#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3U1F9	uniprotkb:Q8C3J5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P22682	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q3V3V9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12601364	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P27870	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q99M51	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q60631	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q62077	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603546|imex:IM-25616-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	rigid:lClAwagvkTGclN0EVgRFE0hXIow	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q8C3J5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603588|imex:IM-25616-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	rigid:d0IQ9G599lA4pca54cIKEjW3A/4	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P27870	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603588|imex:IM-25616-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	rigid:d0IQ9G599lA4pca54cIKEjW3A/4	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603588|imex:IM-25616-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:d0IQ9G599lA4pca54cIKEjW3A/4	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P43404	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603604|imex:IM-25616-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090	rigid:zvtmPD+qlCiqoezI6pS8qC/ifSg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q60631	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603604|imex:IM-25616-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:zvtmPD+qlCiqoezI6pS8qC/ifSg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603604|imex:IM-25616-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:zvtmPD+qlCiqoezI6pS8qC/ifSg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P39688	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603604|imex:IM-25616-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rigid:zvtmPD+qlCiqoezI6pS8qC/ifSg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q99M51	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603604|imex:IM-25616-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:zvtmPD+qlCiqoezI6pS8qC/ifSg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603630|imex:IM-25616-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:lVuwdJDfHzBDzsCtzYxg3qO7Ghs	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P39688	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603630|imex:IM-25616-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 5 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rigid:lVuwdJDfHzBDzsCtzYxg3qO7Ghs	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:Q3TBT3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P43404	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P97372	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8322911|intact:MINT-1856584|uniprotkb:O35562|ensembl:ENSMUSP00000100564|ensembl:ENSMUSP00000123798	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:psme2_mouse(display_long)|uniprotkb:Psme2(gene name)|psi-mi:Psme2(display_short)|uniprotkb:Pa28b1(gene name synonym)|uniprotkb:Proteasome activator 28 subunit beta(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 2(gene name synonym)|uniprotkb:11S regulator complex subunit beta(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001025026.1|refseq:NP_035320.1|refseq:NP_001268401.1|ensembl:ENSMUSG00000078153(gene)|ensembl:ENSMUSG00000079197(gene)|ensembl:ENSMUST00000104958(transcript)|ensembl:ENSMUST00000161807(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0019884"(antigen processing and presentation of exogenous antigen)|go:"GO:0042802"(identical protein binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P97372|rcsb pdb:5MSK|rcsb pdb:5MX5|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	function:Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome|comment:mint	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0b+5nbmgXR+6/3o7J9USVFxJgnM10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q921M7	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8321269|intact:MINT-4094888|ensembl:ENSMUSP00000066359|ensembl:ENSMUSP00000132486|ensembl:ENSMUSP00000154320	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cyrib_mouse(display_long)|uniprotkb:Cyrib(gene name)|psi-mi:Cyrib(display_short)|uniprotkb:Cyri(gene name synonym)|uniprotkb:Fam49b(gene name synonym)|uniprotkb:Protein FAM49B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_011243867.1|refseq:XP_011243865.1|refseq:NP_659095.1|refseq:XP_006520824.1|refseq:XP_006520826.1|refseq:XP_006520827.1|ensembl:ENSMUSG00000022378(gene)|ensembl:ENSMUST00000063838(transcript)|ensembl:ENSMUST00000164532(transcript)|ensembl:ENSMUST00000228226(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000568"(positive regulation of memory T cell activation)|interpro:IPR009828(Protein of unknown function DUF1394)|interpro:IPR039789|mint:Q921M7|rcsb pdb:7AJL|reactome:R-MMU-114608	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:TKMOyqWPIodr3CdX53oO2MiyXHY10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9D1A2	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8318864|uniprotkb:Q3TI32|intact:MINT-1855384|uniprotkb:Q99PV1|uniprotkb:Q3TA80|uniprotkb:Q3U7B9|ensembl:ENSMUSP00000025546|ensembl:ENSMUSP00000128696	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cndp2_mouse(display_long)|uniprotkb:Threonyl dipeptidase(gene name synonym)|uniprotkb:Cndp2(gene name)|psi-mi:Cndp2(display_short)|uniprotkb:Cn2(gene name synonym)|uniprotkb:CNDP dipeptidase 2(gene name synonym)|uniprotkb:Glutamate carboxypeptidase-like protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_075638.2|refseq:NP_001276460.1|ensembl:ENSMUSG00000024644(gene)|ensembl:ENSMUST00000025546(transcript)|ensembl:ENSMUST00000168419(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070573"(metallodipeptidase activity)|go:"GO:0103046"(alanylglutamate dipeptidase activity)|interpro:IPR001261(ArgE/DapE/ACY1/CPG2/YscS, conserved site)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|mint:Q9D1A2|rcsb pdb:2ZOF|rcsb pdb:2ZOG|reactome:R-MMU-174403	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:RipGremEoOV4p1sKZm2WMpDG0j010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P08920	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7175423|ensembl:ENSMUSP00000029456|uniprotkb:Q61394|intact:MINT-1769762	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cd2_mouse(display_long)|uniprotkb:Cd2(gene name)|psi-mi:Cd2(display_short)|uniprotkb:Ly-37(gene name synonym)|uniprotkb:T-cell surface antigen T11/Leu-5(gene name synonym)|uniprotkb:LFA-2(gene name synonym)|uniprotkb:LFA-3 receptor(gene name synonym)|uniprotkb:Lymphocyte antigen 37(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000027863(gene)|ensembl:ENSMUST00000029456(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015632(CD2)|interpro:IPR036179|refseq:NP_038514.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:"CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function"	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:M0nSaBaHNtAvb53rDmA23mkSFUU10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P29352	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8654263|ensembl:ENSMUSP00000029433|uniprotkb:Q7TMP9|intact:MINT-1535132	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ptn22_mouse(display_long)|uniprotkb:Ptpn22(gene name)|psi-mi:Ptpn22(display_short)|uniprotkb:Ptpn8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000027843(gene)|ensembl:ENSMUST00000029433(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|refseq:XP_011238343.1|refseq:XP_011238344.1|refseq:NP_033005.1|refseq:XP_006501211.1|refseq:XP_006501212.1|refseq:XP_006501213.1|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:1JEG|reactome:R-MMU-202427|reactome:R-MMU-202430	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|comment:homomint|function:May be an effector and/or regulator of tyrosine-protein kinase CSK in T-cells and other hemopoietic cells	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:J/oQL2AmSxShta0Bv8oM7uMLaBM10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P14824	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2255608|uniprotkb:Q8BSS4|ensembl:ENSMUSP00000104511	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:anxa6_mouse(display_long)|uniprotkb:Anx6(gene name synonym)|uniprotkb:Annexin-6(gene name synonym)|uniprotkb:Annexin VI(gene name synonym)|uniprotkb:Lipocortin VI(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:p70(gene name synonym)|uniprotkb:Protein III(gene name synonym)|uniprotkb:Chromobindin-20(gene name synonym)|uniprotkb:67 kDa calelectrin(gene name synonym)|uniprotkb:Calphobindin-II(gene name synonym)|uniprotkb:Anxa6(gene name)|psi-mi:Anxa6(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001103681.1|refseq:NP_038500.2|ensembl:ENSMUSG00000018340(gene)|ensembl:ENSMUST00000108883(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003418"(growth plate cartilage chondrocyte differentiation)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008289"(lipid binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051283"(negative regulation of sequestering of calcium ion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR001464(Annexin)|interpro:IPR002393(Annexin, type VI)|interpro:IPR018252|interpro:IPR018502|mint:P14824|interpro:IPR037104	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:gBI/VRVr5rZzywytRgsCwvRu2DQ10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P47941	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2642655|uniprotkb:Q8BGC5|uniprotkb:Q3TQ18|ensembl:ENSMUSP00000006293	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:crkl_mouse(display_long)|uniprotkb:Crkol(gene name synonym)|uniprotkb:Crkl(gene name)|psi-mi:Crkl(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001264160.1|refseq:NP_031790.2|ensembl:ENSMUSG00000006134(gene)|ensembl:ENSMUST00000006293(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P47941|reactome:R-MMU-170968|reactome:R-MMU-186763|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027284|go:"GO:0035690"|reactome:R-MMU-912631	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:pLiTTJ+yoeda+z2DvpqltHFJ9M010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P05202	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-444923|uniprotkb:Q3TIP6|uniprotkb:Q3UD91|uniprotkb:Q5HZH5|uniprotkb:O09188|ensembl:ENSMUSP00000034097	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:aatm_mouse(display_long)|uniprotkb:Transaminase A(gene name synonym)|uniprotkb:Glutamate oxaloacetate transaminase 2(gene name synonym)|uniprotkb:Fatty