#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IXL6	uniprotkb:P25054	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592831|imex:IM-25629-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:dhDSSOuB/tBQ9hLDEpA04Vu0zGw	false	flag tag:c-c	sufficient binding region:1272-1286	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P52655	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592845|imex:IM-25629-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	rigid:VfLalDsyEOat85hzFULUWLdJITs	false	flag tag:c-c	sufficient binding region:273-287	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O14745	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592855|imex:IM-25629-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	rigid:5Kp2ncaTA18x57pH9Sgy67mRFzI	false	flag tag:c-c	sufficient binding region:283-297	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q14653	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-2650369|uniprotkb:Q5FBY1|uniprotkb:Q5FBY2|uniprotkb:Q7Z5G6|uniprotkb:A8K7L2|uniprotkb:B2RAZ3|ensembl:ENSP00000310127|ensembl:ENSP00000366344|ensembl:ENSP00000469113|uniprotkb:Q5FBY4	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:irf3_human(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592869|imex:IM-25629-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001562.1|refseq:NP_001184053.1|ensembl:ENSG00000126456(gene)|ensembl:ENST00000309877(transcript)|ensembl:ENST00000377139(transcript)|ensembl:ENST00000597198(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q14653|rcsb pdb:1J2F|rcsb pdb:1QWT|rcsb pdb:1T2K|rcsb pdb:1ZOQ|rcsb pdb:2O61|rcsb pdb:2O6G|rcsb pdb:2PI0|rcsb pdb:3A77|rcsb pdb:3QU6|rcsb pdb:5JEJ|rcsb pdb:5JEK|rcsb pdb:5JEL|rcsb pdb:5JEM|rcsb pdb:5JEO|rcsb pdb:5JER|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:7JFL|reactome:R-HSA-1169408|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3270619|reactome:R-HSA-877300|reactome:R-HSA-3134973|reactome:R-HSA-9013973|reactome:R-HSA-909733|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:NP_001184051.1|refseq:NP_001184052.1|refseq:NP_001184054.1|refseq:NP_001184055.1|refseq:NP_001184056.1|refseq:NP_001184057.1|refseq:XP_006723260.1|refseq:XP_006723261.1|refseq:XP_016882255.1|refseq:XP_016882256.1|dip:DIP-41448N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:hQC59YXQ7BOkhZzKbxYHcu1YWFA9606	rigid:x7he+AgssC6Hgxyevx2xETivljk	false	flag tag:c-c	sufficient binding region:379-393	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q04206	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592881|imex:IM-25629-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	rigid:xUxIyvyrptQvznzgDjCiIj35GT4	false	flag tag:c-c	sufficient binding region:529-543	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	intact:EBI-12592918	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	-	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:tf65_human_related peptide(display_short)|psi-mi:EBI-12592918(display_long)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592907|imex:IM-25629-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	-	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:n7jJHBk+nVV18YDSDDw6g0e9mX0-2	rigid:umatiTsLalSecVapHdcG5tV9o+Y	false	flag tag:c-c	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01100	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592923|imex:IM-25629-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	rigid:23FJcoQvusK0kvfLnfdqbikg7wg	false	flag tag:c-c	sufficient binding region:225-239	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P11168	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12592947|ensembl:ENSP00000323568|uniprotkb:A8K481|uniprotkb:B2R936|uniprotkb:B7Z547|uniprotkb:F8W8V8|uniprotkb:Q9UCW9	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:gtr2_human(display_long)|uniprotkb:SLC2A2(gene name)|psi-mi:SLC2A2(display_short)|uniprotkb:GLUT2(gene name synonym)|uniprotkb:Glucose transporter type 2, liver(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12592937|imex:IM-25629-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000163581(gene)|ensembl:ENST00000314251(transcript)|go:"GO:0005353"(fructose transmembrane transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0015149"(hexose transmembrane transporter activity)|go:"GO:0015755"(fructose transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002440("Glucose transporter, type 2 (GLUT2)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-HSA-189200|reactome:R-HSA-210745|reactome:R-HSA-422356|reactome:R-HSA-5619098|reactome:R-HSA-8981373|refseq:NP_000331.1|refseq:NP_001265587.1|refseq:NP_001265588.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:Tj2TuL18ZOIHnuZTNXImi2hoIcA9606	rigid:bjkgC+s/keVjOD1LCLFj9D9ikl8	false	flag tag:c-c	sufficient binding region:484-498	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q09666	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-2555881|ensembl:ENSP00000367263|uniprotkb:A1A586	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ahnk_human(display_long)|uniprotkb:PM227(gene name synonym)|uniprotkb:Desmoyokin(gene name synonym)|uniprotkb:AHNAK(gene name)|psi-mi:AHNAK(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593158|imex:IM-25629-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001611.1|ensembl:ENSG00000124942(gene)|ensembl:ENST00000378024(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0031982"(vesicle)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q09666|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRG|refseq:NP_001333374.1|refseq:NP_001333375.1|refseq:NP_076965.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -9-i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:u1oecAyIihgxzfTz0jholE8wksA9606	rigid:rBKad79unSuhr//bz9l5UIxOYKM	false	flag tag:c-c	sufficient binding region:5775-5789	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P10644	uniprotkb:Q8IXL6	intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593170|imex:IM-25629-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:1 E/F -10-j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:SrPFat58Sv+2sEtIXyuE51oP6lU	false	sufficient binding region:94-108	flag tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99640	uniprotkb:Q8IXL6	intact:EBI-495308|uniprotkb:O14731|uniprotkb:Q7LE24|uniprotkb:Q8TCM9|uniprotkb:D3DUA4|uniprotkb:F8W164|uniprotkb:B3KUN8|uniprotkb:B4DXD4|uniprotkb:I3L1V2|intact:EBI-10963121|ensembl:ENSP00000262300	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:pmyt1_human(display_long)|uniprotkb:Myt1 kinase(gene name synonym)|uniprotkb:PKMYT1(gene name)|psi-mi:PKMYT1(display_short)|uniprotkb:MYT1(gene name