#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IXL6	uniprotkb:Q9NRM1	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11892601|uniprotkb:Q17RI5|uniprotkb:Q9H3D1|ensembl:ENSP00000379383	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:enam_human(display_long)|uniprotkb:ENAM(gene name)|psi-mi:ENAM(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892594|imex:IM-25475-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_114095.2|refseq:XP_006714119.1|ensembl:ENSG00000132464(gene)|ensembl:ENST00000396073(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0036305"(ameloblast differentiation)|go:"GO:0070175"(positive regulation of enamel mineralization)|go:"GO:0097186"(amelogenesis)|interpro:IPR015673(Enamelin)|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 A/B, Figure 2—figure supplement 2, 4 A/B/D/G, 5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.4(second -1)|km:14.6x10^-6(molar)	2016/06/15	2016/07/18	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:til0BfEjGQ7KHVYfVpdZ5EP5Fw49606	rigid:8Q57f4UcnvxlcQS9E1VYvLv34F4	false	mutation disrupting interaction rate:478-478|mutation disrupting interaction rate:306-306	mutation decreasing interaction rate:191-191|mutation decreasing interaction rate:216-216|phosphorylated residue:?-?|sufficient binding region:173-277|his tag:n-n|mutation disrupting interaction rate:191-191,216-216	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q6UX39	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11892684|uniprotkb:Q0P503|uniprotkb:Q0P506|ensembl:ENSP00000341013	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:amtn_human(display_long)|uniprotkb:AMTN(gene name)|psi-mi:AMTN(display_short)|uniprotkb:UNQ689/PRO1329(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892666|imex:IM-25475-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001273660.1|refseq:NP_997722.1|ensembl:ENSG00000187689(gene)|ensembl:ENST00000339336(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070175"(positive regulation of enamel mineralization)|interpro:IPR031501|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 A, 4A|comment:AMTN is stated to be aas 17–219, but the molecule only has 209 residues.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:4ebVWuWvf1sHfPzpiBn0KePdGpk9606	rigid:PIcdmV2Dc5mRH20i6Ta0PQWxds0	false	mutation disrupting interaction rate:478-478	phosphorylated residue:?-?|his tag:n-n|sufficient binding region:17-209	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q99217-PRO_0000001199	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11893178	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:q99217-pro_0000001199(display_long)|uniprotkb:AMELX(gene name)|psi-mi:AMELX(display_short)|uniprotkb:AMG(gene name synonym)|uniprotkb:AMGX(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892707|imex:IM-25475-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-11892721(chain-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:17|chain-seq-end:191	figure legend:1 Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:/I96a1ugJrLdn4R2wdMCof7qRfA9606	rigid:jlUJ5c25jbbwRAOfHH5GF8FiZks	false	mutation disrupting interaction rate:478-478	phosphorylated residue:?-?|his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10451-PRO_0000020321	uniprotkb:Q96MK3	intact:EBI-11893188	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:p10451-pro_0000020321(display_long)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:BNSP(gene name synonym)|uniprotkb:OPN(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:PSEC0156(orf name)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893083|imex:IM-25475-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-723648(chain-parent)	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	chain-seq-start:17|chain-seq-end:314	-	figure legend:2F, Figure 4—figure supplement 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:hpMQDe1g7H1gGtQLLA+7mWanSJ09606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:LU6OPWzCeJr1L8yKPyNMB62W1r8	false	phosphorylated residue:?-?|his tag:n-n	mutation increasing interaction rate:258-258	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P10451-PRO_0000020321	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11893188	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:p10451-pro_0000020321(display_long)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:BNSP(gene name synonym)|uniprotkb:OPN(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:PSEC0156(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893197|imex:IM-25475-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-723648(chain-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:17|chain-seq-end:314	figure legend:Figure2—figure supplement 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:hpMQDe1g7H1gGtQLLA+7mWanSJ09606	rigid:fGhvdt6J4u62fiyCqKTzz89vmFw	false	mutation decreasing interaction rate:306-306	phosphorylated residue:?-?