#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O54957 uniprotkb:Q3TTA7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3UPF5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-8399976|uniprotkb:Q9CTU4|intact:MINT-4125302|uniprotkb:Q9DBS7|ensembl:ENSMUSP00000144312 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:zcchv_mouse(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082697.1|refseq:NP_083140.1|ensembl:ENSMUSG00000029826(gene)|ensembl:ENSMUST00000143702(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q3UPF5|rcsb pdb:6L1W - - comment:"fragmentation type: fragment"|comment:mint figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bM3F9xXlRqxjEx6pcBMEXpvjWYw10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BH59 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P27870 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8QZY9 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K1I7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9ES52 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q1HFZ0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602206|ensembl:ENSMUSP00000105321|uniprotkb:A0PJD6|uniprotkb:Q3U972|uniprotkb:Q8BPG9|uniprotkb:Q8CDF9|uniprotkb:Q91YX9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:nsun2_mouse(display_long)|uniprotkb:Nsun2(gene name)|psi-mi:Nsun2(display_short)|uniprotkb:D13Wsu123e(gene name synonym)|uniprotkb:Misu(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000021595(gene)|ensembl:ENSMUST00000109699(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|refseq:NP_663329.3 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:JqDD17n0ZTem7mv/T8ESokakLeE10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C2K5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39054 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3V3E1 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62245 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695 - - crc64:3286088A5BA0A4A6 figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60787 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26450 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BGW0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6389995|ensembl:ENSMUSP00000060129|uniprotkb:Q059Y0|uniprotkb:Q3TEM0|uniprotkb:Q3UU76|uniprotkb:Q8BGP0|uniprotkb:Q8C9S6 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:thms1_mouse(display_long)|uniprotkb:Themis(gene name)|psi-mi:Themis(display_short)|uniprotkb:Grb2-associating protein(gene name synonym)|uniprotkb:Protein thylex(gene name synonym)|uniprotkb:Thymocyte-expressed molecule involved in selection(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001292592.1|ensembl:ENSMUSG00000049109(gene)|ensembl:ENSMUST00000056097(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043383"(negative T cell selection)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025946|interpro:IPR039671|mint:Q8BGW0|dip:DIP-48976N|refseq:NP_848781.1 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:682A2kObXX0ZRZZ/IGHrOpk/U8I10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q06649 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5323518 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding) - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62077 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70218 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60631 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9CX99 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60932 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62351 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70168 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9DBG6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-529941|uniprotkb:Q3TKY0|uniprotkb:Q91XH0|uniprotkb:A2ACG6|ensembl:ENSMUSP00000112081 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rpn2_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_062616.2|ensembl:ENSMUSG00000027642(gene)|ensembl:ENSMUST00000116380(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:Q9DBG6|rcsb pdb:5J6G|rcsb pdb:5J6H - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FeAH2GGWVY8J5dSaAvfrsBSx3co10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60931 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P63037 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42225 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647118 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C3J5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P36371 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6909778|ensembl:ENSMUSP00000025197 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tap2_mouse(display_long)|uniprotkb:Tap2(gene name)|psi-mi:Tap2(display_short)|uniprotkb:Abcb3(gene name synonym)|uniprotkb:Ham-2(gene name synonym)|uniprotkb:Ham2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Histocompatibility antigen modifier 2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000024339(gene)|ensembl:ENSMUST00000025197(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0002591"(positive regulation of antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:P36371|reactome:R-MMU-1236974|reactome:R-MMU-983170|refseq:NP_035660.3 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ZDKMIuISUbt5nfCdizUB1rOvKrw10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99L45 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2527165|uniprotkb:Q9CSH6|uniprotkb:Q9CT12|ensembl:ENSMUSP00000096777|ensembl:ENSMUSP00000128257 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:if2b_mouse(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_080306.1|ensembl:ENSMUSG00000074656(gene)|ensembl:ENSMUST00000099173(transcript)|ensembl:ENSMUST00000166171(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:Q99L45|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rFKfeTTSJtJOwP6jsL1OCSQKsCU10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:O54734 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-773157|uniprotkb:Q8C4P7|ensembl:ENSMUSP00000030538 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ost48_mouse(display_long)|uniprotkb:Ddost(gene name)|psi-mi:Ddost(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_031864.2|ensembl:ENSMUSG00000028757(gene)|ensembl:ENSMUST00000030538(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:O54734|reactome:R-MMU-6798695 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:tXotz8rJCykp2nspz37gYrmrBGo10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q80SU7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-4286311|uniprotkb:Q3U3F2|uniprotkb:Q8BL18|uniprotkb:Q8CBA9|ensembl:ENSMUSP00000102377|ensembl:ENSMUSP00000135898 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gvin1_mouse(display_long)|uniprotkb:Gvin1(gene name)|psi-mi:Gvin1(display_short)|uniprotkb:Very large-inducible GTPase-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001229968.1|refseq:NP_001229969.1|ensembl:ENSMUSG00000078606(gene)|ensembl:ENSMUST00000106766(transcript)|ensembl:ENSMUST00000176467(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR029028|interpro:IPR030383|refseq:XP_017177385.1 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:c/yp0GdfvR786D+mqsLpP5scZNs10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26039 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P11352 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q01965 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q921F2 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K2Z4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602144|uniprotkb:Q6ZQI1|uniprotkb:Q8R0F2|uniprotkb:Q8R3H0|uniprotkb:Q922B7|uniprotkb:Q923A3|uniprotkb:Q9CS25|uniprotkb:Q9CT32 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cnd1_mouse(display_long)|uniprotkb:Ncapd2(gene name)|psi-mi:Ncapd2(display_short)|uniprotkb:Capd2(gene name synonym)|uniprotkb:Cnap1(gene name synonym)|uniprotkb:Kiaa0159(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0042393"(histone binding)|go:"GO:0045120"(pronucleus)|go:"GO:0051301"(cell division)|reactome:R-MMU-2514853|refseq:NP_666283.1|refseq:XP_006506594.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR024324 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Iw0UWS+bh56ekviFvZu3qr+qnxA10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P08113 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K4I3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6272809|uniprotkb:Q8C9V4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BZN6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602119|uniprotkb:F1AHI9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:doc10_mouse(display_long)|uniprotkb:Dock10(gene name)|psi-mi:Dock10(display_short)|uniprotkb:Kiaa0694(gene name synonym)|uniprotkb:Ziz3(gene name synonym)|uniprotkb:Zizimin-3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0060997"(dendritic spine morphogenesis)|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|reactome:R-MMU-983231|interpro:IPR035892|interpro:IPR037809|refseq:NP_001272856.1|refseq:NP_780500.2|interpro:IPR027007|interpro:IPR027357|interpro:IPR026791|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043162 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:as2OJvFaS/MKcK+RbYGJLbWfcxE10090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P68254 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602113|imex:IM-25620-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:4|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/12 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:sPe+2z5s8wUNuewPIcERdQumHQ8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q6PB66 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1371262|uniprotkb:Q8K4V0|uniprotkb:Q9CRX4|ensembl:ENSMUSP00000107927 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:lpprc_mouse(display_long)|uniprotkb:Lrpprc(gene name)|psi-mi:Lrpprc(display_short)|uniprotkb:Lrp130(gene name synonym)|uniprotkb:130 kDa leucine-rich protein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082509.2|ensembl:ENSMUSG00000024120(gene)|ensembl:ENSMUST00000112308(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|reactome:R-MMU-611105|reactome:R-MMU-9707564|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:Q6PB66|reactome:R-MMU-5628897|go:"GO:0005634"(nucleus) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:wNo59nF0OqIHfnoUrxN10z7YIGM10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3TBT3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3TTA7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99JF8 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-8317838|uniprotkb:A2BI11|uniprotkb:Q3TTD7|uniprotkb:Q9CT03|uniprotkb:Q80WQ7|uniprotkb:Q3TEJ7|intact:MINT-4123368|uniprotkb:Q99JF7|uniprotkb:Q3UTA1|uniprotkb:Q99LR4|uniprotkb:A2BI10|ensembl:ENSMUSP00000030207 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:psip1_mouse(display_long)|uniprotkb:Psip1(gene name)|psi-mi:Psip1(display_short)|uniprotkb:Ledgf(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_598709.1|refseq:NP_001277456.1|ensembl:ENSMUSG00000028484(gene)|ensembl:ENSMUST00000030207(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:Q99JF8 - - comment:mint|function:Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Zta4EkVlkXij7w85S8romBaldU010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P19783 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-7174084|ensembl:ENSMUSP00000034276|ensembl:ENSMUSP00000138019|uniprotkb:Q545A9|intact:MINT-1860013 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cox41_mouse(display_long)|uniprotkb:Cox4i1(gene name)|psi-mi:Cox4i1(display_short)|uniprotkb:Cox4(gene name synonym)|uniprotkb:Cox4a(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001280488.1|refseq:NP_034071.2|ensembl:ENSMUSG00000031818(gene)|ensembl:ENSMUST00000034276(transcript)|ensembl:ENSMUST00000181586(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031966"(mitochondrial membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P19783|reactome:R-MMU-5628897|reactome:R-MMU-611105|reactome:R-MMU-9707564 - - function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport|comment:mint figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:zt2qwV/jVAo1B9UISW8R2votzlU10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3UPF5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-8399976|uniprotkb:Q9CTU4|intact:MINT-4125302|uniprotkb:Q9DBS7|ensembl:ENSMUSP00000144312 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:zcchv_mouse(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082697.1|refseq:NP_083140.1|ensembl:ENSMUSG00000029826(gene)|ensembl:ENSMUST00000143702(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q3UPF5|rcsb pdb:6L1W - - comment:"fragmentation type: fragment"|comment:mint figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bM3F9xXlRqxjEx6pcBMEXpvjWYw10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P97370 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600894|ensembl:ENSMUSP00000034983 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:at1b3_mouse(display_long)|uniprotkb:Atp1b3(gene name)|psi-mi:Atp1b3(display_short)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000032412(gene)|ensembl:ENSMUST00000034983(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|reactome:R-MMU-210991|reactome:R-MMU-5578775|reactome:R-MMU-936837|refseq:NP_031528.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:z78ACyXghYUeMg35vowyjhFlqEE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K2Z4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602144|uniprotkb:Q6ZQI1|uniprotkb:Q8R0F2|uniprotkb:Q8R3H0|uniprotkb:Q922B7|uniprotkb:Q923A3|uniprotkb:Q9CS25|uniprotkb:Q9CT32 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cnd1_mouse(display_long)|uniprotkb:Ncapd2(gene name)|psi-mi:Ncapd2(display_short)|uniprotkb:Capd2(gene name synonym)|uniprotkb:Cnap1(gene name synonym)|uniprotkb:Kiaa0159(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0042393"(histone binding)|go:"GO:0045120"(pronucleus)|go:"GO:0051301"(cell division)|reactome:R-MMU-2514853|refseq:NP_666283.1|refseq:XP_006506594.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR024324 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Iw0UWS+bh56ekviFvZu3qr+qnxA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q80SU7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-4286311|uniprotkb:Q3U3F2|uniprotkb:Q8BL18|uniprotkb:Q8CBA9|ensembl:ENSMUSP00000102377|ensembl:ENSMUSP00000135898 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gvin1_mouse(display_long)|uniprotkb:Gvin1(gene name)|psi-mi:Gvin1(display_short)|uniprotkb:Very large-inducible GTPase-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001229968.1|refseq:NP_001229969.1|ensembl:ENSMUSG00000078606(gene)|ensembl:ENSMUST00000106766(transcript)|ensembl:ENSMUST00000176467(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR029028|interpro:IPR030383|refseq:XP_017177385.