acid-binding protein(gene name synonym)|uniprotkb:Plasma membrane-associated fatty acid-binding protein(gene name synonym)|uniprotkb:Kynurenine aminotransferase 4(gene name synonym)|uniprotkb:Kynurenine aminotransferase IV(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase 4(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase IV(gene name synonym)|uniprotkb:Got2(gene name)|psi-mi:Got2(display_short)|uniprotkb:Got-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_034455.1|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043278"(response to morphine)|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0045471"(response to ethanol)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P05202|rcsb pdb:3HLM|rcsb pdb:3PD6|rcsb pdb:3PDB|reactome:R-MMU-389661|reactome:R-MMU-8963693|reactome:R-MMU-8964539|reactome:R-MMU-70263|ensembl:ENSMUST00000034097(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006533"(aspartate catabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0016212"(kynurenine-oxoglutarate transaminase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0019550"(glutamate catabolic process to aspartate)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030315"(T-tubule)|ensembl:ENSMUSG00000031672(gene)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:derWMXIiDl1XkaQdJ48VFA7HMzM10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P10852	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2909397|ensembl:ENSMUSP00000010239|uniprotkb:Q54AH5|intact:EBI-6909270|uniprotkb:G3UWA6	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:4f2_mouse(display_long)|uniprotkb:Slc3a2(gene name)|psi-mi:Slc3a2(display_short)|uniprotkb:Mdu1(gene name synonym)|uniprotkb:Solute carrier family 3 member 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000010095(gene)|ensembl:ENSMUST00000010239(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003824"(catalytic activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015820"(leucine transport)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044225"(apical pole of neuron)|go:"GO:0045202"(synapse)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904273"(L-alanine import across plasma membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:1990184"(amino acid transport complex)|interpro:IPR006047(Glycosyl hydrolase, family 13, catalytic region)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR031984|interpro:IPR042280|mint:P10852|rcsb pdb:6I9Q|rcsb pdb:6SUA|reactome:R-MMU-210991|reactome:R-MMU-352230|reactome:R-MMU-71240|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|refseq:NP_001154885.1|refseq:NP_032603.3|refseq:XP_017173567.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:GqdgSpLSSvJdZn04CPqNthPnSLE10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P14152	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-494462|uniprotkb:Q3TP22|uniprotkb:Q80Y13|uniprotkb:Q9DB45|ensembl:ENSMUSP00000099938|ensembl:ENSMUSP00000159017	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:mdhc_mouse(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:Mdh1(gene name)|psi-mi:Mdh1(display_short)|uniprotkb:Mor2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032644.3|refseq:NP_001303604.1|ensembl:ENSMUSG00000020321(gene)|ensembl:ENSMUST00000102874(transcript)|ensembl:ENSMUST00000239073(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|go:"GO:0006108"(malate metabolic process)|interpro:IPR022383|interpro:IPR036291|mint:P14152|reactome:R-MMU-70263	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:Yq74ALpVIoaMM9Y2LUS4Sdmfztg10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P42228	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6253572	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:stat4_mouse(display_long)|uniprotkb:Stat4(gene name)|psi-mi:Stat4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071310"(cellular response to organic substance)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|rcsb pdb:1BGF|interpro:IPR015988(STAT transcription factor, coiled coil)|refseq:NP_001295195.1|refseq:NP_035617.1|dip:DIP-1170N|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020958	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:MxJC56kUPN/PBYHJ283JvTTx6jI10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P62880	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-356951|uniprotkb:P11016|uniprotkb:P54312|ensembl:ENSMUSP00000031726|ensembl:ENSMUSP00000129353	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gbb2_mouse(display_long)|uniprotkb:Gnb2(gene name)|psi-mi:Gnb2(display_short)|uniprotkb:Transducin beta chain 2(gene name synonym)|uniprotkb:G protein subunit beta-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_034442.1|refseq:XP_006504616.1|ensembl:ENSMUSG00000029713(gene)|ensembl:ENSMUST00000031726(transcript)|ensembl:ENSMUST00000150063(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62880|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-381676|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:dingPUxdpAhe7UMLquv0eqXNtUM10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9Z0E6	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6909837|ensembl:ENSMUSP00000132435|uniprotkb:Q4FK03|uniprotkb:Q8CIC6|uniprotkb:Q921N2|uniprotkb:Q9R1I0	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gbp2_mouse(display_long)|uniprotkb:Interferon-induced guanylate-binding protein 2(gene name synonym)|uniprotkb:Gbp2(gene name)|psi-mi:Gbp2(display_short)|uniprotkb:GTP-binding protein 2(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000028270(gene)|ensembl:ENSMUST00000165774(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q9Z0E6|go:"GO:0003924"(GTPase activity)|refseq:NP_034390.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:Fa/gXTBkiG0hTxS51ahbnensmC010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99MD9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-913410|uniprotkb:O35499|uniprotkb:O88993|uniprotkb:Q3V150|uniprotkb:Q99KE9	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nasp_mouse(display_long)|uniprotkb:Nasp(gene name)|psi-mi:Nasp(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001271158.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001074944.1|interpro:IPR019544|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q99MD9	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:kdLcXZo8FtCJsQJTD5bAIXInfsk10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99LX0	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P30681	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6910056|ensembl:ENSMUSP00000065940|uniprotkb:Q3UXT1|uniprotkb:Q9EQD5	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:hmgb2_mouse(display_long)|uniprotkb:Hmgb2(gene name)|psi-mi:Hmgb2(display_short)|uniprotkb:Hmg2(gene name synonym)|uniprotkb:High mobility group protein 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_006509587.1|ensembl:ENSMUSG00000054717(gene)|ensembl:ENSMUST00000067925(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032075"(positive regulation of nuclease activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR036910|mint:P30681|reactome:R-MMU-140342|refseq:NP_032278.1|dip:DIP-899N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:z+MIQN4YHLlD59sncgaWv7W9+X010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P63242	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2255623|uniprotkb:P10159|uniprotkb:Q16182|uniprotkb:Q5NCX0|uniprotkb:Q78NR3|uniprotkb:Q9D0G2|ensembl:ENSMUSP00000047008|ensembl:ENSMUSP00000067077|ensembl:ENSMUSP00000068651|ensembl:ENSMUSP00000104247|ensembl:ENSMUSP00000104248|ensembl:ENSMUSP00000104249|ensembl:ENSMUSP00000104250|ensembl:ENSMUSP00000104251|ensembl:ENSMUSP00000104252|ensembl:ENSMUSP00000104253|ensembl:ENSMUSP00000132717	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:if5a1_mouse(display_long)|uniprotkb:Eukaryotic initiation factor 5A isoform 1(gene name synonym)|uniprotkb:eIF-4D(gene name synonym)|uniprotkb:Eif5a(gene name)|psi-mi:Eif5a(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_011247360.1|refseq:NP_001160064.1|refseq:NP_001160065.1|refseq:NP_001160066.1|refseq:NP_001160061.1|refseq:NP_001160062.1|refseq:NP_001160063.1|refseq:NP_001160067.1|refseq:NP_001160068.1|refseq:NP_853613.1|ensembl:ENSMUSG00000078812(gene)|ensembl:ENSMUST00000043419(transcript)|ensembl:ENSMUST00000070996(transcript)|ensembl:ENSMUST00000071026(transcript)|ensembl:ENSMUST00000108607(transcript)|ensembl:ENSMUST00000108608(transcript)|ensembl:ENSMUST00000108609(transcript)|ensembl:ENSMUST00000108610(transcript)|ensembl:ENSMUST00000108611(transcript)|ensembl:ENSMUST00000108612(transcript)|ensembl:ENSMUST00000108613(transcript)|ensembl:ENSMUST00000164359(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007568"(aging)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015031"(protein transport)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030425"(dendrite)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045905"(positive regulation of translational termination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0098586"(cellular response to virus)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001884("Eukaryotic initiation factor 5A hypusine (eIF-5A)")|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR019769|interpro:IPR020189|mint:P63242|reactome:R-MMU-204626	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:/smk81DLs+XvrqXmIZpfvdHHauk10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BKC5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q60631	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P12787	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2934751|ensembl:ENSMUSP00000000090|uniprotkb:Q9D2W1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cox5a_mouse(display_long)|uniprotkb:Cox5a(gene name)|psi-mi:Cox5a(display_short)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0043209"(myelin sheath)|go:"GO:0046872"(metal ion binding)|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P12787|reactome:R-MMU-5628897|reactome:R-MMU-611105|reactome:R-MMU-9707564|ensembl:ENSMUSG00000000088(gene)|ensembl:ENSMUST00000000090(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|refseq:NP_031773.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:TSqMPwzrYDOAB4IRLwU8EcFKdY010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q3TGF2	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2552520|ensembl:ENSMUSP00000027965|ensembl:ENSMUSP00000110705|ensembl:ENSMUSP00000110706|ensembl:ENSMUSP00000110707|uniprotkb:Q9CR82	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:f107b_mouse(display_long)|uniprotkb:Fam107b(gene name)|psi-mi:Fam107b(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000026655(gene)|ensembl:ENSMUST00000027965(transcript)|ensembl:ENSMUST00000115053(transcript)|ensembl:ENSMUST00000115054(transcript)|ensembl:ENSMUST00000115055(transcript)|go:"GO:0007605"(sensory perception of sound)|interpro:IPR009533(Protein of unknown function DUF1151)|refseq:NP_079902.