#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667450|imex:IM-25110-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q8BX09 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667450|imex:IM-25110-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q91X20 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667450|imex:IM-25110-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q8BX09 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667502|imex:IM-25110-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) - comment:"A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5." - figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rigid:6/4gOUV4O7tujM4SBeJcuLJW2qI false green fluorescent protein tag:n-n|necessary binding region:853..853-1056(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q91X20 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667502|imex:IM-25110-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - comment:"A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5." - figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rigid:6/4gOUV4O7tujM4SBeJcuLJW2qI false green fluorescent protein tag:n-n|necessary binding region:853..853-1056(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667518|imex:IM-25110-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - comment:"A construct Paxip1/Ptip (delta)BRCT3-6 comprising BRCT domains 1 and 2 followed by the Gln-rich sequence and a not further specified NLS sequence also interacted with Pagr1a/Pa1 but not with Ash2l and Rbbp5. A construct Paxip1/Ptip (delta)BRCT1-2 lacking BRCT domains 1 and 2 does not interact with Pagr1a/Pa1 but retains association with Ash2l and Rbbp5. A Paxip1/Ptip mutant trp75arg interacts with Pagr1a/Pa1." - figure legend:1D and 4C, supplementary 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/06 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false green fluorescent protein tag:n-n|necessary binding region:8..8-183..183(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:P70399 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-11684634|imex:IM-25110-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473 go:"GO:0005634"(nucleus) - - figure legend:supplemental 3C and 4A|comment:Weak interaction in the absence of exogenous DNA damage.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2017/05/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090 rigid:JYwSjg3DkFPkjKR5FfbG006lMU0 false necessary binding region:853..853-989..989(IPR001357)|green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11690971|imex:IM-25110-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - comment:"A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5." - figure legend:1D, 4Ci|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q8BX09 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11690971|imex:IM-25110-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) - comment:"A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5." - figure legend:1D, 4Ci|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q91X20 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11690971|imex:IM-25110-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - comment:"A construct Paxip1/Ptip (delta)BRCT5-6 lacking BRCT domains 5 and 6 retained interaction with Pagr1a/Pa1 but not with Ash2l and Rbbp5." - figure legend:1D, 4Ci|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rigid:dCZJh6oYeOxU2FgcCVOydDNa1Zg false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:P70399 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-11667654|imex:IM-25110-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473 go:"GO:0005634"(nucleus) - - figure legend:supplemental 2D and supplemental 3A|comment:Cells were irradiated|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2017/05/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090 rigid:JYwSjg3DkFPkjKR5FfbG006lMU0 false green fluorescent protein tag:n-n|sufficient binding region:1-852..852|binding-associated region:588..588-852..852 - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q6NZQ4 uniprotkb:P70399 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-11688117|imex:IM-25110-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473 go:"GO:0005634"(nucleus) - - figure legend:supplemental 2D|agonist:irradiation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2017/05/26 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090 rigid:JYwSjg3DkFPkjKR5FfbG006lMU0 false green fluorescent protein tag:c-c - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q6NZQ4 uniprotkb:Q8BX09 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667724|imex:IM-25110-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) - - - figure legend:Supplemental 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rigid:6/4gOUV4O7tujM4SBeJcuLJW2qI false green fluorescent protein tag:n-n|necessary binding region:853..853-1056(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q91X20 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667724|imex:IM-25110-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - - - figure legend:Supplemental 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rigid:6/4gOUV4O7tujM4SBeJcuLJW2qI false green fluorescent protein tag:n-n|necessary binding region:853..853-1056(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11667735|imex:IM-25110-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:Supp 5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2016/03/29 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false mutation disrupting interaction:165-165|green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-11684553|imex:IM-25110-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.1x10^-9(molar) 2016/03/29 2016/04/05 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false sufficient binding region:1-202(IPR001357)|tag:n-n tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-11684575|imex:IM-25110-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/29 2016/04/05 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false sufficient binding region:1-202(IPR001357)|tag:n-n tag:n-n 1 1 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-11684673|imex:IM-25110-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - comment:"A construct Paxip1/Ptip (delta)BRCT3-6 comprising BRCT domains 1 and 2 followed by the Gln-rich sequence and a not further specified NLS sequence also interacted with Pagr1a/Pa1 but not with Ash2l and Rbbp5. A construct Paxip1/Ptip (delta)BRCT1-2 lacking BRCT domains 1 and 2 does not interact with Pagr1a/Pa1 but retains association with Ash2l and Rbbp5. A Paxip1/Ptip mutant trp75arg interacts with Pagr1a/Pa1." - figure legend:supplementary 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/06 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false green fluorescent protein tag:n-n|sufficient binding region:8-183..183(IPR001357) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:1235"(thermal shift binding) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-11688048|imex:IM-25110-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:supplemental 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false