|his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NRM1	uniprotkb:Q96MK3	intact:EBI-11892601|uniprotkb:Q17RI5|uniprotkb:Q9H3D1|ensembl:ENSP00000379383	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:enam_human(display_long)|uniprotkb:ENAM(gene name)|psi-mi:ENAM(display_short)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893247|imex:IM-25475-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114095.2|refseq:XP_006714119.1|ensembl:ENSG00000132464(gene)|ensembl:ENST00000396073(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0036305"(ameloblast differentiation)|go:"GO:0070175"(positive regulation of enamel mineralization)|go:"GO:0097186"(amelogenesis)|interpro:IPR015673(Enamelin)|reactome:R-HSA-381426|reactome:R-HSA-8957275	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:4 A/B/D/E/G, 5F, Figure 4—figure supplement 2, Figure 5—figure supplement 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.76(second -1)|km:5.6x10^-6(molar)	2016/06/15	2016/07/19	rogid:til0BfEjGQ7KHVYfVpdZ5EP5Fw49606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:rEBqmynyOrQki64XJC9JxjbcKb8	false	mutation with no effect:191-191|mutation disrupting interaction rate:191-191,216-216|mutation with no effect:216-216|phosphorylated residue:?-?|sufficient binding region:173-277|his tag:n-n	mutation decreasing interaction rate:430-430|mutation decreasing interaction rate:258-258	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NRM1	uniprotkb:Q8IXL6	intact:EBI-11892601|uniprotkb:Q17RI5|uniprotkb:Q9H3D1|ensembl:ENSP00000379383	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:enam_human(display_long)|uniprotkb:ENAM(gene name)|psi-mi:ENAM(display_short)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893247|imex:IM-25475-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114095.2|refseq:XP_006714119.1|ensembl:ENSG00000132464(gene)|ensembl:ENST00000396073(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0036305"(ameloblast differentiation)|go:"GO:0070175"(positive regulation of enamel mineralization)|go:"GO:0097186"(amelogenesis)|interpro:IPR015673(Enamelin)|reactome:R-HSA-381426|reactome:R-HSA-8957275	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:4 A/B/D/E/G, 5F, Figure 4—figure supplement 2, Figure 5—figure supplement 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.76(second -1)|km:5.6x10^-6(molar)	2016/06/15	2016/07/19	rogid:til0BfEjGQ7KHVYfVpdZ5EP5Fw49606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:rEBqmynyOrQki64XJC9JxjbcKb8	false	mutation with no effect:191-191|mutation disrupting interaction rate:191-191,216-216|mutation with no effect:216-216|phosphorylated residue:?-?|sufficient binding region:173-277|his tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UX39	uniprotkb:Q96MK3	intact:EBI-11892684|uniprotkb:Q0P503|uniprotkb:Q0P506|ensembl:ENSP00000341013	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:amtn_human(display_long)|uniprotkb:AMTN(gene name)|psi-mi:AMTN(display_short)|uniprotkb:UNQ689/PRO1329(orf name)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893268|imex:IM-25475-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273660.1|refseq:NP_997722.1|ensembl:ENSG00000187689(gene)|ensembl:ENST00000339336(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070175"(positive regulation of enamel mineralization)|interpro:IPR031501|reactome:R-HSA-381426|reactome:R-HSA-8957275	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:4A|comment:AMTN is stated to be aas 17–219, but the molecule only has 209 residues.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:4ebVWuWvf1sHfPzpiBn0KePdGpk9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:birg9CWOwFL2zNBZTVSIN/RuaI8	false	phosphorylated residue:?-?|his tag:n-n|sufficient binding region:17-209	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UX39	uniprotkb:Q8IXL6	intact:EBI-11892684|uniprotkb:Q0P503|uniprotkb:Q0P506|ensembl:ENSP00000341013	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:amtn_human(display_long)|uniprotkb:AMTN(gene name)|psi-mi:AMTN(display_short)|uniprotkb:UNQ689/PRO1329(orf name)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893268|imex:IM-25475-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273660.1|refseq:NP_997722.1|ensembl:ENSG00000187689(gene)|ensembl:ENST00000339336(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070175"(positive regulation of enamel mineralization)|interpro:IPR031501|reactome:R-HSA-381426|reactome:R-HSA-8957275	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:4A|comment:AMTN is stated to be aas 17–219, but the molecule only has 209 residues.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	rogid:4ebVWuWvf1sHfPzpiBn0KePdGpk9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:birg9CWOwFL2zNBZTVSIN/RuaI8	false	phosphorylated residue:?-?|his tag:n-n|sufficient binding region:17-209	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P07585	uniprotkb:O75063	intact:EBI-9663608|uniprotkb:Q9P0Z0|uniprotkb:Q9P0Z1|uniprotkb:Q9Y5N8|uniprotkb:Q9Y5N9|ensembl:ENSP00000052754|ensembl:ENSP00000447654	intact:EBI-11090967|uniprotkb:Q5W0C4|uniprotkb:Q5W0C3|ensembl:ENSP00000263733	psi-mi:pgs2_human(display_long)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)|uniprotkb:SLRR1B(gene name synonym)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:PG40(gene name synonym)	psi-mi:xylk_human(display_long)|uniprotkb:FAM20B(gene name)|psi-mi:FAM20B(display_short)|uniprotkb:KIAA0475(gene name synonym)|uniprotkb:Xylose kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893583|imex:IM-25475-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016874406.1|refseq:NP_001911.1|refseq:NP_598010.1|refseq:NP_598011.1|refseq:NP_598012.1|refseq:NP_598013.1|refseq:NP_598014.1|refseq:XP_005268750.1|refseq:XP_006719333.1|ensembl:ENSG00000011465(gene)|ensembl:ENST00000052754(transcript)|ensembl:ENST00000552962(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0003723"(RNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|go:"GO:0042060"(wound healing)	refseq:NP_055679.1|refseq:NP_001311239.1|refseq:NP_001311240.