#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P34900 uniprotkb:P34900 intact:EBI-1173032 intact:EBI-1173032 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-11691521|imex:IM-25119-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 - - - figure legend:Fig. 1B, Fig. 1C, Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/04/27 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rigid:TMaD1jd56WfIj2LSodxfuU+oFsk false his tag:c-c|mutation disrupting interaction strength:157-157|mutation decreasing interaction strength:159-159|mutation decreasing interaction strength:162-162 his tag:c-c|mutation disrupting interaction strength:157-157|mutation decreasing interaction strength:159-159|mutation decreasing interaction strength:162-162 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34901 uniprotkb:P34901 intact:EBI-1173182|ensembl:ENSRNOP00000019386 intact:EBI-1173182|ensembl:ENSRNOP00000019386 psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734769|imex:IM-25119-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 - - - figure legend:Fig. 1B, Fig. 1C, 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rigid:wcVWL+IiMVjHOtPu4dKCozsuKJs false his tag:c-c his tag:c-c - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P34901 intact:EBI-1173032 intact:EBI-1173182|ensembl:ENSRNOP00000019386 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734777|imex:IM-25119-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 - - - figure legend:Fig. 1C, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rigid:rKDj5JubvRwh/8m4EWh/QaZv6oU false his tag:c-c|mutation disrupting interaction strength:157-157|mutation decreasing interaction strength:159-159|mutation with no effect:162-162 glutathione s tranferase tag:n-n|sufficient binding region:150-202 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P34901 intact:EBI-1173032 intact:EBI-1173182|ensembl:ENSRNOP00000019386 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734791|imex:IM-25119-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 - - - figure legend:Fig. 1D, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rigid:rKDj5JubvRwh/8m4EWh/QaZv6oU false glutathione s tranferase tag:n-n|sufficient binding region:145-201 his tag:c-c|mutation decreasing interaction strength:164-164 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34901 uniprotkb:P34901 intact:EBI-1173182|ensembl:ENSRNOP00000019386 intact:EBI-1173182|ensembl:ENSRNOP00000019386 psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734896|imex:IM-25119-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 - - - figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rigid:wcVWL+IiMVjHOtPu4dKCozsuKJs false glutathione s tranferase tag:n-n|sufficient binding region:150-202|mutation with no effect:164-164 glutathione s tranferase tag:n-n|sufficient binding region:150-202|mutation with no effect:164-164 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P34900 intact:EBI-1173032 intact:EBI-1173032 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734908|imex:IM-25119-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 - - - figure legend:fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rigid:TMaD1jd56WfIj2LSodxfuU+oFsk false glutathione s tranferase tag:n-n|sufficient binding region:145-201|mutation disrupting interaction strength:157-157|mutation with no effect:159-159|mutation with no effect:162-162 glutathione s tranferase tag:n-n|sufficient binding region:145-201|mutation with no effect:162-162|mutation disrupting interaction strength:157-157|mutation with no effect:159-159 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P26260 intact:EBI-1173032 intact:EBI-1173127|ensembl:ENSRNOP00000072283 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc1_rat(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385405|imex:IM-25119-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 rgd:3648|refseq:NP_037158.1|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-449836|go:"GO:0042476"(odontogenesis)|reactome:R-RNO-975634|ensembl:ENSRNOG00000059947(gene)|ensembl:ENSRNOT00000086633(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing) - - - figure legend:Figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:F3buN7T0HDUo8QN8s+CTlZoprkE10116 rigid:nmVe3XTJbDWg3NuJxuC6i2PuhVw false his tag:c-c|mutation decreasing interaction strength:159-159|mutation disrupting interaction strength:159-159|mutation with no effect:162-162 his tag:c-c - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34901 uniprotkb:P26260 intact:EBI-1173182|ensembl:ENSRNOP00000019386 intact:EBI-1173127|ensembl:ENSRNOP00000072283 psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:sdc1_rat(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385415|imex:IM-25119-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 rgd:3648|refseq:NP_037158.1|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-449836|go:"GO:0042476"(odontogenesis)|reactome:R-RNO-975634|ensembl:ENSRNOG00000059947(gene)|ensembl:ENSRNOT00000086633(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing) - - - figure legend:Figure 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rogid:F3buN7T0HDUo8QN8s+CTlZoprkE10116 rigid:RF3bneH4U19EuoacDWRBRzM0hyE false his tag:c-c|mutation decreasing interaction strength:164-164 his tag:c-c - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P26260 uniprotkb:P26260 intact:EBI-1173127|ensembl:ENSRNOP00000072283 intact:EBI-1173127|ensembl:ENSRNOP00000072283 psi-mi:sdc1_rat(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd1(gene name