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:VrIZ0/Zw8I5nsNTspJl9Y/nsncE10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C3J5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P08249	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-773487|uniprotkb:Q0QF44|uniprotkb:Q8CF79|uniprotkb:Q8R1P0|ensembl:ENSMUSP00000019323	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:mdhm_mouse(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032643.2|ensembl:ENSMUSG00000019179(gene)|ensembl:ENSMUST00000019323(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P08249|reactome:R-MMU-70263|reactome:R-MMU-71403	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:KG/ilme6qKXuXKp3BqXC5kQ0dM410090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99M51	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P25799	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-643958|uniprotkb:B2RRQ6|uniprotkb:Q3TZE8|uniprotkb:Q3V2V6|uniprotkb:Q6TDG8|uniprotkb:Q75ZL1|uniprotkb:Q80Y21|uniprotkb:Q8C712|ensembl:ENSMUSP00000029812|ensembl:ENSMUSP00000128345	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nfkb1_mouse(display_long)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:NF-kappa-B1 p84/NF-kappa-B1 p98(gene name synonym)|uniprotkb:Nfkb1(gene name)|psi-mi:Nfkb1(display_short)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032715.2|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048535"(lymph node development)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|rcsb pdb:1U3Y|rcsb pdb:1U3Z|rcsb pdb:1U41|rcsb pdb:1U42|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2V2T|rcsb pdb:3JV4|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-5607764|reactome:R-MMU-5621575|rcsb pdb:1U3J|reactome:R-MMU-5684264|reactome:R-MMU-6798695|ensembl:ENSMUSG00000028163(gene)|ensembl:ENSMUST00000029812(transcript)|ensembl:ENSMUST00000164430(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|refseq:XP_006501169.1|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904630"(cellular response to diterpene)|go:"GO:1904632"(cellular response to glucoside)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P25799|rcsb pdb:1BFS|rcsb pdb:1IKN|rcsb pdb:1LE5|rcsb pdb:1LE9|go:"GO:1901653"(cellular response to peptide)|rcsb pdb:1LEI|rcsb pdb:1NFK|rcsb pdb:1OOA|rcsb pdb:1U36|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-933542|reactome:R-MMU-9020702|dip:DIP-85N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:OiCZGnyznh4scSRI6QeIuv4pHbA10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9JL26	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P51881	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q6ZQ38	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-597255|uniprotkb:Q6PFR0|uniprotkb:Q9CV45|ensembl:ENSMUSP00000020315	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cand1_mouse(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:D10Ertd516e(gene name synonym)|uniprotkb:Kiaa0829(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_082270.1|ensembl:ENSMUSG00000020114(gene)|ensembl:ENSMUST00000020315(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:Q6ZQ38|reactome:R-MMU-6798695|reactome:R-MMU-8951664|reactome:R-MMU-917937	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:E6bJujLfT/V3C8Iyk0hUD1m4gT010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P24452	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603150	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:capg_mouse(display_long)|uniprotkb:Capg(gene name)|psi-mi:Capg(display_short)|uniprotkb:Mbh1(gene name synonym)|uniprotkb:Actin regulatory protein CAP-G(gene name synonym)|uniprotkb:Actin-capping protein GCAP39(gene name synonym)|uniprotkb:Myc basic motif homolog 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0001726"(ruffle)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|go:"GO:0030031"(cell projection assembly)|interpro:IPR029006|interpro:IPR029917|dip:DIP-61550N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ADL2NrbHJsHiv+UcH6ES46LMyF010090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P26883	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6379901|ensembl:ENSMUSP00000037206|uniprotkb:Q545E9	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fkb1a_mouse(display_long)|uniprotkb:Fkbp1a(gene name)|psi-mi:Fkbp1a(display_short)|uniprotkb:Fkbp1(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:Rotamase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|mint:P26883|reactome:R-MMU-166208|reactome:R-MMU-2025928|reactome:R-MMU-2173789|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|ensembl:ENSMUSG00000032966(gene)|ensembl:ENSMUST00000044011(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006936"(muscle contraction)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|refseq:NP_001289006.1|refseq:NP_001289007.1|refseq:NP_001289008.1|refseq:NP_001289009.1|dip:DIP-29707N|refseq:NP_032045.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:G3Dq41lUNMncyt6e7S8Ntwy5K3Y10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9CQI6	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603128|ensembl:ENSMUSP00000034285|ensembl:ENSMUSP00000126329	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cotl1_mouse(display_long)|uniprotkb:Clp(gene name synonym)|uniprotkb:Cotl1(gene name)|psi-mi:Cotl1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000031827(gene)|ensembl:ENSMUST00000034285(transcript)|ensembl:ENSMUST00000168698(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR030502|rcsb pdb:1UDM|rcsb pdb:1WM4|reactome:R-MMU-6798695|refseq:NP_082347.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:Em3QFQdUJ8y8vCOISp/RDzYxY6k10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P11352	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BH59	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q62351	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9ES52	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P39688	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603102|imex:IM-25616-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4B, Supplementary Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:RDGs1n4ieKCGIw8bRVrdrMiSwNg	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P24063	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-983966|ensembl:ENSMUSP00000131847	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ital_mouse(display_long)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:Lymphocyte antigen 15(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym)|uniprotkb:Itgal(gene name)|psi-mi:Itgal(display_short)|uniprotkb:Lfa-1(gene name synonym)|uniprotkb:Ly-15(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000030830(gene)|ensembl:ENSMUST00000170971(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-35643N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:+gF/EH5h/001gtCj3z0rC5qtOUc10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P43404	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9JHS9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8338047|uniprotkb:Q3TH98|intact:MINT-4129699|uniprotkb:Q9CTH0|ensembl:ENSMUSP00000004200|ensembl:ENSMUSP00000149476	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cwc15_mouse(display_long)|uniprotkb:Cwc15(gene name)|psi-mi:Cwc15(display_short)|uniprotkb:Ed1(gene name synonym)|uniprotkb:Embryonic development factor 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_075642.1|refseq:XP_006510600.1|ensembl:ENSMUSG00000004096(gene)|ensembl:ENSMUST00000004200(transcript)|ensembl:ENSMUST00000213913(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR006973(Cwf15/Cwc15 cell cycle control protein)|mint:Q9JHS9|reactome:R-MMU-72163	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:Involved in pre-mRNA splicing	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:pgQ5djVtXKeDI0XxT6lCgqOBWz410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P70290	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8315951|ensembl:ENSMUSP00000033775|intact:MINT-4094335	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:em55_mouse(display_long)|uniprotkb:Mpp1(gene name)|psi-mi:Mpp1(display_short)|uniprotkb:Membrane protein, palmitoylated 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000031402(gene)|ensembl:ENSMUST00000033775(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032420"(stereocilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035475|interpro:IPR036028|interpro:IPR036034|mint:P70290|refseq:NP_032647.1|dip:DIP-61219N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:pIVFjZcKNpYbv/lWGedmeKsG/WU10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P54822	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8313878|ensembl:ENSMUSP00000023043|intact:MINT-4109237|uniprotkb:Q8VCD4	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:pur8_mouse(display_long)|uniprotkb:Adsl(gene name)|psi-mi:Adsl(display_short)|uniprotkb:Adl(gene name synonym)|uniprotkb:Adenylosuccinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000022407(gene)|ensembl:ENSMUST00000023043(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004018"("N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006163"(purine nucleotide metabolic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0014850"(response to muscle activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044208"('de novo' AMP biosynthetic process)|go:"GO:0070626"("(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity")|interpro:IPR000362(Fumarate lyase)|interpro:IPR004769(Adenylosuccinate lyase)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR019468|interpro:IPR020557|interpro:IPR022761|mint:P54822|reactome:R-MMU-73817|refseq:NP_033764.