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:c/yp0GdfvR786D+mqsLpP5scZNs10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q6PDI5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11095875|uniprotkb:Q6ZQC9|uniprotkb:A2ALW0|uniprotkb:Q8R3M6|uniprotkb:Q8BSW7|uniprotkb:Q8CAH0|ensembl:ENSMUSP00000099953 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ecm29_mouse(display_long)|uniprotkb:Ecpas(gene name)|psi-mi:Ecpas(display_short)|uniprotkb:Ecm29(gene name synonym)|uniprotkb:Kiaa0368(gene name synonym)|uniprotkb:Proteasome-associated protein ECM29 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_759013.2|refseq:XP_006537911.1|refseq:XP_006537912.1|ensembl:ENSMUSG00000050812(gene)|ensembl:ENSMUST00000102889(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005813"(centrosome)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043248"(proteasome assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024372 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3yOE/Fh8rFkVHGNPhs4hx+SFT2k10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q61823 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-296473|uniprotkb:P97296|uniprotkb:Q3T9A9|ensembl:ENSMUSP00000025931|ensembl:ENSMUSP00000073975|ensembl:ENSMUSP00000133135 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:pdcd4_mouse(display_long)|uniprotkb:Pdcd4(gene name)|psi-mi:Pdcd4(display_short)|uniprotkb:Ma3(gene name synonym)|uniprotkb:Topoisomerase-inhibitor suppressed protein(gene name synonym)|uniprotkb:Protein MA-3(gene name synonym)|uniprotkb:Tis(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007569"(cell aging)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|ensembl:ENSMUSG00000024975(gene)|ensembl:ENSMUST00000025931(transcript)|ensembl:ENSMUST00000074371(transcript)|ensembl:ENSMUST00000165617(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039778|mint:Q61823|rcsb pdb:2HM8|rcsb pdb:2IOL|rcsb pdb:2ION|rcsb pdb:2IOS|rcsb pdb:2KZT|rcsb pdb:2NSZ|rcsb pdb:3EIQ|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|refseq:NP_001161963.1|refseq:NP_001161964.1|refseq:NP_035180.2|refseq:XP_006526825.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ruEZtMgfVyIslPFdsTmuOfZhwuM10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42227 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9R1C7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-645554|uniprotkb:Q61049|uniprotkb:Q8BQ76|uniprotkb:Q8BRW4|uniprotkb:Q8C2U1|ensembl:ENSMUSP00000159339 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:pr40a_mouse(display_long)|uniprotkb:Formin-binding protein 3(gene name synonym)|uniprotkb:Formin-binding protein 11(gene name synonym)|uniprotkb:Prpf40a(gene name)|psi-mi:Prpf40a(display_short)|uniprotkb:Fbp11(gene name synonym)|uniprotkb:Fnbp3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_061255.1|ensembl:ENSMUSG00000061136(gene)|ensembl:ENSMUST00000239398(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005685"(U1 snRNP)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|interpro:IPR039726|mint:Q9R1C7|reactome:R-MMU-72163 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:urpZDf+jd9lovL7obd2Y+a/lBCE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P22682 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:8MpthfXwJFMSMC6mDaTdb063dj010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39688 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q03526 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647969|ensembl:ENSMUSP00000104860 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q6ZQ38 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-597255|uniprotkb:Q6PFR0|uniprotkb:Q9CV45|ensembl:ENSMUSP00000020315 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cand1_mouse(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:D10Ertd516e(gene name synonym)|uniprotkb:Kiaa0829(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082270.1|ensembl:ENSMUSG00000020114(gene)|ensembl:ENSMUST00000020315(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:Q6ZQ38|reactome:R-MMU-6798695|reactome:R-MMU-8951664|reactome:R-MMU-917937 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:E6bJujLfT/V3C8Iyk0hUD1m4gT010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9ERK4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-400836|intact:EBI-4283823|ensembl:ENSMUSP00000002790 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:xpo2_mouse(display_long)|uniprotkb:Cse1l(gene name)|psi-mi:Cse1l(display_short)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Xpo2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_076054.1|ensembl:ENSMUSG00000002718(gene)|ensembl:ENSMUST00000002790(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9ERK4 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:vJpTu+2YjwIRrjM3V815K3lZzAg10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P49718 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-913678|ensembl:ENSMUSP00000126135|ensembl:ENSMUSP00000148525|ensembl:ENSMUSP00000148648|uniprotkb:Q52KC3 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:mcm5_mouse(display_long)|uniprotkb:Mcm5(gene name)|psi-mi:Mcm5(display_short)|uniprotkb:Cdc46(gene name synonym)|uniprotkb:Mcmd5(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|ensembl:ENSMUSG00000005410(gene)|ensembl:ENSMUST00000164309(transcript)|ensembl:ENSMUST00000212426(transcript)|ensembl:ENSMUST00000212811(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052|dip:DIP-45875N|refseq:NP_001289469.1|refseq:NP_032592.2 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:/BtYm9P7ZJQbJh2+8Dre6uHX7Mc10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BH59 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P27870 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8QZY9 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K1I7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9ES52 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q1HFZ0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602206|ensembl:ENSMUSP00000105321|uniprotkb:A0PJD6|uniprotkb:Q3U972|uniprotkb:Q8BPG9|uniprotkb:Q8CDF9|uniprotkb:Q91YX9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:nsun2_mouse(display_long)|uniprotkb:Nsun2(gene name)|psi-mi:Nsun2(display_short)|uniprotkb:D13Wsu123e(gene name synonym)|uniprotkb:Misu(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000021595(gene)|ensembl:ENSMUST00000109699(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|refseq:NP_663329.3 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:JqDD17n0ZTem7mv/T8ESokakLeE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C2K5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39054 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3V3E1 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62245 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695 - - crc64:3286088A5BA0A4A6 figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60787 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26450 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BGW0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6389995|ensembl:ENSMUSP00000060129|uniprotkb:Q059Y0|uniprotkb:Q3TEM0|uniprotkb:Q3UU76|uniprotkb:Q8BGP0|uniprotkb:Q8C9S6 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:thms1_mouse(display_long)|uniprotkb:Themis(gene name)|psi-mi:Themis(display_short)|uniprotkb:Grb2-associating protein(gene name synonym)|uniprotkb:Protein thylex(gene name synonym)|uniprotkb:Thymocyte-expressed molecule involved in selection(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001292592.1|ensembl:ENSMUSG00000049109(gene)|ensembl:ENSMUST00000056097(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043383"(negative T cell selection)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025946|interpro:IPR039671|mint:Q8BGW0|dip:DIP-48976N|refseq:NP_848781.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:682A2kObXX0ZRZZ/IGHrOpk/U8I10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q06649 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5323518 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62077 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70218 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60631 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9CX99 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60932 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62351 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70168 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9DBG6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-529941|uniprotkb:Q3TKY0|uniprotkb:Q91XH0|uniprotkb:A2ACG6|ensembl:ENSMUSP00000112081 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rpn2_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_062616.2|ensembl:ENSMUSG00000027642(gene)|ensembl:ENSMUST00000116380(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:Q9DBG6|rcsb pdb:5J6G|rcsb pdb:5J6H - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FeAH2GGWVY8J5dSaAvfrsBSx3co10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60931 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P63037 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42225 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647118 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C3J5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P36371 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6909778|ensembl:ENSMUSP00000025197 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tap2_mouse(display_long)|uniprotkb:Tap2(gene name)|psi-mi:Tap2(display_short)|uniprotkb:Abcb3(gene name synonym)|uniprotkb:Ham-2(gene name synonym)|uniprotkb:Ham2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Histocompatibility antigen modifier 2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000024339(gene)|ensembl:ENSMUST00000025197(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0002591"(positive regulation of antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:P36371|reactome:R-MMU-1236974|reactome:R-MMU-983170|refseq:NP_035660.3 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ZDKMIuISUbt5nfCdizUB1rOvKrw10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99L45 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2527165|uniprotkb:Q9CSH6|uniprotkb:Q9CT12|ensembl:ENSMUSP00000096777|ensembl:ENSMUSP00000128257 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:if2b_mouse(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_080306.1|ensembl:ENSMUSG00000074656(gene)|ensembl:ENSMUST00000099173(transcript)|ensembl:ENSMUST00000166171(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:Q99L45|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rFKfeTTSJtJOwP6jsL1OCSQKsCU10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:O54734 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-773157|uniprotkb:Q8C4P7|ensembl:ENSMUSP00000030538 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ost48_mouse(display_long)|uniprotkb:Ddost(gene name)|psi-mi:Ddost(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_031864.2|ensembl:ENSMUSG00000028757(gene)|ensembl:ENSMUST00000030538(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:O54734|reactome:R-MMU-6798695 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:tXotz8rJCykp2nspz37gYrmrBGo10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26039 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P11352 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q01965 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q921F2 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P08113 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K4I3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6272809|uniprotkb:Q8C9V4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BZN6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602119|uniprotkb:F1AHI9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:doc10_mouse(display_long)|uniprotkb:Dock10(gene name)|psi-mi:Dock10(display_short)|uniprotkb:Kiaa0694(gene name synonym)|uniprotkb:Ziz3(gene name synonym)|uniprotkb:Zizimin-3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0060997"(dendritic spine morphogenesis)|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|reactome:R-MMU-983231|interpro:IPR035892|interpro:IPR037809|refseq:NP_001272856.1|refseq:NP_780500.2|interpro:IPR027007|interpro:IPR027357|interpro:IPR026791|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043162 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:as2OJvFaS/MKcK+RbYGJLbWfcxE10090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P68254 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602258|imex:IM-25620-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:sF5gYt50UCAGmpChtod9fJr4QhM false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3TTA7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3UPF5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-8399976|uniprotkb:Q9CTU4|intact:MINT-4125302|uniprotkb:Q9DBS7|ensembl:ENSMUSP00000144312 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:zcchv_mouse(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082697.1|refseq:NP_083140.1|ensembl:ENSMUSG00000029826(gene)|ensembl:ENSMUST00000143702(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q3UPF5|rcsb pdb:6L1W - - comment:"fragmentation type: fragment"|comment:mint figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bM3F9xXlRqxjEx6pcBMEXpvjWYw10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BH59 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P27870 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8QZY9 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K1I7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9ES52 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q1HFZ0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602206|ensembl:ENSMUSP00000105321|uniprotkb:A0PJD6|uniprotkb:Q3U972|uniprotkb:Q8BPG9|uniprotkb:Q8CDF9|uniprotkb:Q91YX9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:nsun2_mouse(display_long)|uniprotkb:Nsun2(gene name)|psi-mi:Nsun2(display_short)|uniprotkb:D13Wsu123e(gene name synonym)|uniprotkb:Misu(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000021595(gene)|ensembl:ENSMUST00000109699(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|refseq:NP_663329.3 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:JqDD17n0ZTem7mv/T8ESokakLeE10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C2K5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39054 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3V3E1 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62245 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695 - - crc64:3286088A5BA0A4A6 figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60787 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26450 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BGW0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6389995|ensembl:ENSMUSP00000060129|uniprotkb:Q059Y0|uniprotkb:Q3TEM0|uniprotkb:Q3UU76|uniprotkb:Q8BGP0|uniprotkb:Q8C9S6 