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|ensembl:ENSG00000116199(gene)|ensembl:ENST00000263733(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:4C|comment:Both proteins were not further purified after IP and Flag peptide elution. However  the preparation appears relatively pure  - only two faint  unidentified bands can be seen on the Coomassie gel.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:0QACJEISdDItcqJBJtaLNCvleeg9606	rogid:pk3uDC0WC1Qh0M/cU7ciJwJq5tw9606	rigid:aPdN1QCQGAQMUJHXh3N+DsTqfDc	false	glycosylated residue:?-?|phosphorylated residue:?-?|flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q9NP70	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11893530|uniprotkb:Q3B862|uniprotkb:Q9H2X1|uniprotkb:Q9H4L1|ensembl:ENSP00000313809	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ambn_human(display_long)|uniprotkb:AMBN(gene name)|psi-mi:AMBN(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11894017|imex:IM-25475-18	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_057603.1|ensembl:ENSG00000178522(gene)|ensembl:ENST00000322937(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR007798(Ameloblastin precursor)|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Figure 4—figure supplement 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:UyjFJqGTJgU9sVVUPyJIUJODaHc9606	rigid:MpdJ6g/zzON2cvh7WnzC/zcjWHo	false	mutation disrupting interaction rate:478-478	mutation decreasing interaction rate:43-43|mutation with no effect:46-46|mutation with no effect:36-36|phosphorylated residue:?-?|tag:n-n|sufficient binding region:27-48|mutation with no effect:34-34|mutation with no effect:41-41	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NP70	uniprotkb:Q96MK3	intact:EBI-11893530|uniprotkb:Q3B862|uniprotkb:Q9H2X1|uniprotkb:Q9H4L1|ensembl:ENSP00000313809	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:ambn_human(display_long)|uniprotkb:AMBN(gene name)|psi-mi:AMBN(display_short)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11894049|imex:IM-25475-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057603.1|ensembl:ENSG00000178522(gene)|ensembl:ENST00000322937(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR007798(Ameloblastin precursor)|reactome:R-HSA-381426|reactome:R-HSA-8957275	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:4A, Figure 4—figure supplement 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:UyjFJqGTJgU9sVVUPyJIUJODaHc9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:hUglqkoEJEEFcNS/n4Pd9EbK25E	false	mutation decreasing interaction rate:43-43|mutation with no effect:46-46|mutation with no effect:36-36|phosphorylated residue:?-?|tag:n-n|sufficient binding region:27-48|mutation with no effect:34-34|mutation with no effect:41-41	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NP70	uniprotkb:Q8IXL6	intact:EBI-11893530|uniprotkb:Q3B862|uniprotkb:Q9H2X1|uniprotkb:Q9H4L1|ensembl:ENSP00000313809	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:ambn_human(display_long)|uniprotkb:AMBN(gene name)|psi-mi:AMBN(display_short)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11894049|imex:IM-25475-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057603.1|ensembl:ENSG00000178522(gene)|ensembl:ENST00000322937(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0030345"(structural constituent of tooth enamel)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR007798(Ameloblastin precursor)|reactome:R-HSA-381426|reactome:R-HSA-8957275	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:4A, Figure 4—figure supplement 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:UyjFJqGTJgU9sVVUPyJIUJODaHc9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:hUglqkoEJEEFcNS/n4Pd9EbK25E	false	mutation decreasing interaction rate:43-43|mutation with no effect:46-46|mutation with no effect:36-36|phosphorylated residue:?-?|tag:n-n|sufficient binding region:27-48|mutation with no effect:34-34|mutation with no effect:41-41	mutation disrupting interaction rate:478-478	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P05814-PRO_0000004475	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11896480	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:p05814-pro_0000004475(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)|uniprotkb:CASB(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11896462|imex:IM-25475-20	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-1642112(chain-parent)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:16|chain-seq-end:226	figure legend:Figure2—figure supplement 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/25	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:WjXku59gQO53B6NW1OrfpOb3YGQ9606	rigid:ckSJZLgonXCMdyS/5x4Yzgz4Oyo	false	mutation disrupting interaction rate:306-306	his tag:?-?