#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NYA1-2 uniprotkb:Q7Z6Z7 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O14578 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-8623109|ensembl:ENSP00000261833|uniprotkb:Q6XUH8|intact:MINT-2795177|uniprotkb:Q2M5E1|uniprotkb:Q9UPZ7|uniprotkb:Q86UQ9 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:ctro_human(display_long)|uniprotkb:CIT(gene name)|psi-mi:CIT(display_short)|uniprotkb:KIAA0949(gene name synonym)|uniprotkb:STK21(gene name synonym)|uniprotkb:CRIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000122966(gene)|ensembl:ENST00000261833(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037708|mint:O14578|reactome:R-HSA-5625900|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|refseq:NP_001193928.1|refseq:NP_009105.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system|comment:mint figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:yA7y17lwftFoF2/BfbtC3aanJaI9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q13501 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P04181 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-721662|uniprotkb:Q68CS0|uniprotkb:Q16068|uniprotkb:Q16069|uniprotkb:Q9UD03|intact:EBI-1237002|uniprotkb:Q6IAV9|uniprotkb:D3DRF0|ensembl:ENSP00000357838 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:oat_human(display_long)|uniprotkb:Ornithine--oxo-acid aminotransferase(gene name synonym)|uniprotkb:OAT(gene name)|psi-mi:OAT(display_short)|uniprotkb:Ornithine delta-aminotransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_000265.1|refseq:NP_001165285.1|refseq:NP_001309894.1|refseq:NP_001309895.1|refseq:NP_001309896.1|refseq:NP_001309897.1|refseq:NP_001309898.1|refseq:NP_001309899.1|refseq:NP_001309900.1|rcsb pdb:6OIA|rcsb pdb:6V8C|rcsb pdb:6V8D|rcsb pdb:7JX9|reactome:R-HSA-8964539|ensembl:ENSG00000065154(gene)|ensembl:ENST00000368845(transcript)|go:"GO:0004587"(ornithine-oxo-acid transaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007601"(visual perception)|go:"GO:0010121"(arginine catabolic process to proline via ornithine)|go:"GO:0019544"(arginine catabolic process to glutamate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050155"("ornithine(lysine) transaminase activity")|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR005814(Aminotransferase class-III)|interpro:IPR010164(Ornithine aminotransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1GBN|rcsb pdb:1OAT|rcsb pdb:2BYJ|rcsb pdb:2BYL|rcsb pdb:2CAN|rcsb pdb:2OAT|rcsb pdb:5VWO|rcsb pdb:6HX7 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:j+e5fOgz5Yv7lLp2NV8Uq+eR6909606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P63261 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-351292|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|uniprotkb:Q5U032|uniprotkb:Q96E67|uniprotkb:A8K7C2|ensembl:ENSP00000505060|ensembl:ENSP00000505193|ensembl:ENSP00000505235|ensembl:ENSP00000506126|ensembl:ENSP00000506201|ensembl:ENSP00000506253|ensembl:ENSP00000458162|ensembl:ENSP00000458435|ensembl:ENSP00000459119|ensembl:ENSP00000459124|ensembl:ENSP00000460464|ensembl:ENSP00000460660|ensembl:ENSP00000461672|ensembl:ENSP00000466346|ensembl:ENSP00000477968 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:actg_human(display_long)|uniprotkb:ACTG1(gene name)|psi-mi:ACTG1(display_short)|uniprotkb:ACTG(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001186883.1|refseq:NP_001605.1|ensembl:ENST00000570382(transcript)|ensembl:ENSG00000184009(gene)|ensembl:ENST00000571721(transcript)|ensembl:ENST00000573283(transcript)|ensembl:ENST00000575087(transcript)|ensembl:ENST00000575659(transcript)|ensembl:ENST00000575842(transcript)|ensembl:ENST00000575994(transcript)|ensembl:ENST00000576544(transcript)|ensembl:ENST00000615544(transcript)|ensembl:ENST00000679480(transcript)|ensembl:ENST00000679778(transcript)|ensembl:ENST00000680227(transcript)|ensembl:ENST00000680727(transcript)|ensembl:ENST00000681052(transcript)|ensembl:ENST00000681842(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63261|rcsb pdb:5JLH|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-445095|reactome:R-HSA-446353|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9013418|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P62993 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O94832 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-355634|uniprotkb:Q8NHP9|ensembl:ENSP00000324527|uniprotkb:A6H8V3 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:myo1d_human(display_long)|uniprotkb:MYO1D(gene name)|psi-mi:MYO1D(display_short)|uniprotkb:KIAA0727(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_056009.1|ensembl:ENSG00000176658(gene)|ensembl:ENST00000318217(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0030673"(axolemma)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051641"(cellular