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:thms1_mouse(display_long)|uniprotkb:Themis(gene name)|psi-mi:Themis(display_short)|uniprotkb:Grb2-associating protein(gene name synonym)|uniprotkb:Protein thylex(gene name synonym)|uniprotkb:Thymocyte-expressed molecule involved in selection(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001292592.1|ensembl:ENSMUSG00000049109(gene)|ensembl:ENSMUST00000056097(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043383"(negative T cell selection)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025946|interpro:IPR039671|mint:Q8BGW0|dip:DIP-48976N|refseq:NP_848781.1 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:682A2kObXX0ZRZZ/IGHrOpk/U8I10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q06649 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-5323518 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding) - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62077 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70218 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60631 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9CX99 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60932 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62351 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70168 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9DBG6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-529941|uniprotkb:Q3TKY0|uniprotkb:Q91XH0|uniprotkb:A2ACG6|ensembl:ENSMUSP00000112081 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rpn2_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_062616.2|ensembl:ENSMUSG00000027642(gene)|ensembl:ENSMUST00000116380(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:Q9DBG6|rcsb pdb:5J6G|rcsb pdb:5J6H - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FeAH2GGWVY8J5dSaAvfrsBSx3co10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60931 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P63037 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42225 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647118 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C3J5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P36371 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6909778|ensembl:ENSMUSP00000025197 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tap2_mouse(display_long)|uniprotkb:Tap2(gene name)|psi-mi:Tap2(display_short)|uniprotkb:Abcb3(gene name synonym)|uniprotkb:Ham-2(gene name synonym)|uniprotkb:Ham2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Histocompatibility antigen modifier 2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000024339(gene)|ensembl:ENSMUST00000025197(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0002591"(positive regulation of antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:P36371|reactome:R-MMU-1236974|reactome:R-MMU-983170|refseq:NP_035660.3 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ZDKMIuISUbt5nfCdizUB1rOvKrw10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99L45 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2527165|uniprotkb:Q9CSH6|uniprotkb:Q9CT12|ensembl:ENSMUSP00000096777|ensembl:ENSMUSP00000128257 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:if2b_mouse(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_080306.1|ensembl:ENSMUSG00000074656(gene)|ensembl:ENSMUST00000099173(transcript)|ensembl:ENSMUST00000166171(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:Q99L45|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rFKfeTTSJtJOwP6jsL1OCSQKsCU10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:O54734 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-773157|uniprotkb:Q8C4P7|ensembl:ENSMUSP00000030538 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ost48_mouse(display_long)|uniprotkb:Ddost(gene name)|psi-mi:Ddost(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_031864.2|ensembl:ENSMUSG00000028757(gene)|ensembl:ENSMUST00000030538(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:O54734|reactome:R-MMU-6798695 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:tXotz8rJCykp2nspz37gYrmrBGo10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q80SU7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-4286311|uniprotkb:Q3U3F2|uniprotkb:Q8BL18|uniprotkb:Q8CBA9|ensembl:ENSMUSP00000102377|ensembl:ENSMUSP00000135898 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gvin1_mouse(display_long)|uniprotkb:Gvin1(gene name)|psi-mi:Gvin1(display_short)|uniprotkb:Very large-inducible GTPase-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001229968.1|refseq:NP_001229969.1|ensembl:ENSMUSG00000078606(gene)|ensembl:ENSMUST00000106766(transcript)|ensembl:ENSMUST00000176467(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR029028|interpro:IPR030383|refseq:XP_017177385.1 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:c/yp0GdfvR786D+mqsLpP5scZNs10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26039 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q01965 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q921F2 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K2Z4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602144|uniprotkb:Q6ZQI1|uniprotkb:Q8R0F2|uniprotkb:Q8R3H0|uniprotkb:Q922B7|uniprotkb:Q923A3|uniprotkb:Q9CS25|uniprotkb:Q9CT32 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cnd1_mouse(display_long)|uniprotkb:Ncapd2(gene name)|psi-mi:Ncapd2(display_short)|uniprotkb:Capd2(gene name synonym)|uniprotkb:Cnap1(gene name synonym)|uniprotkb:Kiaa0159(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0042393"(histone binding)|go:"GO:0045120"(pronucleus)|go:"GO:0051301"(cell division)|reactome:R-MMU-2514853|refseq:NP_666283.1|refseq:XP_006506594.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR024324 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Iw0UWS+bh56ekviFvZu3qr+qnxA10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P08113 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K4I3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6272809|uniprotkb:Q8C9V4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BZN6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602119|uniprotkb:F1AHI9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:doc10_mouse(display_long)|uniprotkb:Dock10(gene name)|psi-mi:Dock10(display_short)|uniprotkb:Kiaa0694(gene name synonym)|uniprotkb:Ziz3(gene name synonym)|uniprotkb:Zizimin-3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0060997"(dendritic spine morphogenesis)|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|reactome:R-MMU-983231|interpro:IPR035892|interpro:IPR037809|refseq:NP_001272856.1|refseq:NP_780500.2|interpro:IPR027007|interpro:IPR027357|interpro:IPR026791|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043162 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:as2OJvFaS/MKcK+RbYGJLbWfcxE10090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P68254 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602729|imex:IM-25620-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:4-120 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:GkSFZ4KK+tG0zT5y3GR8bzpSo9c false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3TTA7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3UPF5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-8399976|uniprotkb:Q9CTU4|intact:MINT-4125302|uniprotkb:Q9DBS7|ensembl:ENSMUSP00000144312 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:zcchv_mouse(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_082697.1|refseq:NP_083140.1|ensembl:ENSMUSG00000029826(gene)|ensembl:ENSMUST00000143702(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q3UPF5|rcsb pdb:6L1W - - comment:"fragmentation type: fragment"|comment:mint figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bM3F9xXlRqxjEx6pcBMEXpvjWYw10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P11352 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BH59 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P27870 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8QZY9 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K1I7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9ES52 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q1HFZ0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602206|ensembl:ENSMUSP00000105321|uniprotkb:A0PJD6|uniprotkb:Q3U972|uniprotkb:Q8BPG9|uniprotkb:Q8CDF9|uniprotkb:Q91YX9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:nsun2_mouse(display_long)|uniprotkb:Nsun2(gene name)|psi-mi:Nsun2(display_short)|uniprotkb:D13Wsu123e(gene name synonym)|uniprotkb:Misu(gene name synonym)|uniprotkb:Myc-induced SUN domain-containing protein(gene name synonym)|uniprotkb:NOL1/NOP2/Sun domain family member 2(gene name synonym)|uniprotkb:"mRNA cytosine C(5)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA cytosine C(5)-methyltransferase"(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000021595(gene)|ensembl:ENSMUST00000109699(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001510"(RNA methylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0007286"(spermatid development)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016428"("tRNA (cytosine-5-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0033313"(meiotic cell cycle checkpoint signaling)|go:"GO:0033391"(chromatoid body)|go:"GO:0036416"(tRNA stabilization)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051301"(cell division)|go:"GO:0062152"("mRNA (cytidine-5-)-methyltransferase activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0080009"(mRNA methylation)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR023270|interpro:IPR029063|refseq:NP_663329.3 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:JqDD17n0ZTem7mv/T8ESokakLeE10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C2K5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12601423|ensembl:ENSMUSP00000064084|uniprotkb:A3KMM0|uniprotkb:Q8C2A5|uniprotkb:Q8C9R4|uniprotkb:Q8CDB4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rasl3_mouse(display_long)|uniprotkb:Rasal3(gene name)|psi-mi:Rasal3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001334272.1|ensembl:ENSMUSG00000052142(gene)|ensembl:ENSMUST00000063824(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0098562"(cytoplasmic side of membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR035892|interpro:IPR039360|reactome:R-MMU-5658442|refseq:NP_848900.2|dip:DIP-61657N - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:nUEQv7QhwwWsCndoRkpbGtDSqtQ10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39054 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60932 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62351 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70168 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9DBG6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-529941|uniprotkb:Q3TKY0|uniprotkb:Q91XH0|uniprotkb:A2ACG6|ensembl:ENSMUSP00000112081 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rpn2_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_062616.2|ensembl:ENSMUSG00000027642(gene)|ensembl:ENSMUST00000116380(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:Q9DBG6|rcsb pdb:5J6G|rcsb pdb:5J6H - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FeAH2GGWVY8J5dSaAvfrsBSx3co10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60931 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P63037 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42225 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647118 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C3J5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P36371 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6909778|ensembl:ENSMUSP00000025197 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tap2_mouse(display_long)|uniprotkb:Tap2(gene name)|psi-mi:Tap2(display_short)|uniprotkb:Abcb3(gene name synonym)|uniprotkb:Ham-2(gene name synonym)|uniprotkb:Ham2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Histocompatibility antigen modifier 2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000024339(gene)|ensembl:ENSMUST00000025197(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0002591"(positive regulation of antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:P36371|reactome:R-MMU-1236974|reactome:R-MMU-983170|refseq:NP_035660.3 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ZDKMIuISUbt5nfCdizUB1rOvKrw10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99L45 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2527165|uniprotkb:Q9CSH6|uniprotkb:Q9CT12|ensembl:ENSMUSP00000096777|ensembl:ENSMUSP00000128257 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:if2b_mouse(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_080306.1|ensembl:ENSMUSG00000074656(gene)|ensembl:ENSMUST00000099173(transcript)|ensembl:ENSMUST00000166171(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:Q99L45|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rFKfeTTSJtJOwP6jsL1OCSQKsCU10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:O54734 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-773157|uniprotkb:Q8C4P7|ensembl:ENSMUSP00000030538 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ost48_mouse(display_long)|uniprotkb:Ddost(gene name)|psi-mi:Ddost(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_031864.2|ensembl:ENSMUSG00000028757(gene)|ensembl:ENSMUST00000030538(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:O54734|reactome:R-MMU-6798695 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:tXotz8rJCykp2nspz37gYrmrBGo10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q80SU7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-4286311|uniprotkb:Q3U3F2|uniprotkb:Q8BL18|uniprotkb:Q8CBA9|ensembl:ENSMUSP00000102377|ensembl:ENSMUSP00000135898 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gvin1_mouse(display_long)|uniprotkb:Gvin1(gene name)|psi-mi:Gvin1(display_short)|uniprotkb:Very large-inducible GTPase-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001229968.1|refseq:NP_001229969.1|ensembl:ENSMUSG00000078606(gene)|ensembl:ENSMUST00000106766(transcript)|ensembl:ENSMUST00000176467(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR029028|interpro:IPR030383|refseq:XP_017177385.1 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:c/yp0GdfvR786D+mqsLpP5scZNs10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26039 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q01965 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q921F2 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K2Z4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602144|uniprotkb:Q6ZQI1|uniprotkb:Q8R0F2|uniprotkb:Q8R3H0|uniprotkb:Q922B7|uniprotkb:Q923A3|uniprotkb:Q9CS25|uniprotkb:Q9CT32 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cnd1_mouse(display_long)|uniprotkb:Ncapd2(gene name)|psi-mi:Ncapd2(display_short)|uniprotkb:Capd2(gene name synonym)|uniprotkb:Cnap1(gene name synonym)|uniprotkb:Kiaa0159(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0042393"(histone binding)|go:"GO:0045120"(pronucleus)|go:"GO:0051301"(cell division)|reactome:R-MMU-2514853|refseq:NP_666283.1|refseq:XP_006506594.