#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15051	uniprotkb:O15078	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708312|imex:IM-25311-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	-	-	-	figure legend:3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15051	uniprotkb:P62158	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708312|imex:IM-25311-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:P62158	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708317|imex:IM-25311-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708317|imex:IM-25311-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15051	uniprotkb:O15078	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708358|imex:IM-25311-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	-	-	-	figure legend:3B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	sufficient binding region:287-530|flag tag:?-?|mutation with no effect:547-547|mutation with no effect:550-550|mutation with no effect:551-551|mutation with no effect:548-548	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15051	uniprotkb:P62158	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708358|imex:IM-25311-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:3B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	sufficient binding region:287-530|flag tag:?-?|mutation with no effect:547-547|mutation with no effect:550-550|mutation with no effect:551-551|mutation with no effect:548-548	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62158	uniprotkb:Q15051	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708428|imex:IM-25311-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:3B, 5A,6|comment:Complete loss of binding was achieved only when all three IQ motifs were deleted.|comment:"Two   disease associated  mutations of  NPHP5 -   F142fsX146 (424–425delTT,) and  R332X  result in proteins that did not interact with CAM."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:Hxl0tRZjxyZDV/T+CWGKndmLr+o	false	-	mutation with no effect:547-547|mutation with no effect:548-548|mutation with no effect:549-549|sufficient binding region:168-414|flag tag:?-?|mutation decreasing interaction:393-393|binding-associated region:300-437|mutation with no effect:550-550|mutation with no effect:551-551	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:P62158	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708518|imex:IM-25311-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:supplemental fig. S3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:1+t70QLRFCI1V6Xoxwebw2K0yKM	false	flag tag:?-?|sufficient binding region:696-822	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11739479|imex:IM-25311-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:3Bi, 6|comment:"Several disease associated NPHP5 mutations -(F142fsX146, R332X, R461X, R502X and H506fsX518)  result in proteins that do not bind to CEP290"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/06/09	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:gF6ehvssUydd+EGhWrxPT0Dq14c	false	-	sufficient binding region:287-530|flag tag:?-?|necessary binding region:509-529|necessary binding region:543-555|mutation disrupting interaction:549-549	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708473|imex:IM-25311-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:supplemental fig. S3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:gF6ehvssUydd+EGhWrxPT0Dq14c	false	necessary binding region:790-816|flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15078	uniprotkb:P62158	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708507|imex:IM-25311-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:supplemental fig. S3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	flag tag:?-?|sufficient binding region:696-822	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708507|imex:IM-25311-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:supplemental fig. S3A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	flag tag:?-?|sufficient binding region:696-822	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62161	uniprotkb:O15078	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708583|imex:IM-25311-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	-	-	-	figure legend:supplemental fig. S5B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rigid:hgX0E+pRlmslXhD915PH1mXcR1g	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62161	uniprotkb:Q15051	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708583|imex:IM-25311-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:supplemental fig. S5B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/05/26	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:hgX0E+pRlmslXhD915PH1mXcR1g	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15078	uniprotkb:P62161	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11739833|imex:IM-25311-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	-	-	-	figure legend:supplemental fig. S5Bi|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/05/26	2016/06/10	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rigid:JTXmJHZCoTOy2iAtzl2pXVHTN1g	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0047"(far western blotting)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708575|imex:IM-25311-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:supplemental fig. S3c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/26	2016/05/26	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:gF6ehvssUydd+EGhWrxPT0Dq14c	false	flag tag:?-?|sufficient binding region:580-1695	glutathione s tranferase tag:?-?|sufficient binding region:469-598	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15051	uniprotkb:O15078	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708604|imex:IM-25311-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	-	-	-	figure legend:supplemental fig S5A|antagonist:EGTA|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15051	uniprotkb:P62158	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708604|imex:IM-25311-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:supplemental fig S5A|antagonist:EGTA|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/26	2016/05/26	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:k8QM/orL6C7P+JezMIy0KvwQqEg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62158	uniprotkb:Q15051	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0096"(pull down)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11708621|imex:IM-25311-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	-	-	-	figure legend:supplemental fig S5C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/26	2016/05/26	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:Hxl0tRZjxyZDV/T+CWGKndmLr+o	false	-	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11739852|imex:IM-25311-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	go:"GO:0005814"(centriole)	-	-	figure legend:1D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-htert_rpe1)|taxid:9606(Homo sapiens)	-	2016/05/26	2016/06/10	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:gF6ehvssUydd+EGhWrxPT0Dq14c	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O15078	uniprotkb:Q15051	intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012	intact:EBI-2805823|uniprotkb:Q9BS08|uniprotkb:Q5DKQ7|uniprotkb:Q8NI79|ensembl:ENSP00000311505|uniprotkb:Q3KS08|uniprotkb:Q3KS09	psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym)	psi-mi:iqcb1_human(display_long)|uniprotkb:KIAA0036(gene name synonym)|uniprotkb:NPHP5(gene name synonym)|uniprotkb:Nephrocystin-5(gene name synonym)|uniprotkb:IQCB1(gene name)|psi-mi:IQCB1(display_short)|uniprotkb:p53 and DNA damage-regulated IQ motif protein(gene name synonym)|uniprotkb:OK/SW-cl.85(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Barbelanne et al. (2013)	pubmed:23446637|imex:IM-25311	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11739857|imex:IM-25311-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518	refseq:NP_001306036.1|refseq:NP_001018864.2|refseq:NP_001018865.2|ensembl:ENSG00000173226(gene)|ensembl:ENST00000310864(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028765|reactome:R-HSA-5620912|interpro:IPR027417	go:"GO:0005814"(centriole)	-	-	figure legend:Supp 5D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-htert_rpe1)|taxid:9606(Homo sapiens)	-	2016/05/26	2016/06/10	rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606	rogid:gNs0xsyI7Tu3pHu7GhdQDn8tuy89606	rigid:gF6ehvssUydd+EGhWrxPT0Dq14c	false	-	flag tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)