synonym)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593184|imex:IM-25629-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245379.1|refseq:NP_001245380.1|refseq:NP_004194.3|refseq:XP_011521036.1|refseq:XP_011521037.1|refseq:XP_011521038.1|refseq:NP_872629.1|ensembl:ENSG00000127564(gene)|ensembl:ENST00000262300(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016235(Membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3P1A|rcsb pdb:5VCV|rcsb pdb:5VCW|rcsb pdb:5VCX|rcsb pdb:5VCY|rcsb pdb:5VCZ|rcsb pdb:5VD0|rcsb pdb:5VD1|rcsb pdb:5VD3|reactome:R-HSA-156711|reactome:R-HSA-69273|reactome:R-HSA-69478	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:1 E/F -11-k|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:e91LSQiMxg/UJRZpu67BoIL92V49606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:XSTIGydk0vWLRL1VCnNLJbOFp1A	false	sufficient binding region:419-433	flag tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P30307	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-974439|ensembl:ENSP00000321656|ensembl:ENSP00000424795|uniprotkb:Q96PL3|uniprotkb:Q9H168|uniprotkb:Q9H2E8|uniprotkb:Q9H2E9|uniprotkb:Q9H2F1|uniprotkb:D3DQB8	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:mpip3_human(display_long)|uniprotkb:CDC25C(gene name)|psi-mi:CDC25C(display_short)|uniprotkb:Dual specificity phosphatase Cdc25C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593198|imex:IM-25629-12	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000158402(gene)|ensembl:ENST00000323760(transcript)|ensembl:ENST00000513970(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30307|rcsb pdb:2OJX|rcsb pdb:3BZI|rcsb pdb:3OP3|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|reactome:R-HSA-156711|reactome:R-HSA-176187|reactome:R-HSA-5625740|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-69273|reactome:R-HSA-75035|reactome:R-HSA-8862803|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|refseq:NP_001781.2|refseq:NP_073720.1|refseq:NP_001305027.1|refseq:XP_011542064.1|refseq:NP_001274511.1|dip:DIP-24183N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:1 E/F -12-L|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:YzNTFdiRdWfd4n69U13LgJU5DOs9606	rigid:qm85wgxxJeRCEIPiLhNCyxcMTXY	false	flag tag:c-c	sufficient binding region:184-198	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q16821	uniprotkb:Q8IXL6	intact:EBI-3951750|uniprotkb:A0AVQ2|uniprotkb:A4D0T6|uniprotkb:O43476|uniprotkb:Q75LN8|uniprotkb:Q7KYM8|uniprotkb:Q86UI6|ensembl:ENSP00000284601	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:ppr3a_human(display_long)|uniprotkb:PPP1R3A(gene name)|psi-mi:PPP1R3A(display_short)|uniprotkb:PP1G(gene name synonym)|uniprotkb:Protein phosphatase 1 glycogen-associated regulatory subunit(gene name synonym)|uniprotkb:Protein phosphatase type-1 glycogen targeting subunit(gene name synonym)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593208|imex:IM-25629-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:2001069"(glycogen binding)|interpro:IPR005036(Putative phosphatase regulatory subunit)|interpro:IPR038175|rcsb pdb:5ZQV|go:"GO:0000164"(protein phosphatase type 1 complex)|refseq:NP_002702.2|ensembl:ENSG00000154415(gene)|ensembl:ENST00000284601(transcript)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:1 E/F -13-M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:vWrcRLUsnWG0hDe4bYgR7wb0sNo9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:1vXygoFpp2xbxFjRTNewkAD3BBI	false	sufficient binding region:41-55	flag tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02666	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593233|imex:IM-25629-14	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:2A, supp fig 6|comment:Staurosporine does not inhibit Fam20C kinase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:hEAEa5IfA6MG8UIHsTgGT8ctSTY	false	flag tag:c-c	sufficient binding region:43-55	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q8IXL6	uniprotkb:P05814	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1642112|uniprotkb:Q4VAZ9|uniprotkb:Q9UCM5|ensembl:ENSP00000341030|ensembl:ENSP00000489488	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:casb_human(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)|uniprotkb:CASB(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593252|imex:IM-25629-15	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001882.1|refseq:NP_001289699.1|refseq:XP_016863249.1|ensembl:ENSG00000135222(gene)|ensembl:ENSG00000283030(gene)|ensembl:ENST00000353151(transcript)|ensembl:ENST00000635174(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007595"(lactation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305|mint:P05814|reactome:R-HSA-1251985	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:C7aq7sKFs3i5GOrPLzA0ZWDVefk9606	rigid:c0OaPAHUpQaok5Tjefmzg9rf5mg	false	flag tag:c-c|mutation disrupting interaction rate:478-478	sufficient binding region:16-211|his tag:n-n|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P10451-PRO_0000020321	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-11893188	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:p10451-pro_0000020321(display_long)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:BNSP(gene name synonym)|uniprotkb:OPN(gene name synonym)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:PSEC0156(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593272|imex:IM-25629-16	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-723648(chain-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:17|chain-seq-end:314	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:hpMQDe1g7H1gGtQLLA+7mWanSJ09606	rigid:fGhvdt6J4u62fiyCqKTzz89vmFw	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q9NQ76-PRO_0000021668	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12593305	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:q9nq76-pro_0000021668(display_long)|uniprotkb:Osteoregulin(gene name synonym)|uniprotkb:Osteoblast/osteocyte factor 45(gene name synonym)|uniprotkb:MEPE(gene name)|psi-mi:MEPE(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593291|imex:IM-25629-17	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-1753293(chain-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:18|chain-seq-end:525	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/03	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:BM0y9QKHQpKirCw3DUZe3dXzv/Y9606	rigid:ccrNm4Yljhi1qKbfYd6WKIEVr3E	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P05060	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-712619|uniprotkb:A8K021|uniprotkb:Q59EU9|uniprotkb:Q6IBS6|uniprotkb:Q9UC25|uniprotkb:Q9BQV6|uniprotkb:Q9UJA6|ensembl:ENSP00000368244	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:scg1_human(display_long)|uniprotkb:Secretogranin I(gene name synonym)|uniprotkb:Chromogranin-B(gene name synonym)|uniprotkb:CHGB(gene name)|psi-mi:CHGB(display_short)|uniprotkb:SCG1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594474|imex:IM-25629-51	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000089199(gene)|ensembl:ENST00000378961(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030141"(secretory granule)|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|interpro:IPR018054|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001810.