localization)|go:"GO:0061502"(early endosome to recycling endosome transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097440"(apical dendrite)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|refseq:NP_001290208.1|interpro:IPR036961 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:EjrnXi04BVb6Z59cU3e5LW7EhRI9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q13257 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P49721 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-359335|uniprotkb:P31145|uniprotkb:Q9BWZ9|uniprotkb:D3DPS0|ensembl:ENSP00000362334 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:psb2_human(display_long)|uniprotkb:PSMB2(gene name)|psi-mi:PSMB2(display_short)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_002785.1|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5GJR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-5689603|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000126067(gene)|ensembl:ENST00000373237(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|mint:P49721|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|dip:DIP-33848N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:PvXrk6RLayQ1zqmavn1cONfA9/A9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P25788 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-348380|ensembl:ENSP00000216455|uniprotkb:Q86U83|uniprotkb:Q8N1D8|uniprotkb:Q9BS70|uniprotkb:B2RCK6 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_002779.1|refseq:NP_687033.1|ensembl:ENSG00000100567(gene)|ensembl:ENST00000216455(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR037555|mint:P25788|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:5DSV|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|rcsb pdb:7E55|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:5T0H|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-174084|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-174113|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|dip:DIP-29366N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P60709 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O95793 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O00268 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-1034261|uniprotkb:A6NGD9|uniprotkb:Q5TBP6|uniprotkb:Q99721|uniprotkb:Q9BR40|uniprotkb:Q9BX42|intact:EBI-28988369|ensembl:ENSP00000252996 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:taf4_human(display_long)|uniprotkb:TAF4(gene name)|psi-mi:TAF4(display_short)|uniprotkb:TAF2C(gene name synonym)|uniprotkb:TAF2C1(gene name synonym)|uniprotkb:TAF4A(gene name synonym)|uniprotkb:TAFII130(gene name synonym)|uniprotkb:TAFII135(gene name synonym)|uniprotkb:TBP-associated factor 4(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 135 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 130 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_003176.2|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENSG00000130699(gene)|ensembl:ENST00000252996(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR007900(Transcription initiation factor TFIID component TAF4)|interpro:IPR009072(Histone-fold)|interpro:IPR037249|mint:O00268|rcsb pdb:1H3O|rcsb pdb:2P6V|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|ensembl:ENSP00000252996|dip:DIP-35350N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:gnLBL5GavMLTOKfnt0Gdu2aYMqM9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O75116 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-366288|uniprotkb:Q9UQN5|ensembl:ENSP00000317985|uniprotkb:Q53QZ0|uniprotkb:Q53SJ7 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:rock2_human(display_long)|uniprotkb:ROCK2(gene name)|psi-mi:ROCK2(display_short)|uniprotkb:KIAA0619(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase II(gene name synonym)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 2(gene name synonym)|uniprotkb:p164 ROCK-2(gene name synonym)|uniprotkb:Rho kinase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037311|mint:O75116|rcsb pdb:4L6Q|rcsb pdb:4WOT|rcsb pdb:5U7Q|rcsb pdb:5U7R|rcsb pdb:6ED6|rcsb pdb:6P5M|rcsb pdb:6P5P|rcsb pdb:7JNT|rcsb pdb:7JOV|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5627117|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013407|reactome:R-HSA-9013422|reactome:R-HSA-9679191|refseq:NP_004841.2|ensembl:ENSG00000134318(gene)|ensembl:ENST00000315872(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|refseq:NP_001308572.1|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0150033"(negative regulation of protein localization to lysosome)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process) - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:iCgqC5U/DXAzOEq6edMtL6ncK7U9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P49006 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-4289961|uniprotkb:Q5TEE6|uniprotkb:Q6NXS5|uniprotkb:D3DPQ0|ensembl:ENSP00000362638 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:mrp_human(display_long)|uniprotkb:MARCKSL1(gene name)|psi-mi:MARCKSL1(display_short)|uniprotkb:MLP(gene name synonym)|uniprotkb:MRP(gene name synonym)|uniprotkb:MARCKS-like protein 1(gene name synonym)|uniprotkb:Macrophage myristoylated alanine-rich C kinase substrate(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000175130(gene)|ensembl:ENST00000329421(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002101(Myristoylated alanine-rich C-kinase substrate MARCKS)|mint:P49006|refseq:NP_075385.