|phosphorylated residue:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:15422"	uniprotkb:Q8IXL6	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0880"(atpase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892813|imex:IM-25475-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0005524"(ATP binding)|go:"GO:0016887"(ATP hydrolysis activity)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:2 A/E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/18	-	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	-	false	-	mutation disrupting interaction rate:478-478|mutation disrupting interaction rate:306-306	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:Q96MK3	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0880"(atpase assay)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893070|imex:IM-25475-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	go:"GO:0005524"(ATP binding)|go:"GO:0016887"(ATP hydrolysis activity)	-	-	figure legend:2 E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	-	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	-	false	-	mutation increasing interaction rate:258-258	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:Q8IXL6	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:1235"(thermal shift binding)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892955|imex:IM-25475-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	-	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	-	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:Q96MK3	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:1235"(thermal shift binding)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11892966|imex:IM-25475-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	-	-	-	figure legend:2Bi|comment:Fam20A can bind, but not hydrolyze ATP.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/19	-	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IXL6	uniprotkb:Q96MK3	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0071"(molecular sieving)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893699|imex:IM-25475-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:4Rq0weoOyu+Hjl0pDnGjms+6ah4	false	-	-	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8IXL6	uniprotkb:Q96MK3	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893762|imex:IM-25475-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2016/06/15	2016/07/20	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:4Rq0weoOyu+Hjl0pDnGjms+6ah4	false	flag tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96MK3	uniprotkb:Q96MK3	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893776|imex:IM-25475-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	-	-	-	figure legend:5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2016/06/15	2016/07/20	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:XV0WaeqTUh+rSDX9c/XkvqnYUuk	false	flag tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IXL6	uniprotkb:Q96MK3	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11892970|uniprotkb:B2RN47|uniprotkb:B2RN49|uniprotkb:Q9UF95|ensembl:ENSP00000468308	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fa20a_human(display_long)|uniprotkb:FAM20A(gene name)|psi-mi:FAM20A(display_short)|uniprotkb:UNQ9388/PRO34279(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893840|imex:IM-25475-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001230675.1|refseq:NP_060035.2|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5WRR|rcsb pdb:5WRS|rcsb pdb:5YH2|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0031214"(biomineral tissue development)|ensembl:ENSG00000108950(gene)|ensembl:ENST00000592554(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/15	2016/07/20	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:NzyULTeSpvzeZ84Lrwkq/UgrP/w9606	rigid:4Rq0weoOyu+Hjl0pDnGjms+6ah4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5MJS3	uniprotkb:Q8CID3	intact:EBI-11893898|uniprotkb:Q4FJP0|uniprotkb:Q571A3|uniprotkb:Q6PKA8|uniprotkb:Q8JZP7|ensembl:ENSMUSP00000026972	intact:EBI-11893875|ensembl:ENSMUSP00000020938|ensembl:ENSMUSP00000116687	psi-mi:fa20c_mouse(display_long)|uniprotkb:Fam20c(gene name)|psi-mi:Fam20c(display_short)|uniprotkb:Dmp4(gene name synonym)|uniprotkb:Kiaa4081(gene name synonym)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)	psi-mi:fa20a_mouse(display_long)|uniprotkb:Fam20a(gene name)|psi-mi:Fam20a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cui et al. (2014)	pubmed:25789606|imex:IM-25475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11893873|imex:IM-25475-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085042.2|ensembl:ENSMUSG00000025854(gene)|ensembl:ENSMUST00000026972(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0036179"(osteoclast maturation)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0097187"(dentinogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|reactome:R-MMU-381426|reactome:R-MMU-8957275	refseq:NP_722477.1|ensembl:ENSMUSG00000020614(gene)|ensembl:ENSMUST00000020938(transcript)|ensembl:ENSMUST00000155559(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070166"(enamel mineralization)|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|reactome:R-MMU-381426|reactome:R-MMU-8957275	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mammary gland)|taxid:10090(Mus musculus mammary gland)	-	2016/06/15	2016/07/20	rogid:VTohlrfb6xBVmiCBoIDGoGu7KMM10090	rogid:8Mk7OHAMlxbO6Uj2bE8JASNJlj810090	rigid:VsE0AvjK2vZD9ekZWKKoQMTAMu4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)