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Supp 5C|comment:In the Secretogranin-1 derived peptide there is an Alanine at position/residue 380 which is not found in the naturally occurring protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/12/14	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:GuMpGIqVUx0MZ/+vOJHNnJgcwsg9606	rigid:iah4tDN3AJRTqwH8hCwb8Lbns64	false	flag tag:c-c	mutation:380-380|mutation disrupting interaction rate:377-377|mutation disrupting interaction rate:377-377|mutation disrupting interaction rate:379-379|mutation disrupting interaction rate:377-377,379-379|sufficient binding region:374-385	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	intact:EBI-12594528	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	-	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:s-x-e containing peptide(display_short)|psi-mi:EBI-12594528(display_long)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594510|imex:IM-25629-52	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	-	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	no-uniprot-update:yes	figure legend:Supp 5D|comment:Alanine substitutions  for residues 1-11 inclusive did not alter binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:OsfYjLOHVzMQB+H8/ZJ96Dn+rN49606	rigid:oxJJp86KGA940OuveqmcjoiV9BM	false	flag tag:c-c	mutation disrupting interaction rate:14-14|mutation decreasing interaction rate:15-15|mutation disrupting interaction rate:12-12	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q13316-PRO_0000021110	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12594592	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:q13316-pro_0000021110(display_long)|uniprotkb:DMP1(gene name)|psi-mi:DMP1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594549|imex:IM-25629-53	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-12594563(chain-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:17|chain-seq-end:513	figure legend:Supp 10A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:yqo0ljjbgI1xuRmm1ZuwgMqwWUI9606	rigid:C+pS/PyxFB9l7Jac1vG2acv80Lc	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02810-PRO_0000022137	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12594613	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:p02810-pro_0000022137(display_long)|uniprotkb:PRH1(gene name)|psi-mi:PRH1(display_short)|uniprotkb:PRH2(gene name)|psi-mi:PRH2(display_short)|uniprotkb:Db-s(gene name synonym)|uniprotkb:PRP-1/PRP-2(gene name synonym)|uniprotkb:Parotid acidic protein(gene name synonym)|uniprotkb:Parotid double-band protein(gene name synonym)|uniprotkb:Parotid isoelectric focusing variant protein(gene name synonym)|uniprotkb:Parotid proline-rich protein 1/2(gene name synonym)|uniprotkb:Pr1/Pr2(gene name synonym)|uniprotkb:Protein C(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594597|imex:IM-25629-54	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	intact:EBI-738601(chain-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	chain-seq-start:17|chain-seq-end:166	figure legend:Supp 10B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:4Fcgy4hrJRjdcv4aZgj3eHyVw5g9606	rigid:nYM5rmNwd0yxb0jNN1+HJkW2K0k	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01042	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593499|imex:IM-25629-18	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606	rigid:/hjGVPhDGiT4Aw2pSPDOAn3jcyg	false	flag tag:c-c	sufficient binding region:325-341	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01008	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1039832|uniprotkb:P78439|uniprotkb:P78447|uniprotkb:Q13815|uniprotkb:Q7KZ43|uniprotkb:B2R6P0|uniprotkb:Q5TC78|uniprotkb:Q7KZ97|uniprotkb:Q9UC78|ensembl:ENSP00000356671	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ant3_human(display_long)|uniprotkb:SERPINC1(gene name)|psi-mi:SERPINC1(display_short)|uniprotkb:AT3(gene name synonym)|uniprotkb:PRO0309(orf name)|uniprotkb:Serpin C1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593550|imex:IM-25629-19	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000479.1|ensembl:ENSG00000117601(gene)|ensembl:ENST00000367698(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007584"(response to nutrient)|go:"GO:0007595"(lactation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000266"(regulation of blood coagulation, intrinsic pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015555(Protease inhibitor I4, serpin, antithrombin-III)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033829|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01008|rcsb pdb:1ANT|rcsb pdb:1ATH|rcsb pdb:1AZX|rcsb pdb:1BR8|rcsb pdb:1DZG|rcsb pdb:1DZH|rcsb pdb:1E03|rcsb pdb:1E04|rcsb pdb:1E05|rcsb pdb:1JVQ|rcsb pdb:1LK6|rcsb pdb:1NQ9|rcsb pdb:1OYH|rcsb pdb:1R1L|rcsb pdb:1SR5|rcsb pdb:1T1F|rcsb pdb:1TB6|rcsb pdb:2ANT|rcsb pdb:2B4X|rcsb pdb:2B5T|rcsb pdb:2BEH|rcsb pdb:2GD4|rcsb pdb:2HIJ|rcsb pdb:2ZNH|rcsb pdb:3EVJ|rcsb pdb:3KCG|rcsb pdb:4EB1|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-38009N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:XiPmXyU7CpPTgDR3dPnKeJEItJg9606	rigid:OSzWRFJcREpzyGzbASNU3B793L8	false	flag tag:c-c	sufficient binding region:62-77	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q9UK55	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-3941758|uniprotkb:Q86U20|uniprotkb:A5Z2A5|uniprotkb:Q6UWX9|ensembl:ENSP00000261994|ensembl:ENSP00000376809|ensembl:ENSP00000450971|ensembl:ENSP00000484632	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:zpi_human(display_long)|uniprotkb:SERPINA10(gene name)|psi-mi:SERPINA10(display_short)|uniprotkb:ZPI(gene name synonym)|uniprotkb:Serpin A10(gene name synonym)|uniprotkb:UNQ707/PRO1358(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593561|imex:IM-25629-20	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000140093(gene)|ensembl:ENSG00000278767(gene)|ensembl:ENST00000261994(transcript)|ensembl:ENST00000393096(transcript)|ensembl:ENST00000554173(transcript)|ensembl:ENST00000614630(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR033835|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:3F1S|rcsb pdb:3H5C|rcsb pdb:4AFX|rcsb pdb:4AJU|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001094077.1|refseq:NP_057270.1|refseq:XP_005267790.