#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O92835	uniprotkb:Q8WXG1	intact:EBI-12736594	intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4	psi-mi:o92835_9flav(display_long)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Helbig et al. (2012)	pubmed:23638199|imex:IM-26225	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12736527|imex:IM-26225-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR027287|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504	ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1	go:"GO:0005811"(lipid droplet)	-	-	figure legend:7B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/12/19	2017/01/10	rogid:CEx2f3i6Tdd8tx7dbul1Ma2Rj3011060	rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606	rigid:AvSwzuFtRYup2gqNhURsp7YbdOg	false	sufficient binding region:5..5-112..112(IPR001122)	flag tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q8WXG1	uniprotkb:O92835	intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4	intact:EBI-12736594	psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym)	psi-mi:o92835_9flav(display_long)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Helbig et al. (2012)	pubmed:23638199|imex:IM-26225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12736923|imex:IM-26225-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR027287|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504	go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)	-	-	figure legend:7C|comment:N-terminal Viperin deletion mutant  loses the ability to colocalise to lipid droplets;the pattern of localisation was  solely cytoplasmic.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/12/19	2017/01/10	rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606	rogid:CEx2f3i6Tdd8tx7dbul1Ma2Rj3011060	rigid:AvSwzuFtRYup2gqNhURsp7YbdOg	false	flag tag:n-n	sufficient binding region:1476..1476-2093..2093(IPR001122)|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O92835	uniprotkb:Q8WXG1	intact:EBI-12736594	intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4	psi-mi:o92835_9flav(display_long)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Helbig et al. (2012)	pubmed:23638199|imex:IM-26225	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12737141|imex:IM-26225-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR027287|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504	ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1	go:"GO:0005811"(lipid droplet)	-	-	figure legend:8A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/12/19	2017/01/11	rogid:CEx2f3i6Tdd8tx7dbul1Ma2Rj3011060	rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606	rigid:AvSwzuFtRYup2gqNhURsp7YbdOg	false	sufficient binding region:5..5-112..112(IPR001122)|green fluorescent protein tag:?-?	necessary binding region:345-361|mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O92835	uniprotkb:Q8WXG1	intact:EBI-12736594	intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4	psi-mi:o92835_9flav(display_long)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Helbig et al. (2012)	pubmed:23638199|imex:IM-26225	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12737170|imex:IM-26225-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR027287|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504	ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:8 B/C/D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/12/19	2017/01/11	rogid:CEx2f3i6Tdd8tx7dbul1Ma2Rj3011060	rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606	rigid:AvSwzuFtRYup2gqNhURsp7YbdOg	false	sufficient binding region:1476..1476-2093..2093(IPR001122)|green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
ddbj/embl/genbank:AF038403.1	uniprotkb:Q8WXG1	intact:EBI-16415584	intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4	psi-mi:polyprotein mrna(display_short)|psi-mi:AF038403.1(display_long)	psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Helbig et al. (2012)	pubmed:23638199|imex:IM-26225	taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16415521|imex:IM-26225-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0324"(messenger rna)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1	-	-	-	figure legend:6C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/12/19	2017/09/13	-	rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606	-	false	-	flag tag:n-n	-	-	psi-mi:"MI:1194"(reverse transcription pcr)	psi-mi:"MI:1194"(reverse transcription pcr)