#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q2FZB8	uniprotkb:P07996	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P02751	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:Q13201	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1641616|uniprotkb:Q6P3T8|uniprotkb:Q4W5L1|uniprotkb:Q6ZUL9|ensembl:ENSP00000264790|ensembl:ENSP00000378431	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:mmrn1_human(display_long)|uniprotkb:MMRN1(gene name)|psi-mi:MMRN1(display_short)|uniprotkb:ECM(gene name synonym)|uniprotkb:EMILIN4(gene name synonym)|uniprotkb:MMRN(gene name synonym)|uniprotkb:Endothelial cell multimerin(gene name synonym)|uniprotkb:EMILIN-4(gene name synonym)|uniprotkb:Elastin microfibril interface located protein 4(gene name synonym)|uniprotkb:GPIA*(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_031377.2|refseq:XP_016863382.1|ensembl:ENSG00000138722(gene)|ensembl:ENST00000264790(transcript)|ensembl:ENST00000394980(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001073(Complement C1q protein)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|interpro:IPR033188|reactome:R-HSA-114608	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:eodXQ66PuB5TZwrWkIkETD76F/Y9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:Q9Y6C2	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-744586|ensembl:ENSP00000369677|uniprotkb:A0A0C4DFX3|intact:EBI-902920|uniprotkb:A5PL03|uniprotkb:H0Y7A0|uniprotkb:Q53SY9|uniprotkb:Q96G58|uniprotkb:Q96IH6|uniprotkb:Q9UG76	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:emil1_human(display_long)|uniprotkb:EMILIN1(gene name)|psi-mi:EMILIN1(display_short)|uniprotkb:EMI(gene name synonym)|uniprotkb:Elastin microfibril interface-located protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|mint:Q9Y6C2|rcsb pdb:2KA3|rcsb pdb:2OII|reactome:R-HSA-2129379|ensembl:ENSG00000138080(gene)|ensembl:ENST00000380320(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098640"(integrin binding involved in cell-matrix adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1904027"(negative regulation of collagen fibril organization)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:1990971"(EMILIN complex)|refseq:NP_008977.1|dip:DIP-35733N	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:lJnDOaq3HA5TUGd1Skz/1s3DIxM9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:Q70J99	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-11479429|uniprotkb:B4DWG9|uniprotkb:Q9H7K5|ensembl:ENSP00000207549	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:un13d_human(display_long)|uniprotkb:UNC13D(gene name)|psi-mi:UNC13D(display_short)|uniprotkb:Munc13-4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_954712.1|ensembl:ENSG00000092929(gene)|ensembl:ENST00000207549(transcript)|go:"GO:0002432"(granuloma formation)|go:"GO:0002467"(germinal center formation)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR035892|reactome:R-HSA-6798695	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:caA8/VwktSz+pczqvN/tFLatKWo9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P16109	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1030170|uniprotkb:Q8IVD1|uniprotkb:Q5R344|ensembl:ENSP00000263686	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:lyam3_human(display_long)|uniprotkb:SELP(gene name)|psi-mi:SELP(display_short)|uniprotkb:GMRP(gene name synonym)|uniprotkb:Granule membrane protein 140(gene name synonym)|uniprotkb:Platelet activation dependent granule-external membrane protein(gene name synonym)|uniprotkb:Leukocyte-endothelial cell adhesion molecule 3(gene name synonym)|uniprotkb:CD62 antigen-like family member P(gene name synonym)|uniprotkb:GRMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR002396("Selectin (CD62E/L/P antigen)")|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033991|interpro:IPR035976|rcsb pdb:1FSB|rcsb pdb:1G1Q|rcsb pdb:1G1R|rcsb pdb:1G1S|rcsb pdb:1HES|rcsb