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:nkq8hGJINvCHlZJ3alKkDP+wCxk9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O60762 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-719526|uniprotkb:O15157|uniprotkb:Q96HK0|uniprotkb:Q6IB78|ensembl:ENSP00000360644 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dpm1_human(display_long)|uniprotkb:DPM1(gene name)|psi-mi:DPM1(display_short)|uniprotkb:Dolichol-phosphate mannose synthase subunit 1(gene name synonym)|uniprotkb:Dolichyl-phosphate beta-D-mannosyltransferase subunit 1(gene name synonym)|uniprotkb:Mannose-P-dolichol synthase subunit 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_003850.1|refseq:NP_001303963.1|refseq:NP_001303964.1|refseq:NP_001303965.1|ensembl:ENSG00000000419(gene)|ensembl:ENST00000371588(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0004582"(dolichyl-phosphate beta-D-mannosyltransferase activity)|go:"GO:0005537"(mannose binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006506"(GPI anchor biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0019348"(dolichol metabolic process)|go:"GO:0019673"(GDP-mannose metabolic process)|go:"GO:0033185"(dolichol-phosphate-mannose synthase complex)|go:"GO:0035268"(protein mannosylation)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0043178"(alcohol binding)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR039528|mint:O60762|reactome:R-HSA-162699|reactome:R-HSA-4717374|reactome:R-HSA-4719360|reactome:R-HSA-4719377 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:znbNDwp7t238ByanlbQzsTMvwTY9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O15145 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-351829|uniprotkb:O00554|ensembl:ENSP00000228825 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:arpc3_human(display_long)|uniprotkb:ARPC3(gene name)|psi-mi:ARPC3(display_short)|uniprotkb:ARC21(gene name synonym)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000111229(gene)|ensembl:ENST00000228825(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0061850"(growth cone leading edge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:O15145|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001274151.1|refseq:NP_001265485.1|dip:DIP-33187N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:u4h1270mPo3E3GBrEurYtpUYTQM9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q8TAA3-2 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-12512627|ensembl:ENSP00000345584 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:q8taa3-2(display_long)|uniprotkb:PSMA8(gene name)|psi-mi:PSMA8(display_short)|uniprotkb:PSMA7L(gene name synonym)|uniprotkb:Proteasome alpha 4 subunit(gene name synonym)|uniprotkb:Proteasome subunit alpha-type 7-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000154611(gene)|ensembl:ENST00000343848(transcript)|intact:EBI-16579257(isoform-parent) - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:u4c0829TcIecVXy1he5YqlYO10k9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q14766 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P28072 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q9UHL4 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-372284|uniprotkb:Q969X4|uniprotkb:Q5VSF1|uniprotkb:A8K7U7|ensembl:ENSP00000360635 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dpp2_human(display_long)|uniprotkb:DPP7(gene name)|psi-mi:DPP7(display_short)|uniprotkb:DPP2(gene name synonym)|uniprotkb:QPP(gene name synonym)|uniprotkb:Dipeptidyl peptidase II(gene name synonym)|uniprotkb:Dipeptidyl aminopeptidase II(gene name synonym)|uniprotkb:Quiescent cell proline dipeptidase(gene name synonym)|uniprotkb:Dipeptidyl peptidase 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) ensembl:ENSG00000176978(gene)|ensembl:ENST00000371579(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0031982"(vesicle)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008758(Peptidase S28)|interpro:IPR029058|interpro:IPR042269|rcsb pdb:3JYH|rcsb pdb:3N0T|rcsb pdb:4EBB|reactome:R-HSA-6798695|mint:Q9UHL4|refseq:NP_037511.2 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:MdRmqG846ZvKRuJHrPJ6of20pOU9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q9BPX5 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-711189|ensembl:ENSP00000259477|ensembl:ENSP00000345361|uniprotkb:Q7Z523 