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR024324 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Iw0UWS+bh56ekviFvZu3qr+qnxA10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P08113 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K4I3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6272809|uniprotkb:Q8C9V4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BZN6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602119|uniprotkb:F1AHI9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:doc10_mouse(display_long)|uniprotkb:Dock10(gene name)|psi-mi:Dock10(display_short)|uniprotkb:Kiaa0694(gene name synonym)|uniprotkb:Ziz3(gene name synonym)|uniprotkb:Zizimin-3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0060997"(dendritic spine morphogenesis)|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|reactome:R-MMU-983231|interpro:IPR035892|interpro:IPR037809|refseq:NP_001272856.1|refseq:NP_780500.2|interpro:IPR027007|interpro:IPR027357|interpro:IPR026791|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043162 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:as2OJvFaS/MKcK+RbYGJLbWfcxE10090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P68254 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602776|imex:IM-25620-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:4-30 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:xBMbOYCNMPOTURc+OG6DJlewKo0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q3TTA7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P11352 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8BH59 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-445380|uniprotkb:A2BFG0|ensembl:ENSMUSP00000122103 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cmc1_mouse(display_long)|uniprotkb:Solute carrier family 25 member 12(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Slc25a12(gene name)|psi-mi:Slc25a12(display_short)|uniprotkb:Aralar1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_766024.1|ensembl:ENSMUSG00000027010(gene)|ensembl:ENSMUST00000151937(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q8BH59|reactome:R-MMU-70263|reactome:R-MMU-8963693 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:n5EwQVcmGB37DOgF1haZb8kCnqc10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8QZY9 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P39054 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-642337|uniprotkb:Q9DBE1|ensembl:ENSMUSP00000133564 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dyn2_mouse(display_long)|uniprotkb:Dynamin UDNM(gene name synonym)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001240822.1|refseq:NP_001240823.1|refseq:NP_031897.2|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000172482(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008017"(microtubule binding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39054|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-203641|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-8856828 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:+f91mVsvYvuhsUOSzw37RpZv/2M10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60932 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q62351 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P70168 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q9DBG6 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-529941|uniprotkb:Q3TKY0|uniprotkb:Q91XH0|uniprotkb:A2ACG6|ensembl:ENSMUSP00000112081 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:rpn2_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_062616.2|ensembl:ENSMUSG00000027642(gene)|ensembl:ENSMUST00000116380(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:Q9DBG6|rcsb pdb:5J6G|rcsb pdb:5J6H - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:FeAH2GGWVY8J5dSaAvfrsBSx3co10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q60931 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-771123|uniprotkb:Q8BNG2|ensembl:ENSMUSP00000009036 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:vdac3_mouse(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)|uniprotkb:Vdac3(gene name)|psi-mi:Vdac3(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035826.1|ensembl:ENSMUSG00000008892(gene)|ensembl:ENSMUST00000009036(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q60931|reactome:R-MMU-5689880 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:cBs9pPTPorGZoBuaaQDE1ZEoWGQ10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P63037 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P42225 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-647118 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8C3J5 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P36371 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6909778|ensembl:ENSMUSP00000025197 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tap2_mouse(display_long)|uniprotkb:Tap2(gene name)|psi-mi:Tap2(display_short)|uniprotkb:Abcb3(gene name synonym)|uniprotkb:Ham-2(gene name synonym)|uniprotkb:Ham2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Histocompatibility antigen modifier 2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 ensembl:ENSMUSG00000024339(gene)|ensembl:ENSMUST00000025197(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0002591"(positive regulation of antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:P36371|reactome:R-MMU-1236974|reactome:R-MMU-983170|refseq:NP_035660.3 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:ZDKMIuISUbt5nfCdizUB1rOvKrw10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q99L45 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-2527165|uniprotkb:Q9CSH6|uniprotkb:Q9CT12|ensembl:ENSMUSP00000096777|ensembl:ENSMUSP00000128257 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:if2b_mouse(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit beta(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_080306.1|ensembl:ENSMUSG00000074656(gene)|ensembl:ENSMUST00000099173(transcript)|ensembl:ENSMUST00000166171(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:Q99L45|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:rFKfeTTSJtJOwP6jsL1OCSQKsCU10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:O54734 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-773157|uniprotkb:Q8C4P7|ensembl:ENSMUSP00000030538 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ost48_mouse(display_long)|uniprotkb:Ddost(gene name)|psi-mi:Ddost(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_031864.2|ensembl:ENSMUSG00000028757(gene)|ensembl:ENSMUST00000030538(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:O54734|reactome:R-MMU-6798695 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:tXotz8rJCykp2nspz37gYrmrBGo10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q80SU7 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-4286311|uniprotkb:Q3U3F2|uniprotkb:Q8BL18|uniprotkb:Q8CBA9|ensembl:ENSMUSP00000102377|ensembl:ENSMUSP00000135898 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:gvin1_mouse(display_long)|uniprotkb:Gvin1(gene name)|psi-mi:Gvin1(display_short)|uniprotkb:Very large-inducible GTPase-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001229968.1|refseq:NP_001229969.1|ensembl:ENSMUSG00000078606(gene)|ensembl:ENSMUST00000106766(transcript)|ensembl:ENSMUST00000176467(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR029028|interpro:IPR030383|refseq:XP_017177385.1 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:c/yp0GdfvR786D+mqsLpP5scZNs10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P26039 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q01965 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q921F2 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K2Z4 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-12602144|uniprotkb:Q6ZQI1|uniprotkb:Q8R0F2|uniprotkb:Q8R3H0|uniprotkb:Q922B7|uniprotkb:Q923A3|uniprotkb:Q9CS25|uniprotkb:Q9CT32 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:cnd1_mouse(display_long)|uniprotkb:Ncapd2(gene name)|psi-mi:Ncapd2(display_short)|uniprotkb:Capd2(gene name synonym)|uniprotkb:Cnap1(gene name synonym)|uniprotkb:Kiaa0159(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0042393"(histone binding)|go:"GO:0045120"(pronucleus)|go:"GO:0051301"(cell division)|reactome:R-MMU-2514853|refseq:NP_666283.1|refseq:XP_006506594.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR024324 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:Iw0UWS+bh56ekviFvZu3qr+qnxA10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:P08113 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O54957 uniprotkb:Q8K4I3 intact:EBI-6390034|ensembl:ENSMUSP00000032997 intact:EBI-6272809|uniprotkb:Q8C9V4 psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:arhg6_mouse(display_long)|uniprotkb:Alpha-PIX(gene name synonym)|uniprotkb:Arhgef6(gene name)|psi-mi:Arhgef6(display_short)|uniprotkb:Rac/Cdc42 guanine nucleotide exchange factor 6(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602860|imex:IM-25620-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|rcsb pdb:1V61|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-446388|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013420|interpro:IPR032409|mint:Q8K4I3|refseq:NP_690014.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR003096(SM22/calponin)|interpro:IPR035788|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872 - - - figure legend:4-0 secs|comment:"The protein \"CMCT\" was also found here,and has been entered as CMC1 as no protein \"CMCT\" can be found."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rogid:3qsyAQpus/hb/97AanKkOKb7+uI10090 rigid:V6UQQcIwsf6REZSIha237Hx8dvk false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602965|imex:IM-25620-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:5 A|agonist:pervanadate for 30-300 secs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:IWfYYx5NiSorJCswPCUAOfcydfs false strep ii tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602965|imex:IM-25620-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:5 A|agonist:pervanadate for 30-300 secs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:IWfYYx5NiSorJCswPCUAOfcydfs false strep ii tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61003 uniprotkb:Q60787 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602974|imex:IM-25620-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:5B|agonist:anti-CD3 and anti-CD4 antibodies for 30 secs.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:fxO/OVCb3abOhJPpDYuS0FB876o false - strep ii tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61003 uniprotkb:Q60787 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602983|imex:IM-25620-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:5 C|agonist:anti-CD3 and anti-CD4 antibodies for 2 minutes.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:fxO/OVCb3abOhJPpDYuS0FB876o false - strep ii tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61003 uniprotkb:P27870 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602991|imex:IM-25620-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:5 E|agonist:anti-CD3 and anti-CD4 antibodies for 2 minutes.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:jvt04HpPSfYPzPSt90hDu99AOcI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61003 uniprotkb:Q60787 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738913|imex:IM-25620-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:6E|comment:CD6 was able to recruit SLP-76 in a Lat-independent manner.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2017/01/16 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:fxO/OVCb3abOhJPpDYuS0FB876o false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13094 uniprotkb:P30203 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-2873748|ensembl:ENSP00000323280|uniprotkb:Q9UMF2|uniprotkb:Q9Y4K8|uniprotkb:Q9Y4L0|uniprotkb:Q9Y4K7|uniprotkb:Q9Y4K9|uniprotkb:A4KAD4|uniprotkb:A4KAD5 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_human(display_long)|uniprotkb:CD6(gene name)|psi-mi:CD6(display_short)|uniprotkb:T12(gene name synonym)|uniprotkb:TP120(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12603033|imex:IM-25620-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809 ensembl:ENSG00000013725(gene)|ensembl:ENST00000313421(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|rcsb pdb:5A2E|refseq:XP_011543664.1|refseq:NP_006716.3|refseq:XP_006718801.1|refseq:XP_006718804.1|refseq:NP_001241679.1|refseq:NP_001241680.1|dip:DIP-43704N - - - figure legend:6 B|comment:CD6 was still able to associate with SLP-76 in the absence of Lat.|comment:"In the absence of Zap70, there was no CD25zeta-inducible association between CD6 and SLP-76 (Fig. 6b)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat e6.1)|taxid:9606(Homo sapiens) - 2016/10/20 2016/11/29 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:7GTuuSJHssuyL3S2CiBAN14eP9c9606 rigid:auGV2gyE5FvfDp/7OHSZCJ7uJZA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13094 uniprotkb:P43403 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-1211276|uniprotkb:A6NFP4|uniprotkb:Q6PIA4|uniprotkb:Q8IXD6|uniprotkb:Q9UBS6|ensembl:ENSP00000264972 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:zap70_human(display_long)|uniprotkb:ZAP70(gene name)|psi-mi:ZAP70(display_short)|uniprotkb:SRK(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12603033|imex:IM-25620-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809 refseq:NP_001070.2|refseq:NP_997402.1|dip:DIP-38781N|ensembl:ENSG00000115085(gene)|ensembl:ENST00000264972(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042113"(B cell activation)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070489"(T cell aggregation)|go:"GO:0072678"(T cell migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43403|rcsb pdb:1FBV|rcsb pdb:1M61|rcsb pdb:1U59|rcsb pdb:2CBL|rcsb pdb:2OQ1|rcsb pdb:2OZO|rcsb pdb:2Y1N|rcsb pdb:3ZNI|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4K2R|rcsb pdb:4XZ0|rcsb pdb:4XZ1|rcsb pdb:5O76|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-9013407|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation) - - - figure legend:6 B|comment:CD6 was still able to associate with SLP-76 in the absence of Lat.