pdb:1KJD|reactome:R-HSA-114608|reactome:R-HSA-202733|go:"GO:0043208"(glycosphingolipid binding)|refseq:NP_002996.2|ensembl:ENSG00000174175(gene)|ensembl:ENST00000263686(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033623"(regulation of integrin activation)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042806"(fucose binding)|dip:DIP-37667N|refseq:XP_005245492.1|refseq:XP_005245493.1	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:4TKKvezIRO3QHfWgUF+0wGYXkIM9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P02679	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1034422|uniprotkb:P04469|uniprotkb:P04470|uniprotkb:Q96A14|uniprotkb:Q96KJ3|uniprotkb:A8K057|uniprotkb:Q53Y18|uniprotkb:Q9UC62|uniprotkb:Q9UC63|uniprotkb:Q9UCF3|ensembl:ENSP00000336829	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:fibg_human(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_000500.2|refseq:NP_068656.2|ensembl:ENSG00000171557(gene)|ensembl:ENST00000336098(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0009306"(protein secretion)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR037581|mint:P02679|rcsb pdb:1DUG|rcsb pdb:1FIB|rcsb pdb:1FIC|rcsb pdb:1FID|rcsb pdb:1FZA|go:"GO:0070527"(platelet aggregation)|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2FIB|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2HWL|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:2VR3|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Y7L|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:2Q9I|rcsb pdb:3FIB|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4B60|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29644N	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:QKWesyU4/fduceFtu5zq31oGhYI9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P01024	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P00747	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-999394|uniprotkb:Q15146|uniprotkb:Q5TEH4|uniprotkb:Q6PA00|ensembl:ENSP00000308938	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:plmn_human(display_long)|uniprotkb:PLG(gene name)|psi-mi:PLG(display_short)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479396|imex:IM-25885-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_000292.1|ensembl:ENSG00000122194(gene)|ensembl:ENST00000308192(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1990405"(protein antigen binding)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P00747|rcsb pdb:1B2I|rcsb pdb:1BML|rcsb pdb:1BUI|rcsb pdb:1CEA|rcsb pdb:1CEB|rcsb pdb:1DDJ|rcsb pdb:1HPJ|rcsb pdb:1HPK|rcsb pdb:1I5K|rcsb pdb:1KI0|rcsb pdb:1KRN|rcsb pdb:1L4D|rcsb pdb:1L4Z|rcsb pdb:1PK4|rcsb pdb:1PKR|rcsb pdb:1PMK|rcsb pdb:1QRZ|rcsb pdb:1RJX|rcsb pdb:2DOH|rcsb pdb:2DOI|rcsb pdb:2KNF|rcsb pdb:2L0S|rcsb pdb:2PK4|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:3UIR|rcsb pdb:4A5T|rcsb pdb:4CIK|rcsb pdb:4DCB|rcsb pdb:4DUR|rcsb pdb:4DUU|rcsb pdb:5HPG|rcsb pdb:5UGD|rcsb pdb:5UGG|rcsb pdb:6D3X|rcsb pdb:6D3Y|rcsb pdb:6D3Z|rcsb pdb:6D40|rcsb pdb:6OG4|rcsb pdb:6OQJ|rcsb pdb:6OQK|rcsb pdb:6Q1U|rcsb pdb:6UZ4|rcsb pdb:6UZ5|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-186797|reactome:R-HSA-381426|reactome:R-HSA-75205	-	-	-	figure legend:table 1 and S1|comment:in the presence of 3 mg/ml added fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:f9Y+uCcA1jrDN1AD/clsKtkZWEQ9606	rigid:XNECsxAaNxdHSnjnOMkMR7/zjww	false	his tag:n-n|sufficient binding region:29-165	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q2FZB8	uniprotkb:P02751	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479474|imex:IM-25885-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:5A|agonist:Fibrinogen|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:MKrv/sA+hw6+0oJmnhMG4Ry+CpI	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:P08514	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479474|imex:IM-25885-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:5A|agonist:Fibrinogen|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606	