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:YVnOAsW+VJuwieYbBhCnXBoLka410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O88890	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7910438|intact:MINT-205896|uniprotkb:A2ANL8|uniprotkb:Q9QWV6|ensembl:ENSMUSP00000005839|ensembl:ENSMUSP00000141070	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sh21a_mouse(display_long)|uniprotkb:Sh2d1a(gene name)|psi-mi:Sh2d1a(display_short)|uniprotkb:Xlp(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001300617.1|refseq:NP_001300618.1|refseq:NP_001300620.1|refseq:NP_035494.1|ensembl:ENSMUSG00000005696(gene)|ensembl:ENSMUST00000005839(transcript)|ensembl:ENSMUST00000189753(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|mint:O88890|reactome:R-MMU-198933	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:VdVOCdnlVE4kM2Ecdk0+guAXki410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BH69	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8357612|intact:MINT-4135416|ensembl:ENSMUSP00000027973|ensembl:ENSMUSP00000110671	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sps1_mouse(display_long)|uniprotkb:Sephs1(gene name)|psi-mi:Sephs1(display_short)|uniprotkb:Sps1(gene name synonym)|uniprotkb:Selenophosphate synthase 1(gene name synonym)|uniprotkb:Selenium donor protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_780609.4|refseq:XP_006497372.1|refseq:XP_017170393.1|ensembl:ENSMUSG00000026662(gene)|ensembl:ENSMUST00000027973(transcript)|ensembl:ENSMUST00000115019(transcript)|go:"GO:0004756"(selenide, water dikinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016260"(selenocysteine biosynthetic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR004536(Selenide water dikinase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|interpro:IPR016188(PurM, N-terminal-like)|interpro:IPR036676|interpro:IPR036921|mint:Q8BH69	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:Synthesizes selenophosphate from selenide and ATP	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:fw2roTJdE4UUJxYFynnMPzrWJ2M10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O08795	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8319543|intact:MINT-1863550|uniprotkb:Q921X2|ensembl:ENSMUSP00000003493|ensembl:ENSMUSP00000149936	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:glu2b_mouse(display_long)|uniprotkb:Prkcsh(gene name)|psi-mi:Prkcsh(display_short)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001280579.1|refseq:NP_001280580.1|refseq:NP_032951.1|refseq:XP_006510158.1|refseq:XP_006510159.1|ensembl:ENSMUSG00000003402(gene)|ensembl:ENSMUST00000003493(transcript)|ensembl:ENSMUST00000216344(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006491"(N-glycan processing)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:O08795|rcsb pdb:5F0E|rcsb pdb:5H9O|rcsb pdb:5HJO|rcsb pdb:5HJR|rcsb pdb:5IED|rcsb pdb:5IEE|rcsb pdb:5IEF|rcsb pdb:5IEG|reactome:R-MMU-381426|reactome:R-MMU-8957275|go:"GO:0017177"(glucosidase II complex)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:Regulatory subunit of glucosidase II	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:4KRTfRiI+suQdxgvkhqNwECnxmc10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P47964	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8365611|intact:MINT-4132614	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:rl36_mouse(display_long)|uniprotkb:Rpl36(gene name)|psi-mi:Rpl36(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	interpro:IPR038097|mint:P47964|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR000509(Ribosomal protein L36e)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:LNDybrXOVq0igi414xuHjWUY1gg10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q3U7R1	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8398881|intact:MINT-2633603|uniprotkb:Q9CVH0|uniprotkb:Q8C8R1|uniprotkb:Q91X62|uniprotkb:Q9Z1X6|uniprotkb:Q9Z1X5|ensembl:ENSMUSP00000026427	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:esyt1_mouse(display_long)|uniprotkb:Mbc2(gene name synonym)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:Esyt1(gene name)|psi-mi:Esyt1(display_short)|uniprotkb:Fam62a(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035973.1|dip:DIP-48746N|ensembl:ENSMUSG00000025366(gene)|ensembl:ENSMUST00000026427(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|interpro:IPR037749|interpro:IPR037752|interpro:IPR039010|mint:Q3U7R1|reactome:R-MMU-1660662|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	crc64:71A397EC52DE6DA9|function:May play a role as calcium-regulated intrinsic membrane protein|comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:XtPbblSF9lqmcX3CTTPj/dsEKGg10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q921M7	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8321269|intact:MINT-4094888|ensembl:ENSMUSP00000066359|ensembl:ENSMUSP00000132486|ensembl:ENSMUSP00000154320	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cyrib_mouse(display_long)|uniprotkb:Cyrib(gene name)|psi-mi:Cyrib(display_short)|uniprotkb:Cyri(gene name synonym)|uniprotkb:Fam49b(gene name synonym)|uniprotkb:Protein FAM49B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_011243867.1|refseq:XP_011243865.1|refseq:NP_659095.1|refseq:XP_006520824.1|refseq:XP_006520826.1|refseq:XP_006520827.1|ensembl:ENSMUSG00000022378(gene)|ensembl:ENSMUST00000063838(transcript)|ensembl:ENSMUST00000164532(transcript)|ensembl:ENSMUST00000228226(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000568"(positive regulation of memory T cell activation)|interpro:IPR009828(Protein of unknown function DUF1394)|interpro:IPR039789|mint:Q921M7|rcsb pdb:7AJL|reactome:R-MMU-114608	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:TKMOyqWPIodr3CdX53oO2MiyXHY10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O35601	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2"	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O08547	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:DRKtD169T9eYZ2kFufLapidvcKs10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P22646	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7803432|ensembl:ENSMUSP00000099896|intact:MINT-7895702	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cd3e_mouse(display_long)|uniprotkb:Cd3e(gene name)|psi-mi:Cd3e(display_short)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P22646|rcsb pdb:1JBJ|rcsb pdb:1XMW|rcsb pdb:2K4F|rcsb pdb:3R08|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|ensembl:ENSMUSG00000032093(gene)|ensembl:ENSMUST00000102832(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|refseq:NP_031674.1|refseq:XP_006510029.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:pCHLuaLDHcsqdyl6Cc0NjIH+4xA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P10300	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7541406|uniprotkb:Q60966|intact:MINT-8303335|uniprotkb:Q61811|uniprotkb:Q31127|ensembl:ENSMUSP00000070131	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cd8b_mouse(display_long)|uniprotkb:Cd8b(gene name)|psi-mi:Cd8b(display_short)|uniprotkb:Cd8b1(gene name synonym)|uniprotkb:Ly-3(gene name synonym)|uniprotkb:Lymphocyte antigen 3(gene name synonym)|uniprotkb:Lyt-3(gene name synonym)|uniprotkb:Lyt3(gene name synonym)|uniprotkb:T-cell membrane glycoprotein Ly-3(gene name synonym)|uniprotkb:T-cell surface glycoprotein Lyt-3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033988.1|ensembl:ENSMUSG00000053044(gene)|ensembl:ENSMUST00000065248(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0050776"(regulation of immune response)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042414|rcsb pdb:2ATP|rcsb pdb:3B9K|rcsb pdb:3DMM|reactome:R-MMU-198933	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:IiuCsHRcaED1wVJL89GP19x76H410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8R5A3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7450496|intact:MINT-1215604|uniprotkb:Q8BRU0|uniprotkb:Q99KV8|uniprotkb:O35329|ensembl:ENSMUSP00000014290	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ab1ip_mouse(display_long)|uniprotkb:Apbb1ip(gene name)|psi-mi:Apbb1ip(display_short)|uniprotkb:Prel1(gene name synonym)|uniprotkb:APBB1-interacting protein 1(gene name synonym)|uniprotkb:Proline-rich EVH1 ligand 1(gene name synonym)|uniprotkb:Proline-rich protein 48(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_011237441.1|refseq:NP_062329.2|refseq:XP_006498249.1|ensembl:ENSMUSG00000026786(gene)|ensembl:ENSMUST00000014290(transcript)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR039664|interpro:IPR039665|rcsb pdb:3TCA|rcsb pdb:4KVG|rcsb pdb:4W8P|rcsb pdb:6O6H|rcsb pdb:6OLU|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-5674135|interpro:IPR000159(Ras-association)|dip:DIP-29358N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|function:Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:9jr93w0wAy+3AaySvJ3H7h/Ja2M10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P29352	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-8654263|ensembl:ENSMUSP00000029433|uniprotkb:Q7TMP9|intact:MINT-1535132	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ptn22_mouse(display_long)|uniprotkb:Ptpn22(gene name)|psi-mi:Ptpn22(display_short)|uniprotkb:Ptpn8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000027843(gene)|ensembl:ENSMUST00000029433(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|refseq:XP_011238343.1|refseq:XP_011238344.1|refseq:NP_033005.1|refseq:XP_006501211.1|refseq:XP_006501212.1|refseq:XP_006501213.1|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:1JEG|reactome:R-MMU-202427|reactome:R-MMU-202430	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:mint|comment:homomint|function:May be an effector and/or regulator of tyrosine-protein kinase CSK in T-cells and other hemopoietic cells	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:J/oQL2AmSxShta0Bv8oM7uMLaBM10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9QUM4	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-7910086|intact:MINT-205762|uniprotkb:Q9QXZ3|ensembl:ENSMUSP00000015460	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:slaf1_mouse(display_long)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:Slam(gene name synonym)|uniprotkb:Slamf1(gene name)|psi-mi:Slamf1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_038758.2|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q9QUM4|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|ensembl:ENSMUSG00000015316(gene)|ensembl:ENSMUST00000015460(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001787"(natural killer cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	function:"High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates"|comment:mint	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:yppESR3UEtf7xYxgnHNpGsRrwBw10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q62077	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q61768	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-776129|uniprotkb:Q5BL10|uniprotkb:O08711|uniprotkb:Q61580|ensembl:ENSMUSP00000025083	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:kinh_mouse(display_long)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)|uniprotkb:Kif5b(gene name)|psi-mi:Kif5b(display_short)|uniprotkb:Khcs(gene name synonym)|uniprotkb:Kns1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032474.2|dip:DIP-32053N|ensembl:ENSMUSG00000006740(gene)|ensembl:ENSMUST00000025083(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021766"(hippocampus development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q61768|rcsb pdb:6IGN|rcsb pdb:6IGV|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:11aePhwWZOqqAabjyanVgdHQQso10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9DAW9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-309337|uniprotkb:Q3TW23|ensembl:ENSMUSP00000029773	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cnn3_mouse(display_long)|uniprotkb:Cnn3(gene name)|psi-mi:Cnn3(display_short)|uniprotkb:Calponin, acidic isoform(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_082320.1|ensembl:ENSMUSG00000053931(gene)|ensembl:ENSMUST00000029773(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030425"(dendrite)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001997(Calponin)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:Q9DAW9	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:cn+rHAOQedU+3wMhUjo4gJugQyo10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BTH8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603493|ensembl:ENSMUSP00000034949|ensembl:ENSMUSP00000145947|uniprotkb:E9QPK6	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:kc1g1_mouse(display_long)|uniprotkb:Csnk1g1(gene name)|psi-mi:Csnk1g1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000032384(gene)|ensembl:ENSMUST00000034949(transcript)|ensembl:ENSMUST00000206594(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022247|refseq:NP_775277.2|refseq:XP_011241010.