#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97479	uniprotkb:Q91ZQ5	intact:EBI-1149557|uniprotkb:E9QLP7|uniprotkb:Q5MJ57|ensembl:ENSMUSP00000102745	intact:EBI-11682496|uniprotkb:A1L3D1|uniprotkb:E9QNS6|uniprotkb:H9KUX9|uniprotkb:Q8VHP2|ensembl:ENSMUSP00000029824|ensembl:ENSMUSP00000143654	psi-mi:myo7a_mouse(display_long)|uniprotkb:Myo7a(gene name)|psi-mi:Myo7a(display_short)|uniprotkb:Myo7(gene name synonym)	psi-mi:rpe65_mouse(display_long)|uniprotkb:All-trans-retinyl-palmitate hydrolase(gene name synonym)|uniprotkb:Retinal pigment epithelium-specific 65 kDa protein(gene name synonym)|uniprotkb:Retinol isomerase(gene name synonym)|uniprotkb:Rpe65(gene name)|psi-mi:Rpe65(display_short)|uniprotkb:Meso-zeaxanthin isomerase(gene name synonym)|uniprotkb:Lutein isomerase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lopes et al. (2011)	imex:IM-25079|pubmed:21493626	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682494|imex:IM-25079-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239993.1|refseq:NP_001243010.1|refseq:NP_001243012.1|refseq:NP_032689.2|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007600"(sensory perception)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030507"(spectrin binding)|go:"GO:0031477"(myosin VII complex)|go:"GO:0031982"(vesicle)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042470"(melanosome)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1990435"(upper tip-link density)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|interpro:IPR038185|interpro:IPR041793|ensembl:ENSMUSG00000030761(gene)|ensembl:ENSMUST00000107128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001750"(photoreceptor outer segment)|rcsb pdb:3PVL|rcsb pdb:5WST|rcsb pdb:5WSU|rcsb pdb:5WSV|reactome:R-MMU-2453902|interpro:IPR041794	refseq:NP_084263.2|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0052884"(all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity)|go:"GO:0052885"(all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901827"(zeaxanthin biosynthetic process)|interpro:IPR004294(Carotenoid oxygenase)|reactome:R-MMU-2453902|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016853"(isomerase activity)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050251"(retinol isomerase activity)|ensembl:ENSMUSG00000028174(gene)|ensembl:ENSMUST00000029824(transcript)|ensembl:ENSMUST00000196999(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003407"(neural retina development)|go:"GO:0004744"(retinal isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008286"(insulin receptor signaling pathway)	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2016/03/08	2016/03/31	rogid:CWTUqQmbi4vwfU1RfwyO7qdpmjQ10090	rogid:vw0HBlEwa88X/ECLK/Bm4tfVW+010090	rigid:b0oE/xJqEOmA4vvhppZEOkLgiU0	false	-	variant:450-450	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97479	uniprotkb:Q91ZQ5	intact:EBI-1149557|uniprotkb:E9QLP7|uniprotkb:Q5MJ57|ensembl:ENSMUSP00000102745	intact:EBI-11682496|uniprotkb:A1L3D1|uniprotkb:E9QNS6|uniprotkb:H9KUX9|uniprotkb:Q8VHP2|ensembl:ENSMUSP00000029824|ensembl:ENSMUSP00000143654	psi-mi:myo7a_mouse(display_long)|uniprotkb:Myo7a(gene name)|psi-mi:Myo7a(display_short)|uniprotkb:Myo7(gene name synonym)	psi-mi:rpe65_mouse(display_long)|uniprotkb:All-trans-retinyl-palmitate hydrolase(gene name synonym)|uniprotkb:Retinal pigment epithelium-specific 65 kDa protein(gene name synonym)|uniprotkb:Retinol isomerase(gene name synonym)|uniprotkb:Rpe65(gene name)|psi-mi:Rpe65(display_short)|uniprotkb:Meso-zeaxanthin isomerase(gene name synonym)|uniprotkb:Lutein isomerase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lopes et al. (2011)	imex:IM-25079|pubmed:21493626	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682539|imex:IM-25079-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239993.1|refseq:NP_001243010.1|refseq:NP_001243012.1|refseq:NP_032689.2|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007600"(sensory perception)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030507"(spectrin binding)|go:"GO:0031477"(myosin VII