rigid:MKrv/sA+hw6+0oJmnhMG4Ry+CpI	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:Q13201	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1641616|uniprotkb:Q6P3T8|uniprotkb:Q4W5L1|uniprotkb:Q6ZUL9|ensembl:ENSP00000264790|ensembl:ENSP00000378431	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:mmrn1_human(display_long)|uniprotkb:MMRN1(gene name)|psi-mi:MMRN1(display_short)|uniprotkb:ECM(gene name synonym)|uniprotkb:EMILIN4(gene name synonym)|uniprotkb:MMRN(gene name synonym)|uniprotkb:Endothelial cell multimerin(gene name synonym)|uniprotkb:EMILIN-4(gene name synonym)|uniprotkb:Elastin microfibril interface located protein 4(gene name synonym)|uniprotkb:GPIA*(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479474|imex:IM-25885-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_031377.2|refseq:XP_016863382.1|ensembl:ENSG00000138722(gene)|ensembl:ENST00000264790(transcript)|ensembl:ENST00000394980(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001073(Complement C1q protein)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|interpro:IPR033188|reactome:R-HSA-114608	-	-	-	figure legend:5A|agonist:Fibrinogen|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:eodXQ66PuB5TZwrWkIkETD76F/Y9606	rigid:MKrv/sA+hw6+0oJmnhMG4Ry+CpI	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:P16109	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1030170|uniprotkb:Q8IVD1|uniprotkb:Q5R344|ensembl:ENSP00000263686	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:lyam3_human(display_long)|uniprotkb:SELP(gene name)|psi-mi:SELP(display_short)|uniprotkb:GMRP(gene name synonym)|uniprotkb:Granule membrane protein 140(gene name synonym)|uniprotkb:Platelet activation dependent granule-external membrane protein(gene name synonym)|uniprotkb:Leukocyte-endothelial cell adhesion molecule 3(gene name synonym)|uniprotkb:CD62 antigen-like family member P(gene name synonym)|uniprotkb:GRMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479474|imex:IM-25885-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR002396("Selectin (CD62E/L/P antigen)")|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033991|interpro:IPR035976|rcsb pdb:1FSB|rcsb pdb:1G1Q|rcsb pdb:1G1R|rcsb pdb:1G1S|rcsb pdb:1HES|rcsb pdb:1KJD|reactome:R-HSA-114608|reactome:R-HSA-202733|go:"GO:0043208"(glycosphingolipid binding)|refseq:NP_002996.2|ensembl:ENSG00000174175(gene)|ensembl:ENST00000263686(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033623"(regulation of integrin activation)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042806"(fucose binding)|dip:DIP-37667N|refseq:XP_005245492.1|refseq:XP_005245493.1	-	-	-	figure legend:5A|agonist:Fibrinogen|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:4TKKvezIRO3QHfWgUF+0wGYXkIM9606	rigid:MKrv/sA+hw6+0oJmnhMG4Ry+CpI	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:P07996	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11479474|imex:IM-25885-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	-	-	-	figure legend:5A|agonist:Fibrinogen|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2019/10/18	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	rigid:MKrv/sA+hw6+0oJmnhMG4Ry+CpI	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:Q13201	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1641616|uniprotkb:Q6P3T8|uniprotkb:Q4W5L1|uniprotkb:Q6ZUL9|ensembl:ENSP00000264790|ensembl:ENSP00000378431	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:mmrn1_human(display_long)|uniprotkb:MMRN1(gene name)|psi-mi:MMRN1(display_short)|uniprotkb:ECM(gene name synonym)|uniprotkb:EMILIN4(gene name synonym)|uniprotkb:MMRN(gene name synonym)|uniprotkb:Endothelial cell multimerin(gene name synonym)|uniprotkb:EMILIN-4(gene name synonym)|uniprotkb:Elastin microfibril interface located protein 4(gene name synonym)|uniprotkb:GPIA*(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11506808|imex:IM-25885-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	