#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99836	uniprotkb:Q6SZW1	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11693750|imex:IM-25237-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/03	2016/05/05	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:iIVpLMAx1Gss8X9VJiK8F981w+s	false	green fluorescent protein tag:n-n	v5 tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q99836	uniprotkb:Q6SZW1	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11693592|imex:IM-25237-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/05	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:iIVpLMAx1Gss8X9VJiK8F981w+s	false	sufficient binding region:148-296(IPR000157)|glutathione s tranferase tag:n-n	mutation disrupting interaction strength:601-601|his tag:?-?|sufficient binding region:559-700(IPR000157)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IUC6	uniprotkb:Q6SZW1	intact:EBI-525995|uniprotkb:O75532|uniprotkb:Q86XP8|uniprotkb:Q96GA0|uniprotkb:B3Y691|ensembl:ENSP00000248244	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:tcam1_human(display_long)|uniprotkb:PRVTIRB(gene name synonym)|uniprotkb:TRIF(gene name synonym)|uniprotkb:Proline-rich, vinculin and TIR domain-containing protein B(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502H(gene name synonym)|uniprotkb:TICAM1(gene name)|psi-mi:TICAM1(display_short)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11693607|imex:IM-25237-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_891549.1|ensembl:ENSG00000127666(gene)|ensembl:ENST00000248244(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|rcsb pdb:2M1X|rcsb pdb:2M63|rcsb pdb:3RC4|rcsb pdb:4BSX|rcsb pdb:4C0M|rcsb pdb:5JEL|reactome:R-HSA-140534|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|dip:DIP-33490N	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	-	-	-	figure legend:3Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/05	rogid:QolsJvUL2R6GSyE8ZmpFyJIBoH89606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:ApZWKxUvmlKqG+rzD3jjBM92QH0	false	sufficient binding region:368-537(IPR000157)|glutathione s tranferase tag:n-n	mutation disrupting interaction strength:601-601|his tag:?-?|sufficient binding region:559-700(IPR000157)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99836	uniprotkb:Q6SZW1	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11693719|imex:IM-25237-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	-	-	-	figure legend:7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/05	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:iIVpLMAx1Gss8X9VJiK8F981w+s	false	sufficient binding region:148-296(IPR000157)|his tag:c-c|tag:?-?	mutation disrupting interaction strength:601-601|glutathione s tranferase tag:n-n|sufficient binding region:590-606(IPR000157)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P58753	uniprotkb:Q6SZW1	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694061|imex:IM-25237-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	-	-	-	figure legend:3Cii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/06	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:TyVx+yqcyijJq+EsQJelb9KFgXE	false	glutathione s tranferase tag:n-n	mutation disrupting interaction strength:601-601|his tag:?-?|sufficient binding region:559-700(IPR000157)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86XR7	uniprotkb:Q6SZW1	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694078|imex:IM-25237-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	-	-	-	figure legend:3Ciii|comment:A very weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/06	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:nCT++/919YFvtW6Tb+8Vwg1Av98	false	glutathione s tranferase tag:n-n	his tag:?-?|mutation disrupting interaction strength:601-601|sufficient binding region:559-700(IPR000157)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99836	uniprotkb:Q6SZW1	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	intact:EBI-11693532|uniprotkb:O60277|uniprotkb:Q7LGG3|uniprotkb:Q9NXY5|ensembl:ENSP00000468032	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:sarm1_human(display_long)|uniprotkb:Sterile alpha and Armadillo repeat protein(gene name synonym)|uniprotkb:Sterile alpha motif domain-containing protein 2(gene name synonym)|uniprotkb:Tir-1 homolog(gene name synonym)|uniprotkb:SARM1(gene name)|psi-mi:SARM1(display_short)|uniprotkb:KIAA0524(gene name synonym)|uniprotkb:SAMD2(gene name synonym)|uniprotkb:SARM(gene name synonym)|uniprotkb:"NADP(+) hydrolase SARM1"(gene name synonym)|uniprotkb:Sterile alpha and TIR motif-containing protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Carlsson et al. (2016)	imex:IM-25237|pubmed:26592460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11693775|imex:IM-25237-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	refseq:NP_055892.2|ensembl:ENSG00000004139(gene)|ensembl:ENST00000585482(transcript)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0019677"(NAD catabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034128"(negative regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048678"(response to axon injury)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035897|interpro:IPR039184|rcsb pdb:6O0Q|rcsb pdb:6O0R|rcsb pdb:6O0S|rcsb pdb:6O0T|rcsb pdb:6O0U|rcsb pdb:6O0V|rcsb pdb:6O1B|rcsb pdb:6QWV|rcsb pdb:6WPK|rcsb pdb:6ZFX|rcsb pdb:6ZG0|rcsb pdb:6ZG1|rcsb pdb:7ANW|rcsb pdb:7CM5|rcsb pdb:7CM6|rcsb pdb:7CM7|rcsb pdb:7DJT|rcsb pdb:7LD0|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072	go:"GO:0005739"(mitochondrion)	-	-	figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/03	2016/05/05	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rogid:n7sfGqChRoQGfwzfXUJV8AY3jDY9606	rigid:iIVpLMAx1Gss8X9VJiK8F981w+s	false	green fluorescent protein tag:n-n	rhodamine label:?-?|sufficient binding region:590-606	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)