#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20809	uniprotkb:P25815	intact:EBI-751694|uniprotkb:Q96EB4|uniprotkb:B4DQV5|ensembl:ENSP00000264563|ensembl:ENSP00000467355	intact:EBI-743700|uniprotkb:Q5J7W2|ensembl:ENSP00000296370	psi-mi:il11_human(display_long)|uniprotkb:Adipogenesis inhibitory factor(gene name synonym)|uniprotkb:IL11(gene name)|psi-mi:IL11(display_short)	psi-mi:s100p_human(display_long)|uniprotkb:S100 calcium-binding protein P(gene name synonym)|uniprotkb:S100P(gene name)|psi-mi:S100P(display_short)|uniprotkb:S100E(gene name synonym)|uniprotkb:Protein S100-E(gene name synonym)|uniprotkb:Migration-inducing gene 9 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638473|imex:IM-25658-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000632.1|refseq:NP_001254647.1|dip:DIP-3775N|ensembl:ENSG00000095752(gene)|ensembl:ENST00000264563(transcript)|ensembl:ENST00000585513(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|rcsb pdb:4MHL|rcsb pdb:6O4O|reactome:R-HSA-6788467	refseq:NP_005971.1|ensembl:ENSG00000163993(gene)|ensembl:ENST00000296370(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010033"(response to organic substance)|go:"GO:0031528"(microvillus membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR034325|rcsb pdb:1J55|rcsb pdb:1OZO|rcsb pdb:2MJW|reactome:R-HSA-6798695|interpro:IPR011992(EF-Hand type)	-	-	-	figure legend:1 A/B|comment:"Data fitted  a  heterogeneous  (two)  ligand model with  one analyte molecule, which generates  two Kd values."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:288.0x10^-9(molar)|kd:32.0x10^-9(molar)	2016/12/20	2020/02/18	rogid:fjQ/ZxeH1m7x9fhgZPGV9G2O28A9606	rogid:wuvwIPFST5gUGqRSJmkUw+CbJv49606	-	false	sufficient binding region:23-199	t7 tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P20809	intact:EBI-1169353	intact:EBI-751694|uniprotkb:Q96EB4|uniprotkb:B4DQV5|ensembl:ENSP00000264563|ensembl:ENSP00000467355	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:il11_human(display_long)|uniprotkb:Adipogenesis inhibitory factor(gene name synonym)|uniprotkb:IL11(gene name)|psi-mi:IL11(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638473|imex:IM-25658-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000632.1|refseq:NP_001254647.1|dip:DIP-3775N|ensembl:ENSG00000095752(gene)|ensembl:ENST00000264563(transcript)|ensembl:ENST00000585513(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|rcsb pdb:4MHL|rcsb pdb:6O4O|reactome:R-HSA-6788467	-	-	-	figure legend:1 A/B|comment:"Data fitted  a  heterogeneous  (two)  ligand model with  one analyte molecule, which generates  two Kd values."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:288.0x10^-9(molar)|kd:32.0x10^-9(molar)	2016/12/20	2020/02/18	-	rogid:fjQ/ZxeH1m7x9fhgZPGV9G2O28A9606	-	false	-	sufficient binding region:23-199	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14626	uniprotkb:P20809	intact:EBI-13638581|ensembl:ENSP00000326500|ensembl:ENSP00000394391|ensembl:ENSP00000450565|uniprotkb:Q16542|uniprotkb:Q5VZ80|uniprotkb:Q7KYJ7	intact:EBI-751694|uniprotkb:Q96EB4|uniprotkb:B4DQV5|ensembl:ENSP00000264563|ensembl:ENSP00000467355	psi-mi:i11ra_human(display_long)|uniprotkb:IL11RA(gene name)|psi-mi:IL11RA(display_short)	psi-mi:il11_human(display_long)|uniprotkb:Adipogenesis inhibitory factor(gene name synonym)|uniprotkb:IL11(gene name)|psi-mi:IL11(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638497|imex:IM-25658-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137070(gene)|ensembl:ENST00000318041(transcript)|ensembl:ENST00000441545(transcript)|ensembl:ENST00000555003(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:6O4P|reactome:R-HSA-6788467|refseq:NP_001136256.1|dip:DIP-3776N	refseq:NP_000632.1|refseq:NP_001254647.1|dip:DIP-3775N|ensembl:ENSG00000095752(gene)|ensembl:ENST00000264563(transcript)|ensembl:ENST00000585513(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|rcsb pdb:4MHL|rcsb pdb:6O4O|reactome:R-HSA-6788467	-	-	-	figure legend:1Ai|comment:"Data fitted  a  heterogeneous  (two)  ligand model with  one analyte molecule, which generates  two Kd values."