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:w0lFb4g2YwlRuSLWQWchQ4FwhlQ9606	rigid:IFLY1Pe8FDbzNol7Hui6wlpP0Qk	false	flag tag:c-c	sufficient binding region:47-59	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O14791	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1221934|uniprotkb:O60804|uniprotkb:Q5R3P7|uniprotkb:Q5R3P8|uniprotkb:Q96AB8|uniprotkb:Q96PM4|uniprotkb:Q9BQ03|uniprotkb:A5PLQ4|uniprotkb:B4DU12|uniprotkb:E9PF24|ensembl:ENSP00000380448|ensembl:ENSP00000380449|ensembl:ENSP00000411507	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:apol1_human(display_long)|uniprotkb:APOL1(gene name)|psi-mi:APOL1(display_short)|uniprotkb:APOL(gene name synonym)|uniprotkb:Apolipoprotein L(gene name synonym)|uniprotkb:Apolipoprotein L-I(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593573|imex:IM-25629-21	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001130012.1|refseq:NP_003652.2|refseq:NP_001130013.1|refseq:XP_005261853.1|ensembl:ENSG00000100342(gene)|ensembl:ENST00000397278(transcript)|ensembl:ENST00000397279(transcript)|ensembl:ENST00000422706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0072562"(blood microparticle)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR008405(Apolipoprotein L)|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:fMIhQ/5ozAl1P7l8G/Di1kaGglI9606	rigid:YnBLqOF1pWPefzaLZ88gqwNuVzk	false	flag tag:c-c	sufficient binding region:306-320	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q6Q788	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-3936819|uniprotkb:B0YIV9|uniprotkb:Q6UWK9|uniprotkb:Q9UBJ3|uniprotkb:Q3MIK6|ensembl:ENSP00000227665|ensembl:ENSP00000399701|ensembl:ENSP00000445002	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:apoa5_human(display_long)|uniprotkb:APOA5(gene name)|psi-mi:APOA5(display_short)|uniprotkb:RAP3(gene name synonym)|uniprotkb:Apolipoprotein A5(gene name synonym)|uniprotkb:Regeneration-associated protein 3(gene name synonym)|uniprotkb:UNQ411/PRO773(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593618|imex:IM-25629-22	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0008047"(enzyme activator activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010902"(positive regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035473"(lipase binding)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055090"(acylglycerol homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060229"(lipase activator activity)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0070325"(lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000074(Apolipoprotein A1/A4/E)|reactome:R-HSA-1989781|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-8963889|reactome:R-HSA-8963901|go:"GO:0006869"(lipid transport)|ensembl:ENSG00000110243(gene)|ensembl:ENST00000227665(transcript)|ensembl:ENST00000433069(transcript)|ensembl:ENST00000542499(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006641"(triglyceride metabolic process)|refseq:NP_001160070.1|refseq:NP_443200.2|refseq:XP_016872658.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:csQ+VFmaGt/8iBV1c3fDYCjqCcI9606	rigid:YVKwDOELf4aqU5T88322oEyfJVo	false	flag tag:c-c	sufficient binding region:52-63	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P19823	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-718353|uniprotkb:Q14659|uniprotkb:Q15484|uniprotkb:Q5T986|ensembl:ENSP00000351190	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:itih2_human(display_long)|uniprotkb:Inter-alpha-trypsin inhibitor complex component II(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym)|uniprotkb:ITIH2(gene name)|psi-mi:ITIH2(display_short)|uniprotkb:IGHEP2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593629|imex:IM-25629-23	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_002207.2|ensembl:ENSG00000151655(gene)|ensembl:ENST00000358415(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:mxVXjhb1YohieImPswevFaJ/2Hw9606	rigid:Tm/l+jx8yV/Hjlq2eifbpb74+W4	false	flag tag:c-c	sufficient binding region:60-73	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P10451	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-723648|ensembl:ENSP00000378517|ensembl:ENSP00000477824|uniprotkb:Q15681|uniprotkb:Q15682|uniprotkb:Q15683|uniprotkb:Q8NBK2|uniprotkb:Q96IZ1|uniprotkb:B2RDA1|uniprotkb:Q4W597|uniprotkb:Q567T5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ostp_human(display_long)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:OPN(gene name synonym)|uniprotkb:PSEC0156(orf name)|uniprotkb:BNSP(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593641|imex:IM-25629-24	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000573.1|refseq:NP_001035147.1|ensembl:ENSG00000118785(gene)|ensembl:ENST00000395080(transcript)|ensembl:ENST00000614857(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042995"(cell projection)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|mint:P10451|rcsb pdb:3CXD|rcsb pdb:3DSF|reactome:R-HSA-1474228|reactome:R-HSA-186797|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8949275|reactome:R-HSA-8957275|go:"GO:0046697"(decidualization)|refseq:NP_001035149.1|refseq:NP_001238758.1|refseq:NP_001238759.1|dip:DIP-49933N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -7|comment:"Table S1 states some of these  peptides are from \"secreted phosphoprotein 1 isoform B\".(A13 + A14)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:a1xqyCMAIQpBwLFBbfKN7R+7K3M9606	rigid:0DEdYpFX2bSTlLAUFB+p/EHWYt4	false	flag tag:c-c	sufficient binding region:56-68|sufficient binding region:184-198|sufficient binding region:223-238|sufficient binding region:252-266|sufficient binding region:269-278|sufficient binding region:300-312|sufficient binding region:300-313|sufficient binding region:302-314	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q13103	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12593733|ensembl:ENSP00000168148|ensembl:ENSP00000362466|uniprotkb:A4QMV3|uniprotkb:Q3B892|uniprotkb:Q546M5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:spp24_human(display_long)|uniprotkb:SPP2(gene name)|psi-mi:SPP2(display_short)|uniprotkb:SPP24(gene name synonym)|uniprotkb:Secreted phosphoprotein 2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593691|imex:IM-25629-25	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000072080(gene)|ensembl:ENST00000168148(transcript)|ensembl:ENST00000373368(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0046849"(bone remodeling)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR010892(Secreted phosphoprotein 24)|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_008875.1|refseq:XP_005246159.1|refseq:XP_011510000.1|refseq:XP_011510001.1|refseq:XP_011510002.