#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53871	uniprotkb:P38149	intact:EBI-29079|uniprotkb:D6W0Z6|ensemblfungi:YNL191W	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	psi-mi:dug3_yeast(display_long)|uniprotkb:YNL191W(locus name)|uniprotkb:N1410(orf name)|uniprotkb:DUG3(gene name)|psi-mi:DUG3(display_short)|uniprotkb:GSH degradosomal complex subunit DUG3(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 3(gene name synonym)	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11474943|imex:IM-24873-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014208.1|sgd:S000005135|dip:DIP-3956N|ensemblfungi:YNL191W(gene)|ensemblfungi:YNL191W_mRNA(transcript)|go:"GO:0004044"(amidophosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR017932|interpro:IPR026869|interpro:IPR029055	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	-	crc64:AFAAEFE7152CFE1A	crc64:A24C10BB4E94C344	figure legend:Supp. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/01/07	2016/01/07	rogid:FD4MTztUsug4wkG4Sum7mHoVCV8559292	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rigid:mpZvOhBoZtcM0MEX29NHbrt3k4s	false	-	sufficient binding region:1-424(IPR017986)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38149	uniprotkb:P38149	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11474950|imex:IM-24873-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	-	crc64:A24C10BB4E94C344	crc64:A24C10BB4E94C344	figure legend:Supp. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/01/07	2016/01/07	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rigid:yyfiXrOUMcmoZayGapOHIFLPvt4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38149	uniprotkb:P38149	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11474978|imex:IM-24873-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	-	crc64:A24C10BB4E94C344	crc64:A24C10BB4E94C344	figure legend:Fig. 1A, 1B, Supp. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2016/01/07	2016/01/07	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rigid:L58UY0ZuHJJQ2TcPftMdOuIWayw	false	his tag:n-n|sufficient binding region:425-878(IPR011650)	his tag:n-n|sufficient binding region:425-878(IPR011650)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43616	uniprotkb:P43616	intact:EBI-5137|uniprotkb:D6VTS7|ensemblfungi:YFR044C	intact:EBI-5137|uniprotkb:D6VTS7|ensemblfungi:YFR044C	psi-mi:dug1_yeast(display_long)|uniprotkb:DUG1(gene name)|psi-mi:DUG1(display_short)|uniprotkb:GSH degradosomal complex subunit DUG1(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 1(gene name synonym)|uniprotkb:YFR044C(locus name)	psi-mi:dug1_yeast(display_long)|uniprotkb:DUG1(gene name)|psi-mi:DUG1(display_short)|uniprotkb:GSH degradosomal complex subunit DUG1(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 1(gene name synonym)|uniprotkb:YFR044C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11474990|imex:IM-24873-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116702.1|sgd:S000001940|dip:DIP-6492N|mint:P43616|ensemblfungi:YFR044C(gene)|ensemblfungi:YFR044C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070573"(metallodipeptidase activity)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4G1P|reactome:R-SCE-174403	refseq:NP_116702.1|sgd:S000001940|dip:DIP-6492N|mint:P43616|ensemblfungi:YFR044C(gene)|ensemblfungi:YFR044C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070573"(metallodipeptidase activity)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR017153(Glutathione degradosome, DUG1)|rcsb pdb:4G1P|reactome:R-SCE-174403	-	crc64:3E53773A945F5EBC	crc64:3E53773A945F5EBC	figure legend:Supp. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2016/01/07	2016/01/07	rogid:PWGPSfN2a8aF5FVaFe5CUuMDCnM559292	rogid:PWGPSfN2a8aF5FVaFe5CUuMDCnM559292	rigid:8LDgEiL6TE21a4GLNAaXHbI/hvo	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38149	uniprotkb:P53871	intact:EBI-21176|uniprotkb:D6VQS6|ensemblfungi:YBR281C	intact:EBI-29079|uniprotkb:D6W0Z6|ensemblfungi:YNL191W	psi-mi:dug2_yeast(display_long)|uniprotkb:YBR281C(locus name)|uniprotkb:YBR2018(orf name)|uniprotkb:DUG2(gene name)|psi-mi:DUG2(display_short)|uniprotkb:GSH degradosomal complex subunit DUG2(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 2(gene name synonym)	psi-mi:dug3_yeast(display_long)|uniprotkb:YNL191W(locus name)|uniprotkb:N1410(orf name)|uniprotkb:DUG3(gene name)|psi-mi:DUG3(display_short)|uniprotkb:GSH degradosomal complex subunit DUG3(gene name synonym)|uniprotkb:Deficient in utilization of glutathione