complex)|go:"GO:0031982"(vesicle)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042470"(melanosome)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1990435"(upper tip-link density)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|interpro:IPR038185|interpro:IPR041793|ensembl:ENSMUSG00000030761(gene)|ensembl:ENSMUST00000107128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001750"(photoreceptor outer segment)|rcsb pdb:3PVL|rcsb pdb:5WST|rcsb pdb:5WSU|rcsb pdb:5WSV|reactome:R-MMU-2453902|interpro:IPR041794	refseq:NP_084263.2|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0052884"(all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity)|go:"GO:0052885"(all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901827"(zeaxanthin biosynthetic process)|interpro:IPR004294(Carotenoid oxygenase)|reactome:R-MMU-2453902|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016853"(isomerase activity)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050251"(retinol isomerase activity)|ensembl:ENSMUSG00000028174(gene)|ensembl:ENSMUST00000029824(transcript)|ensembl:ENSMUST00000196999(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003407"(neural retina development)|go:"GO:0004744"(retinal isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008286"(insulin receptor signaling pathway)	-	-	-	figure legend:5i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2016/03/08	2016/03/31	rogid:CWTUqQmbi4vwfU1RfwyO7qdpmjQ10090	rogid:vw0HBlEwa88X/ECLK/Bm4tfVW+010090	rigid:b0oE/xJqEOmA4vvhppZEOkLgiU0	false	-	variant:450-450	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13402	uniprotkb:Q16518	intact:EBI-7417855|uniprotkb:Q13321|uniprotkb:Q92822|intact:MINT-1895479|uniprotkb:Q14785|uniprotkb:Q92821|uniprotkb:F8VUN5|uniprotkb:P78427|uniprotkb:B9A011|ensembl:ENSP00000386331	intact:EBI-11682559|uniprotkb:A8K1L0|uniprotkb:Q5T9U3|ensembl:ENSP00000262340	psi-mi:myo7a_human(display_long)|uniprotkb:MYO7A(gene name)|psi-mi:MYO7A(display_short)|uniprotkb:USH1B(gene name synonym)	psi-mi:rpe65_human(display_long)|uniprotkb:All-trans-retinyl-palmitate hydrolase(gene name synonym)|uniprotkb:Retinal pigment epithelium-specific 65 kDa protein(gene name synonym)|uniprotkb:Retinol isomerase(gene name synonym)|uniprotkb:RPE65(gene name)|psi-mi:RPE65(display_short)|uniprotkb:Meso-zeaxanthin isomerase(gene name synonym)|uniprotkb:Lutein isomerase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lopes et al. (2011)	imex:IM-25079|pubmed:21493626	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682556|imex:IM-25079-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000251.3|refseq:NP_001120652.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042470"(melanosome)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051904"(pigment granule transport)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1990435"(upper tip-link density)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|go:"GO:0034613"(cellular protein localization)|interpro:IPR038185|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030507"(spectrin binding)|go:"GO:0031477"(myosin VII complex)|go:"GO:0031982"(vesicle)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000137474(gene)|ensembl:ENST00000409709(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|interpro:IPR041794|mint:Q13402|rcsb pdb:5MV9|reactome:R-HSA-2453902|reactome:R-HSA-9662360|reactome:R-HSA-9662361|interpro:IPR041793	refseq:NP_000320.1|ensembl:ENSG00000116745(gene)|ensembl:ENST00000262340(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003407"(neural retina development)|go:"GO:0004744"(retinal isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006776"(vitamin A metabolic process)|go:"GO:0007601"(visual perception)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016853"(isomerase activity)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050251"(retinol isomerase activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0052884"(all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity)|go:"GO:0052885"(all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901827"(zeaxanthin biosynthetic process)|interpro:IPR004294(Carotenoid oxygenase)|reactome:R-HSA-2453902	