1E-2|agonist:MLL-GAS7 fusion protein;in the absence of this protein there is no interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q9JIF0	ensembl:ENSMUSG00000038227	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	intact:EBI-2891404	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:hoxa9_mouse_gene(display_short)|psi-mi:ENSMUSG00000038227(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580468|imex:IM-25092-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1	-	-	-	-	figure legend:2B|agonist:MLL-GAS7 or MOZ-TIF2 fusion proteins;in the absence of these proteins there is no interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q8VCD7	ensembl:ENSMUSG00000038227	intact:EBI-11580493|uniprotkb:Q3UNP7|uniprotkb:Q69ZZ5|uniprotkb:Q8BUY6|uniprotkb:Q8BWA1|ensembl:ENSMUSP00000030102|ensembl:ENSMUSP00000077017	intact:EBI-2891404	psi-mi:kdm4c_mouse(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4C"(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3C(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2C(gene name synonym)|uniprotkb:Kdm4c(gene name)|psi-mi:Kdm4c(display_short)|uniprotkb:Jhdm3c(gene name synonym)|uniprotkb:Jmjd2c(gene name synonym)|uniprotkb:Kiaa0780(gene name synonym)	psi-mi:hoxa9_mouse_gene(display_short)|psi-mi:ENSMUSG00000038227(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580484|imex:IM-25092-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001165566.1|refseq:NP_659036.1|refseq:XP_006538415.1|ensembl:ENSMUST00000077851(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|reactome:R-MMU-3214842|reactome:R-MMU-5625886|ensembl:ENSMUSG00000028397(gene)|ensembl:ENSMUST00000030102(transcript)	-	-	-	-	figure legend:3 F/H|agonist:MLL-GAS7, MLL-AF9  or MOZ-TIF2 fusion proteins;in the absence of these proteins there is no interaction.|comment:When using  MLL-AF9 transduced cells, tamoxifen withdrawal   led to a concomitant reduced recruitment of endogenous Kdm4c on Hoxa9 and Meis1 loci.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:tFdMzJVdBk+JwOhSmol2i85MLJI10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
intact:EBI-2890930	ensembl:ENSMUSG00000038227	-	intact:EBI-2891404	psi-mi:mll_af9_human_protein(display_short)|psi-mi:EBI-2890930(display_long)	psi-mi:hoxa9_mouse_gene(display_short)|psi-mi:ENSMUSG00000038227(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580558|imex:IM-25092-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	uniprotkb:Q03164(multiple parent)|uniprotkb:P42568(multiple parent)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:MLL derived protein of the protein corresponds to the CxxC-RD2 portion of the parent protein, only.	-	figure legend:Supp 3B|comment:Upon tamoxifen withdrawal a  marked reduction of MLL fusion binding to the Hoxa9 and Meis1 promoters was observed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:dbe/f+B0o5xYoJoBDcoLm5NTboQ9606	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
intact:EBI-2890930	ensembl:ENSMUSG00000020160	-	intact:EBI-11580332	psi-mi:mll_af9_human_protein(display_short)|psi-mi:EBI-2890930(display_long)	uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)|ensembl:meis1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000020160(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580743|imex:IM-25092-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	uniprotkb:Q03164(multiple parent)|uniprotkb:P42568(multiple parent)	refseq:NP_001180200.1|refseq:NP_034919.1	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:MLL derived protein of the protein corresponds to the CxxC-RD2 portion of the parent protein, only.	-	figure legend:Supp 3Bi|comment:Upon tamoxifen withdrawal a  marked reduction of MLL fusion binding to the Hoxa9 and Meis1 promoters was observed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:dbe/f+B0o5xYoJoBDcoLm5NTboQ9606	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q8VCD7	ensembl:ENSMUSG00000020160	intact:EBI-11580493|uniprotkb:Q3UNP7|uniprotkb:Q69ZZ5|uniprotkb:Q8BUY6|uniprotkb:Q8BWA1|ensembl:ENSMUSP00000030102|ensembl:ENSMUSP00000077017	intact:EBI-11580332	psi-mi:kdm4c_mouse(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4C"(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3C(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2C(gene name synonym)|uniprotkb:Kdm4c(gene name)|psi-mi:Kdm4c(display_short)|uniprotkb:Jhdm3c(gene name synonym)|uniprotkb:Jmjd2c(gene name synonym)|uniprotkb:Kiaa0780(gene name synonym)	uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)|ensembl:meis1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000020160(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Cheung et al. (2016)	imex:IM-25092|pubmed:26766589	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11580754|imex:IM-25092-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001165566.1|refseq:NP_659036.1|refseq:XP_006538415.1|ensembl:ENSMUST00000077851(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|reactome:R-MMU-3214842|reactome:R-MMU-5625886|ensembl:ENSMUSG00000028397(gene)|ensembl:ENSMUST00000030102(transcript)	refseq:NP_001180200.1|refseq:NP_034919.1	-	-	-	figure legend:3 H|agonist:MLL-GAS7, MLL-AF9  or MOZ-TIF2 fusion proteins;in the absence of these proteins there is no interaction.|comment:When using  MLL-AF9 transduced cells, tamoxifen withdrawal   led to a concomitant reduced recruitment of endogenous Kdm4c on Hoxa9 and Meis1 loci.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mll_cells)|taxid:10090(Mouse Mixed lineage leukaemia cells)	-	2016/01/29	2016/02/15	rogid:tFdMzJVdBk+JwOhSmol2i85MLJI10090	-	-	false	-	sufficient binding region:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)