#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9WVQ1 uniprotkb:Q61483 intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85 intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7 psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym) psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699798|imex:IM-25247-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1 go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N - - - figure legend:1A-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090 rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090 rigid:SR8TOk/FCp2sRIqoXcMZdkvNQec false - necessary binding region:718-722 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9WVQ1 uniprotkb:Q9JI71 intact:EBI-297151|uniprotkb:Q3UH81|uniprotkb:Q6GT88|ensembl:ENSMUSP00000085872|uniprotkb:Q8BYT1|uniprotkb:Q8CA85 intact:EBI-11699810|uniprotkb:Q9DBU9|uniprotkb:Q9JHZ7|ensembl:ENSMUSP00000099575 psi-mi:magi2_mouse(display_long)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Arip1(gene name synonym)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Activin receptor-interacting protein 1(gene name synonym) psi-mi:dll4_mouse(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699804|imex:IM-25247-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000040003(gene)|ensembl:ENSMUST00000088516(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|rcsb pdb:6JJZ|rcsb pdb:6KKG|rcsb pdb:7D6F|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|refseq:NP_001164216.1|refseq:NP_001164217.1|refseq:NP_056638.1 refseq:NP_062327.2|ensembl:ENSMUSG00000027314(gene)|ensembl:ENSMUST00000102517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|reactome:R-MMU-9013507 - - - figure legend:1A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:Dj0efnLWnVFm5op5RjDEVBl1NF810090 rogid:bQYJ+yLaHczGOBX31/QDTJuDeLQ10090 rigid:hP8vRZgJm/lwHChZDPSkuGbqXW8 false - necessary binding region:683-686 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9EQJ9 uniprotkb:Q61483 intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8 intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7 psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym) psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699864|imex:IM-25247-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity) go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N - comment:mint - figure legend:1A-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090 rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090 rigid:SVR/jqcYaTzGibJrwYwR1YnbTP0 false - necessary binding region:718-722 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9EQJ9 uniprotkb:Q9JI71 intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8 intact:EBI-11699810|uniprotkb:Q9DBU9|uniprotkb:Q9JHZ7|ensembl:ENSMUSP00000099575 psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym) psi-mi:dll4_mouse(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699870|imex:IM-25247-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity) refseq:NP_062327.2|ensembl:ENSMUSG00000027314(gene)|ensembl:ENSMUST00000102517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|reactome:R-MMU-9013507 - comment:mint - figure legend:1A-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090 rogid:bQYJ+yLaHczGOBX31/QDTJuDeLQ10090 rigid:NjCruoVLO6UPpc5UmJlxF4DT1ho false - necessary binding region:683-686 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VBX6 uniprotkb:Q61483 intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894 intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7 psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym) psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699876|imex:IM-25247-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7 go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N - comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses - figure legend:1A-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090 rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090 rigid:zr14IX858t/2v68XQv6xHs3MaiY false - necessary binding region:718-722 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8VBX6 uniprotkb:Q9JI71 intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894 intact:EBI-11699810|uniprotkb:Q9DBU9|uniprotkb:Q9JHZ7|ensembl:ENSMUSP00000099575 psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym) psi-mi:dll4_mouse(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699882|imex:IM-25247-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7 refseq:NP_062327.2|ensembl:ENSMUSG00000027314(gene)|ensembl:ENSMUST00000102517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|reactome:R-MMU-9013507 - comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses - figure legend:1A-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090 rogid:bQYJ+yLaHczGOBX31/QDTJuDeLQ10090 rigid:P8nHzDT0yviG+VzJl2L8gtts73E false - necessary binding region:683-686 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9D6K5 uniprotkb:Q61483 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 intact:EBI-297125|ensembl:ENSMUSP00000014917|uniprotkb:Q6PFV7 psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:dll1_mouse(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699888|imex:IM-25247-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|ensembl:ENSMUSG00000014773(gene)|ensembl:ENSMUST00000014917(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|reactome:R-MMU-9013507|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|refseq:NP_031891.2|dip:DIP-32600N - - - figure legend:1A-7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 rogid:XF72rbPhGwtIVtvryYqH8opo5Fc10090 rigid:Mqmn4YBd9WVyABxRbKY5DGA6RQM false - necessary binding region:718-722 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9D6K5 uniprotkb:Q9JI71 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 intact:EBI-11699810|uniprotkb:Q9DBU9|uniprotkb:Q9JHZ7|ensembl:ENSMUSP00000099575 psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:dll4_mouse(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699894|imex:IM-25247-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 refseq:NP_062327.2|ensembl:ENSMUSG00000027314(gene)|ensembl:ENSMUST00000102517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|reactome:R-MMU-9013507 - - - figure legend:1A-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/05/10 2016/05/12 