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:arp5l_human(display_long)|uniprotkb:Arp2/3 complex 16 kDa subunit 2(gene name synonym)|uniprotkb:ARPC5L(gene name)|psi-mi:ARPC5L(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_112240.1|ensembl:ENSG00000136950(gene)|ensembl:ENST00000259477(transcript)|ensembl:ENST00000353214(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR030075|interpro:IPR036743|mint:Q9BPX5|rcsb pdb:6YW6|dip:DIP-50399N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:JVproBu8rIrnlk39yXPC+ZrvoOk9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q7Z4W1 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O95816 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O15355 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q9BQI0 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-358576|uniprotkb:Q6ZR40|uniprotkb:Q8NAX7|uniprotkb:Q8WU47|uniprotkb:Q9H9G0|uniprotkb:B2RBC4|ensembl:ENSP00000247291 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:aif1l_human(display_long)|uniprotkb:UNQ672/PRO1306(orf name)|uniprotkb:AIF1L(gene name)|psi-mi:AIF1L(display_short)|uniprotkb:C9orf58(gene name synonym)|uniprotkb:IBA2(gene name synonym)|uniprotkb:Ionized calcium-binding adapter molecule 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001172024.1|refseq:NP_001172025.1|refseq:NP_113614.1|ensembl:ENSG00000126878(gene)|ensembl:ENST00000247291(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097178"(ruffle assembly)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR028453|interpro:IPR042433|rcsb pdb:2JJZ|rcsb pdb:2VTG - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:/FPBcx3gPhY4kmNrngZfmmN2D0A9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:Q16643 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O43795 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-351119|uniprotkb:O43794|uniprotkb:Q7Z6L5|ensembl:ENSP00000306382|ensembl:ENSP00000376132 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:myo1b_human(display_long)|uniprotkb:MYO1B(gene name)|psi-mi:MYO1B(display_short)|uniprotkb:Myosin I alpha(gene name synonym)|uniprotkb:MYH-1c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_001123630.1|refseq:NP_001155291.1|refseq:NP_036355.2|ensembl:ENSG00000128641(gene)|ensembl:ENST00000304164(transcript)|ensembl:ENST00000392318(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030175"(filopodium)|go:"GO:0031982"(vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:O43795|go:"GO:0016459"(myosin complex)|refseq:XP_005246629.1 - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:FYYccaCMhkmUdTdtq4M8zdpFpV89606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:O95425 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-487145|uniprotkb:O60611|uniprotkb:O60612|uniprotkb:Q5VZK5|uniprotkb:Q5VZK6|uniprotkb:Q9H1R7|uniprotkb:D3DRW9|ensembl:ENSP00000348128|uniprotkb:M1J557 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:svil_human(display_long)|uniprotkb:Archvillin(gene name synonym)|uniprotkb:p205/p250(gene name synonym)|uniprotkb:SVIL(gene name)|psi-mi:SVIL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) go:"GO:0007519"(skeletal muscle tissue development)|refseq:NP_003165.2|refseq:NP_068506.2|ensembl:ENSG00000197321(gene)|ensembl:ENST00000355867(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|interpro:IPR007123(Gelsolin region)|interpro:IPR015628(Supervillin)|interpro:IPR029006|interpro:IPR036886|mint:O95425|rcsb pdb:2K6M|rcsb pdb:2K6N|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0042995"(cell projection)|go:"GO:0043034"(costamere)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR003128(Villin headpiece)|interpro:IPR007122(Gelsolin) - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:5FaBAFdOX+nPJzTwEdBt8e5Keng9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-2 uniprotkb:P11142 intact:EBI-12512419|ensembl:ENSP00000313681 intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125 psi-mi:q9nya1-2(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512417|imex:IM-25499-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000323374(transcript)|intact:EBI-985303(isoform-parent)|uniprotkb:Q9NYA1-2(isoform-parent) refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N - isoform-comment:"Variant in position: 34:A->T (in dbSNP:rs346803)." - figure legend:Table 1|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2016/08/24 rogid:u0B+GMqEQcsyzXHaSnKvpiwag1c9606 rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606 rigid:f9J7bJXHhapASumrngWVnFPYtE4 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q7Z6Z7 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P51570 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P63151 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:evS6klM2alZXtMthVsshKkrNgiA9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q99873 