protein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11475041|imex:IM-24873-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009840.3|sgd:S000000485|mint:P38149|dip:DIP-1612N|ensemblfungi:YBR281C(gene)|ensemblfungi:YBR281C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR002933(Peptidase M20)|interpro:IPR011650(Peptidase M20, dimerisation)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017149(Glutathione degradosome, DUG2)|interpro:IPR020472|interpro:IPR036264|interpro:IPR036322	refseq:NP_014208.1|sgd:S000005135|dip:DIP-3956N|ensemblfungi:YNL191W(gene)|ensemblfungi:YNL191W_mRNA(transcript)|go:"GO:0004044"(amidophosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006751"(glutathione catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0061672"(glutathione hydrolase complex)|interpro:IPR017932|interpro:IPR026869|interpro:IPR029055	-	crc64:A24C10BB4E94C344	crc64:AFAAEFE7152CFE1A	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/07	2016/01/07	rogid:cqkscQ4z5jePDhXuu5UiMSlS32M559292	rogid:FD4MTztUsug4wkG4Sum7mHoVCV8559292	rigid:mpZvOhBoZtcM0MEX29NHbrt3k4s	false	his tag:n-n	his tag:c-c|mutation:357-357	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16856"	intenz:3.4.19.13	intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334"	intact:EBI-11473888	psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name)	psi-mi:dug2_dug3_yeast(display_short)|psi-mi:3.4.19.13(display_long)|intact:Glutathione hydrolase complex(complex recommended name)|intact:"DUG2:DUG3"(complex systematic name)|intact:GSH degradosomal complex(complex synonym)	psi-mi:"MI:0990"(cleavage assay)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15488516|imex:IM-24873-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0036374"(glutathione hydrolase activity)|go:"GO:0061672"(glutathione hydrolase complex)|pubmed:22277648(see-also)|evidence ontology:"ECO:0000353"|intact:EBI-11475041(exp-evidence)|go:"GO:0006751"(glutathione catabolic process)|complex portal:CPX-325(complex-primary)	-	-	curated-complex:Glutathione hydrolase/Glutamine Amidotransferase II complex responsible for glutathione degradation. Both DUG2 and DUG3 are depressed under sulfur limitation conditions. Although neither protein alone can cleave glutathione, the complex degrades glutathione by cleaving of the gamma-glutamyl linkage. DUG3 has the GATase activity, while DUG2 probably acts as a scaffold protein, bringing two DUG3 proteins together.|complex-properties:Purified complex is approximately 300 kDa with a Km of 1.2mM.	figure legend:Fig. 4, 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/07	2017/08/04	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17515"	intenz:3.4.19.13	intact:EBI-15986886|chebi:"CHEBI:39975"|chebi:"CHEBI:10566"|chebi:"CHEBI:10570"|chebi:"CHEBI:12400"|chebi:"CHEBI:12404"|chebi:"CHEBI:17971"|chebi:"CHEBI:24185"|chebi:"CHEBI:24194"	intact:EBI-11473888	psi-mi:l-gamma-glutamyl-l-cysteine(display_short)|psi-mi:"CHEBI:17515"(display_long)|intact:5-L-Glutamyl-L-cysteine(synonym)|intact:gamma-Glu-Cys(synonym)|intact:gamma-Glutamylcysteine(synonym)|intact:gamma-L-Glutamyl-L-cysteine(synonym)|intact:gammaGluCys(synonym)|intact:"Glu(-Cys)"(synonym)|intact:L-gamma-glutamyl-L-cysteine(synonym)|intact:L-gamma-Glutamylcysteine(synonym)|intact:L-gamma-glutamyl-L-cysteine(iupac name)	psi-mi:dug2_dug3_yeast(display_short)|psi-mi:3.4.19.13(display_long)|intact:Glutathione hydrolase complex(complex recommended name)|intact:"DUG2:DUG3"(complex systematic name)|intact:GSH degradosomal complex(complex synonym)	psi-mi:"MI:0990"(cleavage assay)	Kaur et al. (2012)	pubmed:22277648|imex:IM-24873	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15985927|imex:IM-24873-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0036374"(glutathione hydrolase activity)|go:"GO:0061672"(glutathione hydrolase complex)|pubmed:22277648(see-also)|evidence ontology:"ECO:0000353"|intact:EBI-11475041(exp-evidence)|go:"GO:0006751"(glutathione catabolic process)|complex portal:CPX-325(complex-primary)	-	-	curated-complex:Glutathione hydrolase/Glutamine Amidotransferase II complex responsible for glutathione degradation. Both DUG2 and DUG3 are depressed under sulfur limitation conditions. Although neither protein alone can cleave glutathione, the complex degrades glutathione by cleaving of the gamma-glutamyl linkage. DUG3 has the GATase activity, while DUG2 probably acts as a scaffold protein, bringing two DUG3 proteins together.|complex-properties:Purified complex is approximately 300 kDa with a Km of 1.2mM.	figure legend:Supp Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/07	2017/08/07	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)