sufficient binding region:1-202(IPR001357)|tag:n-n tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-11688093|imex:IM-25110-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 go:"GO:0005634"(nucleus) - - figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false green fluorescent protein tag:n-n - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q6NZQ4 uniprotkb:Q99LT0 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-3843922|ensembl:ENSMUSP00000108190|ensembl:ENSMUSP00000126702|ensembl:ENSMUSP00000156795|ensembl:ENSMUSP00000156830 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:dpy30_mouse(display_long)|uniprotkb:Dpy30(gene name)|psi-mi:Dpy30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_001139694.1|refseq:NP_001139695.1|refseq:NP_001139696.1|refseq:NP_077746.3|dip:DIP-61810N|ensembl:ENSMUSG00000024067(gene)|ensembl:ENSMUST00000112571(transcript)|ensembl:ENSMUST00000164832(transcript)|ensembl:ENSMUST00000232687(transcript)|ensembl:ENSMUST00000233581(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q99LT0|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:mDxCDIA2qGNoPtuHJgm5w4Spu5k10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q8BRH4 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-4292563|uniprotkb:Q5YLV9|uniprotkb:Q8BK12|uniprotkb:Q8C6M3|uniprotkb:Q923H5|uniprotkb:Q923H6 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:kmt2c_mouse(display_long)|uniprotkb:Kmt2c(gene name)|psi-mi:Kmt2c(display_short)|uniprotkb:Mll3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 mint:Q8BRH4|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|reactome:R-MMU-3214841|reactome:R-MMU-8936459|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007338"(single fertilization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|dip:DIP-61282N - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:t98kF/uJQH6BVGbZJcOLWEbwDHI10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q6PDK2 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-996317|ensembl:ENSMUSP00000135941 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:kmt2d_mouse(display_long)|uniprotkb:Kmt2d(gene name)|psi-mi:Kmt2d(display_short)|uniprotkb:ALL1-related protein(gene name synonym)|uniprotkb:Mll2(gene name synonym)|uniprotkb:Mll4(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 ensembl:ENSMUSG00000048154(gene)|ensembl:ENSMUST00000178486(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001555"(oocyte growth)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR041961|interpro:IPR041964|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|interpro:IPR037890 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:qs+SaIIXAulz8JgzSn6k8JfbSG810090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:O70546 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway) - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q8BX09 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q91X20 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q9JL19 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-4292531|uniprotkb:Q9JLT9 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:ncoa6_mouse(display_long)|uniprotkb:Ncoa6(gene name)|psi-mi:Ncoa6(display_short)|uniprotkb:Aib3(gene name synonym)|uniprotkb:Prip(gene name synonym)|uniprotkb:Rap250(gene name synonym)|uniprotkb:Trbp(gene name synonym)|uniprotkb:Activating signal cointegrator 2(gene name synonym)|uniprotkb:Amplified in breast cancer protein 3(gene name synonym)|uniprotkb:Cancer-amplified transcriptional coactivator ASC-2(gene name synonym)|uniprotkb:Nuclear receptor coactivator RAP250(gene name synonym)|uniprotkb:Nuclear receptor-activating protein, 250 kDa(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor-interacting protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051427"(hormone receptor binding)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR026638|interpro:IPR032715|dip:DIP-61283N|reactome:R-MMU-400206|reactome:R-MMU-9707564 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:CiSgF2XDGZ9bKd0Ttbv6uWiptcQ10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:P61965 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-1247084|uniprotkb:Q91VA5|uniprotkb:Q922C9|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|ensembl:ENSMUSP00000109585 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:wdr5_mouse(display_long)|uniprotkb:Wdr5(gene name)|psi-mi:Wdr5(display_short)|uniprotkb:Big(gene name synonym)|uniprotkb:Big3(gene name synonym)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WD repeat-containing protein BIG-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688169|imex:IM-25110-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_543124.1|refseq:XP_006497735.1|dip:DIP-38618N|ensembl:ENSMUSG00000026917(gene)|ensembl:ENSMUST00000113952(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61965|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-8951664 - comment:A trp75arg mutation does not change the association - figure legend:1A, 4A, supplemental Fig. 5A, B and C, supplemental Fig. 1i|comment:Using a Paxip1/Ptip construct missing BRCT domains 1 and 2 as bait, Pagr1a/PA1 is lost from the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU10090 rigid:ckKg2WswYmBoq0CHhsIyPlaBHXI false green fluorescent protein tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6NZQ4 uniprotkb:Q99L02 intact:EBI-1395317|uniprotkb:Q9Z0W6|ensembl:ENSMUSP00000002291 intact:EBI-11667455|ensembl:ENSMUSP00000144243|ensembl:ENSMUSP00000144469 psi-mi:paxi1_mouse(display_long)|uniprotkb:Paxip1(gene name)|psi-mi:Paxip1(display_short)|uniprotkb:Ptip(gene name synonym)|uniprotkb:PAX transactivation activation domain-interacting protein(gene name synonym) psi-mi:pgr1a_mouse(display_long)|uniprotkb:Pagr1a(gene name)|psi-mi:Pagr1a(display_short)|uniprotkb:Pa1(gene name synonym)|uniprotkb:Pagr(gene name synonym)|uniprotkb:PAXIP1-associated protein 1(gene name synonym)|uniprotkb:PTIP-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Starnes et al. (2016) imex:IM-25110|pubmed:26744420 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11688202|imex:IM-25110-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061366.2|ensembl:ENSMUSG00000002221(gene)|ensembl:ENSMUST00000002291(transcript)|go:"GO:0000416"(positive regulation of histone H3-K36 methylation)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060717"(chorion development)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001357(BRCT)|interpro:IPR036420|interpro:IPR037886|mint:Q6NZQ4|reactome:R-MMU-5693571 refseq:NP_084516.1|ensembl:ENSMUSG00000030680(gene)|ensembl:ENSMUSG00000107068(gene)|ensembl:ENSMUST00000200948(transcript)|ensembl:ENSMUST00000202798(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0060717"(chorion development)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR028213 - - - figure legend:Fig. 4A and B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell) - 2016/03/29 2016/04/21 rogid:Zf/0f7XECNVGnewJWFUJi4IYeWA10090 rogid:oJIzMPutCPeLDrb2zMyFpHD4mw410090 rigid:ztX+vOrndisva3+JRhC/Tie8qrA false green fluorescent protein tag:c-c necessary binding region:8..8-183..183(IPR001357) - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)