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:sFMz+3aMW9Bxvex2ITcUYTfr/yg9606	rigid:vZhEkw4TR30PoFfNEDrBEuRL18k	false	flag tag:c-c	sufficient binding region:163-177	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01024	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593723|imex:IM-25629-26	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:ODG2faOCLu08jPebd6pGB8tEZTo	false	flag tag:c-c	sufficient binding region:291-304	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P12259	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-9640912|uniprotkb:A8K6E8|uniprotkb:Q14285|uniprotkb:Q5R346|uniprotkb:Q8WWQ6|uniprotkb:Q6UPU6|uniprotkb:Q2EHR5|uniprotkb:Q5R347|ensembl:ENSP00000356771	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fa5_human(display_long)|uniprotkb:F5(gene name)|psi-mi:F5(display_short)|uniprotkb:Activated protein C cofactor(gene name synonym)|uniprotkb:Proaccelerin, labile factor(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593764|imex:IM-25629-27	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000121.2|dip:DIP-47331N|ensembl:ENSG00000198734(gene)|ensembl:ENST00000367797(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009271(Coagulation factor V LSPD)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR024715|interpro:IPR033138|mint:P12259|rcsb pdb:1CZS|rcsb pdb:1CZT|rcsb pdb:1CZV|rcsb pdb:1FV4|rcsb pdb:1Y61|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3S9C|rcsb pdb:7KVE|rcsb pdb:7KVF|rcsb pdb:7KXY|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:i1+4mzlwzNvSHZ2CketeTEvnJEQ9606	rigid:fBothxFERK2RL+gI/pABzTSrSVY	false	flag tag:c-c	sufficient binding region:691-706	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q8NBJ4	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-712073|ensembl:ENSP00000373363|ensembl:ENSP00000373364|uniprotkb:Q6IAF4|uniprotkb:Q9NRB9	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:golm1_human(display_long)|uniprotkb:Golgi phosphoprotein 2(gene name synonym)|uniprotkb:Golgi membrane protein GP73(gene name synonym)|uniprotkb:GOLM1(gene name)|psi-mi:GOLM1(display_short)|uniprotkb:PSEC0242(orf name)|uniprotkb:UNQ686/PRO1326(orf name)|uniprotkb:C9orf155(gene name synonym)|uniprotkb:GOLPH2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593784|imex:IM-25629-28	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0019216"(regulation of lipid metabolic process)|interpro:IPR026139|interpro:IPR026143|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000135052(gene)|ensembl:ENST00000388711(transcript)|ensembl:ENST00000388712(transcript)|go:"GO:0005615"(extracellular space)|refseq:NP_057632.2|refseq:NP_808800.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -11+33|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:UTZSkGqBWSsT8rAOnkCcFHD8+EU9606	rigid:MBuqIb1pQ0LvSE+2dLw0L3tYL0U	false	flag tag:c-c	sufficient binding region:254-267|sufficient binding region:253-263	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02671	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593795|imex:IM-25629-29	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -12|comment:"The stated sequence for this protein  (fspmlgefvsetesr) does not belong to \"golgiphosphoprotein 2\"- as stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	rigid:XzHzj17nivEFlisiMbhw2+66Pbc	false	flag tag:c-c	sufficient binding region:533-547	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q6WN34-2	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12593838|ensembl:ENSP00000263671	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:q6wn34-2(display_long)|uniprotkb:CHRDL2(gene name)|psi-mi:CHRDL2(display_short)|uniprotkb:BNF1(gene name synonym)|uniprotkb:CHL2(gene name synonym)|uniprotkb:Breast tumor novel factor 1(gene name synonym)|uniprotkb:Chordin-related protein 2(gene name synonym)|uniprotkb:UNQ765/PRO1557(orf name)|uniprotkb:II(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593827|imex:IM-25629-30	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000054938(gene)|ensembl:ENST00000263671(transcript)|uniprotkb:Q6WN34-2(isoform-parent)|intact:EBI-16579465(isoform-parent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -13|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:ciirTrxSLuxjNHMz4SKRHIUfl9I9606	rigid:CJRmC/LYnXiB6hKCjElJ3sd9D0o	false	flag tag:c-c	sufficient binding region:390-405	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q9BUN1	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12022316|ensembl:ENSP00000357922|uniprotkb:B2RDU8|uniprotkb:Q9NWZ4	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ment_human(display_long)|uniprotkb:MENT(gene name)|psi-mi:MENT(display_short)|uniprotkb:C1orf56(gene name synonym)|uniprotkb:Methylated in normal thymocytes protein(gene name synonym)|uniprotkb:UNQ547/PRO1104(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12593929|imex:IM-25629-31	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000143443(gene)|ensembl:ENST00000368926(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR029292|refseq:NP_060330.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -14|comment:"The protein \"Ment\" is given an identifier  as \"LOC54964\" which does correspond to C1orf56 (Ment)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:V8KUiz087cIcAO369GOK/PDv4ZI9606	rigid:7XmEBgTez5wibGJfKrCkFjgodmA	false	flag tag:c-c	sufficient binding region:97-111	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P04004	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594024|imex:IM-25629-32	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606	rigid:i++4U9MUjK0AaJthLDfzzDy7TRc	false	flag tag:c-c	sufficient binding region:311-324	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P13611	uniprotkb:Q8IXL6	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594038|imex:IM-25629-33	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:"Table S1 -16  (+c19)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:lu80v3Yf294ZDZ6Vh4OGjvcHMJU	false	sufficient binding region:2110-2123|sufficient binding region:2110-2124	flag tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02666	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594051|imex:IM-25629-34	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -17|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/12/14	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:hEAEa5IfA6MG8UIHsTgGT8ctSTY	false	flag tag:c-c	sufficient binding region:48-61	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q14515	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-2682673|uniprotkb:B4E2Z0|uniprotkb:E7ESU2|uniprotkb:Q14800|ensembl:ENSP00000282470|ensembl:ENSP00000414856	