#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21917	uniprotkb:P14416-2	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686321|ensembl:ENSP00000278597	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-2(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Short)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2B(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686319|imex:IM-25098-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000346454(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:1A|comment:"The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. All variants (4.2, 4.4 4.7) of DRD4 interacted with DRD2 short form."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:j1dfrSy0/RGqvm4klQ2aIz0VN4g9606	rigid:pI7Ag9HceGWyGSt8mdvi1+KzH6k	false	sufficient binding region:1-264,297-419|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21917	uniprotkb:P14416-1	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686345|imex:IM-25098-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:1C|comment:"The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described.  All variants of DRD4 tested (4.2, 4.4, 4.7) interacted with DRD2 long form, the lowest number of red clusters being seen for the longest variant of DRD4  (DRD4-7)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	sufficient binding region:1-264,297-419	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P21917	uniprotkb:P14416-1	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686372|imex:IM-25098-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:2|comment:"All variants of DRD4 interacted with DRD2 long form. The DRD4 longest (4-7)  variant shows lesser affinity, with reduced BRETmax and increased BRET50 values, compared to other variants."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	sufficient binding region:1-264,297-419|renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P21917	uniprotkb:P21917	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686387|imex:IM-25098-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	-	comment:mint	comment:mint	figure legend:Supp fig 2|comment:"All variants of DRD4 interacted with DRD2 long form. The DRD4 longest (4-7)  variant shows lesser affinity, with reduced BRETmax and increased BRET50 values, compared to other variants."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	-	sufficient binding region:1-264,297-419|renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P21917	uniprotkb:P14416-1	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686387|imex:IM-25098-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:Supp fig 2|comment:"All variants of DRD4 interacted with DRD2 long form. The DRD4 longest (4-7)  variant shows lesser affinity, with reduced BRETmax and increased BRET50 values, compared to other variants."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	-	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P21917	uniprotkb:P14416-1	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686400|imex:IM-25098-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:Supp fig 2i|comment:"All variants of DRD4 interacted with DRD2 long form. The DRD4 longest (4-7)  variant shows lesser affinity, with reduced BRETmax and increased BRET50 values, compared to other variants."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	sufficient binding region:1-264,297-419|renilla luciferase protein tag:c-c	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P21917	uniprotkb:P14416-1	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686400|imex:IM-25098-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	comment:mint	-	figure legend:Supp fig 2i|comment:"All variants of DRD4 interacted with DRD2 long form. The DRD4 longest (4-7)  variant shows lesser affinity, with reduced BRETmax and increased BRET50 values, compared to other variants."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:TtCYhZTWRc4AhKNgMMMSGnCFQXk	false	sufficient binding region:1-264,297-419|renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P21917	uniprotkb:P21917	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686430|imex:IM-25098-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	-	comment:mint	comment:mint	figure legend:Supplementary fig 3|comment:With regard to  homomer formation, D4.7R  showed the greatest affinity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rigid:zN6K/pJ67tQpbBES120A4H9Sr6w	false	sufficient binding region:1-264,297-419|yellow fluorescent protein tag:c-c	sufficient binding region:1-264,297-419|renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P14416-1	uniprotkb:P14416-1	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	intact:EBI-11686358|ensembl:ENSP00000354859|ensembl:ENSP00000442172	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:p14416-1(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:"D2(Long)"(isoform synonym)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:D2A(isoform synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Borroto-Escuela et al. (2011)	pubmed:21184734|imex:IM-25098	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11686477|imex:IM-25098-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|intact:EBI-2928178(isoform-parent)	-	-	-	figure legend:Supp figure 3|comment:|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/04/11	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	rigid:CRVkrHeAvCUc+jiNkNp4h0DnrsI	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)