#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683031|imex:IM-25081-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683068|imex:IM-25081-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683083|imex:IM-25081-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683094|imex:IM-25081-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683111|imex:IM-25081-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5E, 5F|comment:Deletion of either the N terminal domain, the cyclin domain, or the C-terminal domain of CCNYL1 abrogated or greatly impaired the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04735	uniprotkb:Q8BGU5	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-772904|uniprotkb:Q8CI87|uniprotkb:Q9CYN5|ensembl:ENSMUSP00000050001	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:ccny_mouse(display_long)|uniprotkb:Cyclin fold protein 1(gene name synonym)|uniprotkb:Ccny(gene name)|psi-mi:Ccny(display_short)|uniprotkb:Cfp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683120|imex:IM-25081-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_080760.2|ensembl:ENSMUSG00000024286(gene)|ensembl:ENSMUST00000053917(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000308"(cytoplasmic cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|mint:Q8BGU5	-	-	-	figure legend:Fig. 5E|comment:Weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:Ngxe55AQU1MZAYMVF8jtHDSyMPI10090	rigid:Qmmuq6uIQDzbn9/Bz3tAxX4qWLM	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683131|imex:IM-25081-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Fig. 5G, 7D, 7E, Supp fig 7.|comment:Both the N-terminal and C-terminal of CDK-16 were essential for CCNYL1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/01	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	flag tag:c-c|necessary binding region:205-211|mutation increasing interaction strength:78-78|mutation increasing interaction strength:175-175|mutation decreasing interaction strength:175-175|mutation disrupting interaction strength:146-146|mutation disrupting interaction strength:146-146|mutation decreasing interaction strength:110-110|mutation decreasing interaction strength:110-110|mutation decreasing interaction strength:119-119|mutation increasing interaction strength:153-153|mutation decreasing interaction strength:153-153|mutation disrupting interaction strength:207-207,205-205,210-211	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04735	uniprotkb:D3YUJ3	intact:EBI-11615670|ensembl:ENSMUSP00000033380	intact:EBI-11683033|ensembl:ENSMUSP00000109711	psi-mi:cdk16_mouse(display_long)|uniprotkb:CRK5(gene name synonym)|uniprotkb:Cell division protein kinase 16(gene name synonym)|uniprotkb:PCTAIRE-motif protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PCTAIRE-1(gene name synonym)|uniprotkb:Cdk16(gene name)|psi-mi:Cdk16(display_short)|uniprotkb:Crk5(gene name synonym)|uniprotkb:Pctaire1(gene name synonym)|uniprotkb:Pctk1(gene name synonym)	psi-mi:d3yuj3_mouse(display_long)|uniprotkb:Ccnyl1(gene name)|psi-mi:Ccnyl1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Zi et al. (2015)	imex:IM-25081|pubmed:26305884	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11683171|imex:IM-25081-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297385.1|refseq:NP_035179.1|refseq:XP_006527633.1|ensembl:ENSMUSG00000031065(gene)|ensembl:ENSMUST00000033380(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	ensembl:ENSMUSG00000070871(gene)|ensembl:ENSMUST00000114077(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045859"(regulation of protein kinase activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012399(Uncharacterised conserved protein CG14939, cyclin region)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915	-	-	-	figure legend:Supp Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/16	2016/04/08	rogid:IKtGg8vKACWQ8wChXgdVtoHGKlU10090	rogid:JTSVZ7yQ2tOa+U3UD3Q9a5PI0Ss10090	rigid:OQDlPtDX4Fn245+lVBMCbsstNjY	false	flag tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)