#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WTS6	uniprotkb:Q96RI1	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Balasubramaniyan et al. (2012)	imex:IM-25001|pubmed:22345554	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507453|imex:IM-25001-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	go:"GO:0016279"(protein-lysine N-methyltransferase activity)	-	-	figure legend:6c|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/20	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:4Y4AfMFTVji1kPusV51SAAI8Wrs	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction rate:218-218|mutation disrupting interaction rate:220-220|sufficient binding region:215-224	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WTS6	uniprotkb:Q96RI1	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Balasubramaniyan et al. (2012)	imex:IM-25001|pubmed:22345554	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507489|imex:IM-25001-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:8a|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/01/20	2016/01/21	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:4Y4AfMFTVji1kPusV51SAAI8Wrs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTS6	uniprotkb:Q96RI1	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Balasubramaniyan et al. (2012)	imex:IM-25001|pubmed:22345554	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507513|imex:IM-25001-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:8c|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/20	2016/01/21	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:4Y4AfMFTVji1kPusV51SAAI8Wrs	false	-	glutathione s tranferase tag:?-?|mutation decreasing interaction:220-220|sufficient binding region:215-224	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTS6	uniprotkb:Q96RI1	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Balasubramaniyan et al. (2012)	imex:IM-25001|pubmed:22345554	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507615|imex:IM-25001-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:9|agonist:"GW 4064 (synthetic FXR agonist)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/01/20	2016/01/21	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:4Y4AfMFTVji1kPusV51SAAI8Wrs	false	-	mutation decreasing interaction:220-220|sufficient binding region:215-224	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WTS6	uniprotkb:Q96RI1	intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Balasubramaniyan et al. (2012)	imex:IM-25001|pubmed:22345554	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11507504|imex:IM-25001-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:8b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2016/01/20	2016/01/21	rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rigid:4Y4AfMFTVji1kPusV51SAAI8Wrs	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)