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:sprl1_human(display_long)|uniprotkb:High endothelial venule protein(gene name synonym)|uniprotkb:MAST 9(gene name synonym)|uniprotkb:SPARCL1(gene name)|psi-mi:SPARCL1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594073|imex:IM-25629-35	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001278905.1|refseq:NP_001278906.1|refseq:NP_001121782.1|refseq:NP_004675.3|ensembl:ENSG00000152583(gene)|ensembl:ENST00000282470(transcript)|ensembl:ENST00000418378(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:Q14515|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -18|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:0HWQK3GxsY5R4UiaTQdwJKFKo509606	rigid:UU0caXU/4yPpIDiFh2MFoRIaTfk	false	flag tag:c-c	sufficient binding region:270-283|sufficient binding region:195-205|sufficient binding region:411-424	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P05060	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-712619|uniprotkb:A8K021|uniprotkb:Q59EU9|uniprotkb:Q6IBS6|uniprotkb:Q9UC25|uniprotkb:Q9BQV6|uniprotkb:Q9UJA6|ensembl:ENSP00000368244	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:scg1_human(display_long)|uniprotkb:Secretogranin I(gene name synonym)|uniprotkb:Chromogranin-B(gene name synonym)|uniprotkb:CHGB(gene name)|psi-mi:CHGB(display_short)|uniprotkb:SCG1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594090|imex:IM-25629-36	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000089199(gene)|ensembl:ENST00000378961(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030141"(secretory granule)|interpro:IPR001819(Chromogranin A/B)|interpro:IPR001990(Chromogranin/secretogranin)|interpro:IPR018054|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001810.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -19|comment:"The  sequence aas 235-248 (assqesgeeagsqen) only gives a partial match - the N-terminal \"A\" cannot be found in any identifier and residue 243 should be a \"T\" - the \"A\" given here  is a variant."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:GuMpGIqVUx0MZ/+vOJHNnJgcwsg9606	rigid:iah4tDN3AJRTqwH8hCwb8Lbns64	false	flag tag:c-c	sufficient binding region:139-153|sufficient binding region:180-193|sufficient binding region:235-248|sufficient binding region:259-270|sufficient binding region:309-323|sufficient binding region:374-385|sufficient binding region:400-409|sufficient binding region:617-629	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q92932	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-310576|uniprotkb:Q8N4I5|uniprotkb:Q92662|intact:EBI-947109|uniprotkb:Q9Y4F8|uniprotkb:E9PC57|uniprotkb:Q9Y4I6|ensembl:ENSP00000374069	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ptpr2_human(display_long)|uniprotkb:PTPRN2(gene name)|psi-mi:PTPRN2(display_short)|uniprotkb:KIAA0387(gene name synonym)|uniprotkb:Islet cell autoantigen-related protein(gene name synonym)|uniprotkb:Phogrin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594121|imex:IM-25629-37	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_002838.2|refseq:NP_570857.2|refseq:NP_570858.2|refseq:NP_001295196.1|refseq:NP_001295197.1|ensembl:ENSG00000155093(gene)|ensembl:ENST00000389418(transcript)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|rcsb pdb:2QEP|rcsb pdb:4HTI|rcsb pdb:4HTJ|reactome:R-HSA-6798695	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:afvWmPT2RuvhMQ0X8iCHpp/ouF09606	rigid:TGJ21xTct0gV9j+CDnFC8yUmlq8	false	flag tag:c-c	sufficient binding region:355-368|sufficient binding region:428-442	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P23142	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-726652|uniprotkb:P23143|uniprotkb:P23144|uniprotkb:P37888|uniprotkb:Q5TIC4|uniprotkb:Q8TBH8|uniprotkb:Q9HBQ5|uniprotkb:Q9UC21|uniprotkb:Q9UGR4|uniprotkb:Q9UH41|uniprotkb:B0QY42|intact:EBI-2562209|ensembl:ENSP00000331544|uniprotkb:B1AHL4	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fbln1_human(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594135|imex:IM-25629-38	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001987.2|refseq:NP_006476.2|refseq:NP_006477.2|refseq:NP_006478.2|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0071953"(elastic fiber)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904188"(negative regulation of transformation of host cell by virus)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017048(Fibulin-1)|interpro:IPR018097|interpro:IPR026823|mint:P23142|reactome:R-HSA-2129379|go:"GO:0005201"(extracellular matrix structural constituent)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -21|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606	rigid:OilqxzFWtDhwJ1X+p/jfCQSFFTM	false	flag tag:c-c	sufficient binding region:147-160	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01034	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-948622|ensembl:ENSP00000366124|ensembl:ENSP00000381446|ensembl:ENSP00000381448|uniprotkb:Q6FGW9|uniprotkb:B2R5J9|uniprotkb:D3DW42	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:cytc_human(display_long)|uniprotkb:Cystatin-3(gene name synonym)|uniprotkb:Neuroendocrine basic polypeptide(gene name synonym)|uniprotkb:Gamma-trace(gene name synonym)|uniprotkb:Post-gamma-globulin(gene name synonym)|uniprotkb:CST3(gene name)|psi-mi:CST3(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594159|imex:IM-25629-39	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0060313"(negative regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR018073|rcsb pdb:1G96|rcsb pdb:1R4C|rcsb pdb:1TIJ|rcsb pdb:3GAX|rcsb pdb:3NX0|rcsb pdb:3PS8|rcsb pdb:3QRD|rcsb pdb:3S67|rcsb pdb:3SVA|rcsb pdb:6ROA|rcsb pdb:6RPV|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-977225|ensembl:ENSG00000101439(gene)|ensembl:ENST00000376925(transcript)|ensembl:ENST00000398409(transcript)|ensembl:ENST00000398411(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010711"(negative regulation of collagen catabolic process)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0060311"(negative regulation of elastin catabolic process)|refseq:NP_000090.1|refseq:NP_001275543.