|comment:"In the absence of Zap70, there was no CD25zeta-inducible association between CD6 and SLP-76 (Fig. 6b)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat e6.1)|taxid:9606(Homo sapiens) - 2016/10/20 2016/11/29 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:21kVb/nxY2BBZPBNVwWba+qUOgc9606 rigid:auGV2gyE5FvfDp/7OHSZCJ7uJZA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13094 uniprotkb:P30203 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-2873748|ensembl:ENSP00000323280|uniprotkb:Q9UMF2|uniprotkb:Q9Y4K8|uniprotkb:Q9Y4L0|uniprotkb:Q9Y4K7|uniprotkb:Q9Y4K9|uniprotkb:A4KAD4|uniprotkb:A4KAD5 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_human(display_long)|uniprotkb:CD6(gene name)|psi-mi:CD6(display_short)|uniprotkb:T12(gene name synonym)|uniprotkb:TP120(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738873|imex:IM-25620-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809 ensembl:ENSG00000013725(gene)|ensembl:ENST00000313421(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|rcsb pdb:5A2E|refseq:XP_011543664.1|refseq:NP_006716.3|refseq:XP_006718801.1|refseq:XP_006718804.1|refseq:NP_001241679.1|refseq:NP_001241680.1|dip:DIP-43704N - - - figure legend:6 D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat e6.1)|taxid:9606(Homo sapiens) - 2016/10/20 2017/01/16 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:7GTuuSJHssuyL3S2CiBAN14eP9c9606 rigid:WNzRuczSPbWvGVb80VydGwesgKU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13094 uniprotkb:O43561 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-1222766|uniprotkb:O43919|uniprotkb:B7WPI0|uniprotkb:C7C5T6|uniprotkb:G5E9K3|ensembl:ENSP00000354119 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:lat_human(display_long)|uniprotkb:LAT(gene name)|psi-mi:LAT(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738873|imex:IM-25620-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809 refseq:NP_001014987.1|refseq:NP_001014988.1|refseq:NP_001014989.2|refseq:NP_055202.1|dip:DIP-29231N|ensembl:ENSG00000213658(gene)|ensembl:ENST00000360872(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|mint:O43561|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-5673001 - - - figure legend:6 D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat e6.1)|taxid:9606(Homo sapiens) - 2016/10/20 2017/01/16 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:oBG4calUDTkuXSPcr3x08rFDj6s9606 rigid:WNzRuczSPbWvGVb80VydGwesgKU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60787 uniprotkb:Q3UPF5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-8399976|uniprotkb:Q9CTU4|intact:MINT-4125302|uniprotkb:Q9DBS7|ensembl:ENSMUSP00000144312 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:zcchv_mouse(display_long)|uniprotkb:Zc3hav1(gene name)|psi-mi:Zc3hav1(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_082697.1|refseq:NP_083140.1|ensembl:ENSMUSG00000029826(gene)|ensembl:ENSMUST00000143702(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q3UPF5|rcsb pdb:6L1W - - comment:"fragmentation type: fragment"|comment:mint figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:bM3F9xXlRqxjEx6pcBMEXpvjWYw10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O35601 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N - - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q8K1I7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UND0 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642769|uniprotkb:Q8BK74|uniprotkb:Q9Z2K4|ensembl:ENSMUSP00000145462 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap2_mouse(display_long)|uniprotkb:Src family-associated phosphoprotein 2(gene name synonym)|uniprotkb:Src kinase-associated phosphoprotein 55-related protein(gene name synonym)|uniprotkb:SKAP55 homolog(gene name synonym)|uniprotkb:Src-associated adapter protein with PH and SH3 domains(gene name synonym)|uniprotkb:Pyk2/RAFTK-associated protein(gene name synonym)|uniprotkb:Skap2(gene name)|psi-mi:Skap2(display_short)|uniprotkb:Prap(gene name synonym)|uniprotkb:Saps(gene name synonym)|uniprotkb:Ra70(gene name synonym)|uniprotkb:Scap2(gene name synonym)|uniprotkb:Skap55r(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061243.1|ensembl:ENSMUSG00000059182(gene)|ensembl:ENSMUST00000204778(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042113"(B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|interpro:IPR037781|rcsb pdb:1M0V|rcsb pdb:1U5E|rcsb pdb:1U5F|rcsb pdb:1U5G|rcsb pdb:2OTX|reactome:R-MMU-391160 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:2WPz/JocPjHR9w8dHv5ha396QWQ10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q8C503 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601456|ensembl:ENSMUSP00000030180|uniprotkb:Q9WUU5 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:sit1_mouse(display_long)|uniprotkb:Sit1(gene name)|psi-mi:Sit1(display_short)|uniprotkb:Sit(gene name synonym)|uniprotkb:SHP2-interacting transmembrane adapter protein(gene name synonym)|uniprotkb:Suppression-inducing transmembrane adapter 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000028460(gene)|ensembl:ENSMUST00000030180(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR033269|refseq:NP_062309.2 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:L7RYMt5UaRqKt+CoRBComR4npBY10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q9ES52 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P27870 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3V3E1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UUV5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q62077 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q78ZA7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-645017|uniprotkb:O88701|ensembl:ENSMUSP00000072510 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:np1l4_mouse(display_long)|uniprotkb:Nap1l4(gene name)|psi-mi:Nap1l4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001272418.1|refseq:NP_001272419.1|refseq:NP_032698.1|ensembl:ENSMUSG00000059119(gene)|ensembl:ENSMUST00000072727(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0030425"(dendrite)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043025"(neuronal cell body)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q78ZA7 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:wEHrLDNg3hwUMaUS8fNw0+AjBz410090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P70218 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O54957 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q60631 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q9CX99 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P68254 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P63101 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P61982 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P62259 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12601987|imex:IM-25620-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198 - - - figure legend:Figure 2D,3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 rigid:MO5YX+gI3Y9V1dS0H6b6cs2ZDV8 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3TTA7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O35601 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N - - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q8BGW0 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6389995|ensembl:ENSMUSP00000060129|uniprotkb:Q059Y0|uniprotkb:Q3TEM0|uniprotkb:Q3UU76|uniprotkb:Q8BGP0|uniprotkb:Q8C9S6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:thms1_mouse(display_long)|uniprotkb:Themis(gene name)|psi-mi:Themis(display_short)|uniprotkb:Grb2-associating protein(gene name synonym)|uniprotkb:Protein thylex(gene name synonym)|uniprotkb:Thymocyte-expressed molecule involved in selection(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001292592.1|ensembl:ENSMUSG00000049109(gene)|ensembl:ENSMUST00000056097(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0043368"(positive T cell selection)|go:"GO:0043383"(negative T cell selection)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025946|interpro:IPR039671|mint:Q8BGW0|dip:DIP-48976N|refseq:NP_848781.1 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:682A2kObXX0ZRZZ/IGHrOpk/U8I10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q8QZY9 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6094674|ensembl:ENSMUSP00000075709 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:sf3b4_mouse(display_long)|uniprotkb:Sf3b4(gene name)|psi-mi:Sf3b4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_694693.1|ensembl:ENSMUSG00000068856(gene)|ensembl:ENSMUST00000076372(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|interpro:IPR034159|interpro:IPR035979|mint:Q8QZY9|reactome:R-MMU-72163|reactome:R-MMU-72165 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:eYaqZLWduL1MsiM0jP2BLXuEkBw10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P39688 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P27870 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3V3E1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UUV5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q62077 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q78ZA7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-645017|uniprotkb:O88701|ensembl:ENSMUSP00000072510 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:np1l4_mouse(display_long)|uniprotkb:Nap1l4(gene name)|psi-mi:Nap1l4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001272418.1|refseq:NP_001272419.1|refseq:NP_032698.1|ensembl:ENSMUSG00000059119(gene)|ensembl:ENSMUST00000072727(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0030425"(dendrite)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043025"(neuronal cell body)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q78ZA7 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:wEHrLDNg3hwUMaUS8fNw0+AjBz410090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P70218 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O54957 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q60631 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q9CX99 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P68254 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P63101 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P61982 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P62259 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602076|imex:IM-25620-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198 - - - figure legend:Figure 2D-abs|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 rigid:cv+kjF0CcNKCCt1hZJY/WAbS8d0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O35601 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N - - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UND0 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642769|uniprotkb:Q8BK74|uniprotkb:Q9Z2K4|ensembl:ENSMUSP00000145462 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap2_mouse(display_long)|uniprotkb:Src family-associated phosphoprotein 2(gene name synonym)|uniprotkb:Src kinase-associated phosphoprotein 55-related protein(gene name synonym)|uniprotkb:SKAP55 homolog(gene name synonym)|uniprotkb:Src-associated adapter protein with PH and SH3 domains(gene name synonym)|uniprotkb:Pyk2/RAFTK-associated protein(gene name synonym)|uniprotkb:Skap2(gene name)|psi-mi:Skap2(display_short)|uniprotkb:Prap(gene name synonym)|uniprotkb:Saps(gene name synonym)|uniprotkb:Ra70(gene name synonym)|uniprotkb:Scap2(gene name synonym)|uniprotkb:Skap55r(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061243.1|ensembl:ENSMUSG00000059182(gene)|ensembl:ENSMUST00000204778(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042113"(B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|interpro:IPR037781|rcsb pdb:1M0V|rcsb pdb:1U5E|rcsb pdb:1U5F|rcsb pdb:1U5G|rcsb pdb:2OTX|reactome:R-MMU-391160 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:2WPz/JocPjHR9w8dHv5ha396QWQ10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P27870 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3V3E1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UUV5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q62077 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q78ZA7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-645017|uniprotkb:O88701|ensembl:ENSMUSP00000072510 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:np1l4_mouse(display_long)|uniprotkb:Nap1l4(gene name)|psi-mi:Nap1l4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001272418.1|refseq:NP_001272419.1|refseq:NP_032698.1|ensembl:ENSMUSG00000059119(gene)|ensembl:ENSMUST00000072727(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0030425"(dendrite)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043025"(neuronal cell body)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q78ZA7 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:wEHrLDNg3hwUMaUS8fNw0+AjBz410090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P70218 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O54957 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q9CX99 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P68254 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P63101 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P61982 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P62259 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q60631 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602631|imex:IM-25620-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:uP57PyCU0cizt57tjOxOn3Fox04 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O35601 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N - - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UND0 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642769|uniprotkb:Q8BK74|uniprotkb:Q9Z2K4|ensembl:ENSMUSP00000145462 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap2_mouse(display_long)|uniprotkb:Src family-associated phosphoprotein 2(gene name synonym)|uniprotkb:Src kinase-associated phosphoprotein 55-related protein(gene name synonym)|uniprotkb:SKAP55 homolog(gene name synonym)|uniprotkb:Src-associated adapter protein with PH and SH3 domains(gene name synonym)|uniprotkb:Pyk2/RAFTK-associated protein(gene name synonym)|uniprotkb:Skap2(gene name)|psi-mi:Skap2(display_short)|uniprotkb:Prap(gene name synonym)|uniprotkb:Saps(gene name synonym)|uniprotkb:Ra70(gene name synonym)|uniprotkb:Scap2(gene name synonym)|uniprotkb:Skap55r(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061243.1|ensembl:ENSMUSG00000059182(gene)|ensembl:ENSMUST00000204778(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042113"(B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|interpro:IPR037781|rcsb pdb:1M0V|rcsb pdb:1U5E|rcsb pdb:1U5F|rcsb pdb:1U5G|rcsb pdb:2OTX|reactome:R-MMU-391160 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:2WPz/JocPjHR9w8dHv5ha396QWQ10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3V3E1 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UUV5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q62077 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q78ZA7 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-645017|uniprotkb:O88701|ensembl:ENSMUSP00000072510 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:np1l4_mouse(display_long)|uniprotkb:Nap1l4(gene name)|psi-mi:Nap1l4(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001272418.1|refseq:NP_001272419.1|refseq:NP_032698.1|ensembl:ENSMUSG00000059119(gene)|ensembl:ENSMUST00000072727(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0030425"(dendrite)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043025"(neuronal cell body)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q78ZA7 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:wEHrLDNg3hwUMaUS8fNw0+AjBz410090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P70218 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O54957 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-6390034|ensembl:ENSMUSP00000032997 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:lat_mouse(display_long)|uniprotkb:Lat(gene name)|psi-mi:Lat(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000030742(gene)|ensembl:ENSMUST00000032997(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2454202|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5673001|refseq:NP_034819.