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q15286 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P49411 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P22626 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q16822 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2825219|uniprotkb:O43253|uniprotkb:Q9BV62|intact:EBI-3189808|uniprotkb:Q86U01|ensembl:ENSP00000216780|ensembl:ENSP00000494919|uniprotkb:B4DW73 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:pckgm_human(display_long)|uniprotkb:PCK2(gene name)|psi-mi:PCK2(display_short)|uniprotkb:PEPCK2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001278485.1|refseq:NP_001294983.1|refseq:NP_001018083.2|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0042594"(response to starvation)|go:"GO:0046327"(glycerol biosynthetic process from pyruvate)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR008209(Phosphoenolpyruvate carboxykinase, GTP-utilising)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR018091|interpro:IPR035077|interpro:IPR035078|mint:Q16822|reactome:R-HSA-70263|go:"GO:0030145"(manganese ion binding)|ensembl:ENSG00000100889(gene)|ensembl:ENSG00000285241(gene)|ensembl:ENST00000216780(transcript)|ensembl:ENST00000645217(transcript)|go:"GO:0004611"(phosphoenolpyruvate carboxykinase activity)|go:"GO:0004613"("phosphoenolpyruvate carboxykinase (GTP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0019543"(propionate catabolic process)|refseq:NP_004554.3 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:gbQbu8+tVa1xs/fKesefSJlpSaM9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q5SSJ5 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2880687|ensembl:ENSP00000312625|ensembl:ENSP00000403039|uniprotkb:Q5SWC6|uniprotkb:Q6PIM9|uniprotkb:B3KMZ8|uniprotkb:A8K5D7|uniprotkb:Q8NDF0|uniprotkb:Q05BI0|uniprotkb:B4E210|uniprotkb:A6NI71|uniprotkb:Q9UHY0|uniprotkb:Q5SSJ6 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:hp1b3_human(display_long)|uniprotkb:HP1BP3(gene name)|psi-mi:HP1BP3(display_short)|uniprotkb:Protein HP1-BP74(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENSG00000127483(gene)|ensembl:ENST00000312239(transcript)|ensembl:ENST00000438032(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097298"(regulation of nucleus size)|interpro:IPR005818(Histone H1/H5)|interpro:IPR033061|interpro:IPR036388|interpro:IPR036390|mint:Q5SSJ5|rcsb pdb:2RQP|go:"GO:0005694"(chromosome)|refseq:XP_016856882.1|refseq:XP_016856883.1|refseq:XP_011539834.1|refseq:XP_011539835.1|refseq:XP_011539836.1|refseq:NP_057371.2|refseq:XP_005245932.1|refseq:XP_005245933.1|refseq:XP_005245934.1|refseq:XP_005245935.1|refseq:XP_005245936.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:kLFithZZv+Qn9YLElEnX81awKDw9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O15355 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O00159 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-350423|uniprotkb:Q6NVJ7|intact:EBI-1045431|uniprotkb:Q86Y95|uniprotkb:Q4LE56|ensembl:ENSP00000496954 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:myo1c_human(display_long)|uniprotkb:MYO1C(gene name)|psi-mi:MYO1C(display_short)|uniprotkb:Myosin I beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006605"(protein targeting)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0005829"(cytosol)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|refseq:NP_001074248.1|refseq:NP_001074419.1|refseq:NP_203693.3|ensembl:ENSG00000197879(gene)|ensembl:ENST00000648651(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:O00159|rcsb pdb:4BYF|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-5250924|reactome:R-HSA-9662360|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|reactome:R-HSA-9662361|reactome:R-HSA-9664422|dip:DIP-33109N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:g6wQN0OVKjd3T1kOebWFcqWNzNA9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O95816 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P60709 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P98179 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2949699|ensembl:ENSP00000365946|ensembl:ENSP00000365950 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:rbm3_human(display_long)|uniprotkb:RBM3(gene name)|psi-mi:RBM3(display_short)|uniprotkb:RNPL(gene name synonym)|uniprotkb:RNA-binding motif protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) go:"GO:0030425"(dendrite)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:P98179|go:"GO:0006417"(regulation of translation)|ensembl:ENSG00000102317(gene)|ensembl:ENST00000376755(transcript)|ensembl:ENST00000376759(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_006734.