#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96SD1	uniprotkb:P78527	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694344|imex:IM-25239-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nalm_6)|taxid:9606(Homo sapiens NALM-6 B cell precursor leukemia cells)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:Q13426	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694344|imex:IM-25239-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nalm_6)|taxid:9606(Homo sapiens NALM-6 B cell precursor leukemia cells)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:P49917	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694344|imex:IM-25239-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nalm_6)|taxid:9606(Homo sapiens NALM-6 B cell precursor leukemia cells)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:Q96SD1	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694356|imex:IM-25239-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-n114p2)|taxid:9606(human N114P2- Ligase IV–deficient  pre-B cell line)	-	2016/05/03	2016/05/06	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:vHQc14qB+o3PQer2Hv8xWz5L40E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694374|imex:IM-25239-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-m059j)|taxid:9606(M059J-Human glioblastoma cell line)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:P78527	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694388|imex:IM-25239-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-m059k)|taxid:9606(Human glioblastoma M059JK cells)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rigid:z9Pqj9qJ8Hafy16nDEr1OuvE+a4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694388|imex:IM-25239-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-m059k)|taxid:9606(Human glioblastoma M059JK cells)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:z9Pqj9qJ8Hafy16nDEr1OuvE+a4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694457|imex:IM-25239-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:2B,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	-	flag tag:c-c|sufficient binding region:386-692	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:P49917	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694475|imex:IM-25239-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571|interpro:IPR012308(DNA ligase, N-terminal)	-	-	-	figure legend:2 D/F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	-	sufficient binding region:1-240(IPR012308)|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13426	uniprotkb:P49917	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694487|imex:IM-25239-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	-	-	-	figure legend:2Di|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rigid:FDv7IpIxlmuNzSwH5JDZCf/Uh/4	false	-	sufficient binding region:746-911|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694516|imex:IM-25239-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:3B, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	-	flag tag:n-n|sufficient binding region:475-500	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694541|imex:IM-25239-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	-	flag tag:n-n|sufficient binding region:485-495|myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:P78527	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694551|imex:IM-25239-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	-	-	-	figure legend:3F, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	flag tag:c-c|mutation disrupting interaction strength:401-402,489-489	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:Q13426	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694551|imex:IM-25239-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N	-	-	-	figure legend:3F, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	flag tag:c-c|mutation disrupting interaction strength:401-402,489-489	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:P49917	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694551|imex:IM-25239-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	-	-	-	figure legend:3F, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rigid:+IInGLFVf9woCMGOyHNclH5lgfg	false	flag tag:c-c|mutation disrupting interaction strength:401-402,489-489	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:Q96SD1	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694561|imex:IM-25239-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:3Fi, 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:vHQc14qB+o3PQer2Hv8xWz5L40E	false	-	flag tag:c-c|mutation:492-492|mutation:489-489|mutation:493-493	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:Q13426	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694602|imex:IM-25239-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	rigid:bleu+LVdqpwQsQYzBpVszO1ihJ0	false	flag tag:c-c|mutation:401-402	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96SD1	uniprotkb:P49917	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694602|imex:IM-25239-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/05/03	2016/05/06	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rigid:bleu+LVdqpwQsQYzBpVszO1ihJ0	false	flag tag:c-c|mutation:401-402	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694504|imex:IM-25239-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	sufficient binding region:1-240(IPR012308)|his tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:386-692	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P49917	uniprotkb:Q96SD1	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	intact:EBI-11694104|uniprotkb:D3DRT6|uniprotkb:Q1HCL2|uniprotkb:Q5JSR4|uniprotkb:Q5JSR5|uniprotkb:Q5JSR7|uniprotkb:Q5JSR8|uniprotkb:Q5JSR9|uniprotkb:Q5JSS0|uniprotkb:Q5JSS7|uniprotkb:Q6PK14|uniprotkb:Q8N101|uniprotkb:Q8N132|uniprotkb:Q8TBW9|uniprotkb:Q9BVW9|uniprotkb:Q9HAM4|ensembl:ENSP00000367527	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:dcr1c_human(display_long)|uniprotkb:DNA cross-link repair 1C protein(gene name synonym)|uniprotkb:Protein A-SCID(gene name synonym)|uniprotkb:SNM1 homolog C(gene name synonym)|uniprotkb:SNM1-like protein(gene name synonym)|uniprotkb:DCLRE1C(gene name)|psi-mi:DCLRE1C(display_short)|uniprotkb:ARTEMIS(gene name synonym)|uniprotkb:ASCID(gene name synonym)|uniprotkb:SCIDA(gene name synonym)|uniprotkb:SNM1C(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Malu et al. (2012)	pubmed:22529269|imex:IM-25239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11694583|imex:IM-25239-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571	refseq:NP_001029027.1|refseq:NP_001029029.1|refseq:NP_001029030.1|refseq:NP_001276005.1|refseq:NP_001276006.1|refseq:NP_001276007.1|refseq:NP_001276008.1|refseq:NP_071932.2|refseq:XP_006717554.1|refseq:XP_011517918.1|refseq:XP_011517919.1|refseq:XP_011517921.1|refseq:XP_016872046.1|refseq:XP_016872047.1|ensembl:ENSG00000152457(gene)|ensembl:ENST00000378278(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:4HTP|rcsb pdb:6TT5|rcsb pdb:6WNL|rcsb pdb:6WO0|rcsb pdb:7AF1|rcsb pdb:7AFS|rcsb pdb:7AFU|rcsb pdb:7AGI|rcsb pdb:7APV|reactome:R-HSA-5693571	-	-	-	figure legend:3H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-6(mol)	2016/05/03	2016/05/06	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	rogid:NUefzxHag08NnJ6uhpIUjhd1m409606	rigid:7E2FDB3Bf0tH/WVVayuNEgp8l6I	false	sufficient binding region:1-240(IPR012308)	mutation decreasing interaction strength:489-489|fluorescein label:?-?|sufficient binding region:485-495|mutation decreasing interaction strength:492-492|mutation decreasing interaction strength:493-493	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)