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:tAke3hPnNGdMc9Hkx3iaueO95WA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P39688	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P09528	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-308950|uniprotkb:Q3UI44|ensembl:ENSMUSP00000025563|ensembl:ENSMUSP00000158539	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:frih_mouse(display_long)|uniprotkb:Fth1(gene name)|psi-mi:Fth1(display_short)|uniprotkb:Fth(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_034369.1|ensembl:ENSMUSG00000024661(gene)|ensembl:ENSMUST00000025563(transcript)|ensembl:ENSMUST00000235196(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006826"(iron ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|mint:P09528|rcsb pdb:3WNW|go:"GO:0008285"(negative regulation of cell population proliferation)|rcsb pdb:5OBA|go:"GO:0044754"(autolysosome)|rcsb pdb:5OBB|go:"GO:0048147"(negative regulation of fibroblast proliferation)|rcsb pdb:6S61|rcsb pdb:6SHT|rcsb pdb:6V21|rcsb pdb:7A4M|rcsb pdb:7KOD|go:"GO:0071682"(endocytic vesicle lumen)|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-917937|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:dg7aqsV02liocLxEKKesIMGxyWs10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9JLI8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6908246|ensembl:ENSMUSP00000019118|uniprotkb:Q6ZQI2|uniprotkb:Q8BPK9|uniprotkb:Q8C3B7|uniprotkb:Q8CFU9	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sart3_mouse(display_long)|uniprotkb:Sart3(gene name)|psi-mi:Sart3(display_short)|uniprotkb:Kiaa0156(gene name synonym)|uniprotkb:Tumor-rejection antigen SART3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000018974(gene)|ensembl:ENSMUST00000019118(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005691"(U6atac snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|refseq:NP_058622.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:8sHlrSQvdRLEdh54zyFG1fA4P8410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8CGK3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-911958|ensembl:ENSMUSP00000041814|uniprotkb:Q3TSK9|uniprotkb:Q3TVL2|uniprotkb:Q3TXE4|uniprotkb:Q3TZW3|uniprotkb:Q9DBP9	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:lonm_mouse(display_long)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)|uniprotkb:Lonp1(gene name)|psi-mi:Lonp1(display_short)|uniprotkb:Prss15(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:Q8CGK3|interpro:IPR020568|ensembl:ENSMUSG00000041168(gene)|ensembl:ENSMUST00000047226(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034622"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|refseq:NP_083058.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:v1wc76SqQNtKne3El7ypY6H1pQI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99PV8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-11293861|uniprotkb:Q8C2I1|uniprotkb:Q99PV6|uniprotkb:Q99PV7|uniprotkb:Q9JLF8|ensembl:ENSMUSP00000068258	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:bc11b_mouse(display_long)|uniprotkb:Bcl11b(gene name)|psi-mi:Bcl11b(display_short)|uniprotkb:Ctip2(gene name synonym)|uniprotkb:Rit1(gene name synonym)|uniprotkb:B-cell CLL/lymphoma 11B(gene name synonym)|uniprotkb:COUP-TF-interacting protein 2(gene name synonym)|uniprotkb:Radiation-induced tumor suppressor gene 1 protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001073352.1|refseq:NP_001273272.1|refseq:NP_067374.2|ensembl:ENSMUSG00000048251(gene)|ensembl:ENSMUST00000066060(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043588"(skin development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0071678"(olfactory bulb axon guidance)|go:"GO:0097535"(lymphoid lineage cell migration into thymus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:fcgBt1xNJI9kSOgCa+J7pNo5FNA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P35278	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2551532|ensembl:ENSMUSP00000102987|uniprotkb:Q8R2N8|uniprotkb:Q8R1V8	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:rab5c_mouse(display_long)|uniprotkb:Rab5c(gene name)|psi-mi:Rab5c(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000019173(gene)|ensembl:ENSMUST00000107364(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1HUQ|rcsb pdb:1Z07|rcsb pdb:1Z0D|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-8856828|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0019003"(GDP binding)|refseq:NP_077776.2|dip:DIP-56521N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:+RBgzzjAJ3ddDtcAq0IDIzHekYE10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9CQV8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P14685	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-992014|uniprotkb:Q3TP95|uniprotkb:Q99LL7|ensembl:ENSMUSP00000017365	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:psmd3_mouse(display_long)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:Transplantation antigen P91A(gene name synonym)|uniprotkb:Tum-P91A antigen(gene name synonym)|uniprotkb:Tstap91a(gene name synonym)|uniprotkb:Psmd3(gene name)|psi-mi:Psmd3(display_short)|uniprotkb:P91a(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033465.1|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-MMU-5610785|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|reactome:R-MMU-1169091|reactome:R-MMU-5632684|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-5658442|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-5668541|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-5676590|reactome:R-MMU-2467813|reactome:R-MMU-5687128|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-6798695|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-68827|ensembl:ENSMUSG00000017221(gene)|ensembl:ENSMUST00000017365(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:WUwE+HYUn3TfD5w+LPjn5ouQSCQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99KF1	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603418|ensembl:ENSMUSP00000105531|uniprotkb:Q9CX02	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:tmed9_mouse(display_long)|uniprotkb:Tmed9(gene name)|psi-mi:Tmed9(display_short)|uniprotkb:Gp25l2(gene name synonym)|uniprotkb:Glycoprotein 25L2(gene name synonym)|uniprotkb:p24 family protein alpha-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000058569(gene)|ensembl:ENSMUST00000109905(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048205"(COPI coating of Golgi vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-MMU-6807878|reactome:R-MMU-6811434|refseq:NP_080487.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:8GhpwiVxcXQEEYfeDFAoC4qmpKI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O55131	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-772161	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sept7_mouse(display_long)|uniprotkb:Septin7(gene name)|psi-mi:Septin7(display_short)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:Cdc10(gene name synonym)|uniprotkb:Sept7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001192296.1|interpro:IPR016491(Septin)|interpro:IPR008115(Septin 7)|interpro:IPR030379|interpro:IPR027417|mint:O55131|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030496"(midbody)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031105"(septin complex)|go:"GO:0031270"(pseudopodium retraction)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032160"(septin filament array)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048668"(collateral sprouting)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|reactome:R-MMU-5687128	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:VULb4UyoWVn5vRWIzERa9YQJIYo10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q62418	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1550322|uniprotkb:Q80WP1|uniprotkb:Q8BH56|uniprotkb:Q3TG34|uniprotkb:Q3U5X3|uniprotkb:Q3U8I5|uniprotkb:Q3UZ33|uniprotkb:Q5NCI5|uniprotkb:Q5NCI6|uniprotkb:Q5NCI7|ensembl:ENSMUSP00000020769	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dbnl_mouse(display_long)|uniprotkb:Dbnl(gene name)|psi-mi:Dbnl(display_short)|uniprotkb:Abp1(gene name synonym)|uniprotkb:Sh3p7(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Actin-binding protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001139780.1|refseq:NP_001139781.1|refseq:NP_038838.1|dip:DIP-39835N|ensembl:ENSMUSG00000020476(gene)|ensembl:ENSMUST00000020769(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|interpro:IPR035717|interpro:IPR036028|mint:Q62418|reactome:R-MMU-264870|reactome:R-MMU-6794361|reactome:R-MMU-6798695|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:uRFrfUfKF7cfhsrbleRauR33+g810090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8K4I3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6272809|uniprotkb:Q8C9V4	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:B2RXR6	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-11566298|uniprotkb:B2RXN6|uniprotkb:B7ZWK8|ensembl:ENSMUSP00000137616	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:anr44_mouse(display_long)|uniprotkb:Ankyrin repeat domain-containing protein 44(gene name synonym)|uniprotkb:Ankrd44(gene name)|psi-mi:Ankrd44(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001074902.2|ensembl:ENSMUSG00000052331(gene)|ensembl:ENSMUST00000179030(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:u2gh8Mr3OLcC72DfwHC0bMCFj3c10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q60931	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P13379	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12600513|ensembl:ENSMUSP00000025571	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cd5_mouse(display_long)|uniprotkb:Cd5(gene name)|psi-mi:Cd5(display_short)|uniprotkb:Ly-1(gene name synonym)|uniprotkb:Lymphocyte antigen 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000024669(gene)|ensembl:ENSMUST00000025571(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR003566(T-cell surface glycoprotein CD5)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_031676.3	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:oL33PyDLfKVztM7QSCKKpOvk3DY10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:D3YXK2	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-539539|ensembl:ENSMUSP00000092849	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:safb1_mouse(display_long)|uniprotkb:Safb(gene name)|psi-mi:Safb(display_short)|uniprotkb:Safb1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001156772.1|ensembl:ENSMUST00000095224(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034781|interpro:IPR035979|interpro:IPR036361|mint:D3YXK2|ensembl:ENSMUSG00000071054(gene)|reactome:R-MMU-3899300	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	comment:Author screened murine library then identified protein by homology to rat. Currently no murine sequence in database.	