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -22|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:UJT8nc0DeqGBXeRiy8RnrB1tKGw9606	rigid:rIOMH+V3+5BF/OUYS5NiK5DWrt0	false	flag tag:c-c	sufficient binding region:40-51	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q8WXD2	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12162999|ensembl:ENSP00000220478|uniprotkb:A8K2B0|uniprotkb:B3KQP6|uniprotkb:B4DK99|uniprotkb:F5H3R8|uniprotkb:Q96C83|uniprotkb:Q96GE8|uniprotkb:Q9Y6G7	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:scg3_human(display_long)|uniprotkb:SCG3(gene name)|psi-mi:SCG3(display_short)|uniprotkb:Secretogranin III(gene name synonym)|uniprotkb:UNQ2502/PRO5990(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594171|imex:IM-25629-40	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000104112(gene)|ensembl:ENST00000220478(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033366"(protein localization to secretory granule)|go:"GO:0034774"(secretory granule lumen)|interpro:IPR026197|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001158729.1|refseq:NP_037375.2|dip:DIP-29451N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	crc64:5E6BBDDFFF3B8D82	figure legend:Table S1 -23|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:4FmR4obGCv49kROnQYYVJLDoubE9606	rigid:RplU8+Ytns92N0hYF6Q5rC3P7KY	false	flag tag:c-c	sufficient binding region:35-50	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O94769	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12594193|ensembl:ENSP00000344758|uniprotkb:B2R730|uniprotkb:E2PU11|uniprotkb:Q5T9F2|uniprotkb:Q7Z3D0	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ecm2_human(display_long)|uniprotkb:ECM2(gene name)|psi-mi:ECM2(display_short)|uniprotkb:Matrix glycoprotein SC1/ECM2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594183|imex:IM-25629-41	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000106823(gene)|ensembl:ENST00000344604(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070052"(collagen V binding)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR043184|refseq:NP_001184224.1|refseq:NP_001184225.1|refseq:NP_001384.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:8tGmbz+Bfd3EBDNDRISHPjQPC+89606	rigid:eTdVrHbAGUn9vZCHDJq1ZAjvnBg	false	flag tag:c-c	sufficient binding region:209-220	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P19022	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-2256711|uniprotkb:Q14923|uniprotkb:Q8N173|uniprotkb:A8MWK3|uniprotkb:B0YIY6|ensembl:ENSP00000269141|intact:EBI-28986933	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:cadh2_human(display_long)|uniprotkb:CDH2(gene name)|psi-mi:CDH2(display_short)|uniprotkb:CDHN(gene name synonym)|uniprotkb:NCAD(gene name synonym)|uniprotkb:Neural cadherin(gene name synonym)|uniprotkb:CDw325(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594225|imex:IM-25629-42	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001295105.1|refseq:NP_001783.2|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P19022|reactome:R-HSA-381426|reactome:R-HSA-418990|reactome:R-HSA-525793|reactome:R-HSA-8957275|go:"GO:0044853"(plasma membrane raft)|dip:DIP-43894N|ensembl:ENSG00000170558(gene)|ensembl:ENST00000269141(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|ensembl:ENSP00000269141|ensembl:ENST00000399380|ensembl:ENSP00000382312	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -25|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:lo+u8oH3T9OYU56F5MgXKmwEhuI9606	rigid:HeLPNjIikI+799Pw/pu6/2AkTp4	false	flag tag:c-c	sufficient binding region:125-139	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01008	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1039832|uniprotkb:P78439|uniprotkb:P78447|uniprotkb:Q13815|uniprotkb:Q7KZ43|uniprotkb:B2R6P0|uniprotkb:Q5TC78|uniprotkb:Q7KZ97|uniprotkb:Q9UC78|ensembl:ENSP00000356671	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ant3_human(display_long)|uniprotkb:SERPINC1(gene name)|psi-mi:SERPINC1(display_short)|uniprotkb:AT3(gene name synonym)|uniprotkb:PRO0309(orf name)|uniprotkb:Serpin C1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594237|imex:IM-25629-43	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000479.1|ensembl:ENSG00000117601(gene)|ensembl:ENST00000367698(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007584"(response to nutrient)|go:"GO:0007595"(lactation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000266"(regulation of blood coagulation, intrinsic pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015555(Protease inhibitor I4, serpin, antithrombin-III)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033829|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01008|rcsb pdb:1ANT|rcsb pdb:1ATH|rcsb pdb:1AZX|rcsb pdb:1BR8|rcsb pdb:1DZG|rcsb pdb:1DZH|rcsb pdb:1E03|rcsb pdb:1E04|rcsb pdb:1E05|rcsb pdb:1JVQ|rcsb pdb:1LK6|rcsb pdb:1NQ9|rcsb pdb:1OYH|rcsb pdb:1R1L|rcsb pdb:1SR5|rcsb pdb:1T1F|rcsb pdb:1TB6|rcsb pdb:2ANT|rcsb pdb:2B4X|rcsb pdb:2B5T|rcsb pdb:2BEH|rcsb pdb:2GD4|rcsb pdb:2HIJ|rcsb pdb:2ZNH|rcsb pdb:3EVJ|rcsb pdb:3KCG|rcsb pdb:4EB1|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-38009N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -26|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:XiPmXyU7CpPTgDR3dPnKeJEItJg9606	rigid:OSzWRFJcREpzyGzbASNU3B793L8	false	flag tag:c-c	sufficient binding region:64-78	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02768	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594249|imex:IM-25629-44	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -27|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	rigid:fSNQKkvKjhE3pczlQxD4KRQx054	false	flag tag:c-c	sufficient binding region:76-88	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P01210	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-6656032|ensembl:ENSP00000324248|ensembl:ENSP00000400894|uniprotkb:B2RC23|uniprotkb:Q6FHC6|uniprotkb:Q6FHE6	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:penk_human(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594294|imex:IM-25629-45	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000181195(gene)|ensembl:ENST00000314922(transcript)|ensembl:ENST00000451791(transcript)|go:"GO:0001515"(opioid peptide activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0002118"(aggressive behavior)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007600"(sensory perception)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034592"(synaptic vesicle lumen)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043679"(axon terminus)|go:"GO:0045471"(response to ethanol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0031628"(opioid receptor binding)|go:"GO:0099013"(neuronal dense core vesicle lumen)|go:"GO:0099538"(synaptic signaling via neuropeptide)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000703(Proenkephalin A)|interpro:IPR006024(Opioid neuropeptide precursor)|rcsb pdb:1PLW|rcsb pdb:1PLX|rcsb pdb:2LWC|rcsb pdb:5E33|rcsb pdb:5E3A|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0098586"(cellular response to virus)|refseq:NP_001129162.