synonym) psi-mi:sdc1_rat(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385425|imex:IM-25119-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3648|refseq:NP_037158.1|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-449836|go:"GO:0042476"(odontogenesis)|reactome:R-RNO-975634|ensembl:ENSRNOG00000059947(gene)|ensembl:ENSRNOT00000086633(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing) rgd:3648|refseq:NP_037158.1|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-449836|go:"GO:0042476"(odontogenesis)|reactome:R-RNO-975634|ensembl:ENSRNOG00000059947(gene)|ensembl:ENSRNOT00000086633(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing) - - - figure legend:Figure 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:F3buN7T0HDUo8QN8s+CTlZoprkE10116 rogid:F3buN7T0HDUo8QN8s+CTlZoprkE10116 rigid:k7C8D+LA96R+Qoc4Ji/PTA6zQlQ false his tag:c-c|mutation with no effect:272-272|mutation with no effect:269-269|mutation with no effect:272-272,269-269|sufficient binding region:258-313 his tag:c-c|sufficient binding region:258-313|mutation with no effect:272-272|mutation with no effect:269-269|mutation with no effect:272-272,269-269 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P26260 intact:EBI-1173032 intact:EBI-1173127|ensembl:ENSRNOP00000072283 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc1_rat(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385482|imex:IM-25119-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 rgd:3648|refseq:NP_037158.1|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-449836|go:"GO:0042476"(odontogenesis)|reactome:R-RNO-975634|ensembl:ENSRNOG00000059947(gene)|ensembl:ENSRNOT00000086633(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing) - - - figure legend:"Figure 6D (right panel)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:F3buN7T0HDUo8QN8s+CTlZoprkE10116 rigid:nmVe3XTJbDWg3NuJxuC6i2PuhVw false - his tag:c-c|sufficient binding region:258-313|mutation with no effect:272-272|mutation disrupting interaction strength:269-269|mutation disrupting interaction strength:272-272,269-269 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P33671 intact:EBI-1173032 intact:EBI-1173159|uniprotkb:P97614 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc3_rat(display_long)|uniprotkb:Sdc3(gene name)|psi-mi:Sdc3(display_short)|uniprotkb:Synd3(gene name synonym)|uniprotkb:N-syndecan(gene name synonym)|uniprotkb:Neuroglycan(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385499|imex:IM-25119-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044393"(microspike)|interpro:IPR030479|rgd:621486|refseq:NP_446345.3|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|interpro:IPR027789|interpro:IPR031194 - - - figure legend:"Figure 6E (left pannel)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:UOEmNA1pOqZb4unz0WRh0IAvL2k10116 rigid:Ohj5Rp63iGv92tS/BExSCYLUFhk false his tag:c-c|mutation decreasing interaction strength:159-159 his tag:c-c|sufficient binding region:388-442 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34901 uniprotkb:P33671 intact:EBI-1173182|ensembl:ENSRNOP00000019386 intact:EBI-1173159|uniprotkb:P97614 psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:sdc3_rat(display_long)|uniprotkb:Sdc3(gene name)|psi-mi:Sdc3(display_short)|uniprotkb:Synd3(gene name synonym)|uniprotkb:N-syndecan(gene name synonym)|uniprotkb:Neuroglycan(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-15385511|imex:IM-25119-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044393"(microspike)|interpro:IPR030479|rgd:621486|refseq:NP_446345.3|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|interpro:IPR027789|interpro:IPR031194 - - - figure legend:"Figure 6E (right pannel)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2017/07/02 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rogid:UOEmNA1pOqZb4unz0WRh0IAvL2k10116 rigid:65veJCHOkmW5moRe6PCivI4bF/8 false his tag:c-c|mutation decreasing interaction strength:164-164 his tag:c-c|sufficient binding region:388-442 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34900 uniprotkb:P34901 intact:EBI-1173032 intact:EBI-1173182|ensembl:ENSRNOP00000019386 psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0047"(far western blotting) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734864|imex:IM-25119-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 - - - figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/04/27 2016/12/22 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rigid:rKDj5JubvRwh/8m4EWh/QaZv6oU false mutation decreasing interaction:159-159|his tag:c-c sufficient binding region:150-202|glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34901 uniprotkb:P34900 intact:EBI-1173182|ensembl:ENSRNOP00000019386 intact:EBI-1173032 psi-mi:sdc4_rat(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Synd4(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:sdc2_rat(display_long)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:"MI:0096"(pull down) Kwon et al. (2016) imex:IM-25119|pubmed:26601939 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12734929|imex:IM-25119-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000014297(gene)|ensembl:ENSRNOT00000019386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0001843"(neural tube closure)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:5A2P|rcsb pdb:5G1D|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-975634|rgd:3650|refseq:NP_036781.1 rgd:3649|refseq:NP_037214.1|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR001050(Syndecan)|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-3000170|reactome:R-RNO-381426|reactome:R-RNO-3928662|reactome:R-RNO-8957275|reactome:R-RNO-975634|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR030479|interpro:IPR027789|interpro:IPR031201 - - - figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2016/04/27 2016/12/22 rogid:3gbcHld6lSjVWpQQN5A+7PtnX6U10116 rogid:O9SbH9CmVrBkDpYaa2NTck1YNHI10116 rigid:rKDj5JubvRwh/8m4EWh/QaZv6oU false glutathione s tranferase tag:n-n|sufficient binding region:150-202 his tag:c-c|mutation disrupting interaction strength:159-159 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)