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 rogid:bQYJ+yLaHczGOBX31/QDTJuDeLQ10090 rigid:fZKwoqGdiarll7Uezyai4aigbYg false - necessary binding region:683-686 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00548 uniprotkb:P57105 intact:EBI-11699911|uniprotkb:B2RAK7|uniprotkb:B5M0B3|uniprotkb:Q9NU41|uniprotkb:Q9UJV2|ensembl:ENSP00000355718|ensembl:ENSP00000480905 intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366 psi-mi:dll1_human(display_long)|uniprotkb:DLL1(gene name)|psi-mi:DLL1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym)|uniprotkb:UNQ146/PRO172(orf name) psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11699908|imex:IM-25247-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005609.3|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|rcsb pdb:4XBM|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507|reactome:R-HSA-9022702|go:"GO:0014002"(astrocyte development)|ensembl:ENSG00000198719(gene)|ensembl:ENSG00000275555(gene)|ensembl:ENST00000366756(transcript)|ensembl:ENST00000616526(transcript)|go:"GO:0001709"(cell fate determination)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression) refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission) - - - figure legend:fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/05/10 2016/05/12 rogid:7YwrXyPqpX9ssDQuIWsG12zCiTg9606 rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606 rigid:N71DfpeLRLxwddnFOsqIyuhjVWQ false renilla luciferase protein tag:?-? protein a tag:?-? - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:Q9NR61 uniprotkb:P57105 intact:EBI-11700027|uniprotkb:Q3KP23|uniprotkb:Q9NQT9|ensembl:ENSP00000249749 intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366 psi-mi:dll4_human(display_long)|uniprotkb:DLL4(gene name)|psi-mi:DLL4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym)|uniprotkb:UNQ1895/PRO4341(orf name) psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11700019|imex:IM-25247-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061947.1|ensembl:ENSG00000128917(gene)|ensembl:ENST00000249749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|rcsb pdb:5MVX|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507|reactome:R-HSA-9013700|go:"GO:0010629"(negative regulation of gene expression) refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission) - - - figure legend:fig 1Ci|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2016/05/10 2016/05/12 rogid:7FBGhSzVjZzuKi+ORxNv9N+DucM9606 rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606 rigid:Ly0XrM2cEKoLTdQVXiRVBKv1Fyo false renilla luciferase protein tag:?-? protein a tag:?-? - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:Q9NR61 uniprotkb:P57105 intact:EBI-11700027|uniprotkb:Q3KP23|uniprotkb:Q9NQT9|ensembl:ENSP00000249749 intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366 psi-mi:dll4_human(display_long)|uniprotkb:DLL4(gene name)|psi-mi:DLL4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym)|uniprotkb:UNQ1895/PRO4341(orf name) psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11700601|imex:IM-25247-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061947.1|ensembl:ENSG00000128917(gene)|ensembl:ENST00000249749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|rcsb pdb:5MVX|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507|reactome:R-HSA-9013700|go:"GO:0010629"(negative regulation of gene expression) refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission) - - - figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium) - 2016/05/10 2016/05/13 rogid:7FBGhSzVjZzuKi+ORxNv9N+DucM9606 rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606 rigid:Ly0XrM2cEKoLTdQVXiRVBKv1Fyo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9D6K5 uniprotkb:Q9JI71 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 intact:EBI-11699810|uniprotkb:Q9DBU9|uniprotkb:Q9JHZ7|ensembl:ENSMUSP00000099575 psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:dll4_mouse(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11700153|imex:IM-25247-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 refseq:NP_062327.2|ensembl:ENSMUSG00000027314(gene)|ensembl:ENSMUST00000102517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|reactome:R-MMU-9013507 - - - figure legend:2D|comment:Colocalization was seen with DLL4 in stalk cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina) - 2016/05/10 2016/05/12 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 rogid:bQYJ+yLaHczGOBX31/QDTJuDeLQ10090 rigid:fZKwoqGdiarll7Uezyai4aigbYg false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9NR61 uniprotkb:P57105 intact:EBI-11700027|uniprotkb:Q3KP23|uniprotkb:Q9NQT9|ensembl:ENSP00000249749 intact:EBI-1049004|uniprotkb:Q96IA4|uniprotkb:Q49SH3|ensembl:ENSP00000256366 psi-mi:dll4_human(display_long)|uniprotkb:DLL4(gene name)|psi-mi:DLL4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym)|uniprotkb:UNQ1895/PRO4341(orf name) psi-mi:syj2b_human(display_long)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym)|uniprotkb:SYNJ2BP(gene name)|psi-mi:SYNJ2BP(display_short)|uniprotkb:OMP25(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Adam et al. (2013) pubmed:24025447|imex:IM-25247 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11700614|imex:IM-25247-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061947.1|ensembl:ENSG00000128917(gene)|ensembl:ENST00000249749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|rcsb pdb:5MVX|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507|reactome:R-HSA-9013700|go:"GO:0010629"(negative regulation of gene expression) refseq:NP_060843.2|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|rcsb pdb:2ENO|rcsb pdb:2JIK|rcsb pdb:2JIN|ensembl:ENSG00000213463(gene)|ensembl:ENST00000256366(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005739"(mitochondrion)|go:"GO:0007268"(chemical synaptic transmission) go:"GO:0005886"(plasma membrane) - - figure legend:2A|comment:SYNJ2BP protein expression was observed in intracellular vesicles and also at the cell membrane, and partially colocalized with DLL4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-endothelium)|taxid:9606(Homo sapiens endothelail cells/endothelium) - 2016/05/10 2016/05/13 rogid:7FBGhSzVjZzuKi+ORxNv9N+DucM9606 rogid:6U2Fgt1o1/WTmxeIfpcWYhik06U9606 rigid:Ly0XrM2cEKoLTdQVXiRVBKv1Fyo false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)