#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P58753	uniprotkb:Q8YF53	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-8754687|ensemblbacteria:AAL52855	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11601287|imex:IM-26249-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/01/21	2016/02/22	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rigid:XZrFJt2bd9zM2v2ZBk+V/aT/t7k	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8YF53	uniprotkb:Q8YF53	intact:EBI-8754687|ensemblbacteria:AAL52855	intact:EBI-8754687|ensemblbacteria:AAL52855	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11601651|wwpdb:4lqc|imex:IM-26249-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)|interpro:IPR035897	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)|interpro:IPR035897	-	-	-	figure legend:table 1|3d-resolution:2.3 Å|3d-r-factors:Rfree=0.263, Rworking=0.210|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2017/11/28	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rigid:a4Etg/X8K0JkqRCShDFanx4LXYM	false	sufficient binding region:113-250|mutation:127-127,124-124|strep ii tag:c-c	sufficient binding region:113-250|mutation:127-127,124-124|strep ii tag:c-c	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P58753	uniprotkb:P58753	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11701137|imex:IM-26249-5|wwpdb:4lqd	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:table 1|3d-resolution:2.45 Å|3d-r-factors:Rwork=0.207, RFree=0.218|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2017/11/28	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:7o0diWA2XpIrKZam1iKSdjysbIU	false	sufficient binding region:81-221(IPR035897)	sufficient binding region:81-221(IPR035897)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8YF53	uniprotkb:Q8YF53	intact:EBI-8754687|ensemblbacteria:AAL52855	intact:EBI-8754687|ensemblbacteria:AAL52855	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:"MI:0071"(molecular sieving)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11701180|imex:IM-26249-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:5B|comment:Size exclusion chromatography of the full-length wild type and mutant TcpB samples revealed dimeric and oligomeric species.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/05/13	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rigid:6hH1LXcllJyt4ia86bzosDrj9AQ	false	strep ii tag:c-c	strep ii tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8YF53	uniprotkb:Q8YF53	intact:EBI-8754687|ensemblbacteria:AAL52855	intact:EBI-8754687|ensemblbacteria:AAL52855	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:"MI:0071"(molecular sieving)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11701184|imex:IM-26249-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)|interpro:IPR035897	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)|interpro:IPR035897	-	-	-	figure legend:5B|comment:The chymotrypsin-treated TcpBS124A/S127I yielded a TIR domain fragment that eluted at a volume consistent with a primarily monomeric state.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/05/13	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rigid:6hH1LXcllJyt4ia86bzosDrj9AQ	false	sufficient binding region:113-250|mutation:127-127,124-124|strep ii tag:c-c	sufficient binding region:113-250|mutation:127-127,124-124|strep ii tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8YF53	uniprotkb:Q8YF53	intact:EBI-8754687|ensemblbacteria:AAL52855	intact:EBI-8754687|ensemblbacteria:AAL52855	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:q8yf53_brume(display_long)|uniprotkb:BMEI1674(locus name)	psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange)	Snyder et al. (2014)	pubmed:24275656|imex:IM-26249	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	taxid:224914(brume)|taxid:224914("Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11701226|imex:IM-26249-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)	interpro:IPR035897|interpro:IPR000157(Toll-Interleukin receptor)|rcsb pdb:4LQC|ensemblbacteria:AAL52855(transcript)|ensemblbacteria:BMEI1674(gene)|go:"GO:0007165"(signal transduction)|go:"GO:0039506"(modulation by virus of host molecular function)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:5C and 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/21	2016/05/13	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rogid:5Hzca2UDIujU3XOF2BpcZ9ez7zM224914	rigid:6hH1LXcllJyt4ia86bzosDrj9AQ	false	strep ii tag:c-c	strep ii tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)