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -28|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:xL8ujOb7RFDy5+t+Oe/ph/XOoOM9606	rigid:A1pIhwt3+XuuB6JCN/sM1d6xrw4	false	flag tag:c-c	sufficient binding region:237-252	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q16568	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594310|imex:IM-25629-46	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -29|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:N3PoYTEXZrIrABT6xed52NR63EI9606	rigid:amv8D4E3YDPG0iQyZJxOu2ckiPs	false	flag tag:c-c	sufficient binding region:37-51	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O14791	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1221934|uniprotkb:O60804|uniprotkb:Q5R3P7|uniprotkb:Q5R3P8|uniprotkb:Q96AB8|uniprotkb:Q96PM4|uniprotkb:Q9BQ03|uniprotkb:A5PLQ4|uniprotkb:B4DU12|uniprotkb:E9PF24|ensembl:ENSP00000380448|ensembl:ENSP00000380449|ensembl:ENSP00000411507	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:apol1_human(display_long)|uniprotkb:APOL1(gene name)|psi-mi:APOL1(display_short)|uniprotkb:APOL(gene name synonym)|uniprotkb:Apolipoprotein L(gene name synonym)|uniprotkb:Apolipoprotein L-I(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594322|imex:IM-25629-47	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001130012.1|refseq:NP_003652.2|refseq:NP_001130013.1|refseq:XP_005261853.1|ensembl:ENSG00000100342(gene)|ensembl:ENST00000397278(transcript)|ensembl:ENST00000397279(transcript)|ensembl:ENST00000422706(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0072562"(blood microparticle)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR008405(Apolipoprotein L)|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -30|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:fMIhQ/5ozAl1P7l8G/Di1kaGglI9606	rigid:YnBLqOF1pWPefzaLZ88gqwNuVzk	false	flag tag:c-c	sufficient binding region:306-320	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P84157	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-5660715|uniprotkb:Q0P5W3|ensembl:ENSP00000348050	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:mxra7_human(display_long)|uniprotkb:MXRA7(gene name)|psi-mi:MXRA7(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594334|imex:IM-25629-48	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001008528.1|refseq:NP_001008529.1|refseq:NP_940932.2|ensembl:ENSG00000182534(gene)|ensembl:ENST00000355797(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR026622	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -31|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:5D8yzaF60a+81r61M5IhmtNhiNM9606	rigid:kUcZwEQm9MwEnpd8M7e7HKG6+7Q	false	flag tag:c-c	sufficient binding region:126-140	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P05067	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594346|imex:IM-25629-49	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -32|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rigid:EQpEtdWFSlBc3TWE4L1dTIIivew	false	flag tag:c-c	sufficient binding region:439-449	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q14766	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594361|imex:IM-25629-50	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Table S1 -34|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/09/09	2016/11/07	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:SXj31DgojI6QNO11EGh+c/m9KkQ	false	flag tag:c-c	sufficient binding region:1410-1420	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O95972	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-12594867|ensembl:ENSP00000252677|uniprotkb:Q17RM6|uniprotkb:Q5JST1|uniprotkb:Q9UMS1	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:bmp15_human(display_long)|uniprotkb:BMP15(gene name)|psi-mi:BMP15(display_short)|uniprotkb:GDF9B(gene name synonym)|uniprotkb:Growth/differentiation factor 9B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594865|imex:IM-25629-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000130385(gene)|ensembl:ENST00000252677(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007292"(female gamete generation)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060016"(granulosa cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070698"(type I activin receptor binding)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015923(Bone morphogenetic protein 15)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_005439.2	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Supp 10C|comment:"Catalytically inactive (D478A) FLAG-tagged Fam20C also precipitated BMP15:V5 but without a change in it's electrophoretic mobility."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2016/09/09	2016/11/08	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:La2Oyr6HZVnWtKX1d68mxA5Q0v09606	rigid:AfNZAmog2wjTPXbfrs1uxYwhQsU	false	flag tag:c-c	his tag:c-c|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IXL6	uniprotkb:P10451	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-723648|ensembl:ENSP00000378517|ensembl:ENSP00000477824|uniprotkb:Q15681|uniprotkb:Q15682|uniprotkb:Q15683|uniprotkb:Q8NBK2|uniprotkb:Q96IZ1|uniprotkb:B2RDA1|uniprotkb:Q4W597|uniprotkb:Q567T5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ostp_human(display_long)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:OPN(gene name synonym)|uniprotkb:PSEC0156(orf name)|uniprotkb:BNSP(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Tagliabracci et al. (2012)	imex:IM-25629|pubmed:22582013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12594918|imex:IM-25629-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000573.1|refseq:NP_001035147.1|ensembl:ENSG00000118785(gene)|ensembl:ENST00000395080(transcript)|ensembl:ENST00000614857(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042995"(cell projection)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|mint:P10451|rcsb pdb:3CXD|rcsb pdb:3DSF|reactome:R-HSA-1474228|reactome:R-HSA-186797|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8949275|reactome:R-HSA-8957275|go:"GO:0046697"(decidualization)|refseq:NP_001035149.1|refseq:NP_001238758.1|refseq:NP_001238759.1|dip:DIP-49933N	-	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Supp 13|comment:"The mutation \"L338R\" has been entered as \"lys338arg\" as there is no \"L\" - leucine at residue 338."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2016/09/09	2016/11/08	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:a1xqyCMAIQpBwLFBbfKN7R+7K3M9606	rigid:0DEdYpFX2bSTlLAUFB+p/EHWYt4	false	mutation with no effect:338-338|flag tag:c-c|mutation with no effect:478-478|mutation with no effect:379-379|mutation with no effect:549-549|mutation with no effect:328-328|mutation with no effect:379-379|mutation with no effect:258-258,280-280|mutation with no effect:451-451	his tag:c-c|v5 tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)