refseq:NP_031377.2|refseq:XP_016863382.1|ensembl:ENSG00000138722(gene)|ensembl:ENST00000264790(transcript)|ensembl:ENST00000394980(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001073(Complement C1q protein)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR011489(EMI)|interpro:IPR033188|reactome:R-HSA-114608	-	-	-	figure legend:5A|comment:Interaction in the absence of Fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2016/02/16	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:eodXQ66PuB5TZwrWkIkETD76F/Y9606	rigid:Wtj8f1oSqn8PDRgj18/+r3bv2Dk	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2FZB8	uniprotkb:P16109	intact:EBI-11506795|ensemblbacteria:ABD30228	intact:EBI-1030170|uniprotkb:Q8IVD1|uniprotkb:Q5R344|ensembl:ENSP00000263686	psi-mi:q2fzb8_staa8(display_long)|uniprotkb:SAOUHSC_01114(locus name)	psi-mi:lyam3_human(display_long)|uniprotkb:SELP(gene name)|psi-mi:SELP(display_short)|uniprotkb:GMRP(gene name synonym)|uniprotkb:Granule membrane protein 140(gene name synonym)|uniprotkb:Platelet activation dependent granule-external membrane protein(gene name synonym)|uniprotkb:Leukocyte-endothelial cell adhesion molecule 3(gene name synonym)|uniprotkb:CD62 antigen-like family member P(gene name synonym)|uniprotkb:GRMP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:93061(staa8)|taxid:93061("Staphylococcus aureus (strain NCTC 8325)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11506808|imex:IM-25885-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_499658.1|interpro:IPR021033|interpro:IPR041909|ensemblbacteria:ABD30228(transcript)|ensemblbacteria:SAOUHSC_01114(gene)|go:"GO:0001848"(complement binding)|go:"GO:0005615"(extracellular space)|go:"GO:0035899"(negative regulation of blood coagulation in another organism)|refseq:WP_000791587.1|interpro:IPR036233	go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR002396("Selectin (CD62E/L/P antigen)")|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033991|interpro:IPR035976|rcsb pdb:1FSB|rcsb pdb:1G1Q|rcsb pdb:1G1R|rcsb pdb:1G1S|rcsb pdb:1HES|rcsb pdb:1KJD|reactome:R-HSA-114608|reactome:R-HSA-202733|go:"GO:0043208"(glycosphingolipid binding)|refseq:NP_002996.2|ensembl:ENSG00000174175(gene)|ensembl:ENST00000263686(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033623"(regulation of integrin activation)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042806"(fucose binding)|dip:DIP-37667N|refseq:XP_005245492.1|refseq:XP_005245493.1	-	-	-	figure legend:5A|comment:Interaction in the absence of Fibrinogen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/14	2016/02/16	rogid:f06GytH0YbccxVBTiOTnBnPAynU93061	rogid:4TKKvezIRO3QHfWgUF+0wGYXkIM9606	rigid:Wtj8f1oSqn8PDRgj18/+r3bv2Dk	false	his tag:n-n|sufficient binding region:29-103	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14242	uniprotkb:P16109	intact:EBI-1030190|uniprotkb:Q12775|uniprotkb:Q6GTW7|uniprotkb:Q8N7J7|uniprotkb:B4DQC3|uniprotkb:A8K2Y0|ensembl:ENSP00000447752|uniprotkb:B7Z5C7|uniprotkb:J3KMX6	intact:EBI-1030170|uniprotkb:Q8IVD1|uniprotkb:Q5R344|ensembl:ENSP00000263686	psi-mi:selpl_human(display_long)|uniprotkb:SELPLG(gene name)|psi-mi:SELPLG(display_short)|uniprotkb:Selectin P ligand(gene name synonym)	psi-mi:lyam3_human(display_long)|uniprotkb:SELP(gene name)|psi-mi:SELP(display_short)|uniprotkb:GMRP(gene name synonym)|uniprotkb:Granule membrane protein 140(gene name synonym)|uniprotkb:Platelet activation dependent granule-external membrane protein(gene name synonym)|uniprotkb:Leukocyte-endothelial cell adhesion molecule 3(gene name synonym)|uniprotkb:CD62 antigen-like family member P(gene name synonym)|uniprotkb:GRMP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11582275|imex:IM-25885-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193538.1|refseq:NP_002997.2|go:"GO:0050901"(leukocyte tethering or