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:+KPnDlgXy+KGVDjTilKMXb5dJGs9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O95793 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P35579 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O00515 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2880585|ensembl:ENSP00000375829|uniprotkb:Q96GD8|uniprotkb:O95614 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:lad1_human(display_long)|uniprotkb:LAD1(gene name)|psi-mi:LAD1(display_short)|uniprotkb:LAD(gene name synonym)|uniprotkb:Linear IgA disease antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENST00000391967(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005604"(basement membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR017404(Ladinin 1)|mint:O00515|ensembl:ENSG00000159166(gene)|refseq:NP_005549.2 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:C58/NEfIlDj38lGEIsWtqBNuSis9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P63261 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-351292|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|uniprotkb:Q5U032|uniprotkb:Q96E67|uniprotkb:A8K7C2|ensembl:ENSP00000505060|ensembl:ENSP00000505193|ensembl:ENSP00000505235|ensembl:ENSP00000506126|ensembl:ENSP00000506201|ensembl:ENSP00000506253|ensembl:ENSP00000458162|ensembl:ENSP00000458435|ensembl:ENSP00000459119|ensembl:ENSP00000459124|ensembl:ENSP00000460464|ensembl:ENSP00000460660|ensembl:ENSP00000461672|ensembl:ENSP00000466346|ensembl:ENSP00000477968 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:actg_human(display_long)|uniprotkb:ACTG1(gene name)|psi-mi:ACTG1(display_short)|uniprotkb:ACTG(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001186883.1|refseq:NP_001605.1|ensembl:ENST00000570382(transcript)|ensembl:ENSG00000184009(gene)|ensembl:ENST00000571721(transcript)|ensembl:ENST00000573283(transcript)|ensembl:ENST00000575087(transcript)|ensembl:ENST00000575659(transcript)|ensembl:ENST00000575842(transcript)|ensembl:ENST00000575994(transcript)|ensembl:ENST00000576544(transcript)|ensembl:ENST00000615544(transcript)|ensembl:ENST00000679480(transcript)|ensembl:ENST00000679778(transcript)|ensembl:ENST00000680227(transcript)|ensembl:ENST00000680727(transcript)|ensembl:ENST00000681052(transcript)|ensembl:ENST00000681842(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63261|rcsb pdb:5JLH|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-445095|reactome:R-HSA-446353|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9013418|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P60981 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-745191|uniprotkb:P18282|uniprotkb:Q5W166|uniprotkb:Q6IAW2|uniprotkb:B2R6N2|uniprotkb:B4DYA6|ensembl:ENSP00000246069 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dest_human(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:DSTN(gene name)|psi-mi:DSTN(display_short)|uniprotkb:ACTDP(gene name synonym)|uniprotkb:DSN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001011546.1|refseq:NP_006861.1|refseq:XP_011527444.1|refseq:XP_011527445.1|refseq:XP_011527446.1|ensembl:ENSG00000125868(gene)|ensembl:ENST00000246069(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:3Z7XHPcWp0igOY70XOoGVfW5eBE9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q9NYL9 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-352614|ensembl:ENSP00000308753|uniprotkb:Q9NT43|uniprotkb:Q9NZR0|uniprotkb:B2R6G7 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:tmod3_human(display_long)|uniprotkb:TMOD3(gene name)|psi-mi:TMOD3(display_short)|uniprotkb:Ubiquitous tropomodulin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENSG00000138594(gene)|ensembl:ENST00000308580(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|refseq:NP_055362.1|go:"GO:0048821"(erythrocyte development)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR004934(Tropomodulin)|interpro:IPR030133|interpro:IPR032675|mint:Q9NYL9|reactome:R-HSA-390522|reactome:R-HSA-9013418|reactome:R-HSA-9696264|refseq:XP_016877576.1|refseq:XP_016877577.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:crEfCAAepSPAE8ByBpD4Sr14P5I9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P49006 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-4289961|uniprotkb:Q5TEE6|uniprotkb:Q6NXS5|uniprotkb:D3DPQ0|ensembl:ENSP00000362638 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:mrp_human(display_long)|uniprotkb:MARCKSL1(gene name)|psi-mi:MARCKSL1(display_short)|uniprotkb:MLP(gene name synonym)|uniprotkb:MRP(gene name synonym)|uniprotkb:MARCKS-like protein 1(gene name synonym)|uniprotkb:Macrophage myristoylated alanine-rich C kinase substrate(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) ensembl:ENSG00000175130(gene)|ensembl:ENST00000329421(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002101(Myristoylated alanine-rich C-kinase substrate MARCKS)|mint:P49006|refseq:NP_075385.