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:LMso4UEC19a1UiJ1Frw37cb1cIU10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q9CX99 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12600383|ensembl:ENSMUSP00000004959|uniprotkb:Q0VBE3|uniprotkb:Q3U545 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap_mouse(display_long)|uniprotkb:Grap(gene name)|psi-mi:Grap(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000004837(gene)|ensembl:ENSMUST00000004959(transcript)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035645|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|reactome:R-MMU-1433557|refseq:NP_082093.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:InWJw0OppN2chSsOF+riLQVo31A10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P68254 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P63101 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P61982 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P62259 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q60631 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602669|imex:IM-25620-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:PdrwK4v7df9UnZNeLF0DWcd4UFs false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O35601 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602691|imex:IM-25620-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N - - comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rigid:sFBp364ag4K5uCMdLJAHW391V/o false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q3UUV5 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602691|imex:IM-25620-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:sFBp364ag4K5uCMdLJAHW391V/o false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:O89100 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602691|imex:IM-25620-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rigid:sFBp364ag4K5uCMdLJAHW391V/o false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:Q61003 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602691|imex:IM-25620-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:sFBp364ag4K5uCMdLJAHW391V/o false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q60787 uniprotkb:P27870 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889 psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602691|imex:IM-25620-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090 rigid:sFBp364ag4K5uCMdLJAHW391V/o false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O89100 uniprotkb:Q60787 intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681 intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0 psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym) psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602718|imex:IM-25620-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2 - - - figure legend:Figure 4-0sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090 rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090 rigid:l4glaALb90XiCuHBP01lF8NN7iQ false - strep ii tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8BK67 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641 - - comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P24161 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803400|uniprotkb:P29020|ensembl:ENSMUSP00000005907|intact:MINT-7895650|uniprotkb:Q9D3G3 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3z_mouse(display_long)|uniprotkb:Cd247(gene name)|psi-mi:Cd247(display_short)|uniprotkb:Cd3z(gene name synonym)|uniprotkb:Tcrz(gene name synonym)|uniprotkb:T-cell receptor T3 zeta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:XP_011237047.1|refseq:NP_112439.1|refseq:XP_017168774.1|ensembl:ENSMUSG00000005763(gene)|ensembl:ENSMUST00000005907(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR021663|interpro:IPR024128|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|mint:P24161|refseq:NP_001106862.1 - - comment:mint figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Ac52AvET/m0LboX+dKOOhfmE4B010090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P22646 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803432|ensembl:ENSMUSP00000099896|intact:MINT-7895702 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3e_mouse(display_long)|uniprotkb:Cd3e(gene name)|psi-mi:Cd3e(display_short)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P22646|rcsb pdb:1JBJ|rcsb pdb:1XMW|rcsb pdb:2K4F|rcsb pdb:3R08|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|ensembl:ENSMUSG00000032093(gene)|ensembl:ENSMUST00000102832(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|refseq:NP_031674.1|refseq:XP_006510029.1 - - comment:mint figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:pCHLuaLDHcsqdyl6Cc0NjIH+4xA10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9D358 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8318198|ensembl:ENSMUSP00000106509|intact:MINT-1855654|uniprotkb:O88740|uniprotkb:O88739|uniprotkb:Q9QWF5 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ppac_mouse(display_long)|uniprotkb:Acp1(gene name)|psi-mi:Acp1(display_short)|uniprotkb:Low molecular weight cytosolic acid phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000044573(gene)|ensembl:ENSMUST00000062740(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0042383"(sarcolemma)|interpro:IPR002115(Protein-tyrosine phosphatase, low molecular weight, mammalian)|interpro:IPR017867|interpro:IPR023485|interpro:IPR036196|mint:Q9D358|rcsb pdb:2P4U|rcsb pdb:5JNU|refseq:NP_001103709.1|refseq:NP_067305.2 - - comment:mint|function:Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:kXRd56UxJ8VuIvs5bn7fmluGd+g10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q3V3E1 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q921F2 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P61290 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8763214|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|ensembl:ENSMUSP00000019470 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:psme3_mouse(display_long)|uniprotkb:Psme3(gene name)|psi-mi:Psme3(display_short)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035322.1|ensembl:ENSMUSG00000078652(gene)|ensembl:ENSMUST00000019470(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61003 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04214 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602509 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb6_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:1FO0|rcsb pdb:1KB5|rcsb pdb:1KJ2|rcsb pdb:1NAM|rcsb pdb:2OL3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Qw+M+3kRr5ETL+rnxjIuF6E9xn010090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P42225 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-647118 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8C3J5 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P06320 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602502 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb7_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:wbfqeC3W5lbRb94t34qjouQ/GAA10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9D3G9 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602477|ensembl:ENSMUSP00000031106|ensembl:ENSMUSP00000143810 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rhoh_mouse(display_long)|uniprotkb:Rhoh(gene name)|psi-mi:Rhoh(display_short)|uniprotkb:Arhh(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000029204(gene)|ensembl:ENSMUST00000031106(transcript)|ensembl:ENSMUST00000201533(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045576"(mast cell activation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-9013407|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_001074574.1|refseq:XP_011239081.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:dg5pFS6vBAzA4l8+edklzvnsR5k10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61081 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-2906727|ensembl:ENSMUSP00000019615|uniprotkb:Q3TGP0 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cdc37_mouse(display_long)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q61081|reactome:R-MMU-1227986|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-9013418|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|reactome:R-MMU-9652282|ensembl:ENSMUSG00000019471(gene)|ensembl:ENSMUST00000019615(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|refseq:NP_058022.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:v5zsOwSR7TCF51iF9RkxF1cPeaU10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04213 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602448 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb5_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:6G9Q|rcsb pdb:5WLG|rcsb pdb:5M00|rcsb pdb:5M02|rcsb pdb:1D9K|rcsb pdb:1LP9|rcsb pdb:1U3H|rcsb pdb:2APB|rcsb pdb:2APF|rcsb pdb:2APT|rcsb pdb:2APV|rcsb pdb:2APW|rcsb pdb:2APX|rcsb pdb:2AQ1|rcsb pdb:2AQ2|rcsb pdb:2AQ3|rcsb pdb:2J8U|rcsb pdb:2UWE|rcsb pdb:4NHU|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179|rcsb pdb:5M01 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:s2anfwXxXLnenlnTPxmGGWoSYXU10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04212 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602441 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb4_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:iv0/zWsCvRcz2TOVxuFcYh8rw3o10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P11942 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602408|ensembl:ENSMUSP00000002101 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3g_mouse(display_long)|uniprotkb:Cd3g(gene name)|psi-mi:Cd3g(display_short)|uniprotkb:T-cell receptor T3 gamma chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000002033(gene)|ensembl:ENSMUST00000002101(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070228"(regulation of lymphocyte apoptotic process)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR032052|interpro:IPR036179|rcsb pdb:1JBJ|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_033980.1 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:gVbbmKXSy0KoMYBjfzKcBe2Ndz010090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04235 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602374|ensembl:ENSMUSP00000034602 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3d_mouse(display_long)|uniprotkb:Cd3d(gene name)|psi-mi:Cd3d(display_short)|uniprotkb:T3d(gene name synonym)|uniprotkb:T-cell receptor T3 delta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000032094(gene)|ensembl:ENSMUST00000034602(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR015485(CD3 signaling complex delta subunit)|interpro:IPR032052|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_038515.3 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:SZntIojNx9wJijdQ/gCew5NArfM10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q01965 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01849 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-9010232 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tca_mouse(display_long)|uniprotkb:Tcra(gene name)|psi-mi:Tcra(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602369|imex:IM-25620-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015370(Protein of unknown function DUF1968)|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2Q86|rcsb pdb:3C6L|rcsb pdb:3MBE|rcsb pdb:1LP9|rcsb pdb:5M02|rcsb pdb:6MF8|interpro:IPR036179|rcsb pdb:1NFD|rcsb pdb:5M01|rcsb pdb:6G9Q|go:"GO:0009617"(response to bacterium)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Figure 4-300sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:HMyH8kNX5s+4oKXgaOtffYND0iA10090 rigid:7mNcj/q3Z2O1Zz1LQ5RcD3cHsEE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P24063 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-983966|ensembl:ENSMUSP00000131847 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ital_mouse(display_long)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:Lymphocyte antigen 15(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym)|uniprotkb:Itgal(gene name)|psi-mi:Itgal(display_short)|uniprotkb:Lfa-1(gene name synonym)|uniprotkb:Ly-15(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000030830(gene)|ensembl:ENSMUST00000170971(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-35643N - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:+gF/EH5h/001gtCj3z0rC5qtOUc10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q3TTA7 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-3649276|uniprotkb:E9QMY2|ensembl:ENSMUSP00000153787|ensembl:ENSMUSP00000154755 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cblb_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001028410.1|refseq:XP_006522010.1|refseq:XP_006522011.1|refseq:XP_006522012.1|refseq:XP_006522013.1|refseq:XP_006522015.