#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00522	uniprotkb:Q9ULI3	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-12734419|ensembl:ENSP00000311502|uniprotkb:Q6NX66|uniprotkb:Q8NC40|uniprotkb:Q9BSV0	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:heg1_human(display_long)|uniprotkb:HEG1(gene name)|psi-mi:HEG1(display_short)|uniprotkb:KIAA1237(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734412|imex:IM-25632-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENST00000311127(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0003017"(lymph circulation)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030324"(lung development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0055017"(cardiac muscle tissue growth)|go:"GO:0060039"(pericardium development)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905709"(negative regulation of membrane permeability)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR028720|rcsb pdb:3U7D|rcsb pdb:4HDQ|ensembl:ENSG00000173706(gene)|refseq:NP_065784.1	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/15	2016/12/22	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:F/QCLFsygA0IYdl0loVH1WyNTS09606	rigid:RF9gHveVj6pHxWyh+oqz2sCk/Qo	false	glutathione s tranferase tag:n-n|sufficient binding region:410-736(IPR000299)	sufficient binding region:1274-1381|his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62835	uniprotkb:O00522	intact:EBI-1634972|uniprotkb:P10113|ensembl:ENSMUSP00000088174	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:rap1a_mouse(display_long)|uniprotkb:Rap1a(gene name)|psi-mi:Rap1a(display_short)|uniprotkb:Krev-1(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734750|imex:IM-25632-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_663516.1|refseq:XP_006500970.1|ensembl:ENSMUSG00000068798(gene)|ensembl:ENSMUST00000090678(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0097421"(liver regeneration)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P62835|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8875555	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/15	2016/12/22	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU10090	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:91yfHXWhXbAZFiMnTbCUYGIcDZA	false	ha tag:n-n|mutation:12-12	mutation disrupting interaction strength:452-452|glutathione s tranferase tag:n-n|mutation with no effect:717-717,721-721|sufficient binding region:410-736(IPR000299)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:O00522	uniprotkb:Q9ULI3	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-12734419|ensembl:ENSP00000311502|uniprotkb:Q6NX66|uniprotkb:Q8NC40|uniprotkb:Q9BSV0	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:heg1_human(display_long)|uniprotkb:HEG1(gene name)|psi-mi:HEG1(display_short)|uniprotkb:KIAA1237(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734488|imex:IM-25632-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENST00000311127(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0003017"(lymph circulation)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030324"(lung development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0055017"(cardiac muscle tissue growth)|go:"GO:0060039"(pericardium development)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905709"(negative regulation of membrane permeability)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR028720|rcsb pdb:3U7D|rcsb pdb:4HDQ|ensembl:ENSG00000173706(gene)|refseq:NP_065784.1	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2016/12/15	2017/02/02	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:F/QCLFsygA0IYdl0loVH1WyNTS09606	rigid:RF9gHveVj6pHxWyh+oqz2sCk/Qo	false	tag:?-?|sufficient binding region:417-736(IPR000299)	sufficient binding region:1356-1381|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00522	uniprotkb:Q9ULI3	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-12734419|ensembl:ENSP00000311502|uniprotkb:Q6NX66|uniprotkb:Q8NC40|uniprotkb:Q9BSV0	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:heg1_human(display_long)|uniprotkb:HEG1(gene name)|psi-mi:HEG1(display_short)|uniprotkb:KIAA1237(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734574|imex:IM-25632-3|wwpdb:3U7D	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENST00000311127(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0003017"(lymph circulation)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030324"(lung development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0055017"(cardiac muscle tissue growth)|go:"GO:0060039"(pericardium development)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905709"(negative regulation of membrane permeability)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR028720|rcsb pdb:3U7D|rcsb pdb:4HDQ|ensembl:ENSG00000173706(gene)|refseq:NP_065784.1	-	-	-	figure legend:Table 2|3d-resolution:2.49A|3d-r-factors:RWork =0.234   RFree =0.309|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/15	2016/12/22	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:F/QCLFsygA0IYdl0loVH1WyNTS09606	rigid:RF9gHveVj6pHxWyh+oqz2sCk/Qo	false	sufficient binding region:417-736(IPR000299)	sufficient binding region:1356-1381	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00522	uniprotkb:Q9ULI3	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-12734419|ensembl:ENSP00000311502|uniprotkb:Q6NX66|uniprotkb:Q8NC40|uniprotkb:Q9BSV0	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:heg1_human(display_long)|uniprotkb:HEG1(gene name)|psi-mi:HEG1(display_short)|uniprotkb:KIAA1237(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734675|imex:IM-25632-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENST00000311127(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0003017"(lymph circulation)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030324"(lung development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0055017"(cardiac muscle tissue growth)|go:"GO:0060039"(pericardium development)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905709"(negative regulation of membrane permeability)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR028720|rcsb pdb:3U7D|rcsb pdb:4HDQ|ensembl:ENSG00000173706(gene)|refseq:NP_065784.1	-	-	-	figure legend:4 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/15	2017/01/04	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:F/QCLFsygA0IYdl0loVH1WyNTS09606	rigid:RF9gHveVj6pHxWyh+oqz2sCk/Qo	false	mutation decreasing interaction strength:717-717,721-721|green fluorescent protein tag:n-n|sufficient binding region:410-736(IPR000299)	sufficient binding region:1363-1381|mutation decreasing interaction strength:1380-1381	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00522	uniprotkb:Q9BSQ5	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12734730|imex:IM-25632-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/12/15	2016/12/22	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	mutation with no effect:717-717,721-721|green fluorescent protein tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00522	uniprotkb:Q9ULI3	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	intact:EBI-12734419|ensembl:ENSP00000311502|uniprotkb:Q6NX66|uniprotkb:Q8NC40|uniprotkb:Q9BSV0	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:heg1_human(display_long)|uniprotkb:HEG1(gene name)|psi-mi:HEG1(display_short)|uniprotkb:KIAA1237(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Gingras et al. (2012)	pubmed:23007647|imex:IM-25632	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12735454|imex:IM-25632-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	ensembl:ENST00000311127(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0003017"(lymph circulation)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030324"(lung development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0055017"(cardiac muscle tissue growth)|go:"GO:0060039"(pericardium development)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905709"(negative regulation of membrane permeability)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR028720|rcsb pdb:3U7D|rcsb pdb:4HDQ|ensembl:ENSG00000173706(gene)|refseq:NP_065784.1	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/15	2017/01/05	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rogid:F/QCLFsygA0IYdl0loVH1WyNTS09606	rigid:RF9gHveVj6pHxWyh+oqz2sCk/Qo	false	green fluorescent protein tag:n-n|sufficient binding region:410-736(IPR000299)	sufficient binding region:1356-1381|binding-associated region:1363-1381|mutation with no effect:1367-1367,1370-1370|his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)