-	comment:mint|function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, myosin VIIa might play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity|function:"Defects in MYO7A are the cause of Usher syndrome type 1B (USH1B) [MIM:276900]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"|function:"Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal recessive type 2 (DFNB2) [MIM:600060]; also called neurosensory non-syndromic recessive deafness 2 (NSRD2). DFNB2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information{EC15,EC16}"|function:"Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal dominant type 11 (DFNA11) [MIM:601317]"	-	figure legend:6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-arpe_19)|taxid:9606(Homo sapiens retinal pigment epithelial cell line ARPE-19)	-	2016/03/08	2016/03/31	rogid:OwxpV+yOnwipkRuEY1IAUY3i2/w9606	rogid:+kbuV80swhnecRfPEKVRrf1X8Mo9606	rigid:H0IO2r+k7SwVK1lYk/hBudY961w	false	green fluorescent protein tag:n-n	red fluorescent protein tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P97479	uniprotkb:Q91ZQ5	intact:EBI-1149557|uniprotkb:E9QLP7|uniprotkb:Q5MJ57|ensembl:ENSMUSP00000102745	intact:EBI-11682496|uniprotkb:A1L3D1|uniprotkb:E9QNS6|uniprotkb:H9KUX9|uniprotkb:Q8VHP2|ensembl:ENSMUSP00000029824|ensembl:ENSMUSP00000143654	psi-mi:myo7a_mouse(display_long)|uniprotkb:Myo7a(gene name)|psi-mi:Myo7a(display_short)|uniprotkb:Myo7(gene name synonym)	psi-mi:rpe65_mouse(display_long)|uniprotkb:All-trans-retinyl-palmitate hydrolase(gene name synonym)|uniprotkb:Retinal pigment epithelium-specific 65 kDa protein(gene name synonym)|uniprotkb:Retinol isomerase(gene name synonym)|uniprotkb:Rpe65(gene name)|psi-mi:Rpe65(display_short)|uniprotkb:Meso-zeaxanthin isomerase(gene name synonym)|uniprotkb:Lutein isomerase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lopes et al. (2011)	imex:IM-25079|pubmed:21493626	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682605|imex:IM-25079-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239993.1|refseq:NP_001243010.1|refseq:NP_001243012.1|refseq:NP_032689.2|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007600"(sensory perception)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030507"(spectrin binding)|go:"GO:0031477"(myosin VII complex)|go:"GO:0031982"(vesicle)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042470"(melanosome)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1990435"(upper tip-link density)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|interpro:IPR038185|interpro:IPR041793|ensembl:ENSMUSG00000030761(gene)|ensembl:ENSMUST00000107128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001750"(photoreceptor outer segment)|rcsb pdb:3PVL|rcsb pdb:5WST|rcsb pdb:5WSU|rcsb pdb:5WSV|reactome:R-MMU-2453902|interpro:IPR041794	refseq:NP_084263.2|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0052884"(all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity)|go:"GO:0052885"(all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901827"(zeaxanthin biosynthetic process)|interpro:IPR004294(Carotenoid oxygenase)|reactome:R-MMU-2453902|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016853"(isomerase activity)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0044297"(cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050251"(retinol isomerase activity)|ensembl:ENSMUSG00000028174(gene)|ensembl:ENSMUST00000029824(transcript)|ensembl:ENSMUST00000196999(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003407"(neural retina development)|go:"GO:0004744"(retinal isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008286"(insulin receptor signaling pathway)	-	-	-	figure legend:6D-G|comment:"Colocalization of the two proteins was evident primarily in the central regions of the RPE (retinal pigmented epithelium)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-eye)|taxid:10090(Mouse EYE)	-	2016/03/08	2016/03/31	rogid:CWTUqQmbi4vwfU1RfwyO7qdpmjQ10090	rogid:vw0HBlEwa88X/ECLK/Bm4tfVW+010090	rigid:b0oE/xJqEOmA4vvhppZEOkLgiU0	false	-	variant:450-450	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)