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:nkq8hGJINvCHlZJ3alKkDP+wCxk9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q5T2W1 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-349819|uniprotkb:O60450|uniprotkb:Q5T5P6|uniprotkb:Q9BQ41|ensembl:ENSP00000342143|ensembl:ENSP00000394485|uniprotkb:B4DPB9|uniprotkb:E7EU02 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:nhrf3_human(display_long)|uniprotkb:PDZK1(gene name)|psi-mi:PDZK1(display_short)|uniprotkb:CFTR-associated protein of 70 kDa(gene name synonym)|uniprotkb:Na/Pi cotransporter C-terminal-associated protein 1(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 3(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger regulatory factor 3"(gene name synonym)|uniprotkb:CAP70(gene name synonym)|uniprotkb:NHERF3(gene name synonym)|uniprotkb:PDZD1(gene name synonym)|uniprotkb:PDZ domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001188254.1|refseq:NP_002605.2|ensembl:ENSG00000174827(gene)|rcsb pdb:3TMH|rcsb pdb:4Q2P|rcsb pdb:6EZI|ensembl:ENST00000344770(transcript)|ensembl:ENST00000417171(transcript)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0015879"(carnitine transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1904064"(positive regulation of cation transmembrane transport)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|mint:Q5T2W1|rcsb pdb:2EEI|rcsb pdb:2EEJ|rcsb pdb:2VSP|refseq:NP_001188255.1|refseq:XP_016856953.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:sU0SZ8m9Or0LFmLo9dh6B7RBJWs9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:P21291 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-3959636|uniprotkb:A8K268|uniprotkb:Q5U0J2|ensembl:ENSP00000345079|ensembl:ENSP00000356275|ensembl:ENSP00000434147|ensembl:ENSP00000436792 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:csrp1_human(display_long)|uniprotkb:CSRP1(gene name)|psi-mi:CSRP1(display_short)|uniprotkb:CSRP(gene name synonym)|uniprotkb:CYRP(gene name synonym)|uniprotkb:Cysteine-rich protein 1(gene name synonym)|uniprotkb:Epididymis luminal protein 141(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001180499.1|refseq:NP_001180500.1|refseq:NP_001180501.1|refseq:NP_004069.1|ensembl:ENSG00000159176(gene)|ensembl:ENST00000367306(transcript)|ensembl:ENST00000532460(transcript)|ensembl:ENST00000533432(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|interpro:IPR001781(Zinc finger, LIM-type)|reactome:R-HSA-5660489|ensembl:ENST00000340006(transcript) - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:7mB03gFR0px7OTsYWr2F1XD0U209606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q6P1M3 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-2434001|uniprotkb:Q14521|uniprotkb:Q9BR62|ensembl:ENSP00000376333 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:l2gl2_human(display_long)|uniprotkb:LLGL2(gene name)|psi-mi:LLGL2(display_short)|uniprotkb:HGL(gene name synonym)|uniprotkb:"Lethal(2) giant larvae protein homolog 2"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001015002.1|refseq:NP_001026973.1|refseq:NP_004515.2|refseq:XP_016880115.1|refseq:XP_016880119.1|ensembl:ENSG00000073350(gene)|ensembl:ENST00000392550(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0015820"(leucine transport)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045159"(myosin II binding)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR001680(WD40 repeat)|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:6N8P|rcsb pdb:6N8Q|rcsb pdb:6N8R|rcsb pdb:6N8S - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:tjKeW1HtbomKoKQcHWeJVIoCxAk9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q13085 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-717681|intact:EBI-3962262|uniprotkb:B2ZZ90|uniprotkb:Q6KEV6|uniprotkb:Q6XDA8|uniprotkb:Q7Z2G8|uniprotkb:Q7Z561|uniprotkb:Q7Z563|uniprotkb:Q7Z564|uniprotkb:Q86WB2|uniprotkb:Q86WB3|uniprotkb:B2RP68|ensembl:ENSP00000478547|ensembl:ENSP00000483674 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:acaca_human(display_long)|uniprotkb:ACACA(gene name)|psi-mi:ACACA(display_short)|uniprotkb:ACAC(gene name synonym)|uniprotkb:ACC1(gene name synonym)|uniprotkb:ACCA(gene name synonym)|uniprotkb:Acetyl-Coenzyme A carboxylase alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_942131.1|refseq:NP_942133.1|refseq:NP_942134.1|refseq:NP_942135.1|refseq:NP_942136.1|refseq:XP_016880044.1|refseq:XP_011523005.1|ensembl:ENSG00000275176(gene)|ensembl:ENSG00000278540(gene)|ensembl:ENST00000613687(transcript)|ensembl:ENST00000614428(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:Q13085|rcsb pdb:2YL2|rcsb pdb:3COJ|rcsb pdb:4ASI|rcsb pdb:6G2D|rcsb pdb:6G2H|rcsb pdb:6G2I|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|reactome:R-HSA-3371599|reactome:R-HSA-75105|dip:DIP-36122N - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:P9d0QlkoP1zrBdF1WOrK68ueGng9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O94832 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-355634|uniprotkb:Q8NHP9|ensembl:ENSP00000324527|uniprotkb:A6H8V3 