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:wGs3hvKUEDoWR83eBl9+qv4JWzs10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q6A068	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2552123|ensembl:ENSMUSP00000024727|uniprotkb:Q8K1J9	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cdc5l_mouse(display_long)|uniprotkb:Cdc5l(gene name)|psi-mi:Cdc5l(display_short)|uniprotkb:Kiaa0432(gene name synonym)|uniprotkb:Cdc5-like protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000023932(gene)|ensembl:ENSMUST00000024727(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|refseq:NP_690023.1|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q6A068|reactome:R-MMU-72163|go:"GO:0005737"(cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ehcu1kQlVD4/J1K3a77EcsjqRbI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:D3Z6Q9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603400	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:bin2_mouse(display_long)|uniprotkb:Bin2(gene name)|psi-mi:Bin2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071800"(podosome assembly)|go:"GO:0097320"(plasma membrane tubulation)|reactome:R-MMU-6798695|interpro:IPR027267|interpro:IPR003005(Amphiphysin)|interpro:IPR004148(BAR)|interpro:IPR028827	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:s13b0CeidFjiMunz+WaNMmv8eQA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P42208	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-772099|uniprotkb:Q3U9Y5|uniprotkb:B2RRZ2|ensembl:ENSMUSP00000027495|ensembl:ENSMUSP00000132850|ensembl:ENSMUSP00000136366	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sept2_mouse(display_long)|uniprotkb:Sept2(gene name synonym)|uniprotkb:Septin2(gene name)|psi-mi:Septin2(display_short)|uniprotkb:Nedd5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001153189.1|refseq:NP_001153190.1|refseq:NP_001153191.1|refseq:NP_035021.1|refseq:XP_006529304.1|refseq:XP_006529305.1|dip:DIP-32438N|ensembl:ENSMUSG00000026276(gene)|ensembl:ENSMUSG00000116048(gene)|ensembl:ENSMUST00000027495(transcript)|ensembl:ENSMUST00000168776(transcript)|ensembl:ENSMUST00000179353(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0002036"(regulation of L-glutamate import across plasma membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051258"(protein polymerization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:3FTQ|reactome:R-MMU-5620912|mint:P42208	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:vk7UVRzpfbNxL4cxXJhd94mfQxc10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8CG47	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6921575|ensembl:ENSMUSP00000047872|uniprotkb:Q8BTS7|uniprotkb:Q8BTY9|uniprotkb:Q99K21	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:smc4_mouse(display_long)|uniprotkb:Smc4(gene name)|psi-mi:Smc4(display_short)|uniprotkb:Capc(gene name synonym)|uniprotkb:Smc4l1(gene name synonym)|uniprotkb:Chromosome-associated polypeptide C(gene name synonym)|uniprotkb:XCAP-C homolog(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_006502109.1|ensembl:ENSMUSG00000034349(gene)|ensembl:ENSMUST00000042901(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041738|mint:Q8CG47|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853|refseq:NP_598547.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:SF4vyf1kJkH5VuPPgdXoHrPCxaA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P50516	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-769977|uniprotkb:Q3TKS0|uniprotkb:Q3U5W3|uniprotkb:Q3U777|uniprotkb:Q3UDZ9|uniprotkb:Q3US31|uniprotkb:Q8CHX2|ensembl:ENSMUSP00000066886|ensembl:ENSMUSP00000110314	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vata_mouse(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Atp6v1a(gene name)|psi-mi:Atp6v1a(display_short)|uniprotkb:Atp6a1(gene name synonym)|uniprotkb:Atp6a2(gene name synonym)|uniprotkb:Atp6v1a1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_031534.2|refseq:XP_011244111.1|refseq:XP_006521783.1|refseq:XP_006521784.1|ensembl:ENSMUSG00000052459(gene)|ensembl:ENSMUST00000063661(transcript)|ensembl:ENSMUST00000114666(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P50516|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:E6xeAhJA1x3386eC6JZXXKgRU0Q10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P27546	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2526714|uniprotkb:Q05BJ2|uniprotkb:Q3UIS2|uniprotkb:Q3UUH5|uniprotkb:Q3UY36|uniprotkb:Q7TPC6|uniprotkb:Q7TPD4|uniprotkb:Q80YQ5|uniprotkb:Q8CFP5|ensembl:ENSMUSP00000035055	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:map4_mouse(display_long)|uniprotkb:Map4(gene name)|psi-mi:Map4(display_short)|uniprotkb:Mtap4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001192259.1|refseq:NP_001192261.1|refseq:NP_032659.2|ensembl:ENSMUSG00000032479(gene)|ensembl:ENSMUST00000035055(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR027323|mint:P27546|go:"GO:0043005"(neuron projection)|refseq:NP_001298092.1|refseq:NP_001298093.1|refseq:XP_017168653.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:DVblnhNfUaxX6rpvxn660Pq09L410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q03526	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9WVJ2	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-992301|uniprotkb:Q3TB19|uniprotkb:Q3TR74|uniprotkb:Q542R0|ensembl:ENSMUSP00000026560	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:psd13_mouse(display_long)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:Psmd13(gene name)|psi-mi:Psmd13(display_short)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_036005.1|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-187577|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|ensembl:ENSMUSG00000025487(gene)|ensembl:ENSMUST00000026560(transcript)|go:"GO:0000502"(proteasome complex)|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-6798695|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043248"(proteasome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9WVJ2|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|go:"GO:0004175"(endopeptidase activity)|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ZmfKfV5qD2TnuJyJvUV8RPpNX1810090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P68254	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q61210	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9EQH3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P22682	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8K1B8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603349|ensembl:ENSMUSP00000037858	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:urp2_mouse(display_long)|uniprotkb:Fermt3(gene name)|psi-mi:Fermt3(display_short)|uniprotkb:Kind3(gene name synonym)|uniprotkb:Urp2(gene name synonym)|uniprotkb:Kindlin-3(gene name synonym)|uniprotkb:Unc-112-related protein 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000024965(gene)|ensembl:ENSMUST00000040772(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005178"(integrin binding)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033622"(integrin activation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037843|interpro:IPR040790|rcsb pdb:5L81|reactome:R-MMU-114608|interpro:IPR037837|refseq:NP_722490.1|refseq:XP_006526656.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:abQWJ455PRZh9JISQXv3eql4XFY10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P23116	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2552342|uniprotkb:E9QQ50|ensembl:ENSMUSP00000025955|uniprotkb:Q62162|uniprotkb:Q60697	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:eif3a_mouse(display_long)|uniprotkb:Eif3a(gene name)|psi-mi:Eif3a(display_short)|uniprotkb:Csma(gene name synonym)|uniprotkb:Eif3(gene name synonym)|uniprotkb:Eif3s10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)|uniprotkb:p162(gene name synonym)|uniprotkb:Centrosomin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000024991(gene)|ensembl:ENSMUST00000025955(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:P23116|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|go:"GO:0014069"(postsynaptic density)|refseq:NP_034253.3	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:oL2Xlz5tghN0YkjvCd3nXOj15Hk10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q3V3E1	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P11835	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644501|uniprotkb:Q64482	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99KJ8	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-776048|ensembl:ENSMUSP00000026479	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dctn2_mouse(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:Growth cone membrane protein 23-48K(gene name synonym)|uniprotkb:Dctn2(gene name)|psi-mi:Dctn2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_081427.1|ensembl:ENSMUSG00000025410(gene)|ensembl:ENSMUST00000026479(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q99KJ8|reactome:R-MMU-2132295|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-8854518	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:D7u4MT5Zl5mRBQ/zsTwhYP0WHoU10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BJS4	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-646914|uniprotkb:Q3TBU0|uniprotkb:Q3U160|uniprotkb:Q6B4H2|ensembl:ENSMUSP00000047864	