#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32639	intact:EBI-10825220	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS0000514318_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snr7s_u5_yeast(display_short)|psi-mi:EBI-10825220(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658079|imex:IM-26611-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/04/01	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c	binding-associated region:95-100	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10824938	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00006184A9_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658079|imex:IM-26611-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/04/01	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c	binding-associated region:13-44,48-80	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10860871	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS000023C730_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:lsr1_snr20_u2 yeast(display_short)|psi-mi:EBI-10860871(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658079|imex:IM-26611-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/04/01	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c	-	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10054797	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00001143F5_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snr14_u4_yeast(display_short)|psi-mi:EBI-10054797(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658079|imex:IM-26611-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/04/01	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c	binding-associated region:30-75,128-158	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
intact:EBI-10824938	uniprotkb:P32639	rnacentral:URS00006184A9_559292	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11705262|imex:IM-26611-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	figure legend:Fig7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/23	-	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	false	binding-associated region:93-112,13-44,48-80	sufficient binding region:1-1313|tandem tag:c-c|mutation:858-858	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10825220	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS0000514318_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snr7s_u5_yeast(display_short)|psi-mi:EBI-10825220(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708238|imex:IM-26611-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5-mutation+|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/26	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c|mutation increasing interaction strength:858-858	binding-associated region:95-100	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10824938	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00006184A9_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708238|imex:IM-26611-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5-mutation+|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/26	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c|mutation increasing interaction strength:858-858	binding-associated region:48-80	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10054797	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00001143F5_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snr14_u4_yeast(display_short)|psi-mi:EBI-10054797(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708238|imex:IM-26611-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5-mutation+|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/26	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c|mutation increasing interaction strength:858-858	binding-associated region:128-158	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10824938	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00006184A9_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708258|imex:IM-26611-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5-mutation2-less|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/26	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c|mutation decreasing interaction strength:858-858	binding-associated region:13-44	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
uniprotkb:P32639	intact:EBI-10054797	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	rnacentral:URS00001143F5_559292	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:snr14_u4_yeast(display_short)|psi-mi:EBI-10054797(display_long)	psi-mi:"MI:2194"(crac)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11708258|imex:IM-26611-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	-	figure legend:fig1, fig 2, fig 3A, B, Fig7, Suppl fig5-mutation2-less|comment:"mutation G858R in Brr2 alters the interaction with snRNAs:   it  increases the one with U5 and U6, decreases the interaction with U2 ,  it decreases interaction with region 30-80 of U4 and increases it with region 128-158"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2016/03/16	2016/05/26	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	-	false	sufficient binding region:1-1313|tandem tag:c-c|mutation decreasing interaction strength:858-858	binding-associated region:30-75	-	-	psi-mi:"MI:1179"(partial nucleotide sequence identification)	psi-mi:"MI:1179"(partial nucleotide sequence identification)
intact:EBI-10824938	uniprotkb:P32639	rnacentral:URS00006184A9_559292	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658228|imex:IM-26611-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	-	-	crc64:DFAF7E3B7168D944	figure legend:"Fig 2D, (Supp fig  2)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/16	2016/05/26	-	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	-	false	binding-associated region:?-?|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-10824938	intact:EBI-10054797	rnacentral:URS00006184A9_559292	rnacentral:URS00001143F5_559292	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:snr14_u4_yeast(display_short)|psi-mi:EBI-10054797(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658228|imex:IM-26611-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	-	-	-	figure legend:"Fig 2D, (Supp fig  2)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/16	2016/05/26	-	-	-	false	binding-associated region:?-?|32p radiolabel:?-?	binding-associated region:?-?|necessary binding region:93-141	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-10824938	intact:EBI-10054797	rnacentral:URS00006184A9_559292	rnacentral:URS00001143F5_559292	psi-mi:snru6_yeast(display_short)|psi-mi:EBI-10824938(display_long)	psi-mi:snr14_u4_yeast(display_short)|psi-mi:EBI-10054797(display_long)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Hahn et al. (2012)	pubmed:23124065|imex:IM-26611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11658276|imex:IM-26611-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	-	-	-	figure legend:Suppl Fig 2 B,C,D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/03/16	2016/04/04	-	-	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)