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q3TTA7|rcsb pdb:5AXI|reactome:R-MMU-983168|interpro:IPR011992(EF-Hand type)|ensembl:ENSMUST00000226593(transcript)|ensembl:ENSMUST00000227879(transcript)|ensembl:ENSMUSG00000022637(gene)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical) - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:hNC8+H3fIw/6kZWLR9tt2Zerv/Y10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01851 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8661312|intact:MINT-1520015 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tcb2_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0003823"(antigen binding)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1L0Y|rcsb pdb:2Q86|rcsb pdb:1MWA|rcsb pdb:1L0X|rcsb pdb:5M01|rcsb pdb:5M02|interpro:IPR036179 - - comment:mint figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:nYtFud2Mf/E0N+XSxb3l0uvDWMw10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P19783 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7174084|ensembl:ENSMUSP00000034276|ensembl:ENSMUSP00000138019|uniprotkb:Q545A9|intact:MINT-1860013 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cox41_mouse(display_long)|uniprotkb:Cox4i1(gene name)|psi-mi:Cox4i1(display_short)|uniprotkb:Cox4(gene name synonym)|uniprotkb:Cox4a(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001280488.1|refseq:NP_034071.2|ensembl:ENSMUSG00000031818(gene)|ensembl:ENSMUST00000034276(transcript)|ensembl:ENSMUST00000181586(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031966"(mitochondrial membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P19783|reactome:R-MMU-5628897|reactome:R-MMU-611105|reactome:R-MMU-9707564 - - function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport|comment:mint figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:zt2qwV/jVAo1B9UISW8R2votzlU10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8BK67 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641 - - comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P24161 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803400|uniprotkb:P29020|ensembl:ENSMUSP00000005907|intact:MINT-7895650|uniprotkb:Q9D3G3 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3z_mouse(display_long)|uniprotkb:Cd247(gene name)|psi-mi:Cd247(display_short)|uniprotkb:Cd3z(gene name synonym)|uniprotkb:Tcrz(gene name synonym)|uniprotkb:T-cell receptor T3 zeta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:XP_011237047.1|refseq:NP_112439.1|refseq:XP_017168774.1|ensembl:ENSMUSG00000005763(gene)|ensembl:ENSMUST00000005907(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR021663|interpro:IPR024128|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|mint:P24161|refseq:NP_001106862.1 - - comment:mint figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Ac52AvET/m0LboX+dKOOhfmE4B010090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P22646 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803432|ensembl:ENSMUSP00000099896|intact:MINT-7895702 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3e_mouse(display_long)|uniprotkb:Cd3e(gene name)|psi-mi:Cd3e(display_short)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P22646|rcsb pdb:1JBJ|rcsb pdb:1XMW|rcsb pdb:2K4F|rcsb pdb:3R08|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|ensembl:ENSMUSG00000032093(gene)|ensembl:ENSMUST00000102832(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|refseq:NP_031674.1|refseq:XP_006510029.1 - - comment:mint figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:pCHLuaLDHcsqdyl6Cc0NjIH+4xA10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9D358 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8318198|ensembl:ENSMUSP00000106509|intact:MINT-1855654|uniprotkb:O88740|uniprotkb:O88739|uniprotkb:Q9QWF5 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ppac_mouse(display_long)|uniprotkb:Acp1(gene name)|psi-mi:Acp1(display_short)|uniprotkb:Low molecular weight cytosolic acid phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000044573(gene)|ensembl:ENSMUST00000062740(transcript)|go:"GO:0003993"(acid phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0042383"(sarcolemma)|interpro:IPR002115(Protein-tyrosine phosphatase, low molecular weight, mammalian)|interpro:IPR017867|interpro:IPR023485|interpro:IPR036196|mint:Q9D358|rcsb pdb:2P4U|rcsb pdb:5JNU|refseq:NP_001103709.1|refseq:NP_067305.2 - - comment:mint|function:Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:kXRd56UxJ8VuIvs5bn7fmluGd+g10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q99JR1 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-775916|uniprotkb:Q3UB44|uniprotkb:Q9CZG4|ensembl:ENSMUSP00000021930 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:sfxn1_mouse(display_long)|uniprotkb:Sfxn1(gene name)|psi-mi:Sfxn1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_081600.1|refseq:XP_006516912.2|refseq:XP_006516913.1|ensembl:ENSMUSG00000021474(gene)|ensembl:ENSMUST00000021930(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006826"(iron ion transport)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q99JR1 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Fw53Bii/EOp13qU53qI4/06lIaE10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q60631 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P54775 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-991934|uniprotkb:Q6ZWN9|ensembl:ENSMUSP00000032824 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:prs6b_mouse(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:MB67-interacting protein(gene name synonym)|uniprotkb:MIP224(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:CIP21(gene name synonym)|uniprotkb:Psmc4(gene name)|psi-mi:Psmc4(display_short)|uniprotkb:Tbp7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_036004.2|ensembl:ENSMUSG00000030603(gene)|ensembl:ENSMUST00000032824(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|mint:P54775|rcsb pdb:3AJI|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-2871837 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:sMGdo51UJT7c6ngmxSDrYfLvkLc10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8CC88 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602574|ensembl:ENSMUSP00000048925|uniprotkb:Q3U4P9|uniprotkb:Q6ZQ94|uniprotkb:Q8CDH8|uniprotkb:Q8VCU3 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:vwa8_mouse(display_long)|uniprotkb:Vwa8(gene name)|psi-mi:Vwa8(display_short)|uniprotkb:Kiaa0564(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000058997(gene)|ensembl:ENSMUST00000040990(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|mint:Q8CC88|refseq:NP_082182.1|refseq:NP_776119.2 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:JRlZvEqyEowI+W/4vQZy0mZEQk810090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8C503 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12601456|ensembl:ENSMUSP00000030180|uniprotkb:Q9WUU5 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:sit1_mouse(display_long)|uniprotkb:Sit1(gene name)|psi-mi:Sit1(display_short)|uniprotkb:Sit(gene name synonym)|uniprotkb:SHP2-interacting transmembrane adapter protein(gene name synonym)|uniprotkb:Suppression-inducing transmembrane adapter 1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000028460(gene)|ensembl:ENSMUST00000030180(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR033269|refseq:NP_062309.2 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:L7RYMt5UaRqKt+CoRBComR4npBY10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01735 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602567 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb86_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0w22LtAC2Cef+Zclc/9lMaPQI6g10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01734 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602560 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb1_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:h4g/Ybqj7RNCx8eYaA9eVPhsgy810090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P68254 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q62351 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-3869520|uniprotkb:Q61560|ensembl:ENSMUSP00000023486 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tfr1_mouse(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035768.1|refseq:XP_006522062.1|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q62351|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-917977|reactome:R-MMU-9696270|reactome:R-MMU-9696273|ensembl:ENSMUSG00000022797(gene)|ensembl:ENSMUST00000023486(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding) - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:VFnVdK5loK3683nCBW7vxIe7M6Y10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P49718 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-913678|ensembl:ENSMUSP00000126135|ensembl:ENSMUSP00000148525|ensembl:ENSMUSP00000148648|uniprotkb:Q52KC3 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:mcm5_mouse(display_long)|uniprotkb:Mcm5(gene name)|psi-mi:Mcm5(display_short)|uniprotkb:Cdc46(gene name synonym)|uniprotkb:Mcmd5(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|ensembl:ENSMUSG00000005410(gene)|ensembl:ENSMUST00000164309(transcript)|ensembl:ENSMUST00000212426(transcript)|ensembl:ENSMUST00000212811(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052|dip:DIP-45875N|refseq:NP_001289469.1|refseq:NP_032592.2 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:/BtYm9P7ZJQbJh2+8Dre6uHX7Mc10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P25206 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-913666|uniprotkb:Q61492|ensembl:ENSMUSP00000059192 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:mcm3_mouse(display_long)|uniprotkb:Mcm3(gene name)|psi-mi:Mcm3(display_short)|uniprotkb:Mcmd(gene name synonym)|uniprotkb:Mcmd3(gene name synonym)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000041859(gene)|ensembl:ENSMUST00000053266(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25206|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052|refseq:NP_032589.1|dip:DIP-45878N - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:X36cGhJW1lAq2x928zZS9WI2reE10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9ERK4 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-400836|intact:EBI-4283823|ensembl:ENSMUSP00000002790 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:xpo2_mouse(display_long)|uniprotkb:Cse1l(gene name)|psi-mi:Cse1l(display_short)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Xpo2(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_076054.1|ensembl:ENSMUSG00000002718(gene)|ensembl:ENSMUST00000002790(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9ERK4 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:vJpTu+2YjwIRrjM3V815K3lZzAg10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q3V3E1 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q921F2 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P61290 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8763214|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|ensembl:ENSMUSP00000019470 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:psme3_mouse(display_long)|uniprotkb:Psme3(gene name)|psi-mi:Psme3(display_short)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035322.1|ensembl:ENSMUSG00000078652(gene)|ensembl:ENSMUST00000019470(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61003 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04214 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602509 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb6_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:1FO0|rcsb pdb:1KB5|rcsb pdb:1KJ2|rcsb pdb:1NAM|rcsb pdb:2OL3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Qw+M+3kRr5ETL+rnxjIuF6E9xn010090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P42225 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-647118 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8C3J5 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P06320 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602502 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb7_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:wbfqeC3W5lbRb94t34qjouQ/GAA10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9D3G9 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602477|ensembl:ENSMUSP00000031106|ensembl:ENSMUSP00000143810 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rhoh_mouse(display_long)|uniprotkb:Rhoh(gene name)|psi-mi:Rhoh(display_short)|uniprotkb:Arhh(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000029204(gene)|ensembl:ENSMUST00000031106(transcript)|ensembl:ENSMUST00000201533(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045576"(mast cell activation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-9013407|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_001074574.1|refseq:XP_011239081.1 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:dg5pFS6vBAzA4l8+edklzvnsR5k10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61081 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-2906727|ensembl:ENSMUSP00000019615|uniprotkb:Q3TGP0 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cdc37_mouse(display_long)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q61081|reactome:R-MMU-1227986|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-9013418|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|reactome:R-MMU-9652282|ensembl:ENSMUSG00000019471(gene)|ensembl:ENSMUST00000019615(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|refseq:NP_058022.1 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:v5zsOwSR7TCF51iF9RkxF1cPeaU10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04213 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602448 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb5_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:6G9Q|rcsb pdb:5WLG|rcsb pdb:5M00|rcsb pdb:5M02|rcsb pdb:1D9K|rcsb pdb:1LP9|rcsb pdb:1U3H|rcsb pdb:2APB|rcsb pdb:2APF|rcsb pdb:2APT|rcsb pdb:2APV|rcsb pdb:2APW|rcsb pdb:2APX|rcsb pdb:2AQ1|rcsb pdb:2AQ2|rcsb pdb:2AQ3|rcsb pdb:2J8U|rcsb pdb:2UWE|rcsb pdb:4NHU|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179|rcsb pdb:5M01 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:s2anfwXxXLnenlnTPxmGGWoSYXU10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04212 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602441 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb4_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:iv0/zWsCvRcz2TOVxuFcYh8rw3o10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P11942 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602408|ensembl:ENSMUSP00000002101 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3g_mouse(display_long)|uniprotkb:Cd3g(gene name)|psi-mi:Cd3g(display_short)|uniprotkb:T-cell receptor T3 gamma chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000002033(gene)|ensembl:ENSMUST00000002101(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070228"(regulation of lymphocyte apoptotic process)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR032052|interpro:IPR036179|rcsb pdb:1JBJ|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_033980.1 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:gVbbmKXSy0KoMYBjfzKcBe2Ndz010090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04235 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602374|ensembl:ENSMUSP00000034602 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3d_mouse(display_long)|uniprotkb:Cd3d(gene name)|psi-mi:Cd3d(display_short)|uniprotkb:T3d(gene name synonym)|uniprotkb:T-cell receptor T3 delta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000032094(gene)|ensembl:ENSMUST00000034602(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR015485(CD3 signaling complex delta subunit)|interpro:IPR032052|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_038515.3 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:SZntIojNx9wJijdQ/gCew5NArfM10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q01965 