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sun2_mouse(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Sun2(gene name)|psi-mi:Sun2(display_short)|uniprotkb:Unc84b(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001192274.1|refseq:NP_001192275.1|refseq:NP_919323.2|dip:DIP-49694N|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|rcsb pdb:5ED8|rcsb pdb:5ED9|ensembl:ENSMUSG00000042524(gene)|ensembl:ENSMUST00000046259(transcript)|go:"GO:0000781"(chromosome, telomeric region)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:F+gOC6NhX2BXG3iU0TI2DNxYWYQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q3TBD2	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-11569517|uniprotkb:Q8BI83|uniprotkb:Q3TSW0|uniprotkb:Q3TXM6|uniprotkb:Q3UZ72|uniprotkb:Q3TDD2|uniprotkb:Q9CU46	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:hmha1_mouse(display_long)|uniprotkb:Arhgap45(gene name)|psi-mi:Arhgap45(display_short)|uniprotkb:Hmha1(gene name synonym)|uniprotkb:Minor histocompatibility protein HA-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	interpro:IPR027267|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|interpro:IPR000198(RhoGAP)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR031160|refseq:NP_001136173.1|refseq:NP_081797.1|refseq:NP_001334003.1|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0090630"(activation of GTPase activity)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:qRGZ7VRf87D+9YlzAdWJNGJJ6Bg10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P70268	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603283|ensembl:ENSMUSP00000005616|uniprotkb:Q3UEA6|uniprotkb:Q7TST2|uniprotkb:Q8BTL8	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:pkn1_mouse(display_long)|uniprotkb:Pkn1(gene name)|psi-mi:Pkn1(display_short)|uniprotkb:Pkn(gene name synonym)|uniprotkb:Prk1(gene name synonym)|uniprotkb:Prkcl1(gene name synonym)|uniprotkb:Protein kinase C-like 1(gene name synonym)|uniprotkb:Protein kinase C-like PKN(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 1(gene name synonym)|uniprotkb:Serine-threonine protein kinase N(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000057672(gene)|ensembl:ENSMUST00000005616(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003014"(renal system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035407"(histone H3-T11 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048536"(spleen development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037317|interpro:IPR037784|reactome:R-MMU-5625740|reactome:R-MMU-5625886|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|refseq:NP_001186522.1|refseq:NP_796236.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2JXdBC4pG/j3ZEp0jfkrk1Qekso10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P70460	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-990384|uniprotkb:Q3UDF1|uniprotkb:Q91VD2|uniprotkb:Q9R214|uniprotkb:Q3TAP0|uniprotkb:Q3TCD2|uniprotkb:Q3U0C2|ensembl:ENSMUSP00000032561	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vasp_mouse(display_long)|uniprotkb:Vasp(gene name)|psi-mi:Vasp(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000030403(gene)|ensembl:ENSMUST00000032561(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P70460|rcsb pdb:2V8C|reactome:R-MMU-376176|reactome:R-MMU-446353|refseq:NP_033525.2|refseq:NP_001268950.1|refseq:NP_001268951.1|dip:DIP-29360N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:AgIQZ6LcYTav4f8CrTLmaO9fpo410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q61466	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-371529|uniprotkb:P70384|uniprotkb:Q8R0I7|ensembl:ENSMUSP00000023759	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:smrd1_mouse(display_long)|uniprotkb:Smarcd1(gene name)|psi-mi:Smarcd1(display_short)|uniprotkb:Baf60a(gene name synonym)|uniprotkb:D15Kz1(gene name synonym)|uniprotkb:SWI/SNF complex 60 kDa subunit(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit A(gene name synonym)|uniprotkb:BRG1-associated factor 60A(gene name synonym)|uniprotkb:Protein D15KZ1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000023018(gene)|ensembl:ENSMUST00000023759(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR036885|interpro:IPR038041|mint:Q61466|rcsb pdb:1UHR|reactome:R-MMU-3214858|reactome:R-MMU-8939243|refseq:NP_114030.2|dip:DIP-33019N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:Jn7+Fss6GbjcN8ys8cI5T5fw1qE10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q7TSI3	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-4286465|uniprotkb:Q80TJ4|ensembl:ENSMUSP00000066736	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:pp6r1_mouse(display_long)|uniprotkb:Ppp6r1(gene name)|psi-mi:Ppp6r1(display_short)|uniprotkb:Kiaa1115(gene name synonym)|uniprotkb:Pp6r1(gene name synonym)|uniprotkb:Saps1(gene name synonym)|uniprotkb:SAPS domain family member 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_766482.2|refseq:XP_011248858.1|ensembl:ENSMUSG00000052296(gene)|ensembl:ENSMUST00000064099(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-204005	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ET7IE429eaRNAHpRwjds5XF7nrA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P42225	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-647118	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C147	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-11566633|uniprotkb:Q9DBQ2|uniprotkb:Q6PIS0|uniprotkb:Q7TMQ5|uniprotkb:Q6KAM7|uniprotkb:Q8CAP6|uniprotkb:Q8K105|ensembl:ENSMUSP00000025831	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dock8_mouse(display_long)|uniprotkb:Dock8(gene name)|psi-mi:Dock8(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_083061.2|ensembl:ENSMUSG00000052085(gene)|ensembl:ENSMUST00000025831(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061485"(memory T cell proliferation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|rcsb pdb:3VHL|rcsb pdb:7CLX|rcsb pdb:7CLY|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013409|reactome:R-MMU-983231	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:xAjdT7y7XRy54NjvlQ6tt8Rm9ko10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8BPU7	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644143|uniprotkb:Q8BSY9|uniprotkb:Q8K2C5|uniprotkb:Q91ZU3|ensembl:ENSMUSP00000072334	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:elmo1_mouse(display_long)|uniprotkb:Protein ced-12 homolog(gene name synonym)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_525027.1|refseq:XP_006516610.1|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030029"(actin filament-based process)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-8849471|refseq:NP_932761.1|dip:DIP-41244N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P26039	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P06240	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8K2H4	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12603245|ensembl:ENSMUSP00000001631|uniprotkb:Q3U441|uniprotkb:Q571H6	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:acap1_mouse(display_long)|uniprotkb:Acap1(gene name)|psi-mi:Acap1(display_short)|uniprotkb:Centb1(gene name synonym)|uniprotkb:Kiaa0050(gene name synonym)|uniprotkb:Centaurin-beta-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000001588(gene)|ensembl:ENSMUST00000001631(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|refseq:NP_722483.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:5QGbOyS4yFiTXZkNmgM4f+qvfAI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P26450	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P42232	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q64697	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1666|ensembl:ENSMUSP00000053412	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ptca_mouse(display_long)|uniprotkb:Ptprcap(gene name)|psi-mi:Ptprcap(display_short)|uniprotkb:CD45-associated protein(gene name synonym)|uniprotkb:LSM-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_058629.2|ensembl:ENSMUSG00000045826(gene)|ensembl:ENSMUST00000061086(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR016553(Receptor tyrosine-protein phosphatase C-associated protein CD45-AP)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:AkXI7f1aInDyvwpdvlWQx9STdzk10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P08752	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-771937|uniprotkb:Q3TXK7|uniprotkb:Q6P1C0|ensembl:ENSMUSP00000057543|ensembl:ENSMUSP00000142326	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gnai2_mouse(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:Gnai2(gene name)|psi-mi:Gnai2(display_short)|uniprotkb:Gnai-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032164.2|refseq:XP_006511700.1|dip:DIP-605N|ensembl:ENSMUSG00000032562(gene)|ensembl:ENSMUST00000055704(transcript)|ensembl:ENSMUST00000192615(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P08752|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-400042|reactome:R-MMU-418594|reactome:R-MMU-9009391|interpro:IPR001408(G-protein alpha subunit, group I)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ZeBicuRGylbh8IORXPZnsDjSQWU10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P27601	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2255627|uniprotkb:Q6PF99|ensembl:ENSMUSP00000020930	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gna13_mouse(display_long)|uniprotkb:Gna-13(gene name synonym)|uniprotkb:Gna13(gene name)|psi-mi:Gna13(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_034433.3|dip:DIP-46241N|ensembl:ENSMUSG00000020611(gene)|ensembl:ENSMUST00000020930(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P27601|rcsb pdb:1SHZ|rcsb pdb:1ZCB|rcsb pdb:3AB3|rcsb pdb:3CX6|rcsb pdb:3CX7|rcsb pdb:3CX8|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-428930|reactome:R-MMU-456926|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:lG592gVBa3xiDv+BVn5SF8Rj/pA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C2K1	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2121188|uniprotkb:A1KXF9|uniprotkb:Q0VBU6|uniprotkb:Q3V3M7|uniprotkb:Q80XA9|uniprotkb:Q9CRJ2|uniprotkb:B2KF17	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:defi6_mouse(display_long)|uniprotkb:Def6(gene name)|psi-mi:Def6(display_short)|uniprotkb:Ibp(gene name synonym)|uniprotkb:Slat(gene name synonym)|uniprotkb:IRF4-binding protein(gene name synonym)|uniprotkb:SWAP-70-like adapter of T-cells(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_081461.2|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013148|interpro:IPR011992(EF-Hand type)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0KttET/hiJXkbtToKBLSFQs0jzs10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q60631	