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-9(molar)|kd:22.0x10^-9(molar)	2016/12/20	2017/02/20	rogid:7qBenN620qP2tYZOSDkEq4MOQhk9606	rogid:fjQ/ZxeH1m7x9fhgZPGV9G2O28A9606	rigid:KwIIEkimwuM4HYdUx0+9/gZxqsI	false	his tag:c-c|sufficient binding region:1-363	sufficient binding region:23-199	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P20809	intact:EBI-1169353	intact:EBI-751694|uniprotkb:Q96EB4|uniprotkb:B4DQV5|ensembl:ENSP00000264563|ensembl:ENSP00000467355	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:il11_human(display_long)|uniprotkb:Adipogenesis inhibitory factor(gene name synonym)|uniprotkb:IL11(gene name)|psi-mi:IL11(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638635|imex:IM-25658-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000632.1|refseq:NP_001254647.1|dip:DIP-3775N|ensembl:ENSG00000095752(gene)|ensembl:ENST00000264563(transcript)|ensembl:ENST00000585513(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|rcsb pdb:4MHL|rcsb pdb:6O4O|reactome:R-HSA-6788467	-	-	-	figure legend:2A|comment:The affinity of S100P to  the strongest IL-11 binding site was derived from the 1st stage of the titration curve  using  the single site binding model.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:50.0x10^-9(molar)	2016/12/20	2020/02/18	-	rogid:fjQ/ZxeH1m7x9fhgZPGV9G2O28A9606	-	false	-	sufficient binding region:23-199	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P25815	intact:EBI-1169353	intact:EBI-743700|uniprotkb:Q5J7W2|ensembl:ENSP00000296370	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s100p_human(display_long)|uniprotkb:S100 calcium-binding protein P(gene name synonym)|uniprotkb:S100P(gene name)|psi-mi:S100P(display_short)|uniprotkb:S100E(gene name synonym)|uniprotkb:Protein S100-E(gene name synonym)|uniprotkb:Migration-inducing gene 9 protein(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638635|imex:IM-25658-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005971.1|ensembl:ENSG00000163993(gene)|ensembl:ENST00000296370(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010033"(response to organic substance)|go:"GO:0031528"(microvillus membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR034325|rcsb pdb:1J55|rcsb pdb:1OZO|rcsb pdb:2MJW|reactome:R-HSA-6798695|interpro:IPR011992(EF-Hand type)	-	-	-	figure legend:2A|comment:The affinity of S100P to  the strongest IL-11 binding site was derived from the 1st stage of the titration curve  using  the single site binding model.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:50.0x10^-9(molar)	2016/12/20	2020/02/18	-	rogid:wuvwIPFST5gUGqRSJmkUw+CbJv49606	-	false	-	t7 tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25815	uniprotkb:P20809	intact:EBI-743700|uniprotkb:Q5J7W2|ensembl:ENSP00000296370	intact:EBI-751694|uniprotkb:Q96EB4|uniprotkb:B4DQV5|ensembl:ENSP00000264563|ensembl:ENSP00000467355	psi-mi:s100p_human(display_long)|uniprotkb:S100 calcium-binding protein P(gene name synonym)|uniprotkb:S100P(gene name)|psi-mi:S100P(display_short)|uniprotkb:S100E(gene name synonym)|uniprotkb:Protein S100-E(gene name synonym)|uniprotkb:Migration-inducing gene 9 protein(gene name synonym)	psi-mi:il11_human(display_long)|uniprotkb:Adipogenesis inhibitory factor(gene name synonym)|uniprotkb:IL11(gene name)|psi-mi:IL11(display_short)	psi-mi:"MI:0030"(cross-linking study)	Kazakov et al. (2015)	imex:IM-25658|pubmed:26551460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638654|imex:IM-25658-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005971.1|ensembl:ENSG00000163993(gene)|ensembl:ENST00000296370(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010033"(response to organic substance)|go:"GO:0031528"(microvillus membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR034325|rcsb pdb:1J55|rcsb pdb:1OZO|rcsb pdb:2MJW|reactome:R-HSA-6798695|interpro:IPR011992(EF-Hand type)	refseq:NP_000632.1|refseq:NP_001254647.1|dip:DIP-3775N|ensembl:ENSG00000095752(gene)|ensembl:ENST00000264563(transcript)|ensembl:ENST00000585513(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|rcsb pdb:4MHL|rcsb pdb:6O4O|reactome:R-HSA-6788467	-	-	-	figure legend:2B|comment:Evidence is shown  of higher order quaternary structures.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/27	rogid:wuvwIPFST5gUGqRSJmkUw+CbJv49606	rogid:fjQ/ZxeH1m7x9fhgZPGV9G2O28A9606	rigid:2hp6zdoKB+abES98INAW2MqkmzU	false	t7 tag:n-n	sufficient binding region:23-199	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)