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:myo1d_human(display_long)|uniprotkb:MYO1D(gene name)|psi-mi:MYO1D(display_short)|uniprotkb:KIAA0727(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_056009.1|ensembl:ENSG00000176658(gene)|ensembl:ENST00000318217(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030424"(axon)|go:"GO:0030673"(axolemma)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051641"(cellular localization)|go:"GO:0061502"(early endosome to recycling endosome transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097440"(apical dendrite)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|refseq:NP_001290208.1|interpro:IPR036961 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:EjrnXi04BVb6Z59cU3e5LW7EhRI9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q7Z4W1 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q16643 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-351394|uniprotkb:Q9UFZ5|uniprotkb:B2RBG0|ensembl:ENSP00000308532|intact:EBI-4404710|uniprotkb:A8MV58 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:dreb_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)|uniprotkb:D0S117E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_004386.2|refseq:NP_543157.1|refseq:XP_005265884.1|ensembl:ENSG00000113758(gene)|ensembl:ENST00000309007(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0042641"(actomyosin)|go:"GO:0030425"(dendrite)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|interpro:IPR029006|mint:Q16643|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|rcsb pdb:5Y1Z|rcsb pdb:5ZZ9|reactome:R-HSA-9013405|reactome:R-HSA-9013407|reactome:R-HSA-9013418|reactome:R-HSA-9013422|go:"GO:0032507"(maintenance of protein location in cell)|refseq:XP_016864629.1 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:0+VPJM5mTuG2jzmzGG3iLswmCUc9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:Q9UH62 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-717832|uniprotkb:Q53HC6|uniprotkb:Q7LCF5|uniprotkb:Q9NPE4|ensembl:ENSP00000340672|ensembl:ENSP00000439032|ensembl:ENSP00000454483 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:armx3_human(display_long)|uniprotkb:ARM protein lost in epithelial cancers on chromosome X 3(gene name synonym)|uniprotkb:ARMCX3(gene name)|psi-mi:ARMCX3(display_short)|uniprotkb:ALEX3(gene name synonym)|uniprotkb:BM-017(orf name)|uniprotkb:UNQ2517/PRO6007(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) refseq:NP_057691.1|refseq:NP_808816.1|refseq:NP_808817.1|refseq:XP_005262198.1|ensembl:ENSG00000102401(gene)|ensembl:ENST00000341189(transcript)|ensembl:ENST00000471229(transcript)|ensembl:ENST00000537169(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR000225(Armadillo)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|reactome:R-HSA-9013404 - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:Svmu819cxCJThLvYapRMLQpAszw9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NYA1-1 uniprotkb:O95425 intact:EBI-12512636|ensembl:ENSP00000376285|ensembl:ENSP00000440970|ensembl:ENSP00000465726 intact:EBI-487145|uniprotkb:O60611|uniprotkb:O60612|uniprotkb:Q5VZK5|uniprotkb:Q5VZK6|uniprotkb:Q9H1R7|uniprotkb:D3DRW9|ensembl:ENSP00000348128|uniprotkb:M1J557 psi-mi:q9nya1-1(display_long)|uniprotkb:Acetyltransferase SPHK1(gene name synonym)|uniprotkb:SK1(gene name synonym)|uniprotkb:SPHK1(gene name)|psi-mi:SPHK1(display_short)|uniprotkb:SPHK(gene name synonym)|uniprotkb:SPK(gene name synonym) psi-mi:svil_human(display_long)|uniprotkb:Archvillin(gene name synonym)|uniprotkb:p205/p250(gene name synonym)|uniprotkb:SVIL(gene name)|psi-mi:SVIL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yagoub et al. (2014) imex:IM-25499|pubmed:25216046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12512634|imex:IM-25499-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176170(gene)|ensembl:ENST00000392496(transcript)|ensembl:ENST00000545180(transcript)|ensembl:ENST00000592299(transcript)|intact:EBI-985303(isoform-parent) go:"GO:0007519"(skeletal muscle tissue development)|refseq:NP_003165.2|refseq:NP_068506.2|ensembl:ENSG00000197321(gene)|ensembl:ENST00000355867(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|interpro:IPR007123(Gelsolin region)|interpro:IPR015628(Supervillin)|interpro:IPR029006|interpro:IPR036886|mint:O95425|rcsb pdb:2K6M|rcsb pdb:2K6N|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0042995"(cell projection)|go:"GO:0043034"(costamere)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR003128(Villin headpiece)|interpro:IPR007122(Gelsolin) - - - figure legend:Table 2|author-confidence:High|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2016/08/18 2018/04/06 rogid:gD4CFoO6CgCmdD9x5nBwAFY4d+49606 rogid:5FaBAFdOX+nPJzTwEdBt8e5Keng9606 rigid:9Wqk35fDbbbhw0VJFeYb3Qc6vbI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)