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P27870	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P52332	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-646320|uniprotkb:Q62126	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:jak1_mouse(display_long)|uniprotkb:Janus kinase 1(gene name synonym)|uniprotkb:Jak1(gene name)|psi-mi:Jak1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	dip:DIP-41965N|mint:P52332|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-1169408|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020591|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-9674555|reactome:R-MMU-9705462	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:UIkyfJs6ggPxf4nXciyTLPqerSA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O54957	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-6390034|ensembl:ENSMUSP00000032997	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P11352	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q99M51	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C2K5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C3J5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P06332	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1404|ensembl:ENSMUSP00000024044	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:cd4_mouse(display_long)|uniprotkb:Cd4(gene name)|psi-mi:Cd4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)|uniprotkb:T-cell differentiation antigen L3T4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_038516.1|ensembl:ENSMUSG00000023274(gene)|ensembl:ENSMUST00000024044(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P06332|reactome:R-MMU-1462054|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:80TDw5kSJXFKGKJpjZ7Rdb9gD1g10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q3V3V9	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12601364	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:carl2_mouse(display_long)|uniprotkb:Carmil2(gene name)|psi-mi:Carmil2(display_short)|uniprotkb:Lrrc16c(gene name synonym)|uniprotkb:Rltpr(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker 2(gene name synonym)|uniprotkb:F-actin-uncapping protein RLTPR(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16C(gene name synonym)|uniprotkb:RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061339"(establishment or maintenance of monopolar cell polarity)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902745"(positive regulation of lamellipodium organization)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR041245|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_001028492.1|interpro:IPR029763|interpro:IPR031943|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:CymgM5Yt1FAGKeu564LYjdBOt3410090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P06800	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1672|uniprotkb:E9QLT5|uniprotkb:Q61812|uniprotkb:Q61813|uniprotkb:Q61814|uniprotkb:Q61815|uniprotkb:Q78EF1|ensembl:ENSMUSP00000138350|uniprotkb:S4R1S4|uniprotkb:S4R2V1	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ptprc_mouse(display_long)|uniprotkb:Ptprc(gene name)|psi-mi:Ptprc(display_short)|uniprotkb:Ly-5(gene name synonym)|uniprotkb:Lymphocyte antigen 5(gene name synonym)|uniprotkb:T200(gene name synonym)|uniprotkb:Leukocyte common antigen(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:XP_006529323.1|ensembl:ENSMUSG00000026395(gene)|ensembl:ENSMUST00000183301(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0002923"(regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:NP_001104786.2|refseq:XP_006529320.1|refseq:XP_006529321.1|refseq:XP_006529322.1|refseq:NP_035340.3|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032059"(bleb)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0044855"(plasma membrane raft distribution)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048539"(bone marrow development)|go:"GO:0048864"(stem cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0098857"(membrane microdomain)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000473"(positive regulation of hematopoietic stem cell migration)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050857"(positive regulation of antigen receptor-mediated signaling pathway)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016335(Leukocyte common antigen)|interpro:IPR024739|interpro:IPR029021|interpro:IPR036116|mint:P06800|reactome:R-MMU-202427|reactome:R-MMU-416700|reactome:R-MMU-6798695|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:rVsavXUDYPWKoE9O8SxF2EvjLFQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q8C503	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-12601456|ensembl:ENSMUSP00000030180|uniprotkb:Q9WUU5	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:sit1_mouse(display_long)|uniprotkb:Sit1(gene name)|psi-mi:Sit1(display_short)|uniprotkb:Sit(gene name synonym)|uniprotkb:SHP2-interacting transmembrane adapter protein(gene name synonym)|uniprotkb:Suppression-inducing transmembrane adapter 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000028460(gene)|ensembl:ENSMUST00000030180(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR033269|refseq:NP_062309.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:L7RYMt5UaRqKt+CoRBComR4npBY10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:O55033	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2642725|ensembl:ENSMUSP00000083611	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:nck2_mouse(display_long)|uniprotkb:Nck2(gene name)|psi-mi:Nck2(display_short)|uniprotkb:Grb4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035009.3|ensembl:ENSMUSG00000066877(gene)|ensembl:ENSMUST00000086421(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O55033|reactome:R-MMU-186763|reactome:R-MMU-373753|reactome:R-MMU-3928664|reactome:R-MMU-4420097|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:mFoknzNaD3XbNFCp57d5BUqEtAo10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:A2A8L5	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-771868|uniprotkb:Q6PG86|uniprotkb:Q9EQ17|ensembl:ENSMUSP00000039368	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ptprf_mouse(display_long)|uniprotkb:Ptprf(gene name)|psi-mi:Ptprf(display_short)|uniprotkb:Lar(gene name synonym)|uniprotkb:Leukocyte common antigen related(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_035343.2|ensembl:ENSMUSG00000033295(gene)|ensembl:ENSMUST00000049074(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060076"(excitatory synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900121"(negative regulation of receptor binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3PXH|rcsb pdb:6X39|reactome:R-MMU-388844|reactome:R-MMU-8849932	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:+BPaDKLeYgJ+Yz6UKakFSmlXPxg10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9JL26	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q9ES52	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P47941	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2642655|uniprotkb:Q8BGC5|uniprotkb:Q3TQ18|ensembl:ENSMUSP00000006293	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:crkl_mouse(display_long)|uniprotkb:Crkol(gene name synonym)|uniprotkb:Crkl(gene name)|psi-mi:Crkl(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603117|imex:IM-25616-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001264160.1|refseq:NP_031790.2|ensembl:ENSMUSG00000006134(gene)|ensembl:ENSMUST00000006293(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P47941|reactome:R-MMU-170968|reactome:R-MMU-186763|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027284|go:"GO:0035690"|reactome:R-MMU-912631	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 4A  Supplemental Table|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2018/04/06	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:pLiTTJ+yoeda+z2DvpqltHFJ9M010090	rigid:sbL5eAWdtAIfN3RFJWKuYEJj7Fk	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603685|imex:IM-25616-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 3 C|agonist:Pervanadate and anti-CD3/4 antibodies.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/30	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:F/KEzJNupcgeTPfmhcy1hjvfOOw	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603065|imex:IM-25616-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 2 A/B|agonist:Pervanadate and  anti-CD3/4 antibodies.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-thymocyte)|taxid:10090(MOUSE THYMOCYTE)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:F/KEzJNupcgeTPfmhcy1hjvfOOw	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P41241	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603085|imex:IM-25616-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:Fig. 3 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2016/11/29	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	rigid:F/KEzJNupcgeTPfmhcy1hjvfOOw	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U1F9	uniprotkb:P43404	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603725|imex:IM-25616-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm)	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2017/01/13	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090	rigid:/r+Ps1hSUw+9urQEUQz55W70Hio	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q3U1F9	uniprotkb:Q60631	intact:EBI-8468834|uniprotkb:Q8BFS1|intact:UNK-5409398|uniprotkb:Q9EQF3|ensembl:ENSMUSP00000104021|ensembl:ENSMUSP00000124529	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:phag1_mouse(display_long)|uniprotkb:Pag1(gene name)|psi-mi:Pag1(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Pag(gene name synonym)|uniprotkb:Csk-binding protein(gene name synonym)|uniprotkb:Transmembrane phosphoprotein Cbp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Reginald et al. (2015)	pubmed:26512138|imex:IM-25616	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12603725|imex:IM-25616-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246453.1|refseq:NP_001181960.1|refseq:NP_444412.2|refseq:XP_006530170.1|ensembl:ENSMUSG00000027508(gene)|ensembl:ENSMUST00000108384(transcript)|ensembl:ENSMUST00000161949(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR032748|mint:Q3U1F9|reactome:R-MMU-180292|reactome:R-MMU-202427	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	function:"Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling"|comment:mint|comment:homomint	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2016/10/20	2017/01/13	rogid:Ztch34HmvE8oKkgdA4zVJ+jH3EE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:/r+Ps1hSUw+9urQEUQz55W70Hio	false	strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)