#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738199|imex:IM-25733-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:2A, 3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false flag tag:?-?|sufficient binding region:163-249 myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738301|imex:IM-25733-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:3E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false flag tag:?-? myc tag:?-?|sufficient binding region:218-361 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738328|imex:IM-25733-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:lMnNZrr4yher0jWzVBlzj1GhYdY false flag tag:?-? mutation:232-232|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738339|imex:IM-25733-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5A-RHS|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:lMnNZrr4yher0jWzVBlzj1GhYdY false flag tag:?-? mutation:232-232|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738350|imex:IM-25733-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:5Ai|comment:In the presence of viperin, the level of immunoprecipitated myc–NS5A was markedly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738350|imex:IM-25733-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5Ai|comment:In the presence of viperin, the level of immunoprecipitated myc–NS5A was markedly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false flag tag:?-? mutation:232-232|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q8WXG1 intact:EBI-6863748 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738366|imex:IM-25733-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5A-RHS|comment:The level of immunoprecipitated FLAG–hVAP-33 in cells transfected with HA–viperin was greatly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232|myc tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q9P0L0 intact:EBI-6863748 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738366|imex:IM-25733-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5A-RHS|comment:The level of immunoprecipitated FLAG–hVAP-33 in cells transfected with HA–viperin was greatly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232|myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037552 uniprotkb:Q8WXG1 intact:EBI-9005440 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wmx2-pro_0000037552(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738487|imex:IM-25733-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - chain-seq-start:2420|chain-seq-end:3010 - figure legend:6A-LHS|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:4d6fo8km49QSX5eITFjOoXs8UL0333284 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:BlsPe4vMqtNBM+iMRkqjTi9auVE false myc tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037552 uniprotkb:Q9P0L0 intact:EBI-9005440 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q9wmx2-pro_0000037552(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738487|imex:IM-25733-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:2420|chain-seq-end:3010 - figure legend:6A-LHS|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:4d6fo8km49QSX5eITFjOoXs8UL0333284 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:BlsPe4vMqtNBM+iMRkqjTi9auVE false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037552 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-9005440 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037552(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738502|imex:IM-25733-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:2420|chain-seq-end:3010 figure legend:6A-LHS|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:4d6fo8km49QSX5eITFjOoXs8UL0333284 rigid:JXh4cWa/esnPmzLQCOPMrou/6Ck false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738512|imex:IM-25733-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:6A RHS|comment:"Very little myc-NS5B appears to have been precipitated (lanes 3 and 4)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:BlsPe4vMqtNBM+iMRkqjTi9auVE false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037552 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-9005440 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037552(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738512|imex:IM-25733-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:2420|chain-seq-end:3010 figure legend:6A RHS|comment:"Very little myc-NS5B appears to have been precipitated (lanes 3 and 4)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:4d6fo8km49QSX5eITFjOoXs8UL0333284 rigid:BlsPe4vMqtNBM+iMRkqjTi9auVE false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037552 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-9005440 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037552(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738526|imex:IM-25733-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:2420|chain-seq-end:3010 figure legend:6A -RHS|comment:"Very little myc-NS5B appears to have been precipitated (lanes 3 and 4)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:4d6fo8km49QSX5eITFjOoXs8UL0333284 rigid:JXh4cWa/esnPmzLQCOPMrou/6Ck false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738261|imex:IM-25733-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WXG1 uniprotkb:Q9P0L0 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738280|imex:IM-25733-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - - - figure legend:2C, 3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false green fluorescent protein tag:?-? red fluorescent protein tag:n-n|sufficient binding region:163-249 - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q8WXG1 uniprotkb:Q9P0L0 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738315|imex:IM-25733-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - - - figure legend:3E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:VR7VWHkH6fSC/aBPpJpDKRJEnZM false green fluorescent protein tag:?-?|sufficient binding region:218-361 red fluorescent protein tag:n-n - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q8WXG1 intact:EBI-6863748 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738470|imex:IM-25733-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232 ha tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q9P0L0 intact:EBI-6863748 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738470|imex:IM-25733-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232 red fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738393|imex:IM-25733-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:lMnNZrr4yher0jWzVBlzj1GhYdY false flag tag:?-? mutation:232-232|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q8WXG1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738403|imex:IM-25733-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - - - figure legend:5Ci|comment:In the presence of viperin, the level of immunoprecipitated myc–NS5A was markedly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738403|imex:IM-25733-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5Ci|comment:In the presence of viperin, the level of immunoprecipitated myc–NS5A was markedly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false flag tag:?-? mutation:232-232|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q8WXG1 intact:EBI-6863748 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738417|imex:IM-25733-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5C-RHS|comment:The level of immunoprecipitated FLAG–hVAP-33 in cells transfected with HA–viperin was greatly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232|myc tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q9P0L0 intact:EBI-6863748 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738417|imex:IM-25733-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5C-RHS|comment:The level of immunoprecipitated FLAG–hVAP-33 in cells transfected with HA–viperin was greatly reduced.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232|myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9P0L0 uniprotkb:Q9WMX2-PRO_0000037551 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-6863748 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-12738432|imex:IM-25733-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) intact:EBI-710918(chain-parent) - - chain-seq-start:1973|chain-seq-end:2419 figure legend:5C-RHS|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rigid:lMnNZrr4yher0jWzVBlzj1GhYdY false flag tag:?-? myc tag:?-?|mutation:232-232 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q8WXG1 intact:EBI-6863748 intact:EBI-12736320|ensembl:ENSP00000371471|ensembl:ENSP00000506390|uniprotkb:Q8WVI4 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:rsad2_human(display_long)|uniprotkb:RSAD2(gene name)|psi-mi:RSAD2(display_short)|uniprotkb:CIG5(gene name synonym)|uniprotkb:Cytomegalovirus-induced gene 5 protein(gene name synonym)|uniprotkb:Viperin(gene name synonym)|uniprotkb:Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738452|imex:IM-25733-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) ensembl:ENSG00000134321(gene)|ensembl:ENST00000382040(transcript)|ensembl:ENST00000680607(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016829"(lyase activity)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043621"(protein self-association)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051607"(defense response to virus)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013785(Aldolase-type TIM barrel)|reactome:R-HSA-909733|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_542388.2|refseq:XP_011508716.1 - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:QnLTJeMdPIWXBGvLNOj12/BzJWw9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9WMX2-PRO_0000037551 uniprotkb:Q9P0L0 intact:EBI-6863748 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q9wmx2-pro_0000037551(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2012) pubmed:21957124|imex:IM-25733 taxid:333284(hcvco)|taxid:333284("Hepatitis C virus genotype 1b (isolate Con1) (HCV)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-12738452|imex:IM-25733-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-710918(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:1973|chain-seq-end:2419 - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2016/12/19 2017/01/12 rogid:dkkgGI4Apbz9im+o4Uqn8t9r8kw333284 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rigid:b9sVzOm9QkstxrpVmb/4YtC2SHE false mutation:232-232 red fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)