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-11569501|uniprotkb:Q9ES35|uniprotkb:Q9ES36|uniprotkb:Q9ES29|ensembl:ENSMUSP00000069319 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ly9_mouse(display_long)|uniprotkb:Cell surface molecule Ly-9(gene name synonym)|uniprotkb:Ly-9(gene name synonym)|uniprotkb:Lymphocyte antigen 9(gene name synonym)|uniprotkb:SLAM family member 3(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 3(gene name synonym)|uniprotkb:Ly9(gene name)|psi-mi:Ly9(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001264897.1|refseq:NP_032560.2|ensembl:ENSMUSG00000004707(gene)|ensembl:ENSMUST00000068878(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:u1JQR4GuNJZc0Cu1WPQRzpiPPJA10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01849 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-9010232 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tca_mouse(display_long)|uniprotkb:Tcra(gene name)|psi-mi:Tcra(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602534|imex:IM-25620-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015370(Protein of unknown function DUF1968)|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2Q86|rcsb pdb:3C6L|rcsb pdb:3MBE|rcsb pdb:1LP9|rcsb pdb:5M02|rcsb pdb:6MF8|interpro:IPR036179|rcsb pdb:1NFD|rcsb pdb:5M01|rcsb pdb:6G9Q|go:"GO:0009617"(response to bacterium)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Figure 3|comment:Results from figure 3 show interactions before - as well as at 30, 120 and 300 s after pervanadate stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2019/05/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:HMyH8kNX5s+4oKXgaOtffYND0iA10090 rigid:288Yhf8oI1s4/qp8EI7zIperENY false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8BK67 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641 - - comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P24161 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803400|uniprotkb:P29020|ensembl:ENSMUSP00000005907|intact:MINT-7895650|uniprotkb:Q9D3G3 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3z_mouse(display_long)|uniprotkb:Cd247(gene name)|psi-mi:Cd247(display_short)|uniprotkb:Cd3z(gene name synonym)|uniprotkb:Tcrz(gene name synonym)|uniprotkb:T-cell receptor T3 zeta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:XP_011237047.1|refseq:NP_112439.1|refseq:XP_017168774.1|ensembl:ENSMUSG00000005763(gene)|ensembl:ENSMUST00000005907(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR021663|interpro:IPR024128|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|mint:P24161|refseq:NP_001106862.1 - - comment:mint figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Ac52AvET/m0LboX+dKOOhfmE4B010090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P22646 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-7803432|ensembl:ENSMUSP00000099896|intact:MINT-7895702 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3e_mouse(display_long)|uniprotkb:Cd3e(gene name)|psi-mi:Cd3e(display_short)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P22646|rcsb pdb:1JBJ|rcsb pdb:1XMW|rcsb pdb:2K4F|rcsb pdb:3R08|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|ensembl:ENSMUSG00000032093(gene)|ensembl:ENSMUST00000102832(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|refseq:NP_031674.1|refseq:XP_006510029.1 - - comment:mint figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:pCHLuaLDHcsqdyl6Cc0NjIH+4xA10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q3V3E1 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q921F2 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P61290 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8763214|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|ensembl:ENSMUSP00000019470 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:psme3_mouse(display_long)|uniprotkb:Psme3(gene name)|psi-mi:Psme3(display_short)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035322.1|ensembl:ENSMUSG00000078652(gene)|ensembl:ENSMUST00000019470(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61003 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04214 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602509 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb6_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:1FO0|rcsb pdb:1KB5|rcsb pdb:1KJ2|rcsb pdb:1NAM|rcsb pdb:2OL3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Qw+M+3kRr5ETL+rnxjIuF6E9xn010090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P42225 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-647118 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8C3J5 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P06320 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602502 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb7_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:wbfqeC3W5lbRb94t34qjouQ/GAA10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q9D3G9 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602477|ensembl:ENSMUSP00000031106|ensembl:ENSMUSP00000143810 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rhoh_mouse(display_long)|uniprotkb:Rhoh(gene name)|psi-mi:Rhoh(display_short)|uniprotkb:Arhh(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000029204(gene)|ensembl:ENSMUST00000031106(transcript)|ensembl:ENSMUST00000201533(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045576"(mast cell activation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-9013407|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|refseq:NP_001074574.1|refseq:XP_011239081.1 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:dg5pFS6vBAzA4l8+edklzvnsR5k10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61081 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-2906727|ensembl:ENSMUSP00000019615|uniprotkb:Q3TGP0 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cdc37_mouse(display_long)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q61081|reactome:R-MMU-1227986|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-9013418|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|reactome:R-MMU-9652282|ensembl:ENSMUSG00000019471(gene)|ensembl:ENSMUST00000019615(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|refseq:NP_058022.1 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:v5zsOwSR7TCF51iF9RkxF1cPeaU10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04213 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602448 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb5_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:6G9Q|rcsb pdb:5WLG|rcsb pdb:5M00|rcsb pdb:5M02|rcsb pdb:1D9K|rcsb pdb:1LP9|rcsb pdb:1U3H|rcsb pdb:2APB|rcsb pdb:2APF|rcsb pdb:2APT|rcsb pdb:2APV|rcsb pdb:2APW|rcsb pdb:2APX|rcsb pdb:2AQ1|rcsb pdb:2AQ2|rcsb pdb:2AQ3|rcsb pdb:2J8U|rcsb pdb:2UWE|rcsb pdb:4NHU|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179|rcsb pdb:5M01 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:s2anfwXxXLnenlnTPxmGGWoSYXU10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04212 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602441 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb4_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:iv0/zWsCvRcz2TOVxuFcYh8rw3o10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P11942 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602408|ensembl:ENSMUSP00000002101 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3g_mouse(display_long)|uniprotkb:Cd3g(gene name)|psi-mi:Cd3g(display_short)|uniprotkb:T-cell receptor T3 gamma chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000002033(gene)|ensembl:ENSMUST00000002101(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070228"(regulation of lymphocyte apoptotic process)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR032052|interpro:IPR036179|rcsb pdb:1JBJ|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_033980.1 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:gVbbmKXSy0KoMYBjfzKcBe2Ndz010090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04235 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602374|ensembl:ENSMUSP00000034602 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd3d_mouse(display_long)|uniprotkb:Cd3d(gene name)|psi-mi:Cd3d(display_short)|uniprotkb:T3d(gene name synonym)|uniprotkb:T-cell receptor T3 delta chain(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000032094(gene)|ensembl:ENSMUST00000034602(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR015485(CD3 signaling complex delta subunit)|interpro:IPR032052|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_038515.3 - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:SZntIojNx9wJijdQ/gCew5NArfM10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P01849 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-9010232 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tca_mouse(display_long)|uniprotkb:Tcra(gene name)|psi-mi:Tcra(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602897|imex:IM-25620-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015370(Protein of unknown function DUF1968)|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2Q86|rcsb pdb:3C6L|rcsb pdb:3MBE|rcsb pdb:1LP9|rcsb pdb:5M02|rcsb pdb:6MF8|interpro:IPR036179|rcsb pdb:1NFD|rcsb pdb:5M01|rcsb pdb:6G9Q|go:"GO:0009617"(response to bacterium)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Figure 4-120sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:HMyH8kNX5s+4oKXgaOtffYND0iA10090 rigid:pIvWiiDDdq7DiiZI/HUapbgYO3E false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8BK67 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641 - - comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P61290 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8763214|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|ensembl:ENSMUSP00000019470 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:psme3_mouse(display_long)|uniprotkb:Psme3(gene name)|psi-mi:Psme3(display_short)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_035322.1|ensembl:ENSMUSG00000078652(gene)|ensembl:ENSMUST00000019470(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k10090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q61003 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12601992|ensembl:ENSMUSP00000079172|uniprotkb:Q60679|uniprotkb:Q61004|uniprotkb:Q8BGK1 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:cd6_mouse(display_long)|uniprotkb:Cd6(gene name)|psi-mi:Cd6(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000024670(gene)|ensembl:ENSMUST00000080292(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|refseq:NP_001032890.1|refseq:NP_033982.3 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:QYPVI+qJSVZ/FCgRmcuaPPlhOsM10090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P04214 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12602509 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:tvb6_mouse(display_long) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) go:"GO:0002250"(adaptive immune response)|go:"GO:0042101"(T cell receptor complex)|rcsb pdb:1FO0|rcsb pdb:1KB5|rcsb pdb:1KJ2|rcsb pdb:1NAM|rcsb pdb:2OL3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:Qw+M+3kRr5ETL+rnxjIuF6E9xn010090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:P42225 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-647118 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8C3J5 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602922|imex:IM-25620-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455 - - - figure legend:Figure 4-30sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090 rigid:Ndiz7DnpPhsPmbhfL7e5t66REZ0 false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q8BK67 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602945|imex:IM-25620-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641 - - comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 figure legend:Figure 4-0sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090 rigid:P3NDuf90ky4zlAFUBG9mk/p8ISE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P43404 uniprotkb:Q3V3E1 intact:EBI-3862932|uniprotkb:P97455|uniprotkb:Q80VV2|uniprotkb:Q8CHJ3|ensembl:ENSMUSP00000027291 intact:EBI-12600397|ensembl:ENSMUSP00000158544|uniprotkb:Q3TED7 psi-mi:zap70_mouse(display_long)|uniprotkb:Zap70(gene name)|psi-mi:Zap70(display_short)|uniprotkb:Srk(gene name synonym)|uniprotkb:Zap-70(gene name synonym)|uniprotkb:Syk-related tyrosine kinase(gene name synonym)|uniprotkb:70 kDa zeta-chain associated protein(gene name synonym) psi-mi:ubs3a_mouse(display_long)|uniprotkb:Ubash3a(gene name)|psi-mi:Ubash3a(display_short)|uniprotkb:Suppressor of T-cell receptor signaling 2(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 1(gene name synonym)|uniprotkb:Sts2(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12602945|imex:IM-25620-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033565.2|refseq:NP_001276541.1|refseq:NP_001276694.1|refseq:XP_006495959.1|ensembl:ENSMUSG00000026117(gene)|ensembl:ENSMUST00000027291(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0043366"(beta selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-9013407|go:"GO:0005737"(cytoplasm) ensembl:ENSMUSG00000042345(gene)|ensembl:ENSMUST00000236745(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035634|interpro:IPR036028|rcsb pdb:3D4I|rcsb pdb:3D6A|rcsb pdb:3DB1|refseq:NP_808491.2 - - - figure legend:Figure 4-0sec|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2016/10/20 2016/11/28 rogid:/6vag4l7UgKTQxiRJVx2KU23r1410090 rogid:KosxJHHBvb6mQKsNx+6y9fcn6Cw10090 rigid:P3NDuf90ky4zlAFUBG9mk/p8ISE false strep ii tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13094 uniprotkb:P30203 intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794 intact:EBI-2873748|ensembl:ENSP00000323280|uniprotkb:Q9UMF2|uniprotkb:Q9Y4K8|uniprotkb:Q9Y4L0|uniprotkb:Q9Y4K7|uniprotkb:Q9Y4K9|uniprotkb:A4KAD4|uniprotkb:A4KAD5 psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym) psi-mi:cd6_human(display_long)|uniprotkb:CD6(gene name)|psi-mi:CD6(display_short)|uniprotkb:T12(gene name synonym)|uniprotkb:TP120(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Roncagalli et al. (2014) imex:IM-25620|pubmed:24584089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738897|imex:IM-25620-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809 ensembl:ENSG00000013725(gene)|ensembl:ENST00000313421(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|rcsb pdb:5A2E|refseq:XP_011543664.1|refseq:NP_006716.3|refseq:XP_006718801.1|refseq:XP_006718804.1|refseq:NP_001241679.1|refseq:NP_001241680.1|dip:DIP-43704N - - - figure legend:6 D|comment:CD6 was still able to associate with SLP-76 in the absence of Lat.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jcam2.5)|taxid:9606(Homo sapiens) - 2016/10/20 2017/01/16 rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606 rogid:7GTuuSJHssuyL3S2CiBAN14eP9c9606 rigid:bI0SxztbNha9PIjWOMVb8Qs43l8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)