rolling)|ensembl:ENSG00000110876(gene)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0071354"(cellular response to interleukin-6)|ensembl:ENST00000550948(transcript)|go:"GO:0001618"(virus receptor activity)|interpro:IPR026195|go:"GO:0001931"(uropod)|rcsb pdb:1G1S|reactome:R-HSA-202733|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030097"(hemopoiesis)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0050900"(leukocyte migration)|dip:DIP-37668N	go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR002396("Selectin (CD62E/L/P antigen)")|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033991|interpro:IPR035976|rcsb pdb:1FSB|rcsb pdb:1G1Q|rcsb pdb:1G1R|rcsb pdb:1G1S|rcsb pdb:1HES|rcsb pdb:1KJD|reactome:R-HSA-114608|reactome:R-HSA-202733|go:"GO:0043208"(glycosphingolipid binding)|refseq:NP_002996.2|ensembl:ENSG00000174175(gene)|ensembl:ENST00000263686(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033623"(regulation of integrin activation)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042806"(fucose binding)|dip:DIP-37667N|refseq:XP_005245492.1|refseq:XP_005245493.1	-	-	-	figure legend:7B|antagonist:Q2FZB8 -EFB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2016/01/14	2016/02/16	rogid:9UTaluLRA9WEeiqsCXJMkKOmbhc9606	rogid:4TKKvezIRO3QHfWgUF+0wGYXkIM9606	rigid:k6Yo5GiRKlo6fO2cjsW0LE3URfw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14242	uniprotkb:P16109	intact:EBI-1030190|uniprotkb:Q12775|uniprotkb:Q6GTW7|uniprotkb:Q8N7J7|uniprotkb:B4DQC3|uniprotkb:A8K2Y0|ensembl:ENSP00000447752|uniprotkb:B7Z5C7|uniprotkb:J3KMX6	intact:EBI-1030170|uniprotkb:Q8IVD1|uniprotkb:Q5R344|ensembl:ENSP00000263686	psi-mi:selpl_human(display_long)|uniprotkb:SELPLG(gene name)|psi-mi:SELPLG(display_short)|uniprotkb:Selectin P ligand(gene name synonym)	psi-mi:lyam3_human(display_long)|uniprotkb:SELP(gene name)|psi-mi:SELP(display_short)|uniprotkb:GMRP(gene name synonym)|uniprotkb:Granule membrane protein 140(gene name synonym)|uniprotkb:Platelet activation dependent granule-external membrane protein(gene name synonym)|uniprotkb:Leukocyte-endothelial cell adhesion molecule 3(gene name synonym)|uniprotkb:CD62 antigen-like family member P(gene name synonym)|uniprotkb:GRMP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Posner et al. (2015)	pubmed:26627825|imex:IM-25885	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11582290|imex:IM-25885-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193538.1|refseq:NP_002997.2|go:"GO:0050901"(leukocyte tethering or rolling)|ensembl:ENSG00000110876(gene)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0071354"(cellular response to interleukin-6)|ensembl:ENST00000550948(transcript)|go:"GO:0001618"(virus receptor activity)|interpro:IPR026195|go:"GO:0001931"(uropod)|rcsb pdb:1G1S|reactome:R-HSA-202733|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030097"(hemopoiesis)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0050900"(leukocyte migration)|dip:DIP-37668N	go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR002396("Selectin (CD62E/L/P antigen)")|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033991|interpro:IPR035976|rcsb pdb:1FSB|rcsb pdb:1G1Q|rcsb pdb:1G1R|rcsb pdb:1G1S|rcsb pdb:1HES|rcsb pdb:1KJD|reactome:R-HSA-114608|reactome:R-HSA-202733|go:"GO:0043208"(glycosphingolipid binding)|refseq:NP_002996.2|ensembl:ENSG00000174175(gene)|ensembl:ENST00000263686(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033623"(regulation of integrin activation)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034097"(response to cytokine)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042806"(fucose binding)|dip:DIP-37667N|refseq:XP_005245492.1|refseq:XP_005245493.1	-	-	-	figure legend:7C|antagonist:Q2FZB8 -EFB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2016/01/14	2016/03/03	rogid:9UTaluLRA9WEeiqsCXJMkKOmbhc9606	rogid:4TKKvezIRO3QHfWgUF+0wGYXkIM9606	rigid:k6Yo5GiRKlo6fO2cjsW0LE3URfw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)