#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16070	uniprotkb:Q12891	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-2806068|ensembl:ENSP00000350387|ensembl:ENSP00000378571|ensembl:ENSP00000401853|ensembl:ENSP00000406657|uniprotkb:Q9BW29|uniprotkb:O15177|uniprotkb:B3KRZ2	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:hyal2_human(display_long)|uniprotkb:LUCA2(gene name synonym)|uniprotkb:Hyaluronoglucosaminidase-2(gene name synonym)|uniprotkb:Lung carcinoma protein 2(gene name synonym)|uniprotkb:HYAL2(gene name)|psi-mi:HYAL2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hida et al. (2015)	pubmed:25864644|imex:IM-25061	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11665428|imex:IM-25061-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	ensembl:ENSG00000068001(gene)|ensembl:ENST00000357750(transcript)|ensembl:ENST00000395139(transcript)|ensembl:ENST00000442581(transcript)|ensembl:ENST00000447092(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001618"(virus receptor activity)|refseq:NP_003764.3|refseq:NP_149348.2|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004415"(hyalurononglucosaminidase activity)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030294"(receptor signaling protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0001822"(kidney development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033906"(hyaluronoglucuronidase activity)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0042117"(monocyte activation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051216"(cartilage development)|go:"GO:0051607"(defense response to virus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070295"(renal water absorption)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018155|reactome:R-HSA-2160916|go:"GO:0043407"(negative regulation of MAP kinase activity)|refseq:XP_005265581.1|refseq:XP_005265582.1	-	-	-	figure legend:Figure 5C and 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-c28_i2)|taxid:9606(Human chondrocyte C-28/I2 cell)	-	2016/03/23	2016/03/29	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:NzGpBZoflXudvd2QPKOWRc2NOyk9606	rigid:cCd+yhw62qTwJ46fX/K+IQlFv1Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)